MAPKAPK3_Hsap MDGETAEEQ------------------------GG-------------PV--PP------
MAPKAPK2_Hsap MLSNSQGQS------------------------PP------------VPFPAPA------
MAPk-Ak2_Dmel MLSLQN------------------------------------------------------
MAPKAPK3_Mmus MDGETAGEK------------------------GS-------------LV--PP------
MAPKAPK2_Mmus MLSGSPGQT------------------------PP------------APFPSPP------
K08F8.1_Cele MMFEYEEDEDPMEQQKHEEFKHHSTDHSGSPQENPFRFSYDTGKRAASMFVTPSSEDLIA
C44C8.6_Cele MQIRVLCVSTA--------------------DFSP------------KNLLGPSSLIF--
MAPKAPK2_Spur MI----------------------------------------------------------
MAPKAPK5a_Spur MDFRTG------------------------------------------------------
AqueK073_Aque MSSHPLTGKA-----------------------PP------------D-FAA--------
*
MAPKAPK3_Hsap ------------------P-V-------------------------APGG---------P
MAPKAPK2_Hsap ------------------PPP-------------------------QPPT---------P
MAPk-Ak2_Dmel ------------------------------------------------------------
MAPKAPK3_Mmus ------------------P-G-------------------------ALGG---------S
MAPKAPK2_Mmus ------------------P-P-------------------------A-------------
K08F8.1_Cele YGTKHL---------LDSPTAVQRSLVLNATTSLNIDCDLSSDDDLSPTT------QRKI
C44C8.6_Cele --RVFFGGFLYANVKLEAPEA-------------------------QKSTRGSFFSRIGC
MAPKAPK2_Spur ------------------------------------------------------------
MAPKAPK5a_Spur ------------------------------------------------------------
AqueK073_Aque ------------------------------------------------------------
MAPKAPK3_Hsap --GLGG-----A----P-----------GGRREPKKYAVTDDYQLS-KQVLGLGVNGKVL
MAPKAPK2_Hsap --ALPHPPAQPP----PPPPQQFPQFHVKSGLQIKKNAIIDDYKVT-SQVLGLGINGKVL
MAPk-Ak2_Dmel ------------------------------QRQPKTTPLTDDYVTS-NTVLGYGINGKVV
MAPKAPK3_Mmus --ALGGAP---A----P-----------GVRREPKKYAVTDDYQLS-KQVLGLGVNGKVL
MAPKAPK2_Mmus -------PAQPP----PP----FPQFHVKSGLQIRKNAITDDYKVT-SQVLGLGINGKVL
K08F8.1_Cele CFCASQNPAETQEQGLRPAKS-TL----AISFPCHQHQITEDYTIS-AEIIGIGESGKVM
C44C8.6_Cele CLSTKSSPAEKI----KPP---------DEIMAFHEYPVTQDYRIS-RKVLGVGINGKVV
MAPKAPK2_Spur ------------------------------------------------------------
MAPKAPK5a_Spur --------------------------------FFETVSILEDYTIDWTQKLGTGINGPVR
AqueK073_Aque -----HVPSA------------------QKPLIPKKHAITGDYTIL-TRSLGVGVNGKVL
MAPKAPK3_Hsap ECFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILDVYENMHH------GKRC
MAPKAPK2_Hsap QIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYA------GRKC
MAPk-Ak2_Dmel QCTHRRTQQNYALKVLLDSERARREVDLHWRVSGCRYIVNIIDVYENTFK------DRKC
MAPKAPK3_Mmus ECYHRRSGQKCALKLLYDSPKARQEVDHHWQASGGPHIVRILDVYENMHH------GKRC
MAPKAPK2_Mmus RIFDKRTQQKFALKMLQDCPKARREVELHWRASQCPHIVHIVDVYENLYA------GRKC
K08F8.1_Cele ACYQKVTGEKFALKVLRDSQKARREVELHWLTNAHENVVSILDIYENTFD------NVKC
C44C8.6_Cele ECEHRQSGDKFALKVLRDTQKARREVELHVMASGHGHVVSVHDVYKNSYN------GVDC
MAPKAPK2_Spur ------------------------------------------------------------
MAPKAPK5a_Spur PCQHKRSEDRFALKLLLDKPGARAEVNLHSRCSGHANIVKIIEVFSNEVQFPGEPAPKSR
AqueK073_Aque ECIHKATGERRALKILRENPKSRRELDLHWRSCSHENIVNICDVYENVFM------GHRS
MAPKAPK3_Hsap LLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLL
MAPKAPK2_Hsap LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL
MAPk-Ak2_Dmel LLVVMECMEGGELFQRIQDKADGAFTEREAAQIMHEICAAVDYLHSRDIAHRDLKPENLL
MAPKAPK3_Mmus LLIVMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSRNIAHRDVKPENLL
MAPKAPK2_Mmus LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL
K08F8.1_Cele LLMVVEFLEGGDLLSQFESQGSIPYTEKKVGEIIRQIGNAVMYLHDMNIAHRDIKLENIL
C44C8.6_Cele LLVVMENMKGGELFNRIQERGQKAFTEREAAGIVNEICSAVAHLHRMSIAHRDLKPENLL
MAPKAPK2_Spur -------------------------RLTEAAEIVRSIGQAVHHLHVMNIAHRDLKPENLL
MAPKAPK5a_Spur LLVVMELMDGGELFDRISKQ--KRFTERQAVILTKQIASAVLQCHSLNIAHRDLKPENLL
AqueK073_Aque LLVVMECMEGGELFDRIQDKG--HFTEREAAEVVRCISLAVAHLHHMDIAHRDLKPENLL
:. : . * *: * .*****:* **:*
MAPKAPK3_Hsap YTSKEKDAVLKLTDFGFAKETTQ---NALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGV
MAPKAPK2_Hsap YTSKRPNAILKLTDFGFAKETTSH--NSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGV
MAPk-Ak2_Dmel YTTTQPNATLKLTDFGFAKETFTS--YTLQTPCYTPYYVAPEVLGPEKYDKSCDIWSLGV
MAPKAPK3_Mmus YTSKEKDAVLKLTDFGFAKETTQ---NALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGV
MAPKAPK2_Mmus YTSKRPNAILKLTDFGFAKETTSH--NSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGV
K08F8.1_Cele CSGTGDNCVYKLGDYGFAKRPERN--VLMESPCCTPFYAPPEVLGRERYDKSCDMWSLGV
C44C8.6_Cele YVTTASNAALKLTDFGFAKKTDESEPQGLKTACFTPYYCAPEVLGTEKYDKSCDLWSIGV
MAPKAPK2_Spur YRDRTPNSLLKLTDFGFAKETTT---TNLQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGV
MAPKAPK5a_Spur LKDNSEDSPVKLSDFGFAKVDD----GTLMTPHFTPYYVAPQVSTSL-------------
AqueK073_Aque YSDKTPSAKLKLTDFGFAKENHGS--KALTTPCYTPYYVAPEVLGPEKYDTSCDMWSIGV
.. ** *:**** : :. **:* .*:*
MAPKAPK3_Hsap IMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPT
MAPKAPK2_Hsap IMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPT
MAPk-Ak2_Dmel VMYIIMCGFPPFYSNHGLAISPGMKNRIRTGQYDFPDPEWTNVSQAAKDLIKGMLNVDPS
MAPKAPK3_Mmus IMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYSFPNPEWLDVSEDAKQLIRLLLKTDPT
MAPKAPK2_Mmus IMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPT
K08F8.1_Cele AMYILLCGYPPFYSMKGVALSPGMRSRIANAYYAFPHEEWDCVSKDTKDDIRCLLRTNPS
C44C8.6_Cele IMYILLCGYPPFYSQHGQPMSPGMKAKIKSGQYTFPSPEWDCVSEAAKDLIRKLLRTEPT
MAPKAPK2_Spur IMYILLCGFPPFYSNHGMAISPGMKRRIRNGQYEFPDPEWSQVSEDAKNLIKKLLRTDPA
MAPKAPK5a_Spur ------------------------------------------------------------
AqueK073_Aque ITYILLCGFPPFYSYGGAPISPGMKKRIRQGQYGFPDPEWTNVSSQAKDLIKGLLKTNPA
MAPKAPK3_Hsap ERLTITQFMNHPWINQSMVVPQTPLHTARVLQED--------------------------
MAPKAPK2_Hsap QRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKED--------------------------
MAPk-Ak2_Dmel KRLRIQDVISNKWIAQYNAVPQTPLCTGRMLKEA--------------------------
MAPKAPK3_Mmus ERLTIMQFMNHPWINQSMVVPQTPLYTARVLQED--------------------------
MAPKAPK2_Mmus QRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKED--------------------------
K08F8.1_Cele DRLTIHELMATPLVTGEPIVPGKHITTAIAIPGADESECGGGVFDDGFIVEEEETPDTVA
C44C8.6_Cele ERITIEQTMEHKWISHYRRVPDTPLFTSSNLNDQ--------------------------
MAPKAPK2_Spur ERLSIQEFMNSPWVRQCSAVPATPLHTSSVMKEE--------------------------
MAPKAPK5a_Spur ----------------------TPIA----------------------------------
AqueK073_Aque DRFTIDDVLRHRWIAGYQEVPQTPLACIQVLQDD--------------------------
. :
MAPKAPK3_Hsap -----------------KDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSNNRLLNKRRK
MAPKAPK2_Hsap -----------------KERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRK
MAPk-Ak2_Dmel -----------------EETWPEVQEEMTRSLATMRVDYDQMQIKALDKSNNPLLTKRRK
MAPKAPK3_Mmus -----------------KDHWDDVKEEMTSALATMRVDYDQVKIKDLKTSNNRLLNKRRK
MAPKAPK2_Mmus -----------------KERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRK
K08F8.1_Cele EILPVPKSVRFLRDGVKAPRLHSIQEEVGRAMEIMRMGTDQVYIKNPTASCNNLFERRRA
C44C8.6_Cele -----------------REQWTDMQDEMEATLASMRVGPENIQIKSLGDSNNKLLAKRRK
MAPKAPK2_Spur --------------G--VNQWADIQDEMTNALATMRVDYDQIKIKEVNVSTNPLLAKRRK
MAPKAPK5a_Spur ------------------------------------------------------------
AqueK073_Aque -----------------KELWPDIQDEMSHALATMRVADEPSKIKKVADANNPILARRAK
MAPKAPK3_Hsap KQAGSSSA------------SQGCNNQ
MAPKAPK2_Hsap KARALEAA---------------ALAH
MAPk-Ak2_Dmel KIEEMELY------------MANATRN
MAPKAPK3_Mmus KQAGSSSA------------SQGCNNQ
MAPKAPK2_Mmus KARAVEDA---------------ALAH
K08F8.1_Cele VHLSI-----------------PRVYC
C44C8.6_Cele GGASPKDDPMDDIKEEEKDDEEEKMIS
MAPKAPK2_Spur KELAM-------------------QAE
MAPKAPK5a_Spur -------------------QLEYKLHF
AqueK073_Aque KNS----------------------GK