Protein (view, download) , Domain (view, download)
B0414.7_Cele    MSSNQYKRIKRC--KSMPTIDDETVG----------------------------------
Mekk1_Dmel      MSNRRRVR----------TIDYLALQQS-LRLQKTPAATTNAEEQVAREEENGNGHHSTV
MAP3K4_Mmus     MRDAIAEP-----------V------PP-PALADTPAAAM--------------------
MAP3K4_Hsap     MREAAAAL-----------V------PP-PAFAVTPAAAM--------------------
MEKK4_Spur      T-----------------------------------------------------------
AqueK228_Aque   MAEGEGEEESYFPDHVVEGIDEEASGETDDKLSSLPVDSTSEEE----EEESG-------


B0414.7_Cele    -------------------------------------EAVR----------K--------
Mekk1_Dmel      TAETPPTPPIPPIPPIRLRREQSVEE-DVARVEYRVKQTPSRPVQMTRNRIGALEEDLPP
MAP3K4_Mmus     -EELRPAPPPQPE-P-------DPECCPAARQECMLGESAR----------KSMESDPED
MAP3K4_Hsap     -EEPPPPPPPPPP-PPEPETESEPECCLAARQEGTLGDSAC----------KSPESDLED
MEKK4_Spur      ------------------------------------------------------------
AqueK228_Aque   ------------------------------------------------------------


B0414.7_Cele    -----------------------------------------T------------------
Mekk1_Dmel      EDELAAHYEAFGTTPPRTRLKIKNRDWER-KQKVVNVTASADL------------PASVG
MAP3K4_Mmus     FSDETNTETLYGTSPPSTPRQMKRLSAKH-QRNSAGR------------------PASRS
MAP3K4_Hsap     FSDETNTENLYGTSPPSTPRQMKRMSTKH-QRNNVGR------------------PASRS
MEKK4_Spur      -----------------TPTQQQQLVRLR-QKNSLNR------------------VVTRN
AqueK228_Aque   ----SYDEGLTGSTPPSNSRL-HKMSRRGHKYKTSRKIMSSSSENQSPYRVKDITRAKSA


B0414.7_Cele    IMKKVATRMNTSK-RE----Y---MGRRSLGVAT---VS---TKIKRKKSKTERDRDMYD
Mekk1_Dmel      GTPKKTRTARSRV-LRRNTMDCALLNE--MFVNDESK--RTDKRLQSLLRDSEREMKNSL
MAP3K4_Mmus     NLKEKMNTPSQSP-HKD-------LGKGVETVEEYSY--KQEKKIRATLRTTERDHKKNA
MAP3K4_Hsap     NLKEKMNAPNQPP-HKD-------TGKTVENVEEYSY--KQEKKIRAALRTTERDRKKNV
MEKK4_Spur      SLKMEMEALIQKI-IQEIIQDLMNFGQSAQNTKQKLH--QRKMRSIHLDRTSEREFKQKA
AqueK228_Aque   DWSESVSTPSDSLIHK----RYSLTGEGEEISSELCQVSLCDKKRKEKSRQMERNVKSAI
                               .         ..                :        **: .

B0414.7_Cele    DMYDDEGYAASPTSSSSCTYRCIPILERSNRNSQNYLPSAESSSSDSNDRVISHPNHRPI
Mekk1_Dmel      --ATTA-VAA--PRGNS-------------------FHETAHPLESLDQ-IMPLNS-EAM
MAP3K4_Mmus     --QCSF-MLD--SVAGS-------------------LPKKSIPDVDLNKPYLSLGCSNAK
MAP3K4_Hsap     --QCSF-MLD--SVGGS-------------------LPKKSIPDVDLNKPYLSLGCSNAK
MEKK4_Spur      --I---------TYDGS-------------------ELHVPLTPTHVFRPFDSLPSPNLK
AqueK228_Aque   --NHPE-MST--SPSSTANYTN----------TEPPRPSFSSPS-PSNPPYPVLAHSHSS
                            .  .:                         .              .

B0414.7_Cele    LLY---------------------------------------------------------
Mekk1_Dmel      API---P------LR----------------IA--SKVVESCNRYRCVSSRPIGYR----
MAP3K4_Mmus     LPV---------------------------------------------------------
MAP3K4_Hsap     LPV---------------------------------------------------------
MEKK4_Spur      ID----------------------------------------------------------
AqueK228_Aque   PPPSSHPPPSHPPSHPPPSHSPLPPPSSPPALPPPSPSHPPPPSYSPSSPSPLSYNVPPP


B0414.7_Cele    -STALS------------------------------------------------------
Mekk1_Dmel      -SSAPP------------------------------------------------------
MAP3K4_Mmus     -SMPMP------------------------------------------------------
MAP3K4_Hsap     -SVPMP------------------------------------------------------
MEKK4_Spur      ------------------------------------------------------------
AqueK228_Aque   SSYPLPPPNQSPSVDTSLYPPPIDPHYLPTGDSPVLYPLPHLSPETYSSKLSSSPYPSKL


B0414.7_Cele    ---------------------------------------MA---------P-QQNLSVES
Mekk1_Dmel      ---------------------------------------LA---------F-AAQLPAGM
MAP3K4_Mmus     ---------------------------------------IA---------R---------
MAP3K4_Hsap     ---------------------------------------IA---------R---------
MEKK4_Spur      ------------------------------------------------------------
AqueK228_Aque   GKVGSPNPMLSPGIPSHMRPSFSYTTDNIIPYYSLSSLSHAPPGVSIERSQSDAQLSLTL


B0414.7_Cele    -LSDALDELEGADRSKLHMEITQFLK------KADGEKS-------KQIQMSQRLMNCPQ
Mekk1_Dmel      LRSDGRATPGLGKRKDFHETFANLIKLGSVDRQDA-KLS-------QEE---HTW-----
MAP3K4_Mmus     TARQTSRTDCPADRLKFFETLRLLLKLTSVSKKKDREQR-------GQENTAAFW-----
MAP3K4_Hsap     PARQTSRTDCPADRLKFFETLRLLLKLTSVSKKKDREQR-------GQENTSGFW-----
MEKK4_Spur      ----------SSERVDFHRTFSALIRMGSAKKENSQEITQRIRR--QDGMTQDVF-----
AqueK228_Aque   SSSSSHSMHCPPDRKQFYRNFSKRLKMIAKRQQQSSTQPGHIPRQHSEDLNAKNP-----
                            .* .:.  :   ::      :              :

B0414.7_Cele    FGQTMRLIVEESEHTRYTFENILWLILKSYFSTTSTGRDVMIGKSEWIAEDEKIVKARKQ
Mekk1_Dmel      ---------------QTELKDLIWLELQAWQADRTVE-----------QQDKYLFEARQG
MAP3K4_Mmus     ---------------FNRSNELIWLELQAWHAGRTIN-----------DQDLFLYTARQA
MAP3K4_Hsap     ---------------LNRSNELIWLELQAWHAGRTIN-----------DQDFFLYTARQA
MEKK4_Spur      ---------------QMQWNEILWLELTAYHNELSIT-----------DQDLHLINARKK
AqueK228_Aque   ---------------FGPDNEQLRMELRAYLNNHTLE-----------DQEEADYQLQCE
                                   :: : : * ::    :              ::      :

B0414.7_Cele    YMMVMDMIKEFKFEVGKND---KD--D---------------------------------
Mekk1_Dmel      VSDLLTHIINYKFQPRYRREPSLISLDSGTH-----------------------------
MAP3K4_Mmus     IPDIINEILTFKVNYGSIA---FSSNGAGFN-----------------------------
MAP3K4_Hsap     IPDIINEILTFKVDYGSFA---FVRDRAGFN-----------------------------
MEKK4_Spur      VAEVFDEIMKFKYQSGRSS----SSSGSSSH-----------------------------
AqueK228_Aque   SGSILYRIIHYSFSSDSTLSGY-FR-GLSESAKSLPAQLNELKRGSLRRRKMMPLQENKE
                   ::  *  :. .

B0414.7_Cele    ----------------SPFESLN-----------------------RR------------
Mekk1_Dmel      --------SDSNSNA-----S-------------------SPLPSKM-------CQGC--
MAP3K4_Mmus     --------GPLVE------------------------GQCRTPQETN-------RVG---
MAP3K4_Hsap     --------GTSVE------------------------GQCKATPGTK-------IVG---
MEKK4_Spur      --------GDSVETS-----QMN---------GNACDTCCNPNPVQRRHPSVSDNGFCMP
AqueK228_Aque   EEEEVEEKGEEEEGDETPLTSINNPSVRWEDGGGETEGEDEYGPQTL-IQQESNDSDALS


B0414.7_Cele    M-EFSP-DYCENLRDARKRVSDVLDKYETLVDLFPNQNALWKVVELDRGEAEKKLLEGRM
Mekk1_Dmel      -MSLYCKDCMDHQKLALREVEGMLTRLEAAEALYPSSQAMGALH----PIYKSQSFVGRI
MAP3K4_Mmus     -CSSY-HEHLQRQRVSFEQVKRIMELLEYMEALYPSLQALQKDY----ERYAAKDFEDRV
MAP3K4_Hsap     -YSTH-HEHLQRQRVSFEQVKRIMELLEYIEALYPSLQALQKDY----EKYAAKDFQDRV
MEKK4_Spur      LSAAL-NAYITDTSEAWYKVHALLEDLEKVQLLYPNSKALQNDC----VELSTPEFTKRL
AqueK228_Aque   VEFSFDNFLSEEQLQAIEDVDSLLSDLERVELLYASSKRVVD------KQYQQLPFKRRR
                               :   *  ::   *    *:.. : :               :  *

B0414.7_Cele    TSMRVWLNTLDDLTDKFKALGVLFEIETMPDAE---------------------------
Mekk1_Dmel      KSMCLWYNITKQNKLKLSILGKILARLQDEKFSWPVCTSSYIATDSGSSSA----SGVEN
MAP3K4_Mmus     QALCLWLNITKDLNQKLRIMGTVLGIKNLSDIGWPVFEIPSPRPSKGYEPE----DEVED
MAP3K4_Hsap     QALCLWLNITKDLNQKLRIMGTVLGIKNLSDIGWPVFEIPSPRPSKGNEPE----YEGDD
MEKK4_Spur      ETLCLWMNITNDISHKFELTSQILGVVDLEGLWWPYLDLPGYCVENPFQSESCIESEMDD
AqueK228_Aque   AALVLWLKITEGLAKHLVNLSKWFGVIVNP------------------------VRRSED
                 :: :* :  .    ::   .  :

B0414.7_Cele    -EC---------------------------------------------------------
Mekk1_Dmel      DDSAVNSMDSSKPPSMAGSASRKGVTPCHKVQFMLNDATHVPGETSSSNESTSTEVSQ-W
MAP3K4_Mmus     TEVELRELESGTEESDEEPT------PSPRV----------PE----LRLSTDAILDS-R
MAP3K4_Hsap     TEGELKELESSTDESEEEQI------SDPRV----------PE----IRQPIDNSFDI-Q
MEKK4_Spur      EVKPMNEFDDSTPNLEGTEQP-----ALTST----------PQ----YRSPRT-------
AqueK228_Aque   DLIPCN-VEPGTPSRQG-SGGSGGNPPLPTPPLFTSDISVDPEESLS-LSALSFASSFFQ


B0414.7_Cele    -----------------------WFRPLDENNKIFALE-DVRAVFLEYVKNSLNLKGMKK
Mekk1_Dmel      SSEC---SHSHMRKGSMHDINIFSVEPLGTCSSNGTGE-QSTGLYRKFIENVLKSRGLAK
MAP3K4_Mmus     SQGC---VSRKLERLESEEDSIGWGTAD--CGPEASRH-CLTSIYRPFVDKALKQMGLRK
MAP3K4_Hsap     SRDC---ISKKLERLESEDDSLGWGAPDWSTEAGFSRH-CLTSIYRPFVDKALKQMGLRK
MEKK4_Spur      ---D---ESPRTNRIFSE------------CHFSFDYD-SSTSIYRPFVDRSLKHQGLRK
AqueK228_Aque   TQNSISSSRGTLQRLFSSRN-IY----------SIDEERVSSKGYSRFVDQVLKRKSLDW
                                                     .      :  ::.. *:  .:

B0414.7_Cele    VLSRVEKIIELTLVKTAILMQKPPT----SYAAA-----------TA-----SNGPSF--
Mekk1_Dmel      SLAFLHKLHNVALYKAHIALEKPGA---EDF-DYE-----SDAESIE-----EDVPRL--
MAP3K4_Mmus     LILRLHKLMNGSLQRARVALVKD--DRPVEFSDFPGPMWGS---D---------YVQL--
MAP3K4_Hsap     LILRLHKLMDGSLQRARIALVKN--DRPVEFSEFPDPMWGS---D---------YVQL--
MEKK4_Spur      MTKRLDKMLGHTMRKIRLALEKMKLDTLIEFMDHKCPMWYSLQSDIDLTLKPSGTPQF--
AqueK228_Aque   LIEKLIKSIKPILKTAKEAMKQLEV--EEDKSEDSDNE--DNSSFLE-RLSPFRLIHFGG
                    : *     :      : :       .                           :

B0414.7_Cele    P-FSQTMKDRY--GDMIEWRFCNSTSISLNLPPLNNLFFFLVAVPMQLVVHWLEIRAATE
Mekk1_Dmel      --DPEISREQV--VELRTYGYWSEEAQSINLPSYIPTFVFLSGIPLQFMHEFLRMRLETR
MAP3K4_Mmus     SGTP-PSSEQKC--S---AVSW-EELRAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQR
MAP3K4_Hsap     SRTP-PSSEEKC--S---AVSW-EELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQR
MEKK4_Spur      FETPSPSTEQTHGTQLQSHGAWSKEFQDMSLPSFMPAYLFLVRIPLDVMHECLRFRLEHK
AqueK228_Aque   VSTPGPAQMKRA--SSVAPKCWNDEFQDMNLPPFAEQYLRLTRVPLDIMQESMRLRTEVN
                   .     .    .        .    :.**.    :. *  : ::.: . :.:*   .

B0414.7_Cele    PPDSCLLDELTFDAMITDSRDCVEEAVRIKKNYLTILQS-MCSKCAMPG-FL-YPL-KYN
Mekk1_Dmel      PV-RP--NPLSLEQLMKELREGLTLALTHRERYQRHITTALVENEAEL-GSYISILNHYD
MAP3K4_Mmus     PAGEP--SLLSIKQLVRECKEVLKGGLLMKQYYQFMLQE-VLGG----LEKTDCNMDAFE
MAP3K4_Hsap     PAGEP--SLLSIKQLVRECKEVLKGGLLMKQYYQFMLQE-VLED----LEKPDCNIDAFE
MEKK4_Spur      PEADP--SRHSIQQLIREYKEVIGACTHVKQYYHDMVSA-VTLGDVRAQEHVDNDIDDYE
AqueK228_Aque   K--SP--TPYSVGMLVQESCVTLKKAVRVRKFYRSKVRL-LIANDPSGAELVDNDMACYE
                          :.  :: :    :      :: *   :   :              :  ::

B0414.7_Cele    TYVLDVFKKYIHYVKCWSNC-DSVRKDPPLLFSRLEMEWSSAVQCAKSVKSALELLCTTY
Mekk1_Dmel      ATVRKTFELYLEYIDQLV--LVAVPEG--NQKSVLEKEWMFTKLISPMIKGMHTLASQKF
MAP3K4_Mmus     EDLQKMLMVYFDYMRSWIQMLQQLPQASHSLKNLLEEEWNFTKEITHYIRGGEAQAGKLF
MAP3K4_Hsap     EDLHKMLMVYFDYMRSWIQMLQQLPQASHSLKNLLEEEWNFTKEITHYIRGGEAQAGKLF
MEKK4_Spur      NDLQEMLQVYFEYVHSRMLMLQKLPQASVSLKNVLEEEWAFAKEMCPCIRGGEAQAGKRF
AqueK228_Aque   KHLQSVLQLYFSYVERLV-------QVSSTDRNLLESQWEITKDICNDISTGEIEAGLRF
                  : . :  *: *:           :      . ** :*  :      :          :

B0414.7_Cele    CDIVESLIREVVEVYADDQIEDIKNRYVYNTDSENEDEEDDEDMITIGSPKKPLVELKAK
Mekk1_Dmel      CGIISKLLRSISER-LVKRTVELDQQIDG-TADTDDNEEVKWQLLTICRE----------
MAP3K4_Mmus     CDIAGMLLKSTGSF-LESGLQESCAELWTSADDNGAADELRRSVIEISRA----------
MAP3K4_Hsap     CDIAGMLLKSTGSF-LEFGLQESCAEFWTSADDSSASDEIRRSVIEISRA----------
MEKK4_Spur      CIMASNLLHSTAEY-LEQRVDDECAHLQD---SHSGGGAIKRIITGSCRK----------
AqueK228_Aque   CSMASQLIENLEVD-LKSRIDDCCDKLHEHSNNLDDPDERKHAFIELCRE----------
                * :   *:..           :   .      . .        .

B0414.7_Cele    HRFMLELNSLTREVKERELRIFSLLRITLNDSHDAVGYELRSGVD---------------
Mekk1_Dmel      ------TQSLLTVERERSIKVLFFAKTFCRDVETT-DFHREHYEHDVA------------
MAP3K4_Mmus     ------LKELFHEARERASKALGFAKMLRKDLEIAAEFVLSASARELLDALKAKQYVKVQ
MAP3K4_Hsap     ------LKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRDLLDVLKSKQYVKVQ
MEKK4_Spur      ------FRELFHEVRDRAAKALGFAKMLTKDLEIASEFTLNTSLGDLMNNLKLSSHVKVK
AqueK228_Aque   ------FKSIIQKSRESSMKGLGFSKTLMTDLEIAAEFSITCTRE-------------VI
                       ..:    ::   : : : :    * . :  :

B0414.7_Cele    --RA-QMFHEMVPDF------CLIQLTMA---------SDEQGDVNDDDDHVNLKIVLFV
Mekk1_Dmel      -----------------NQ-----------------------------------------
MAP3K4_Mmus     IPG-LENLHVFVPDSLAEEKKIILQLLNAATGKDC---------SKDP-DDVFM------
MAP3K4_Hsap     IPG-LENLQMFVPDTLAEEKSIILQLLNAAAGKDC---------SKDS-DDVLI------
MEKK4_Spur      MLGIFPGYQVFVPQHLHQNTPQILHLLNDLCGREDFL------STSDPSSPDAS------
AqueK228_Aque   IPQ-YHACMLFVPHNIADNQQEIQKLLGVSFGHPVVEVGGPGGHSHR-HSVHYN------


B0414.7_Cele    YRTSVDKAYVETCMLAISEGRKIDDGCIVIVPD--KDHKL---RKHWKGRVVKIVIDEET
Mekk1_Dmel      ------------------------------------------------------------
MAP3K4_Mmus     ------------------------DAFLLLTKHGDRARDSEDGWGTWEARAVKIVPQVET
MAP3K4_Hsap     ------------------------DAYLLLTKHGDRARDSEDSWGTWEAQPVKVVPQVET
MEKK4_Spur      ------------------------DGYLLLVKD--EEREAE---SKWGGDTTSVNPNIET
AqueK228_Aque   ------------------------DSYLLFVKFSA-AGDS---IPIWTGEKINLTLSAET


B0414.7_Cele    RICYRWLRDDIILCLANGSIRADMEHKYKNFLKCI-------SPACSSNFLITSRIQQLT
Mekk1_Dmel      -----------------------------------------QHDFIC--SDVKAAFKLLQ
MAP3K4_Mmus     VDTLRSMQVDNLLLVVMESAHLV--LQRKAFQQSIEGLMTVRHEQTSSQPIIAKGLQQLK
MAP3K4_Hsap     VDTLRSMQVDNLLLVVMQSAHLT--IQRKAFQQSIEGLMTLCQEQTSSQPVIAKALQQLK
MEKK4_Spur      TIATSDIQVESILLVVNHSSQLT--TQRKAFQRAMGSTVTLINEQTSSHNTIAEALGELK
AqueK228_Aque   IVSISEMQVEGIKLVVNDSSRLE--RNQMSFLRCMGTNVEITNKRTSSHHSVAERINELK
                                                              .    :   :  *

B0414.7_Cele    EESLLPHLDEERKRIGILLEKTEIRL--EP--KEEQSKEKSALSSLGFKLEKHFLVAFQI
Mekk1_Dmel      QDVL--QV---RNKLTAIIEGVQKRCCLSNMRDLDEQDKQAVLSRTREILHQGYKFGFEY
MAP3K4_Mmus     NDAL--EL---CNRISDAIDRVDHMFTLEFDAEVEESESATLQQYYREAMIQGYNFGFEY
MAP3K4_Hsap     NDAL--EL---CNRISNAIDRVDHMFTSEFDAEVDESESVTLQQYYREAMIQGYNFGFEY
MEKK4_Spur      DNAL--TL---CETLVAAICQVEENLILDSMVDVEESERNNILKYSRDGMCQCFSVGFEY
AqueK228_Aque   LVLC--HF---GHTIIEIVERVSGNLSLE-----EISEREDLLQQYLPTMHACYNFGFE-
                       .    . :   :  ..     .     : ..     .     :   : ..*:

B0414.7_Cele    HRDVAKVVSDSF-MD---------GLGNEMVEKALALTRQWMQYVEVKSTIPSPTLPMWA
Mekk1_Dmel      HKDVIRLFEQKI-MDQKDSGAHTVDLAL----GIIAYAKMWMHFVMERCERGRGMRPRWA
MAP3K4_Mmus     HKEVVRLMSGEF-RQ---------KIGD----KYISFAQKWMNYVLTKCESGRGTRPRWA
MAP3K4_Hsap     HKEVVRLMSGEF-RQ---------KIGD----KYISFARKWMNYVLTKCESGRGTRPRWA
MEKK4_Spur      HKEVSRLLSNK---R---------GLGE----SILKLAQQWMNFALNKWERGKGRRPRWA
AqueK228_Aque   --DLSRLFGDEYIHQ---------KLGA----EMLHFSQQWIVFATTKCIRGHGKQPRWA
                  :: ::.  .              :.       :  :: *: :.  :        * **

B0414.7_Cele    SPGFTFLQYITEPRWSNPEIMTNDQFQEFNDLVKLFEAKVIKSSSN--------------
Mekk1_Dmel      SQGLEFLILACDPQIT--QHLDDDEFEALKQQMDRCISHVIGITSEPEK---VAKKKASP
MAP3K4_Mmus     TQGFDFLQ-AIEPAFI--SALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSP
MAP3K4_Hsap     TQGFDFLQ-AIEPAFI--SALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSP
MEKK4_Spur      NQGLEFLILACEPRNV--AHLIEEEFQDLQRLMKQCIEHVIGKTTP-QSPD---------
AqueK228_Aque   VLGLEFILLSCSPRML--STISPSRYENVKKQMERCLDHVIGEVP---------------
                  *: *:    .*       :  . :  .:  :.    :**

B0414.7_Cele    ----------------IGTPGNTGTPMQR-NTRSTSSK----------------------
Mekk1_Dmel      RT-------------------------RKTSSPATSRSRTPTRTPMSAGM-VL-------
MAP3K4_Mmus     RPVKVPRCHSDPPNPHLIIPTPEGFSTRSVPSDARTHGNSVAAAAAVAAAATTAAGRPGP
MAP3K4_Hsap     RPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAA-AA-AAAAAAVAASRPSP
MEKK4_Spur      ---------------RMGSPDFLGGKM--MRSRSSKSIRSSSSS----------------
AqueK228_Aque   ------LLSSNTFSEAYTSPQYIGGWTRQ-KSRMKKSGNSLSRTPVIEERDE--------
                                               :   .

B0414.7_Cele    ----------------T-------------------------------------------
Mekk1_Dmel      -----N--------PNTPPLQSPPY-NKLLHPQFSLKEDV-SGTSYSPVDSSDYVDTPC-
MAP3K4_Mmus     GGGDSVPAKPVNTAPDTRGSSVPEN-DRLASIAAELQFRSL-SRHSSPTEERDEPAYPRS
MAP3K4_Hsap     SGGDSVLPKSISSAHDTRGSSVPEN-DRLASIAAELQFRSL-SRHSSPTEERDEPAYPRG
MEKK4_Spur      ---------------DQ-SITSPTSMGDLRRIPSVERFLSITSSNTSPTEDRLDPGFPRY
AqueK228_Aque   ----------FDAGADSSGIDSPVLSGD-ISFAASEPLYSL-P--KSPPTTMLIPKMDRG


B0414.7_Cele    -----SSSSME-N-------------------------------HKRTRKENQMLKLQEL
Mekk1_Dmel      ----QRS-------ANGELRLLVPQTPPTPASPGKSSLESTPLA---LRQERVRDAVNRL
MAP3K4_Mmus     DSSGSTR-------RSWELRTLISQTKDSAS--------------KQGPIEAIQKSVRLF
MAP3K4_Hsap     DSSGSTR-------RSWELRTLISQSKDTAS--------------KLGPIEAIQKSVRLF
MEKK4_Spur      DKRASPNPGCSSPMPSNHVFRAVSRDPDYAPRGANNGTPTGPAGQRRDRRSHKVQALERL
AqueK228_Aque   DSVAVYSSPLS-HTPSQEV--------------------PPPVNQRQIKFKTIEEECKRI
                                                                  .      . :

B0414.7_Cele    EDKRNRIDYDNLQIGKVITDDNR--RNFVLATDKKITTKAPFQWALLDHIASGSFGS-VH
Mekk1_Dmel      DMDLEDGLRERRLIGQVKSLNS---SDK-VHIR---ARSVHFRWHRGIKIGQGRFGK-VY
MAP3K4_Mmus     EERRYREMRRKNIIGQVCDTPKS--YDNVMHVG---LRKVTFKWQRGNKIGEGQYGK-VY
MAP3K4_Hsap     EEKRYREMRRKNIIGQVCDTPKS--YDNVMHVG---LRKVTFKWQRGNKIGEGQYGK-VY
MEKK4_Spur      EQARNDKLQRESMIGRISDQHTS--H-EVVNIN---CKKVTFRWQRGFKIGEGQFGTTVY
AqueK228_Aque   DKVRDDELRVKRIIGRVTERSGASVFELSRLTD---LKQSHFTWRRGRKLGEGQFGV-VY
                :         .  **::                     .  * *    ::..* :*  *:

B0414.7_Cele    RAMDIDSHRVIAAKVMRIQRENHKAIE---SEINIFRQLIHENLVKYYGVQVEDSDV---
Mekk1_Dmel      TAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHKNLVRYYGIEVHREEL---
MAP3K4_Mmus     TCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEM---
MAP3K4_Hsap     TCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEM---
MEKK4_Spur      SCINMNTGETLAVKEMRFQRNDHQVIRDIADEIKNLEGIRHPNLVRYYGVEIHRVRYPHS
AqueK228_Aque   ECINLDRGEVQAVKMISLKEKSHNTVRDILSEVGVFQSINHKNIVHFHGVEIHDTDL---
                 .:. :  .  * * : ::  . ..:.   .*:  :. : * *:*::.*:::.

B0414.7_Cele    -IIFMEYCSQ--GTLERICHG--KMDLKMVRQYTNSLLRAVQYLHSHKIIHRDIKPANIF
Mekk1_Dmel      -LIFMELCSE--GTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIF
MAP3K4_Mmus     -YIFMEYCDE--GTLEEVSRL--GLQEHVIRLYTKQITVAINVLHEHGIVHRDIKGANIF
MAP3K4_Hsap     -YIFMEYCDE--GTLEEVSRL--GLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIF
MEKK4_Spur      VIGVLNHHSETRTTLKFVCHL--E--------------------HEISLIIKNMNDL---
AqueK228_Aque   -YLFMEYCNQ--GTLWGAAKQ--GLEERMIRLYTRDLLRAVDVLHDRGIVHRDIKGANIF
                   .::  .:   **    .                        *.  :: ::::

B0414.7_Cele    LDK-CTVLKLGDFGCSSRLVE-SSTVYGEFQTTAG---TPQFMAPEIYSYGEKDETTGSY
Mekk1_Dmel      LVDGSNSLKLGDFGSAVKIQA-HTTVPGELQGYVG---TQAYMAPEVFTKTN-------S
MAP3K4_Mmus     LTS-SGLIKLGDFGCSVKLKNNAQTMPGEVNSTLG---TAAYMAPEVITRAK-------G
MAP3K4_Hsap     LTS-SGLIKLGDFGCSVKLKNNAQTMPGEVNSTLG---TAAYMAPEVITRAK-------G
MEKK4_Spur      ---------------------NQHFMPYKIYSKMLSAYHNSYMAPEVINQTGK-----DK
AqueK228_Aque   LSD-D-SVKLGDFGLSVQLHNVNKTAPQEIKHQRG---TIPYMSPEVVLMQ---------
                                            :.           :*:**:

B0414.7_Cele    SGYGRSVDIWALGATVVNMMTGKVPFEG-QTR-HQIAFALCFRKQKPTYP-DIADKRPDV
Mekk1_Dmel      DGHGRAADIWSVGCVVVEMASGKRPWAQFDSN-FQIMFKVG-MGEKPQAP-ES--LSQEG
MAP3K4_Mmus     EGHGRAADIWSLGCVVIEMVTGKRPWHEYEHN-FQIMYKVG-MGHKPPIP-ER--LSPEG
MAP3K4_Hsap     EGHGRAADIWSLGCVVIEMVTGKRPWHEYEHN-FQIMYKVG-MGHKPPIP-ER--LSPEG
MEKK4_Spur      PGYGRQADIWSLGCVVIEMVTGKRPWHDYDHE-FTIMYKVG-EGAVPHIP-DA--MNPEG
AqueK228_Aque   -DMGRPMDIWAVGCVVVEMFTSKRPWIELEDNAMAIMFQLG-NKKSPSYPAEK--MNDEM
                 . **  ***::*..*::* :.* *:   : .   * : :      *  * :      :

B0414.7_Cele    KRFFDNCFEFLPNDRPTAAELLQTTFANVNITDENHIPDYQSQSSKDKSSPSSFFLV
Mekk1_Dmel      HDFIDHCLQHDPKRRLTAVELLEHNFCKYGR-DECSSEQLQMQVRGSFRRNVATSSS
MAP3K4_Mmus     KAFLSHCLESDPKIRWTASQLLDHAFVKVCT-----------------------DEE
MAP3K4_Hsap     KDFLSHCLESDPKMRWTASQLLDHSFVKVCT-----------------------DEE
MEKK4_Spur      KEFLSNCLKHDCTKRWTANKLLDHPFLKVK-------------------------YV
AqueK228_Aque   IDFLDLCFETDPKQRAVASKLLSHSFVKVMD--S------------------CDDNS
                  *:. *::   . * .* :**.  * :