mek-2_Cele MSS---------GKRRNPLGLSLPPTVNEQ------------------------------
Dsor1_Dmel MSKN-------K-LNLVLPPVNTEATVAAA-----TV-----------------------
MAP2K1_Mmus MPK----------KKPT--PIQLNPAP-DG------------------------------
MAP2K2_Mmus MLA---------RRKPVLPALTINPTIAEG------------------------------
MAP2K1_Hsap MPK----------KKPT--PIQLNPAP-DG------------------------------
MAP2K2_Hsap MLA---------RRKPVLPALTINPTIAEG------------------------------
MEK_Spur MSKT-------PGKNKNLLNLTIMPIQSES------------------------------
CC1G_02205_Ccin MTDLFVQASGPLRTKRNFKGLALSAEPPSPPPPG-------------------GKKRPPP
CC1G_03368_Ccin MATP-------IRKKRNFKALQLNVGDPQPASPSSTEPDPISIRTAPTAVGPRLKKKPPP
AqueK243_Aque MAEK--------RKKPKPSPLSLQSSVETL------------------------------
GK083_Glam MK-----------RRP--MALTLDASTASA------------------------------
* . :
mek-2_Cele --------------S-------------------------E-SGEATA-EEATATVPL-E
Dsor1_Dmel ------------A-PT----PP----------FKTPSGTDTHSLLGKP-K--TSIDAL-T
MAP2K1_Mmus --------------S------------------------AV-NGTSSA-E--TNLEAL-Q
MAP2K2_Mmus --------------P------------------------SP-TSEGAS-E--ANLVDL-Q
MAP2K1_Hsap --------------S------------------------AV-NGTSSA-E--TNLEAL-Q
MAP2K2_Hsap --------------P------------------------SP-TSEGAS-E--ANLVDL-Q
MEK_Spur --------------NG----GG----------QKAQSATTA-TEKSTS-G--IKVDAL-T
CC1G_02205_Ccin LGAAMALGG---G-PA----PL----GGLPLLDDLPGESPA-TG-----RHSAMQATL-S
CC1G_03368_Ccin MTLAAPKINSVGNVVASVDPPEDSGSGNFLVVSNGPNSAPL-TGTNINVRRNTLHATL-S
AqueK243_Aque --------------D------------------------SP-D--GSI-P--DKVPDPSK
GK083_Glam --------------DG---------------------GVED-VQKGGS-G--TQYIKI-T
mek-2_Cele EQLKKLGLTEPQTQRL--SEFLQVKEG---IKELSEDMLQTEGELGHGNGGVVNKCVHRK
Dsor1_Dmel ETLEGLDMGDTERKRI--KMFLSQKEK---IGELSDEDLEKLGELGSGNGGVVMKVRHTH
MAP2K1_Mmus KKLEELELDEQQRKRL--EAFLTQKQK---VGELKDDDFEKISELGAGNGGVVFKVSHKP
MAP2K2_Mmus KKLEELDLDEQQRKRL--EAFLTQKAK---VGELKDDDFERISELGAGNGGVVTKARHRP
MAP2K1_Hsap KKLEELELDEQQRKRL--EAFLTQKQK---VGELKDDDFEKISELGAGNGGVVFKVSHKP
MAP2K2_Hsap KKLEELELDEQQKKRL--EAFLTQKAK---VGELKDDDFERISELGAGNGGVVTKVQHRP
MEK_Spur KKLDNLDLDEPQRKRL--EEFMVDKRKIMEIGEFCNDDFEVLKELGAGNGGVVTKVKHKM
CC1G_02205_Ccin DKLAKLEL----------------KKR---IKDLKNDDLKKLSDLGQGNGGSVEKVEHLP
CC1G_03368_Ccin TTLANLDM---------------NKET---KLELRNEDLVDIHDLGQGNGGSVKKVEHTP
AqueK243_Aque PSAAPEPMTEQQALQM--KTFLGQKEEFLTHGELKDNQFERLSELGHGNGGVVLKVMHKP
GK083_Glam DSGSLNTLHESLQISAHGITKTSSPEH---ILNVQESDLEVVKPLGAGAFGTVNLVKVKT
: :. :. : ** * * *
mek-2_Cele TGVIMARKLVHLEIKPSVRQQIVKELAV--LHKCNSPFIVGFYGAFVDNNDI-SICMEYM
Dsor1_Dmel THLIMARKLIHLEVKPAIKKQILRELKV--LHECNFPHIVGFYGAFYSDGEI-SICMEYM
MAP2K1_Mmus SGLVMARKLIHLEIKPAIRNQIIRELQV--LHECNSPYIVGFYGAFYSDGEI-SICMEHM
MAP2K2_Mmus SGLIMARKLIHLEIKPAVRNQIIRELQV--LHECNSPYIVGFYGAFYSDGEI-SICMEHM
MAP2K1_Hsap SGLVMARKLIHLEIKPAIRNQIIRELQV--LHECNSPYIVGFYGAFYSDGEI-SICMEHM
MAP2K2_Hsap SGLIMARKLIHLEIKPAIRNQIIRELQV--LHECNSPYIVGFYGAFYSDGEI-SICMEHM
MEK_Spur SGMVMARKLIKLEIKPAIRNQIIRELKV--LHECNSPYIVGFFGAYYSDGEI-CICMENM
CC1G_02205_Ccin TGTIMAKKSVLIDAKSSVRKQILRELDI--MHECQSDYIISCFGSFLAEPNI-CICMEFM
CC1G_03368_Ccin TKMIMAKKTVLIDAKPSVRKQILRELHI--MHDCRSDYIISFYGAFLADNNI-CICMEFM
AqueK243_Aque SGIIMARKMILLDIKPTVRNQIMRELKV--LHDCNASYIVGFFGSFHVNNEI-SILMQHM
GK083_Glam TGQLCAMKEIRISDEEQTQKNIYREIKASISLSCN-PYMVKTYNIYSHPGSILHILLEFC
: : * * : :. : :::* :*: .*. .:: :. : .* * ::
mek-2_Cele DGLSLDIVLKKV--GRLPEKFVGRISVAVVRGLTYLKDEIKILHRDVKPSNMLVNSNGEI
Dsor1_Dmel DGGSLDLILKRA--GRIPESILGRITLAVLKGLSYLRDNHAIIHRDVKPSNILVNSSGEI
MAP2K1_Mmus DGGSLDQVLKKA--GRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEI
MAP2K2_Mmus DGGSLDQVLKEA--KRIPEDILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEI
MAP2K1_Hsap DGGSLDQVLKKA--GRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEI
MAP2K2_Hsap DGGSLDQVLKEA--KRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEI
MEK_Spur DGGSLDQVMKSAPKGRIPENILGKVTVAVLRGLIYLRDVHDIMHRDVKPSNILVNSRGEI
CC1G_02205_Ccin DKGSFDGIYKKL--GPLQVEVVGMVALSVLEGLTYLYDVHRIMHRDIKPSNILFNSQGQI
CC1G_03368_Ccin DKGSLDGIYKKI--GAIDIDIVGKIALAVLEGLTYLYDVHRIIHRDIKPSNILCNSRGQI
AqueK243_Aque DGGSLDLVLN-T--GRIPVDMIGQITVAVLNGLKYLRDTHHIIHRDVKPSNILVNSEGEI
GK083_Glam KYGSSQDMLKKLKTGKLTENALAVFIIDTLRGLAYLHDNCKIIHRDIKSANILIDEHGYC
. * : : : : . :. . : .:.** ** : *:***:*.:*:* :. *
mek-2_Cele KLCDFGVSGMLID----SMANSFVGTRSYMAPERLT--GSHYTISSDIWSFGLSLVELLI
Dsor1_Dmel KICDFGVSGQLID----SMANSFVGTRSYMSPERLQ--GTHYSVQSDIWSLGLSLVEMAI
MAP2K1_Mmus KLCDFGVSGQLID----SMANSFVGTRSYMSPERLQ--GTHYSVQSDIWSMGLSLVEMAV
MAP2K2_Mmus KLCDFGVSGQLID----SMANSFVGTRSYMSPERLQ--GTHYSVQSDIWSMGLSLVELAI
MAP2K1_Hsap KLCDFGVSGQLID----SMANSFVGTRSYMSPERLQ--GTHYSVQSDIWSMGLSLVEMAV
MAP2K2_Hsap KLCDFGVSGQLID----SMANSFVGTRSYMAPERLQ--GTHYSVQSDIWSMGLSLVELAV
MEK_Spur KLCDFGVSGQLID----SMANSFVGTRSYMSPERLQ--GTHYTVQSDIWSLGLSLVEMAI
CC1G_02205_Ccin KLCDFGVSGEVIN----SIANTFVGTSVYMSPERIQSHGDGYSVKSDVWSLGMSLVELAL
CC1G_03368_Ccin KICDFGVSGELIN----SIADTFVGTSTYMSPERIQ--GAQYTVKSDVWSLGISLIELAL
AqueK243_Aque KLCDFGVSGQLIN----SMANSFVGTRSYMAPERLQ--GEVYSVLSDIWSLGVSLIEMAI
GK083_Glam KLADFGVASSVLPNDDEAAMKTFVGSLSYMSPERIQ--NQPYSYVSDVWSMGLTYVELLT
*:.****:. :: : .:***: **:***: . *: **:**:*:: :*:
mek-2_Cele GRYPVPAPSQAEYATMFNVAENEIELADSLE-EPNY-----H------------------
Dsor1_Dmel GMYPIPPPNTATLESIFADNAEES--GQ--------------------------------
MAP2K1_Mmus GRYPIPPPDAKELELLFGCHV----EGDAAETPPRP-----R------------------
MAP2K2_Mmus GRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRP-----R------------------
MAP2K1_Hsap GRYPIPPPDAKELELMFGCQV----EGDAAETPPRP-----R------------------
MAP2K2_Hsap GRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRP-----R------------------
MEK_Spur GRYPIPAPDETALANLFGYELQA---GETKN-IRKT-----R------------------
CC1G_02205_Ccin GAFPFTDPPDDDDDDL-SDLEG--DS---SSPSPSDAQ-HQRTPTHRDSFLLSKKTAKRA
CC1G_03368_Ccin GRFPFSQSDSDESDDEFSDASD--YEGT-LSPQPAGSVSLADLP--------------PP
AqueK243_Aque GSYPIPAPPKEQLDEEMRNPP----AG---SLPPRR------------------------
GK083_Glam GSYPYDNV----------------------------------------------------
* :*
mek-2_Cele PP-----------SNPASMAIFEMLDYIVNGPPPTL-PK-RFFTDEVIGFVSKCLRKLPS
Dsor1_Dmel -----------PTDEPRAMAIFELLDYIVNEPPPKL-EH-KIFSTEFKDFVDICLKKQPD
MAP2K1_Mmus TPGRPLS-SY-GMDSRPPMAIFELLDYIVNEPPPKL-PS-GVFSLEFQDFVNKCLIKNPA
MAP2K2_Mmus PPGRPISVGH-GMDSRPAMAIFELLDYIVNEPPPKL-PS-GVFSSDFQEFVNKCLIKNPA
MAP2K1_Hsap TPGRPLS-SY-GMDSRPPMAIFELLDYIVNEPPPKL-PS-GVFSLEFQDFVNKCLIKNPA
MAP2K2_Hsap PPGRPVS-GH-GMDSRPAMAIFELLDYIVNEPPPKL-PN-GVFTPDFQEFVNKCLIKNPA
MEK_Spur -----VG-GV-FSDSPRPMAIFELLNYIVEEHPPRL-PS-RAFSEEFVDFVDVCLIKNPN
CC1G_02205_Ccin SKRRSKL-TYNPDGQLSTMSIFELIHQIVQEPSPRL-PS-DKFPADAVDLVDICLLKNPE
CC1G_03368_Ccin KPRRQKN-AN-GNGSTTKKDKRKSKGHIVNEPAPRLTPE-GRYPKAAESFIDACLLKDPD
AqueK243_Aque ---NPYA-SH-A--NAIRMPVFELLQMIFTDDPPRL-PD-EYFDDKFKSFVALCLQKDVK
GK083_Glam ------------------NSFWDAMNVIVNGAPPLL-KEDAGYSPGLCDLVNAMLEKDPS
. *. .* * : :: * *
mek-2_Cele ERATLKSLTA--DVFFTQYADHDDQGE----FAVFVKGTINLPK-----------LNP
Dsor1_Dmel ERADLKTLLS--HPWIRKAE--LEEVD----ISGWVCKTMDLP-P-STPK--RNTSPN
MAP2K1_Mmus ERADLKQLMV--HAFIKRSD--AEEVD----FAGWLCSTIGLNQP-STPT---HAASI
MAP2K2_Mmus ERADLKLLMN--HAFIKRSE--GEEVD----FAGWLCRTLRLKQP-STPT----RTAV
MAP2K1_Hsap ERADLKQLMV--HAFIKRSD--AEEVD----FAGWLCSTIGLNQP-STPT---HAAGV
MAP2K2_Hsap ERADLKMLTN--HTFIKRSE--VEEVD----FAGWLCKTLRLNQP-GTPT----RTAV
MEK_Spur ERADLKKLKV--HTFAIMSE--EARVD----FAGWICATMGMSPP-HNDTVKPLQTAV
CC1G_02205_Ccin ERQTPKALLVRNHPWIVAIR--ESDFD----IQAFA-------------------ATV
CC1G_03368_Ccin ARQTPKDLLK--HEWIENAR--MSSVD----VEAWA-------------------NTF
AqueK243_Aque KRGTLSALLE--HKFVEESS--KAKVD----FASWVKRTIDANALIGTP-----TSIT
GK083_Glam KRMTAAQLLK--LPFCKKYL--AKEEDLRKLFVKWVQDN-----------------LK
* * : : . :