Protein (view, download) , Domain (view, download)
ROCK2_Hsap      MSRPPPTGKMPGAPETAPG----DGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLD
ROCK1_Hsap      MST---------------G----D-SFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYD
rok_Dmel        MPAGRE---------TVTKQRSMDVERRRRANTLEREMRDPTSICNVDCLLDTVSALVSD
let-502_Cele    ME----------------------------QDELRDQLVDPKSPINIESLLDTITALVND
ROCK1_Mmus      MST---------------G----D-SFETRFEKIDNLLRDPKSEVNSDCLLDGLDALVYD
ROCK2_Mmus      MSRPPPTGKMPGAPETAPG----DGAGAGRQRKLEALIRDPRSPINVESLLDGLNSLVLD
ROCK_Spur       MS------------------------LTQRYQTLENRIKDPKCLINYEALLDSICALTRD
AqueK006_Aque   MAT---------------E----HSSLKARHKTLLGSLTDNKGLLHVEGLLDAVVAVYSD
                *                                :   : *     : : *** : ::  *

ROCK2_Hsap      LDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQK
ROCK1_Hsap      LDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRK
rok_Dmel        CDHESLRRLKNIEQYAAKYKPLAMQINQLRMNVEDFHFIKLIGAGAFGEVQLVRHKSSSQ
let-502_Cele    CKIPVLMRMKSVDNFISRYERVVESLAALRMKAADFRQLKVIGRGAFGEVHLVRHTRTNT
ROCK1_Mmus      LDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRK
ROCK2_Mmus      LDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQK
ROCK_Spur       CGIPALRKSKNVENFLSRYEQKAGDITTHRLSSHDFQMIKVIGRGAFGEVKVVRERTSKK
AqueK006_Aque   CNYPTLHRNKNLDTFRRRYEGVVPVISNNRLSSHDFQLIKVIGRGAFGEVHLVRMKETKK
                     * : *.:: :  :*:     :   ::.  *:  :*:** ******::**   :

ROCK2_Hsap      VYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGD
ROCK1_Hsap      VYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGD
rok_Dmel        VYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEWIVQLHFAFQDAKYLYMVMDFMPGGD
let-502_Cele    VYAMKMLNKDDMIKRADSAFFWEERDIMAHANSEWIVRLQYAFQDPRHLYMVMEYMPGGD
ROCK1_Mmus      VYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGD
ROCK2_Mmus      VYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFCAFQDDRYLYMVMEYMPGGD
ROCK_Spur       VYAMKCLSKFEMIKRSDSAFYWEERDIMAHANSEWIVQLHYAFQDEKYLYMVMDYMPGGD
AqueK006_Aque   IFAMKILSKFEMIRRSDTAFFWEERDIMAHTTSEWIVQLHYAFQDSSNLYMVMDYMPGGN
                ::*** *.* :*::*.*:**:****.***.:.* *:*:*  ****   *****::****:

ROCK2_Hsap      LVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTC
ROCK1_Hsap      LVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTC
rok_Dmel        IVSLMGDYDIPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTC
let-502_Cele    LVNLMTSYEVSEKWTRFYTAEIVEALAALHSMGYIHRDVKPDNMLISISGHIKLADFGTC
ROCK1_Mmus      LVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTC
ROCK2_Mmus      LVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTC
ROCK_Spur       LVNLMSNYEIPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDSSGHLKLADFGTC
AqueK006_Aque   IVSLMERYEIPEEWAQFYIAELVLALEAVHSMGYVHRDVKPENMLLDGRGHLKLADFGTC
                :*.**  *::.*:*: **  *:* ** ::*.** :******:***:.  **:********

ROCK2_Hsap      MKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYA
ROCK1_Hsap      MKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYA
rok_Dmel        MRMGANGQVVSSNAVGTPDYISPEVLQSQGVDNEYGRECDWWSVGIFLYEMLFGETPFYA
let-502_Cele    VKMNANGVVRCSTAVGTPDYISPEVLRNQGQDAEFGKEVDWWSVGVFIYEMLVGETPFYA
ROCK1_Mmus      MKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYA
ROCK2_Mmus      MKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLFEMLVGDTPFYA
ROCK_Spur       MRMERDGMVRSDTAVGTPDYISPEVLKSQAGNGQYGRECDWWSVGVFIYEMLVGDTPFYA
AqueK006_Aque   MKVDKNGKVRCETAVGTPDYISPEVLKSQGGDGYYGKECDWWSVGVVMFEMLCGDLPFYS
                :::   * * ...*************:.*. :  :*:* ******:.::*** *: ***:

ROCK2_Hsap      DSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKN
ROCK1_Hsap      DSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKN
rok_Dmel        DSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIRAFLTDRTQRLGRYGIEDIKAHPFFRN
let-502_Cele    EALVSTYTNIMNHKTSLKFPDEPLISTQAKDIIKKFLSAAPDRLGRNSVDDIRNHKFFVN
ROCK1_Mmus      DSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKN
ROCK2_Mmus      DSLVGTYSKIMDHKNSLCFPEDTEISKHAKNLICAFLTDREVRLGRNGVEEIKQHPFFKN
ROCK_Spur       DSLVGTYSKIMDHRNSLEFPDDISISGPAKDLICKFLTDRDTRLGKNGIDEIKLHRFFKN
AqueK006_Aque   DSLIGTYSNIMNHKNTLQFT-DVQLSANAKNIIVHFLEDASNRLGLNGVEEVKAHPFFVT
                ::*:.** :**:*:.:* *. :  :*  ** :*  **     ***  .::::: * ** .

ROCK2_Hsap      DQWHWDNIRETAAPVVPELSSDIDSSNFDDIED-DKGDVETFPIPKAFVGNQLPFIGFTY
ROCK1_Hsap      DQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEE-DKGEEETFPIPKAFVGNQLPFVGFTY
rok_Dmel        DTWSFDNIRESVPPVVPELSSDDDTRNFEDIER-DEKPEEVFPVPKGFDGNHLPFIGFTY
let-502_Cele    DEWTFATLREASPPVIPSLKSDDDTTHFEEIETRDRDNAGDFQLPKTFNGNQLPFIGFTY
ROCK1_Mmus      DQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEE-DKGDEETFPIPKAFVGNQLPFVGFTY
ROCK2_Mmus      DQWNWDNIRETAAPVVPELSSDIDSSNFDDIED-DKGDVETFPIPKAFVGNQLPFIGFTY
ROCK_Spur       DMWTYDNIRNTVPPVVPELISDVDTSNFDEIEP-EDHPEESFQSPKTFAGNNLPFIGFTY
AqueK006_Aque   DQWNWENIRSTVAYVVPELKSEIDTAYFDDIED-TSTQPQAFSQPMEFQGNHLPFVGFTF
                * * : .:*.: . *:*.* *: *:  *:::*         *  *  * **:***:***:

ROCK2_Hsap      YRENLLLSDSPS-CRETDSIQS---------------------RKNEESQEIQKKLYTLE
ROCK1_Hsap      YSNRRYLSSANP-NDNRTSSN----------------------ADKSLQESLQKTIYKLE
rok_Dmel        TGDYQLLSSDTVDAESKEANVANSG-----AASNNHG--HG--HNHRHRPSNSNELKRLE
let-502_Cele    SNEYSPVKN--L-LKGHGA----------------------GSKQNGI--EQHKPQTVVE
ROCK1_Mmus      YSNRRYLPSANA-SENRSSSN----------------------VDKSLQESLQKTIYKLE
ROCK2_Mmus      FRENLLLSDSPP-CRENDAIQT---------------------RKSEESQEIQKKLYALE
ROCK_Spur       NKSNKLFTSVEGGVKEADGHVSAPNVGGRGGVKEADGHVSAPNVGGREYEEMKRKTHSLE
AqueK006_Aque   VKDSNILEGEREQVSSVE---A----------------------------TPIKPSKEIE
                  .   . .                                            .    :*

ROCK2_Hsap      EHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNA
ROCK1_Hsap      EQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRIN
rok_Dmel        ALLERERGRSEALEQQDAGLRQQIELITKR-------EAELQRIASEYEKDLALRQHNYK
let-502_Cele    QPLTNG-HASGVPEEKYEAVKMELDSKNREFE---------------------LLKDSIA
ROCK1_Mmus      EQLHNEMQLKDEMEQKCRTSNLKLDKIMKELDEEGNQRRNLESAVSQIEKEKMLLQHRIN
ROCK2_Mmus      EHLSSEVQAKEELEQKCKSINTRLEKTAKELEEEITLRKSVESTLRQLEREKALLQHKNA
ROCK_Spur       KQIEAEMRRNKDLDQKNKHIASKFDRIKQDLELENNDKLHLQNKLMDKEREYVQLKHKHT
AqueK006_Aque   EQLTLLTKQKEDLETHIKKTEEKLQRMEKENREVQASLNQVTQKYNQSEKDLGLSRIDMK
                  :      .   : :      .::   :                          :

ROCK2_Hsap      EYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRT
ROCK1_Hsap      EYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRT
rok_Dmel        VAMQKVEQEIELRKKTEALLVETQRNLENEQKTRARDLNINDKVVSLEKQLLEMEQSYKT
let-502_Cele    RNEIRAKMIENEKNSLST------------------------KISDLERELKDNKDKLRH
ROCK1_Mmus      EYQRKVEQENEKRRNIENEVSTLKDQLEDLRKASQTSQLANEKLTQLQKQLEEANDLLRT
ROCK2_Mmus      EYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQSSQISTEKVNQLQKQLDEANALLRT
ROCK_Spur       ELARRAEQEQEGRKRVERQVSHITDMERELKEL----KLRSEKTTILERQVENLNKQLQT
AqueK006_Aque   ELTRKCEENEETISQLRARINEAESQLKG-----------AESPSKLLTEIEQLKCELKS
                    : .   :                               .   *  :: : :   :

ROCK2_Hsap      ESDTAARLRKTQAESSKQI---QQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESE
ROCK1_Hsap      ESDTAVRLRKSHTEMSKSI---SQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAE
rok_Dmel        ETENTQKLKKHNAELDFTV---KSQEEKVRDMVDMIDTLQKHKEELGQENAELQALVVQE
let-502_Cele    GADSDAKVNELAVELRMSKEYNSEMESE--------------------------------
ROCK1_Mmus      ESDTAVRLRKSHTEMSKSI---SQLESLNRELQERNRILENSKSQADKDYYQLQAVLEAE
ROCK2_Mmus      ESDTAARLRKTQAESSKQI---QQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESE
ROCK_Spur       EGDQHARSKKMFGDHQKNY---AHLEQEISELRDKYTRELNNKMMLDQEVIRMQTQLEEE
AqueK006_Aque   EFQNSASLKEATQKLKQEL---LVKESVIDHLESRSKELSVERDRIDSDMITVQDELEKQ
                  :     .:   .           *.

ROCK2_Hsap      RRDRTHGSE---------------------------------------------------
ROCK1_Hsap      RRDRGHDSE---------------------------------------------------
rok_Dmel        KNLRSQLKE---------------------------------------------------
let-502_Cele    ------------------------------------------------------------
ROCK1_Mmus      RRDRGHDSE---------------------------------------------------
ROCK2_Mmus      RRDRTHGSE---------------------------------------------------
ROCK_Spur       QRGRSRMEDLKAELEMGGREPSMTTLEVNKEQEGSGWGGNNDKLHLQNKLMDKEREYVQL
AqueK006_Aque   HKLTAKLKT---------------------------------------------------


ROCK2_Hsap      ------------------------------------------------------------
ROCK1_Hsap      ------------------------------------------------------------
rok_Dmel        ------------------------------------------------------------
let-502_Cele    ------------------------------------------------------------
ROCK1_Mmus      ------------------------------------------------------------
ROCK2_Mmus      ------------------------------------------------------------
ROCK_Spur       KHKHTELARRAEQEQEGRKRVERQVSHITDMERELKELKLRSEKTTILERQVENLNKQLQ
AqueK006_Aque   ------------------------------------------------------------


ROCK2_Hsap      ------------------------------------------------------------
ROCK1_Hsap      ------------------------------------------------------------
rok_Dmel        ------------------------------------------------------------
let-502_Cele    ---------------LSKFRDKCEQLKEDLRKKSGELAQEKNE-----------------
ROCK1_Mmus      ------------------------------------------------------------
ROCK2_Mmus      ------------------------------------------------------------
ROCK_Spur       TEGDQHARSKKMFGDHQKNYAHLEQEISELRDKYTRELNNKMMLDQEVIRMQTQLEEEQR
AqueK006_Aque   ------------------------------------------------------------


ROCK2_Hsap      -------IINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTY
ROCK1_Hsap      -------MIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNY
rok_Dmel        -------MHKEAENKMQTLINDIERTMCREQKAQEDNRALLEKISDLEKAHAGLD----F
let-502_Cele    ------------------------------------TQRVFQQKKDA--DEAFAEIKRDY
ROCK1_Mmus      -------MIGDLQARITSLQEEVKHLKHNLERVEGERKEAQDMLNHSEKEKNNLEIDLNY
ROCK2_Mmus      -------IINDLQGRISGLEEDLKTGKALLAKVELEKRQLQEKLTDLEKEKSNMEIDMTY
ROCK_Spur       GRSRMEDLKAELERQNAQATQEMNRLKQGESRSIATMQNHQESIIILEKTKASLE----F
AqueK006_Aque   -------SNEELKKLSETQNQSISSLKSRLSEISDENQRIKRSQAESEKDKTSLEL----
                                                     :            .   :

ROCK2_Hsap      QLKVIQQSLEQEEAEHKAT-KARLADKNKIYESIEEAKSEAMKEMEKKLLEERT--LKQK
ROCK1_Hsap      KLKSLQQRLEQEVNEHKVT-KARLTDKH---QSIEEAKSVAMCEMEKKLKEERE--AREK
rok_Dmel        ELKAAQGRYQQEVKAHQETEKSRLVSR-------EEANLQEVKALQSKLNEEKS--ARIK
let-502_Cele    EL--LQTR-----------------------------ENEKSVQLKKALDERKENGAYQQ
ROCK1_Mmus      KLKSIQQRLEQEVNEHKVT-KARLTDKH---QSIEEAKSVAMCEMEKKLKEERE--AREK
ROCK2_Mmus      QLKVIQQSLEQEEAEHKTT-KARLADKNKIYESIEEAKSEAMKEMEKKLLEERS--LKQK
ROCK_Spur       DLKALQNTHEQGVKEHRDA-MAAVNAEK---KRITRT---QEDELQKTLVQERE--MR--
AqueK006_Aque   NLKSLQQRYDQMSKSHEQL-SVQFKSTS---TSVEES----VSQLRSQLDSEVS--ARQT
                .*   *                                      :.. * ..

ROCK2_Hsap      V--ENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQ
ROCK1_Hsap      A--ENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQ
rok_Dmel        A--DQHSQEKERQLSMLSVDYRQIQLRLQKLEGECRQESEKVAALQSQLDQEHSKRNALL
let-502_Cele    SVAKATDAEWERKMQFYEK-------QLEHA--NDE------------RKREEQKRTAAE
ROCK1_Mmus      A--ENRVVETEKQCSMLDVDLKQSQQKLEHLTENKERMEDEVKNLALQLEQESNKRLLLQ
ROCK2_Mmus      V--ENLLLEAEKRCSILDCDLKQSQQKLNELLKQKDVLNEDVRNLTLKIEQETQKRCLMQ
ROCK_Spur       -------VQVDKQNSILELDLKQAQQKIERMENMIKMEEQKTKEKMLQLEQEEQRHRFTQ
AqueK006_Aque   A--ERTASDLEHQTSFLRLDLKQTNEEVSDLKQQIHDLEES-------LRQEKRLREREE
                        : ::: .:          .:.                     :*   :

ROCK2_Hsap      NDLKMQTQQ-VNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQL
ROCK1_Hsap      NELKTQAFE-ADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQL
rok_Dmel        SELSLHSSE-VAHLRSRENQLQKELSTQREAKRRFEEDLTQLKSTHHEALANNRELQAQL
let-502_Cele    FDQSRVAR-KLAGIEANYELLQNDYKSMKEARKDLERDLQDVITEKRRLEIRVEQLMDSR
ROCK1_Mmus      NELKTQAFE-ADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQL
ROCK2_Mmus      NDLKMQTQQ-VNTLKMSEKQIKQENNHLMEMKMNLEKQNTELRKERQDADGQMKELQDQL
ROCK_Spur       NDLKASKQT-SSGYQTDIKRLRNELNTIKEQGKNFEEALEKSKSIASLNGSQISDLQEQL
AqueK006_Aque   AEAKKQQKELTDRLAGREQDIRAQLQELKNEKQKMEDTIYRLKSEGKAADASLKETLEEL
                 : .              : :: : .   :    :*       .          :   .

ROCK2_Hsap      EAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLE-ITLTKADSE
ROCK1_Hsap      EAEQYFSTLYKTQVKELKEEIEEKNR---ENLKKIQELQNEKETLATQLD-LAETKAESE
rok_Dmel        EAEQCFSRLYKTQANENREESAER-------LSKIEDLEEERVSLKHQVQ-VAVARADSE
let-502_Cele    NTDERVLSLCQDELVESQEEAKYK-----------------EDGLRGKID-GFKHELENE
ROCK1_Mmus      EAEQYFSTLYKTQVKELKEEIEEKNR---ENLRKIQELQSEKETLSTQLD-LAETKAESE
ROCK2_Mmus      EAEQYFSTLYKTQVRELKEENEEKTKLCKELQQKKQDLQDERDSLAAQLE-ITLTKADSE
ROCK_Spur       EAEHTFNALYKSQNQVLSEELMESKQEYQQLQQDYHQLSNEKESLAAQLE-LTLTKADSE
AqueK006_Aque   EQERKLTNSLRGRINNMGEAGVN--------EKEITRLKSENSELNSKLENVTQIK----
                : :. .    : .     *                      .  *  :::     .

ROCK2_Hsap      QLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANL
ROCK1_Hsap      QLARGLLEEQYFELTQ-------ESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEIL
rok_Dmel        ALARSIAEETVADLEKEKTIKELELKDFVMKHRNEINAKEAALATLKEAENELHKKLGQK
let-502_Cele    KMKTQTLEENLLVADKERGMLKMEVQELMQRHKWEITNKDQTLKHLETQLDEIKQ-----
ROCK1_Mmus      QLARGILEEQYFELTQ-------ESKKAASRNRQEITDKDHTVSRLEETNSVLTKDIEML
ROCK2_Mmus      QLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDTTIASLEETNRTLTSDVANL
ROCK_Spur       QLARTIAEDQYTDLEREKTMVELEYKEQIQRHKCTLNDKNSHLNKLEDDKTQLNNRIMTL
AqueK006_Aque   ----AAAEAKLADFEREKMMIELDIKEIIARHKTEVTERMAWSSKMKDQLIIMENKLNQK
                       *       :       : :.   :::  :. :      ::     : .

ROCK2_Hsap      ANEKEELNNKLKDVQEQLSRL---KDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIM
ROCK1_Hsap      RRENEELTEKMKKAEEEYKLE---KEEEIS--NLKAAFEKNINTERTLKTQAVNKLAEIM
rok_Dmel        AAEYEDLVQQHKKQQEELALMRSSKDEEIT--K----LLDKCKNEVLLKQVAVNKLAEVM
let-502_Cele    ----------------QSKIES-S-EQESNDKQTIADLRKKLDLEKAHKKAVINKLEEEM
ROCK1_Mmus      RKENEELNERMRTAEEEYKLK---KEEEIN--NLKAAFEKNISTERTLKTQAVNKLAEIM
ROCK2_Mmus      ANEKEELNNKLKDSQEQLSKL---KDEEMSAAAIKAQFEKQLLNERTLKTQAVNKLAEIM
ROCK_Spur       NTEKDELNKKLKESSEAQEAME-TKHQEME--KQMEQNKKLLGEEKLKKEQAVSKLAEIM
AqueK006_Aque   NLENEQLQDNLKRALIRLDDYQTF-DETR-DDEI-KKMSKQLETEKMMKKEAINKLTRIM
                                         .:            .    *   *  .:.** . *

ROCK2_Hsap      NRKEP---V---KRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIA
ROCK1_Hsap      NRKDFKIDR---KKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLV
rok_Dmel        NRRDSDLPKQKNKARSTAELRKKEKEMRRLQQELSQERDKFNQLLLKHQ----DLQQLCA
let-502_Cele    AKRQPL--KKGEKGVTKSALIKKEREIMALEQERDTMSKRIAALFYENDKQAEHFNIAIQ
ROCK1_Mmus      NRKDFKIDR---KKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLV
ROCK2_Mmus      NRKEP---V---KRGSDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIA
ROCK_Spur       NRKDFNPSSRKGKKVSQAAMNQKEKECRKLQQQLNQERDKYSQMVIKFTKEKEELTVQYT
AqueK006_Aque   LERKSL-PS-NVKKP--EPRRAHEREIRKLRGELQQETQKYKRVVEKYQQQLEEIQRQIQ
                 .:.        *         :*:*   *. : .   .:    . :      .:

ROCK2_Hsap      EESQIRIELQMTLDSKDSDIEQLRSQLQALHIG---LDSSSIGSGPGDAEADDGF---PE
ROCK1_Hsap      EECAHRNELQMQLASKESDIEQLRAKLLDLS------DSTSVASFPSADETDGNL---PE
rok_Dmel        EEQQLKQKMVMEIDCKATEIENLQSKLNETA------SLSSADNDPEDSQHSSLLSLTQD
let-502_Cele    -------DMQTTQDALRDELKECKEELANRNVNTRYEDKRSLDSREGIPSSL---SN-QH
ROCK1_Mmus      EECTHRNELQMQLASKESDIEQLRAKLLDLS------DSTSVASFPSADETDGNL---PE
ROCK2_Mmus      EESQIRIELQMTLDSKDSDIEQLRSQLQALHIG---MDSSSIGSGPGDAEPDDGF---PE
ROCK_Spur       EEYSKHCELQLELDSRDSELEQLQQQIKNLTAMH-ASDSASINSA---GEAE-NG---QG
AqueK006_Aque   EETQMRLELQHQLHTSEGKLQQLQQGIG-----------SYVSNGPSTETHDGAS---AI
                       .:         .::: :  :                .

ROCK2_Hsap      SRLEGW-LSLPVR-NNTKK-FGWVKKYVIVS--SKKILFYDSEQDKEQ-SNPYMVLDIDK
ROCK1_Hsap      SRIEGW-LSVPNR-GNIKR-YGWKKQYVVVS--SKKILFYNDEQDKEQ-SNPSMVLDIDK
rok_Dmel        SVFEGW-LSVPNK-QNRRRGHGWKRQYVIVS--SRKIIFYNSDIDKHNTTDAVLILDLSK
let-502_Cele    IQMEGW-LSLRDNTKKSRK-PKWTNCFVALN--EYSFTIYVDE---KAV-SVILLIEAGA
ROCK1_Mmus      SRIEGW-LSVPNR-GNIKR-YGWKKQYVVVS--SKKILFYNDEQDKEQ-SSPSMVLDIDK
ROCK2_Mmus      SRLEGW-LSLPVR-NNTKK-FGWVKKYVIVS--SKKILFYDSEQDKEQ-SNPYMVLDIDK
ROCK_Spur       GRLEGW-LSLPGK--NLRR-HGWKKHFVEVS--SKKILFYESEDQKAQ-KKPYLVLAIDK
AqueK006_Aque   YQRETLLVQVPKG-NNARK-NGWKDVFLVLSFTNKKLLIYDRPEDMGTDIPPSFTLELSQ
                   *   :.:     : ::   *   :: :.  . .: :*             : :  .

ROCK2_Hsap      LFHVRPVTQTDVYR--ADAKEIPRIFQILYANEGESKK-EQEFP-VEPV--------GEK
ROCK1_Hsap      LFHVRPVTQGDVYR--AETEEIPKIFQILYANEGECRK-DVEME-PVQQ--------AEK
rok_Dmel        VYHVRSVTQGDVIR--ADAKEIPRIFQLLYAGEGASHR-PDEQS-QLDVSVLHGNCNEER
let-502_Cele    MAHVRHVTAADLRN--VDDSQLPKIFHIMYDDASCNSSRHASNS-DLSM--------IES
ROCK1_Mmus      LFHVRPVTQGDVYR--AETEEIPKIFQILYANEGECRK-DIEVE-PVQQ--------GEK
ROCK2_Mmus      LFHVRPVTQTDVYR--ADAKEIPRIFQILYANEGESKK-EPEFP-VEPV--------GEK
ROCK_Spur       LFHVRAVTQGDVIR--AEARDIPRIFQLLYAGEGENRR-MVPDEANENP------GQDDE
AqueK006_Aque   VYSVRSLTQGEHERVRIKPNDSKRVLQVAYVDQQSEQS-IIAHPP----------VE---
                :  ** :*  :  .   .  :  ::::: * .

ROCK2_Hsap      SNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEII
ROCK1_Hsap      TNFQNHKGHEFIPTLYHFPANCDACAKPLWHVFKPPPALECRRCHVKCHRDHLDKKEDLI
rok_Dmel        PGTIVHKGHEFVHITYHMPTACEVCPKPLWHMFKPPAAYECKRCRNKIHKEHVDKH-DPL
let-502_Cele    FREESWKRHDFQELSYHIRTFCDVCNKKLSDIIRPTPAFECKNCHFKTHKDHVAQG-S-L
ROCK1_Mmus      TNFQNHKGHEFIPTLYHFPANCEACAKPLWHVFKPPPALECRRCHVKCHRDHLDKKEDLI
ROCK2_Mmus      SNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEII
ROCK_Spur       EGTIVHKNHKFTVVHFHMPTTCECCSKTLSHLVRPPPALECKLCRLKVHKEHYDKQEEFC
AqueK006_Aque   -GEVHVRGHHFVESRNSSRSSCDVCGKTLPLALLSGGILECKHCQMKCHKDDVDKT-DLI
                      : *.*        : *: * * *   . .    **: *: * *::.  :  .

ROCK2_Hsap      APCKVYYDISTAKNLLLLANSTEEQQKWVSRLVK--KIPKKPPAPDP-------------
ROCK1_Hsap      CPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVK--KIPKNPPS--G-------------
rok_Dmel        APCKLNHDPRSARDMLLLAATPEDQSLWVARLLK--RIQKSGYKAAS-------------
let-502_Cele    PMCR--YNTGLSRELVLMAPQTDNCNKWVSQLRR--FIESSRSAAVS-------------
ROCK1_Mmus      SPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVK--KIPKNPPS--G-------------
ROCK2_Mmus      APCKVYYDISSAKNLLLLANSTEEQQKWVSRLVK--KIPKKPPAPDP-------------
ROCK_Spur       PPCKVNIDAETAKHMLLMANSKEEQQRWIGKLGK--QIQDKRVSL---------------
AqueK006_Aque   RPCVAG--EQDQKKLLLLIKSDDDRSRWLSMLQAGEVVPSNKSPSASSNSLVPAGVNTKR
                  *         :.::*:    :: . *:  *     : ..

ROCK2_Hsap      ----------------FARSSPRT-SMKIQQNQSIRR-----------------------
ROCK1_Hsap      ----------------FVRASPRTLSTRSTANQSFRK-----------------------
rok_Dmel        ----------------YNNNST--DGSKISPSQSTRSSYKPYA-----------------
let-502_Cele    ----------------VSRVSSR------------RHAP---------------------
ROCK1_Mmus      ----------------FVRASPRTLSTRSTANQSFRK-----------------------
ROCK2_Mmus      ----------------FARSSPRT-SMKIQQNQSIRR-----------------------
ROCK_Spur       ---------------------PRTSS-----INSP-R-----------------------
AqueK006_Aque   DRTNSLRFNKRPTSAQHGRGSPSGSSNRTYSVSTQRQRSTDVGGVGGGAANYGTVPGPGG
                                     .

ROCK2_Hsap      -----------PSRQLAPNKPS
ROCK1_Hsap      -----------VVKN-TSGKTS
rok_Dmel        ------VNVQRSATLPANSSLK
let-502_Cele    ------------GSSNSSTIYQ
ROCK1_Mmus      -----------VVKN-TSGKTS
ROCK2_Mmus      -----------PSRQLAPNKPS
ROCK_Spur       -----------YIRA-VEGTNP
AqueK006_Aque   IGMRQIEFVRSNDSDTNPPQSQ