PLK3_Hsap ME--------PAAGF---------------LSPRPFQRAAAA-PAPPAGPGPPPSALRGP
PLK2_Hsap MELLRTITYQPAAST--------------KMCEQALGKGCGA-DSKKKRPPQPPEESQPP
PLK2_Spur MPLTRSPV-LPVGLSKDVRYTMDQLQKPAPLSPEDTPKTTPSLSSKPHGAGR-EENVKPP
PLK5_Mmus MEPR--------------------------------------------------------
PLK2_Mmus MELLRTITYQPAAGT--------------KMCEQALGKACGG-DSKKKRPQQPSEDGQP-
PLK3_Mmus ME--------PAAGF---------------LSPRPFPRAAAP-SAPPAGPGPPANASPRS
*
PLK3_Hsap ELEML------------AGLPTS-DPGRLITDPRSGRTYLKGRLLGKGGFARCYEATDTE
PLK2_Hsap QSQAQVPPA-APHHHHHHSHSGP-EISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLT
PLK2_Spur -----IPPARAPKAT-PAVSKLP-ELPAVIVDPESGERYRRGRLLG-GGFARCYELTHLD
PLK5_Mmus ---------SRRR------RSRQ-LVATFLRDPGSGRVYRRGKLIGKGAFSRCYKLTDMS
PLK2_Mmus Q--AQVTPA-APHHHHHHSHSGP-EISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLT
PLK3_Mmus EPEVL------------AGPRAPDPPGRLITDPLSGRTYTKGRLLGKGGFARCYEATDTE
.: ** :*. * :*:::* *.*::**: *.
PLK3_Hsap TGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCS
PLK2_Hsap NNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCS
PLK2_Spur THYVYAGKIVPKERISKPSQREKMEREIAVHAQLRHPHIVGFHKHFQDAENIYILLELCR
PLK5_Mmus TSAVFALKVVPRGGAGRLRLRGKVEREIALHSRLRHRNIVAFHAHFADRDHVYMVLEYCS
PLK2_Mmus NNKVYAAKIIPHSRVAKPHQREKIDKEIELHRLLHHKHVVQFYHYFEDKENIYILLEYCS
PLK3_Mmus SGIAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCS
. .:* *::*: .: * *: .** :* *:* ::* * :* * :::*:.** *
PLK3_Hsap R----KSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMEL
PLK2_Hsap R----RSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMEL
PLK2_Spur H----KSLLHMLKLRKHLTEPEVRYFMLQIIEGVRYLHSHCVIHRDLKLGNMFLTDTMGV
PLK5_Mmus RQVPLQSLAHVLKVRRTLTEPEVRYYLRGLVSGLRYLHQQRIVHRDLKPSNFFLNKNMEV
PLK2_Mmus R----RSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMEL
PLK3_Mmus R----KSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITDNMEL
: :*: *: * *: * ******:: ::.*::***.: ::***** .*:*:.. * :
PLK3_Hsap KVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPP
PLK2_Hsap KVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPP
PLK2_Spur KIGDFGLAAKLEFEGDRKRTMCGTPNYIAPEVLGKIGHSFEADVWALGCIMYTMLVGRPP
PLK5_Mmus KIGDLGLAARVGPAGRCHRVLCGTPNFQAPEVVSRNGHSCKSDIWALGCIMYTVLTGTPP
PLK2_Mmus KVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPP
PLK3_Mmus KVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPP
*:**:****:: ::.:*****: :***: : **. ::*:*:***:***:* * **
PLK3_Hsap FETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFFTKGYT
PLK2_Hsap FETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFT
PLK2_Spur FETSSLKETYARIKHNKYHFPETLSPVAKEIISDLLSSDPEERPPLEVVIDHEFFTQGFV
PLK5_Mmus FAAAPLSEMYQNIRDGHYLEPTHLSPSARSLIARLLAPDPAERPSLDHLLQDDFFSQGFT
PLK2_Mmus FETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFT
PLK3_Mmus FETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIEQILRHDFFTKGYT
* :: *.* * *:. :* * * *: ::: :* .* :**.:: :: .:** :*:.
PLK3_Hsap PDRLPISSCVTVPDLTPPNPARSLFA-KVTKSLFGRKKKS-K------NHAQERDEVSGL
PLK2_Hsap PDRLSSSCCHTVPDFHLSSPAKNFFK-KAAAALFGGKKDKARYIDTHNRVSKEDEDIYKL
PLK2_Spur PETLSPTACVTAPDFPITKVLISDRKGDLVTNEFCRLKREST---------LQRRDVTAP
PLK5_Mmus PERLPPHSCHSPPVFAFPPPLGRLFR-KVGQLLLTQCRPPCP---------FTSK-----
PLK2_Mmus PDRLSSSCCHTVPDFHLSSPAKNFFK-KAAAALFGGKKDKARYNDTHNKVSKEDEDIYKL
PLK3_Mmus PDRLPVSSCVTVPDLTPPNPARSLFA-KVTKSLFGRKKNKNK------NHSEDQDNVSCL
*: *. .* : * : . . : :
PLK3_Hsap VSGLMRTSVGHQDARPEAPAASGPAPVSLVETA-P---EDS---------SPRGTLASSG
PLK2_Hsap RHDLKKTSITQQPSKHRTDEELQPPTTTVARSG-TPAVENKQQIGDAIRMIVRGTLGSCS
PLK2_Spur LSELINNDSSKQGSGTTSQNSGKPSSQPKLRTR-ITGSRPMTPVTSAIKTAMVNVIEKRS
PLK5_Mmus -------------------EASGPGEEGTEPDHMEAGNEERDPLCTEGRIHL-LTLGTPR
PLK2_Mmus RHDLKKVSITQQPSKHRADEEPQPPPTTVARSG-TSAVENKQQIGDAIRMIVRGTLGSCS
PLK3_Mmus VSGLMRTSIGHPDVRPEAPVVSGQAPASLVETA-A---EDS---------SPRGTLASSG
. .: .
PLK3_Hsap DG--FEEGLTVATVVESALCALRNCIAFMPPAEQNPAPLAQPEP--LVWVSKWVDYSNKF
PLK2_Hsap SSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQL-STS--FQWVTKWVDYSNKY
PLK2_Spur AAVTMVKSA-SICSMDKVYEMLNTCLEHMPKEDHRTTPKYKPNPSEVVWVIKWVDYSNKY
PLK5_Mmus TGLAGPKGS-LALQLEVATRKLFLCLDAGPMAGQDP--PGEQRP--VLWAPKWVDYSLKY
PLK2_Mmus SSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQL-STS--FQWVTKWVDYSNKY
PLK3_Mmus DG--FEEGLTVATVVESALCALRNCVAFMPPAEQNPAPLAQPEP--LVWVSKWVDYSNKF
. :. : . * *: * . . . *. ****** *:
PLK3_Hsap GFGYQLSSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSVGAVPRALQPQLGILRY
PLK2_Hsap GFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKY
PLK2_Spur GFGYQLSNKVVGVMFNDKSRISFTPDRSSVQYLSTDSKVHSFPLSSVPSRLSKKVTLLDY
PLK5_Mmus GFGYQLSDGGSGVLFRDGSHMALRPQGGHVSYQPDQGTLWTFTLRDVPSPLRAKLAVLRL
PLK2_Mmus GFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKY
PLK3_Mmus GFGYQLSSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSMGSVPRALQPQLGILRY
*******. .*:*.: ::::: .: * * . *. .* : :: :*
PLK3_Hsap FASYMEQHLMKGGDLPSVEEVEVPAP---------------PLLLQWVKTDQALLMLFSD
PLK2_Hsap FSHYMEENLMDGGDLPSVTDIRRPR----------------LYLLQWLKSDKALMMLFND
PLK2_Spur FATYMDEHLIKGIDSDKKDGIRSPSPKRKGVDKPGPVNSAQPYLEKWNRTGKAITMYLSN
PLK5_Mmus FACYMQRRLREEGTVPMPATPASPD----------------ISLLSFIADSQAMVMLFSN
PLK2_Mmus FSHYMEENLMDGGDLPSVTDIRRPR----------------LYLLQWLKSDKALMMLFND
PLK3_Mmus FASYMEQHLMKGGDLPSVEEAEVPAP---------------PLLLQWVKTDQALLMLFSD
*: **:..* . * * .: .:*: * :.:
PLK3_Hsap GTVQVNFYGDHTKLILSG-WEPLLVTFVARN--RSACTYLASHLRQLGCSPDLRQRLRYA
PLK2_Hsap GTFQVNFYHDHTKIIICSQNEEYLLTYINED--RISTTFRLTTLLMSGCSSELKNRMEYA
PLK2_Spur GTLQVNFFEDHTKVILSHNNNDHLVTYINES--RTPTTYRVLHITHHGCTKALHTRLSYA
PLK5_Mmus GTVQVSLKTSQTQLVLSGEDEDLLLTLQEPGGPAVGVSYTLDVLRSHGFTLAVHHHLRHG
PLK2_Mmus GTFQVNFYHDHTKIIICNQSEEYLLTYINED--RISTTFRLTTLLMSGCSLELKNRMEYA
PLK3_Mmus GTVQVNFYGDHTKLILSG-WEPLLVTFVARN--RSACTYLASHLRQLGCSPDLRQRLRYA
**.**.: .:*::::. : *:* . :: : * : :: :: :.
PLK3_Hsap LRLLRDR--------SPA
PLK2_Hsap LNMLLQR---------CN
PLK2_Spur RHVLYSMMGKGEEDNEKL
PLK5_Mmus LHLLQ-----------SV
PLK2_Mmus LNMLLQR---------CN
PLK3_Mmus LRLLRDQ--------SPA
.:*