Gene 84943.m00149 (T.vaginalis)

84943.m00149

Species: T.vaginalis
Alias: TvagK0863, 84943.m00149
External Links:
Annotation:

Classification

Group: CMGC
Family: CK2

Sequence

Name Sequence Type Origin Length Description Download
84943.m00149.AA Protein None 320 None Fasta, JSON
84943.m00149.kin_dom Protein Kinase Domain None 271 None Fasta, JSON

Protein domain

Protein domains of 84943.m00149.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 84943.m00149.AA CK2 47-222 29 1.6e-25 72.52 In-house 2-184 (288) Show / Hide 
Range on Protein: 47-222
Range on HMM: 2-184/288
Sequence Identity: 29% (54 aa)

DSNNYIGKGFFSIV-RKRETLNGTTV--AVKKFKIFDRKSLIREMQTLRALNDTPNVVHILGLT--GNYEHPSVVYSYHQSKNED----YLNMSLPNFKW
   . ||.| .| |   ..  |   .   .|  |    |   ||.. |. ||  ||...... .    .  |..|. |   .| |    |  .. .. ..
EVIRKIGRGKYSEVFEGINIKNNEKCKIVIKILKPVKKKKIKREIKILENLNGGPNIIKLYDIVKDPYSKVPALVFEYV--NNTDFRQLYQTLTDYDIRY

FLKHTLTILKDIHARGVIHNDMNIGNILFDLENKSLTLIDFGLAAFYRPEKHYKLKGGMFRIQPPEFLVDRNHWDCGVDIWSLGI
..   |  |   |  |..| |    ||. | |.. | ||| ||| || |.. |  . .     .|| ||| . .|  .|.||||.
YMFELLKALDYCHSMGIMHRDVKPHNIMIDHEKRKLRLIDWGLAEFYHPGQDYNVRVASRYYKGPELLVDYQYYDYSLDMWSLGC
Kinase 84943.m00149.AA Pkinase 52-316 24 4.2e-19 68.61 Pfam 7-293 (293) Show / Hide 
Range on Protein: 52-316
Range on HMM: 7-293/293
Sequence Identity: 24% (72 aa)

IGKGFFSIVRK-RETLNGTTVAVKKFKIFDRKSLIR-------EMQTLRALNDTPNVVHILGLTGNYEHPSVVYSYHQS-----KNEDYLN------M--
||.| |. |.| ..  .| .||||..|  ..||  .       | | .. | . ||.| ...   .  |. .|  |..         ||.       .  
IGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYF

SLPNFKWFLKHTLTILKDIHARGVIHNDMNIGNILFDLENKSL----TLIDFGLAAF--YRPEKHYKLKGGMFRIQPPEFLVDRNHWDCGVDIWSLGITC
|    | ... .|  |. .|..|.|| |.   |||.| .|  .     ..|||||..  | .   ..   |  .  .|| . ......  ||.||.|...
SEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCIL

LDLVLGIKGNYLPKDDR----DSREFMNRYFGKQLAPYLKSKGIKIEPGDSDLFEL---AMPGTEQLITKDVMDLIGKMLTIDPKKRITARDALKHPLF
  ...|     .| ...    . .. | ... .  .|.  .   .... ..  |     ...    .....  |.| ..|. |||||.||...|.|| |
YEMLCGR----PPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRHWHFHWTF--HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
S_TKc 84943.m00149.AA S_TKc 46-316 22 4.2e-18 67.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 46-316
Range on HMM: 1-231/231
Sequence Identity: 22% (66 aa)

KDSNNYIGKGFFSIVRKRETLN-GTTVAVKKFKIFDRKSLIREMQTLRALNDTPNVVHILGLTGNYEHPSVVYSYHQS---KNEDYLN----------MS
 .  . |||| |. |.|    . |  ||.|. |    ....||.| |.   . ||.|....   . .|  .|  |         ||.           ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

LPNFKWFLKHTLTILKDIHARGVIHNDMNIGNILFDLENKSLTLIDFGLAAFYRPEKHYKLKGGMFRIQPPEFLVDRNHWDC-GVDIWSLGITCLDLVLG
    . ... ..  |. .| .|.|| |    |||.|     . ..|||||...     . . |  .   .|| |    ....  .|.||.|..   .. |
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-----TTFCGTPW-YMAPEVL----GYGKCKCDWWSCGCILYEMLCG

IKGNYLPKDDRDSREFMNRYFGKQLAPYLKSKGIKIEPGDSDLFELAMPGTEQLITKDVMDLIGKMLTIDPKKRITARDALK-------HPLF
    .           |.. | | .                              .... |.| |.|. ||.||.|| .||.       || |
YPPFP----------QMQMMFKKIG------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 84943.m00149.AA Ciliate-E2-Unclassified 47-316 18 3.6e-17 56.13 In-house 2-352 (352) Show / Hide 
Range on Protein: 47-316
Range on HMM: 2-352/352
Sequence Identity: 18% (68 aa)

DSNNYIGKGFFSIVRKRETLNGTTVA-----VKKFKIFDRKSL------IREMQTLRALNDTPNVVH----ILG-LTGNYEHPSVVYSYHQSKNE-----
  .  ||.| |..|.| .  .    .      ||..|...|.       ..||...  ..   ...     |.  .  |  || .|. ... ...     
KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK--YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

-----------DYLN---------------------MSLPNFK-----WFLKHTLTILKDIHARG-VIHNDMNIGNILFDLENK--SLTLIDFGLAAFYR
           .|..                      .  . |      .... |  |. .|  . .|| |    ||||| ..|   . .||||.. .| 
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

----------------PEKHYKLKGGMFRIQ----PPEFLVDRNHWD---CGVDIWSLGITCLDLVLGIKGNYLPKDDRDSRE----------------F
                ...... . |  . .    .|| |   |. .     .||||||. .  .. |    |.| .|... .                .
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFG----YYPFYDNNCEQHQQLITQWINNAYRKQL

MNRYFGKQLAPYLKSK-----GIKIEPGDSDLFELAMPGTEQLITKDVMDLIGKMLTIDPKKRITARDALKHPLF
 .  . |..     ..     ..  |  |                    ||. |||  .|.||||. ..|.||.|
YQNIKQKNIQFPKFPWQQIPKHWSPEAKDFIN-----------------DLLQKMLKKNPNKRITFEQILNHPWF
Kinase 84943.m00149.AA CDK-DD1 288-316 55 6.8e-16 44.98 In-house 351-379 (379) Show / Hide 
Range on Protein: 288-316
Range on HMM: 351-379/379
Sequence Identity: 55% (16 aa)

DVMDLIGKMLTIDPKKRITARDALKHPLF
...||| .||| .|||||....|| || |
SFLDLIERMLTLCPKKRINTKEALQHPWF
Kinase 84943.m00149.AA CMGC 282-316 48 6.2e-15 44.6 In-house 479-513 (513) Show / Hide 
Range on Protein: 282-316
Range on HMM: 479-513/513
Sequence Identity: 48% (17 aa)

EQLITKDVMDLIGKMLTIDPKKRITARDALKHPLF
. .....  ||. |||..||.||||| .||.|| |
RKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 84943.m00149.AA CK2 280-316 37 2.4e-14 38.51 In-house 252-288 (288) Show / Hide 
Range on Protein: 280-316
Range on HMM: 252-288/288
Sequence Identity: 37% (14 aa)

GTEQLITKDVMDLIGKMLTIDPKKRITARDALKHPLF
....| . ...|.. ||| .|...||||..|..|| |
ENKHLAHPEAIDFLDKMLRYDHQERITAKEAMEHPYF
Kinase 84943.m00149.AA GIN4 278-316 51 1.8e-13 38.99 In-house 256-293 (293) Show / Hide 
Range on Protein: 278-316
Range on HMM: 256-293/293
Sequence Identity: 51% (20 aa)

MPGTEQLITKDVMDLIGKMLTIDPKKRITARDALKHPLF
||  .. | ..  |||.|.|..||.|||. || ||||| 
MP-SDDEISREAQDLIRKILVVDPEKRIKTRDILKHPLI
Kinase 84943.m00149.AA CAMK 285-316 43 1.7e-12 35.86 In-house 394-425 (425) Show / Hide 
Range on Protein: 285-316
Range on HMM: 394-425/425
Sequence Identity: 43% (14 aa)

ITKDVMDLIGKMLTIDPKKRITARDALKHPLF
......||| |||. ||.||.|. ..|.|| .
VSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 84943.m00149.AA MSK 146-223 33 1.8e-12 38.45 In-house 114-199 (277) Show / Hide 
Range on Protein: 146-223
Range on HMM: 114-199/277
Sequence Identity: 33% (29 aa)

LKDIHARGVIHNDMNIGNILFDLE--NKSLTLIDFGLAAFYRPEKHYKLKGGMFRIQ--PPEFLVD---RNH-WDCGVDIWSLGIT
.. .| .|.|| |.   ||||| |  |  . |||||.|    ... ...|   | ..  .|| | .    .   |  .|.||||..
VDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVI
Kinase 84943.m00149.AA Ciliate-E2 285-316 43 1.2e-11 36.18 In-house 329-365 (365) Show / Hide 
Range on Protein: 285-316
Range on HMM: 329-365/365
Sequence Identity: 43% (16 aa)

ITKDVMDLIGK----MLTIDPKKRIT-ARDALKHPLF
......||| |    ||  ||.|||| . ..|.|| |
WSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 84943.m00149.AA CAMKL 285-316 40 2e-10 29.36 In-house 267-297 (297) Show / Hide 
Range on Protein: 285-316
Range on HMM: 267-297/297
Sequence Identity: 40% (13 aa)

ITKDVMDLIGKMLTIDPKKRITARDALKHPLF
.  |. ||| |||. .|.||.|. . ..|| .
VS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 84943.m00149.AA CAMKL 149-188 32 3.8e-08 21.94 In-house 143-188 (297) Show / Hide 
Range on Protein: 149-188
Range on HMM: 143-188/297
Sequence Identity: 32% (15 aa)

IHARGVIHNDMNIGNILFDLENKS-LTLIDFGLAAFYRP-----EK
.| .|..| |    |||.|  ... . .||||....|||     ..
CHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQ
Kinase 84943.m00149.AA Ciliate-E2 149-223 23 1.2e-07 22.26 In-house 176-285 (365) Show / Hide 
Range on Protein: 149-223
Range on HMM: 176-285/365
Sequence Identity: 23% (27 aa)

IHARG-VIHNDMNIGNILFDLENKSLTLIDFGLAAFYRPE----------KHYKLKG-----------------------GMFRIQPPEFLV--------
.| .. .|| |    ||||      . .|||||. .| ..          | |.  .                       |.   ..|| |         
LHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQ

DRNHWDCGVDIWSLGIT
.....|  .||||||..
KQKGYDYKCDIWSLGVI
Kinase 84943.m00149.AA STE 46-105 14 4.1e-07 21.3 In-house 1-97 (359) Show / Hide 
Range on Protein: 46-105
Range on HMM: 1-97/359
Sequence Identity: 14% (14 aa)

KDSNNYIGKGFFS-IVRKRETL---------------NGTTVAVKKFKI--------------------FDRKSLIREMQTLRALND-TPNVVHILG
 .    |||| |   ....                  .|. .|.|. ..                     .......|..... .|.  ||.|. .|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYG
Kinase 84943.m00149.AA CAMK 149-224 17 6.6e-07 17.53 In-house 195-324 (425) Show / Hide 
Range on Protein: 149-224
Range on HMM: 195-324/425
Sequence Identity: 17% (23 aa)

IHARGVIHNDMNIGNILFDLEN----------------KSLTLIDFGLAAFYRP------------------------EKHYKLKGGMFRIQP-PEFLVD
.| ....| |    |||.|  |                  . .||||.|....|                         . .|   |     . || |  
CHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNG

-------------RNHWDCGVDIWSLGITC
             .   .  .|.||.|. .
KGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 84943.m00149.AA GIN4 150-230 27 8.1e-07 17.35 In-house 151-231 (293) Show / Hide 
Range on Protein: 150-230
Range on HMM: 151-231/293
Sequence Identity: 27% (22 aa)

HARGVIHNDMNIGNILFDLENKSLTLIDFGLAAFYRPEKHYKLKGGMFRIQPPEFLVDRNHWDCGVDIWSLGITCLDLVLG
|| ...| |.   |.| |  .. . . |||.||   ..|  .   |      ||    .       |.|| |.    |. |
HAFNICHRDLKPENLLLDHKYNRIKIADFGMAALETDNKLLETSCGSPHYAAPEIVMGIPYHGFASDVWSCGVILFALLTG
Kinase 84943.m00149.AA STE 286-316 42 1e-06 19.59 In-house 327-359 (359) Show / Hide 
Range on Protein: 286-316
Range on HMM: 327-359/359
Sequence Identity: 42% (14 aa)

TKDVMDLIGKMLTIDPKKRITARDALK--HPLF
...  | | | |..||.|| || . ||  || .
SPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 84943.m00149.AA STE 136-225 21 2e-06 19.05 In-house 154-259 (359) Show / Hide 
Range on Protein: 136-225
Range on HMM: 154-259/359
Sequence Identity: 21% (25 aa)

KWFLKHTLTI-LKDIHARGVIHNDMNIGNILFDLENKSLTLIDFGLAAFYRPE------------------KHYKLKGGMFRIQPPEFLVD-----RNHW
..... .|   |. .|  ..|| |   .|||.        |.|||...   ..                  | . . |       || .       ... 
AYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP--WMAPEVIQQNGQGRDKGY

DCGVDIWSLGITCL
|. .||||||.|..
DTKCDIWSLGCTII
Kinase 84943.m00149.AA CAMK 51-104 15 3e-06 15.18 In-house 1-104 (425) Show / Hide 
Range on Protein: 51-104
Range on HMM: 1-104/425
Sequence Identity: 15% (16 aa)

YIGKGFFSIVRKRETL-NG------------TTVAVKKFKIF-------------------------------DRKSLIREMQTLRALN------DTPNV
 .|.| |..|.. .   ..            . ||.|  .                                 |||.. ||.. .. |.      | ||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VHIL
....
IKLY
Kinase 84943.m00149.AA TyrKc 46-316 18 4e-06 -124.07 SMART 1-280 (280) Show / Hide 
Range on Protein: 46-316
Range on HMM: 1-280/280
Sequence Identity: 18% (61 aa)

KDSNNYIGKGFFSIVRKRETLNGTTVAVKKFK--IFDRKSLIREMQTLRAL-NDTPNVVHILGLTGNY-------EHPSVVYSYHQSKN-EDYLNMSLPN
   .  .| |.| .|.| .    ..||||. |     |. ..||.. .. |  . ||.| ..|            | . .|  |    .  |||  . |.
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

FKWFLKHTLTILKDI-------HARGVIHNDMNIGNILFDLENKSLTLIDFGLAAFYRPE-------KHYKLK---GGM----FRIQPPEFLVDRNHWDC
    .|. | .  .|       | ...|| |    |.| . ..      ||||. .   .       . |. |   ||      |  .|| . . .    
--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTT

GVDIWS----------------LG-----ITCLDLVLGIK-GNYLPKDDRDSREFMNRYFGKQLAPYLKSKGIKIEPGDSDLFELAMPGTEQLITKDVMD
  |.||                 |     ..  ...  .| |...|. . |  . |                          |           .... .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS-------------------------F--------VCCPDEMYQ

LIGKMLTIDPKKRITARDALKHPLF
.. .    ||..| | ..   | .|
IMKQCWHEDPEDRPTFSEI--HECF
Kinase 84943.m00149.AA CMGC 46-104 18 3.1e-05 12.15 In-house 1-104 (513) Show / Hide 
Range on Protein: 46-104
Range on HMM: 1-104/513
Sequence Identity: 18% (19 aa)

KDSNNYIGKGFFSIVRK---RETL------------NGTTVAVKKFK-IFDRK--------------SLIREMQTLRALN----------------DTPN
 .  ..||.| ...| |   ..|             ..  ||.||.|  |  .              . .|| . |. ||                . .|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVHIL
.|...
IVKLY
Kinase 84943.m00149.AA CMGC 149-184 24 4.4e-05 11.65 In-house 198-254 (513) Show / Hide 
Range on Protein: 149-184
Range on HMM: 198-254/513
Sequence Identity: 24% (14 aa)

IHARG--VIHNDMNIGNILFDLENKS-------------------LTLIDFGLAAFY
.| ..  .|| |.   |||.. ....                   | ..||||| .|
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWY
Kinase 84943.m00149.AA MSK 291-316 46 0.000125 11.57 In-house 252-277 (277) Show / Hide 
Range on Protein: 291-316
Range on HMM: 252-277/277
Sequence Identity: 46% (12 aa)

DLIGKMLTIDPKKRITARDALKHPLF
|||...|| ||||| .. | ..|   
DLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase 84943.m00149.AA CDK-DD1 130-184 32 0.001179 6.48 In-house 95-148 (379) Show / Hide 
Range on Protein: 130-184
Range on HMM: 95-148/379
Sequence Identity: 32% (18 aa)

MSLPNFKWFLKHTLTILKDIHARGVIHNDMNIGNILFDLENKSLTLIDFGLAAFY
||||  | | .  |  ....|  |. | |    | |    . .| . |||..  |
MSLPCIKCFFHQLLEGINECHNQGIMHRDIKPANLLIN-NRGDLKITDFGFTTYY
Kinase 84943.m00149.AA CMGC 201-221 26 0.016601 3.01 In-house 293-322 (513) Show / Hide 
Range on Protein: 201-221
Range on HMM: 293-322/513
Sequence Identity: 26% (8 aa)

PPEFLVDR---------NHWDCGVDIWSLG
.|| |.           .|.....|.||.|
APEILLGWKHYTNHNYSMHYTTPIDMWSVG
Kinase 84943.m00149.AA Ciliate-E2 46-101 15 0.090073 1.84 In-house 1-95 (365) Show / Hide 
Range on Protein: 46-101
Range on HMM: 1-95/365
Sequence Identity: 15% (15 aa)

KDSNNYIGKGFFSIVRKRET-LNGT-----------------------TVAVKKFK---IFDRKSLIREMQTLR------------ALNDTPNVV
 . .. ||.| |..|.| .  ...                         .|.| .|   |.  |. |..|....             ... ||..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNII