MAP3K2_Mmus     WRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFN--------PESPETSKEVNALECEI
MAP3K3_Mmus     WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFD--------PDSPETSKEVSALECEI
MAP3K2_Hsap     WRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFD--------PDSPETSKEVNALECEI
MAP3K3_Hsap     WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFD--------PDSPETSKEVSALECEI
MEKK2_Spur      WQRGKLLGQGAFGVVYVCYDADTGRELAVKQVPTE--------NSNTDARKEVQSLKQEI
AqueK227_Aque   WSKGRLLGTGAFGQVFLCTDLDTQMDMAVKVVDIDHIENIKPSLDSLKMSKEVRSFETEV
                *  *:*** **** *::* * **  ::* * *  :         .. .  *** ::: *:

MAP3K2_Mmus     QLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQI
MAP3K3_Mmus     QLLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQI
MAP3K2_Hsap     QLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQI
MAP3K3_Hsap     QLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQI
MEKK2_Spur      ELLRNLQHPRIVQYFGCLEE--NGTLSIFMEFMSGGSVKDELRLYGPLTDTVTRKYTRQI
AqueK227_Aque   QLLKNIHHERVVGYYGTER--REGKLFIFMEYLAGGSIYQHLKNTGALSEALTRKYTRQI
                :**:*: * *:* *:*  .   :  * ****::.***: :.*:  *.*:: :********

MAP3K2_Mmus     LEGVHYLHSNMIVHRDIKGANILRDSTGNIKLGDFGASKRLQTICLSGTGMKSVTGTPYW
MAP3K3_Mmus     LEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYW
MAP3K2_Hsap     LEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYW
MAP3K3_Hsap     LEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYW
MEKK2_Spur      LEGTAYLHDHHIVHRDIKGANVLR-SSGNVKLADFGASTRLQTIHSHITGMKTVTGTPYW
AqueK227_Aque   LEGVAFLHGMKIVHRDIKGANILRDSNGNVKLADFGASKRLQTIR---SGIGSVHGTPYW
                ***  :**.  **********:** * **:**.*****.*****    :*: :* *****

MAP3K2_Mmus     MSPEVISGE-GYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHV
MAP3K3_Mmus     MSPEVISGE-GYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHI
MAP3K2_Hsap     MSPEVISGE-GYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHV
MAP3K3_Hsap     MSPEVISGE-GYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHI
MEKK2_Spur      MSPEIINGE-GYGRRADVWSIGCTVVEMLTTKPPWADYEAMAAIFKIATKETEPVLPQSV
AqueK227_Aque   MAPEVIKGDDPYTFKADIWSVGATVVEMLKCRPPWSDFEPTAAMFKIVMNDTKPDLPPHC
                *:**:*.*:  *  :**:**:..******. :***:::*. **:***. : *:* **

MAP3K2_Mmus     SDYTRDFLKRIFVEA-KLRPSAEELLRHMFV
MAP3K3_Mmus     SEHGRDFLRRIFVEA-RQRPSAEELLTHHFA
MAP3K2_Hsap     SDYTRDFLKRIFVEA-KLRPSADELLRHMFV
MAP3K3_Hsap     SEHGRDFLRRIFVEA-RQRPSAEELLTHHFA
MEKK2_Spur      SQDARNFLTLCFKKILADRPSAAELLRHNFV
AqueK227_Aque   SEQAHNFIELCFIKDKNERPSAMDLLSHSFC
                *:  ::*:   * :    **** :** * *