Gene GL50803_27520 (G.lamblia)

GL50803_27520

Species: G.lamblia
Alias: GL50803_27520, GK027
External Links: GiardiaDB ,
Annotation:

Classification

Group: CMGC
Family: CK2

Sequence

Name Sequence Type Origin Length Description Download
GL50803_27520.AA Protein None 477 None Fasta, JSON
GL50803_27520.kin_dom Protein Kinase Domain None 285 None Fasta, JSON

Protein domain

Protein domains of GL50803_27520.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_27520.AA CK2 67-351 48 8.20000000001e-134 402.18 In-house 1-288 (288) Show / Hide 
Range on Protein: 67-351
Range on HMM: 1-288/288
Sequence Identity: 48% (139 aa)

YEIGRKLGHGKYSDVFEGYCVDTDSSV--VIKILKPVRRKKIYREIKILTNLLAGPNCINLLDVVSVRDSDYPALILEH-GGLSLAHSVQMLNDEQIRIV
||..||.| ||||.||||......  .  ||||||||. |||.||||||.||  ||| |.|.|.|  ..|  |||. |.       . .| |.|  ||  
YEVIRKIGRGKYSEVFEGINIKNNEKCKIVIKILKPVKKKKIKREIKILENLNGGPNIIKLYDIVKDPYSKVPALVFEYVNNTDFRQLYQTLTDYDIRYY

LFQTLRALEWFHIHGIVHRDTKPGNIAYDPTSHRLKLLDYGLAEFYSYGTPLHHRVASRHYKSPEILVNYQLYDYSLDIWSLGTLAAGLIFKRHPFFRGT
.|. |.||.. |  ||.||| || ||. |..  .|.| | ||||||  |.    |||||.|| || ||.|| ||||||.||||.. |..|||. |||.|.
MFELLKALDYCHSMGIMHRDVKPHNIMIDHEKRKLRLIDWGLAEFYHPGQDYNVRVASRYYKGPELLVDYQYYDYSLDMWSLGCMFASMIFKKEPFFHGH

NNINQLDKIVEVLGSADFFAMINKYNIKLSSSRTYDLQGYERMQFDAFTNHDNHYLVTDQALDFLNKTLVYDPEKRLTVREALLHPYF
.|. || ||| |||  |... ..||.|.| ..    .| ... ..  | ...|. |....|.|||.| |.||...|.| .||. ||||
DNYDQLVKIVKVLGTEDLYKYLDKYGIHLDPQFHDIMQQHKKKPWERFIHQENKHLAHPEAIDFLDKMLRYDHQERITAKEAMEHPYF
Kinase GL50803_27520.AA CMGC 67-351 20 2.7e-79 260.01 In-house 1-513 (513) Show / Hide 
Range on Protein: 67-351
Range on HMM: 1-513/513
Sequence Identity: 20% (103 aa)

YEIGRKLGHGKYSDVFEGYCVDTDSS--------------VVIKILKPVRRKKIY---------------REIKILTNL----------------LAGPN
||| .|.|.| |. |..... .|.                | ||..| .  ...                |||||| .|                   .|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

CINLLDVVSVRDSD---------------YPALILEHGGLSLAHSVQM------------LNDEQ------------IRIVL------FQTLRALE--WF
...|.|..  ..||               .  |. |. . .|..  ..            |.. .            |.  .      .| ||.|.    
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HIHG--IVHRDTKPGNIAYDPT-------------------SHRLKLLDYGLAEFYSYG----------------------TPLHHRVASRHYKSPEILV
| |.  |.||| || ||  ...                   . |||. | ||| .|.                         |. |.|..|.|..||||.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

NYQLYD---------YSLDIWSLGTLAAGL-------IFKRHPFFRGTNN-----------INQLDKIVEVLG------------------SADFFAMIN
... |.         .. |.||.|   | .       ||...|.| | ..           |.||.||..|||                  . ... ||.
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

KYNIKL--------------SSSRTYDLQG---YERMQFDAFTNHDNHYL---------------------------------VTDQALDFLNKTLVYDP
... ..              |..    .|    . . ..  ..|    .                                   ..||.|.|.| |.|||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

EKRLTVREALLHPYF
.||.|. .|| ||||
DKRITAEQALQHPYF
Kinase GL50803_27520.AA S_TKc 67-351 26 1.1e-62 215.43 SMART 1-231 (231) Show / Hide 
Range on Protein: 67-351
Range on HMM: 1-231/231
Sequence Identity: 26% (80 aa)

YEIGRKLGHGKYSDVFEGYCVDTDSSVVIKILKPVRRKKIYREIKILTNLLAGPNCINLLDVVSVRDSDYPALILEHGGL---SLAHSVQM---------
|||.||.|.| .. |. .. ..|.  | |||.|    ..|.|||.|| .    || ..|.||      |.  ...|. .    .| .  .          
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LNDEQIRIVLFQTLRALEWFHIHGIVHRDTKPGNIAYDPTSHRLKLLDYGLAEFYSYGTPLHHRVASRHYKSPEILVNYQLYDY-SLDIWSLGTLAAGLI
..  ..| .. |...|||  | |||.||| || ||  |    ..|. | ||| ..      .. . ...| .||.|     |.. . |.||.| . . ..
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

FKRHPFFRGTNNINQLDKIVEVLGSADFFAMINKYNIKLSSSRTYDLQGYERMQFDAFTNHDNHYLVTDQALDFLNKTLVYDPEKRLTVREALL------
  . ||        |.... ...|                                           ...|.||..| |..|||||.|. |||       
CGYPPFP-------QMQMMFKKIG-------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

-HPYF
 ||.|
CHPWF
Kinase GL50803_27520.AA Pkinase 67-351 25 4.7e-56 197.34 Pfam 1-293 (293) Show / Hide 
Range on Protein: 67-351
Range on HMM: 1-293/293
Sequence Identity: 25% (79 aa)

YEIGRKLGHGKYSDVFEGYCVDTDSSVVIKILKPVRRKKIYR-------EIKILTNLLAGPNCINLLDVVSVRDSDYPALILEHGGL-----SLAHSVQ-
|.||||.| | .. |.... ..|   |..||.| ...|.  .       ||.|. .|   || . |.|..    .|.. ...|. .      .|.. .. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

----ML--NDEQIRIVLFQTLRALEWFHIHGIVHRDTKPGNIAYDPTSHR---LKLLDYGLAEF--YSYGTPLHHRVASRHYKSPEILVNYQLYDYSLDI
     .   ..... .. |.||.||  | .||.||| || || .| . |    .|. | |||..  |  .. ..... ...| .||..  .| |... |.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSLGTLAAGLIFKRHPFFRGT----NNINQLDKIVEVLG---SADFFAMINKYNIKLSSSRTYDLQGYERMQFDAFTNHDNHYLVTDQALDFLNKTLVYD
||.| . . ....| ||  |     | ..|. .|....|   . |..  ..... .  .  .             | .  . ..... ..||... | .|
WSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-----------F-HWTF-HNWSEECKDFIKWCLCKD

PEKRLTVREALLHPYF
|.||.| ...| ||.|
PKKRPTAEQILQHPWF
Kinase GL50803_27520.AA p38 153-351 38 4e-42 141.6 In-house 101-289 (289) Show / Hide 
Range on Protein: 153-351
Range on HMM: 101-289/289
Sequence Identity: 38% (77 aa)

QMLNDEQIRIVLFQTLRALEWFHIHGIVHRDTKPGNIAYDPTSHRLKLLDYGLAEFYSYGTPLHHRVASRHYKSPEILVNYQLYDYSLDIWSLGTLAAGL
| |.|..|.. ..| ||.|   |  ||.||| ||.|||    .  |. ||.|||   .  . .   || | |..|||. |   |.   ||||.|  .| |
QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCE-LRILDFGLAR--HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAEL

IFKRHPFFRGTNNINQLDKIVEVLGSADFFAMINKYNIKLSSSRTYDLQGYERMQFDAFTNHDNHYLVTDQALDFLNKTLVYDPEKRLTVREALLHPYF
|  | . |.|.. |.|| .|..|.|. |   ...|  |.  ..|.| .|.|  |.   |..    . .  ||.| | | |. ||.||.|. ||. ||||
ITGR-TLFPGDDHIDQLQRIMKVCGTPD-EEFWQK--IQSEEARNY-IQSYPQMPRRDFHHVFMGANP--QAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase GL50803_27520.AA MAPK 150-351 32 3.1e-38 129.7 In-house 107-328 (328) Show / Hide 
Range on Protein: 150-351
Range on HMM: 107-328/328
Sequence Identity: 32% (74 aa)

HSVQMLNDEQIRIVLFQTLRA--LEWFHIHGIVHRDTKPGNIAYDPTSHRLKLLDYGLAE----FYSYGT-----------PLHHRVASRHYKSPEILVN
.| |.|.|. |.  ..| ||.  |   |  ...||| ||.||. .     ||..| |||     .|.. .            .   || | | .|||. |
KSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENC-DLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLN

--YQLYDYSLDIWSLGTLAAGLIFKRHPFFRGTNNINQLDKIVEVLGSADFFAMINKYNIKLS-SSRTYDLQGYERMQFDAFTNHDNHYL-----VTDQA
  .. |. . |.||.|   | ..  |.|.|.|.. |.|. .|.||||.     .|..     | . |.| .|..  ..     . .. .      ...||
WIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTP-SEEFIQCICM--SEHARNY-IQSLGNLPKYPKKPWEKMFPNANFNANPQA

LDFLNKTLVYDPEKRLTVREALLHPYF
.|.| | || ||.||.|| ||| ||||
IDLLEKMLVFDPDKRITVEEALQHPYF
Kinase GL50803_27520.AA ERK7 67-351 28 1.8e-36 122.07 In-house 1-292 (292) Show / Hide 
Range on Protein: 67-351
Range on HMM: 1-292/292
Sequence Identity: 28% (87 aa)

YEIGRKLGHGKYSDVFEGYCVDTDSSVVIKILKPVRRKKI-----YREIKILTNLLAGPNCINLLDVVSVRDSDYPALILEHGGLSLAHSVQ---MLNDE
||| ..|| | |  |   |.  |   | .|      | ..     .||| .| ..   || | |..|.         |. |.    |   ..   .| | 
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIRKGNILKDI

QIRIVLFQTLRALEWFHIHGIVHRDTKPGNIAYDPTSHRLKLLDYGLAEFYSYGT-------PLHHRVASRHYKSPEILVNYQLYDYSLDIWSLGTLAAG
  . ...| |||. . |   ..||| || ||  | .  ..|. |.|||   .           |   || | | .||||.  . |    | ||.|   . 
HKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLD-SECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGE

LIFKRHPFFRGTNNINQLDKIVEVLGSADFFAMINKYNIKLSSSRTYDLQGYERMQFDAFTNHDNHYLVTDQALDFLNKTLVYDPEKRLTVREALLHPYF
.. .. | | ||  .||..||.|...     . |.  . .....    ..  .| ..|..  .       |.|.| | . ||. |.||||. .|| ||| 
MLRGK-PMFPGTSTMNQIEKILETIPKPT-QEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQ-----CCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase GL50803_27520.AA CAMK 72-246 16 1.8e-25 78.4 In-house 1-321 (425) Show / Hide 
Range on Protein: 72-246
Range on HMM: 1-321/425
Sequence Identity: 16% (54 aa)

KLGHGKYSDVFEGYCVDTD------------SSVVIKILK-------------------------------PVRRKKIYREIKILTNL------LAGPNC
.||.| .. |....   |               | |||..                               |. ||...|||.|. .|      |  || 
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

INLLDVVSVRD-----------------SDYPALIL---EHGGLS------LAHSVQM-----------------LNDEQIRIVLFQTLRALEWFHIHGI
|.|..|   ..                  ..  ...   |.          . . |.                  .. .. | .  | . |..  | |.|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDTKPGNIAYDPTS----------------HRLKLLDYGLAEFYSY------------------------GTPLHHRVASRHYKS-PEILVN------
|||| || || .|  .                . .|. | |.| ..                          | ... .. . .| . ||.|        
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------YQLYDYSLDIWSLG
        . |... |.||.|
QNATDEEKPYYGPKCDMWSCG
Kinase GL50803_27520.AA CDK4 158-277 36 6.2e-25 82.31 In-house 110-226 (290) Show / Hide 
Range on Protein: 158-277
Range on HMM: 110-226/290
Sequence Identity: 36% (44 aa)

EQIRIVLFQTLRALEWFHIHGIVHRDTKPGNIAYDPTSHRLKLLDYGLAEFYSYGTPLHHRVASRHYKSPEILVNYQLYDYSLDIWSLGTLAAGLIFKRH
..|. . .| ||.... | | |.||| || ||     . ..|| |.|||  ||. . |   |    | .||.|   . |    |.||.|   |  ...| 
CTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVT-SDGHVKLADFGLARIYSFQMALTPVVVTLWYRAPEVLLQ-SYYNTPVDMWSVGCIFAE-MYCRR

PFFRGTNNINQLDKIVEVLG
| |.|..  .||.|| .| |
PLFCGQSEKDQLHKIFDVMG
Kinase GL50803_27520.AA CDKL 155-277 34 8.2e-25 81.76 In-house 95-217 (286) Show / Hide 
Range on Protein: 155-277
Range on HMM: 95-217/286
Sequence Identity: 34% (43 aa)

LNDEQIRIVLFQTLRALEWFHIHGIVHRDTKPGNIAYDPTSHRLKLLDYGLAEFYS-YGTPLHHRVASRHYKSPEILVNYQLYDYSLDIWSLGTLAAGLI
......| ...|.|.|... |.| ..||| || ||   | . ..|| | |.|   .  |  .   || | |..|| || .  |  . |||..| . | .|
VDEHVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMI

FKRHPFFRGTNNINQLDKIVEVLG
   .|.. | . | || .|. .||
-DGQPLWPGQSDIDQLYHIQKCLG
Kinase GL50803_27520.AA CDK 108-278 28 4.9e-24 73.65 In-house 57-243 (284) Show / Hide 
Range on Protein: 108-278
Range on HMM: 57-243/284
Sequence Identity: 28% (56 aa)

REIKILTNLLAGPNCINLLDVVSVRDSDYP---------ALILEHGGLSLAHSVQMLNDEQIRIVLFQTLRALEWFHIHGIVHRDTKPGNIAYDPTSH--
|||..| .|   || ..|.||.   ..|.           .. |.    |..         |.  ..| ||.|.  | ..|.||| || || .. . .  
REISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVK

--RLKLLDYGLAEFYSY-------GTPLHHRVASRHYKSPEILVNYQLYD--YSLDIWSLGTLAAGLIF--KRHPFFRGTNNINQLDKIVEVLGS
  |||. | |||  ..          .. |.|  . | .||.|   . |.   . |.||.|   | ..    | |.| |.. |.||.|| ...|.
CGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGT
Kinase GL50803_27520.AA GSK 317-351 45 1.8e-15 43.15 In-house 292-328 (328) Show / Hide 
Range on Protein: 317-351
Range on HMM: 292-328/328
Sequence Identity: 45% (17 aa)

HYLVTDQ--ALDFLNKTLVYDPEKRLTVREALLHPYF
... ||   ..|...|.|||||.|||. .||..||.|
KWCHTDMQDWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase GL50803_27520.AA CDK 299-351 33 1.4e-12 36.41 In-house 254-284 (284) Show / Hide 
Range on Protein: 299-351
Range on HMM: 254-284/284
Sequence Identity: 33% (18 aa)

DLQGYERMQFDAFTNHDNHYLVTDQALDFLNKTLVYDPEKRLTVREALLHPYF
.|..|                      |.||| |.|||.||..  .|| ||||
KLPDY----------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase GL50803_27520.AA GSK 160-204 46 9.5e-12 31.56 In-house 118-162 (328) Show / Hide 
Range on Protein: 160-204
Range on HMM: 118-162/328
Sequence Identity: 46% (21 aa)

IRIVLFQTLRALEWFHIHGIVHRDTKPGNIAYDPTSHRLKLLDYG
|..  .| .|.|   | |||.||| || || .|| ...||. |.|
IKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFG
Kinase GL50803_27520.AA CDK4 323-351 44 1.6e-11 35.58 In-house 262-290 (290) Show / Hide 
Range on Protein: 323-351
Range on HMM: 262-290/290
Sequence Identity: 44% (13 aa)

QALDFLNKTLVYDPEKRLTVREALLHPYF
|..|.|.| | |...||.. ...| ||||
QGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase GL50803_27520.AA CAMK 320-351 32 2.8e-11 31.86 In-house 386-425 (425) Show / Hide 
Range on Protein: 320-351
Range on HMM: 386-425/425
Sequence Identity: 32% (13 aa)

VTDQ--------ALDFLNKTLVYDPEKRLTVREALLHPYF
..|.        . |...| |..|||||.|. ..| || .
ISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase GL50803_27520.AA GSK 221-278 34 5.7e-11 29.13 In-house 181-237 (328) Show / Hide 
Range on Protein: 221-278
Range on HMM: 181-237/328
Sequence Identity: 34% (20 aa)

SRHYKSPEILVNYQLYDYSLDIWSLGTLAAGLIFKRHPFFRGTNNINQLDKIVEVLGS
||.|  || . ... |. . |.||.|.  | .. |..|.| | . ..||  |...||.
SRYYRAPELIFGCTNYTCQIDVWSCGCVMAEML-KGQPLFPGDSSVDQLVEIIKMLGT
Kinase GL50803_27520.AA CDKL 324-351 50 1.3e-08 25.6 In-house 259-286 (286) Show / Hide 
Range on Protein: 324-351
Range on HMM: 259-286/286
Sequence Identity: 50% (14 aa)

ALDFLNKTLVYDPEKRLTVREALLHPYF
||||. | |  || .|.|. ... ||||
ALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase GL50803_27520.AA GSK 67-126 30 2.3e-08 21.04 In-house 1-70 (328) Show / Hide 
Range on Protein: 67-126
Range on HMM: 1-70/328
Sequence Identity: 30% (21 aa)

YEIGRKLGHGKYSDVFEGYCV----DTDSS----VVIKILKPVRRKKIYREIKILTNL--LAGPNCINLL
||. .. |||  . |...|      .|.      |.||   . .| |  || .|...|  |  ||...|.
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIMKMLGKLDHPNIVRLK
Kinase GL50803_27520.AA TyrKc 67-306 16 2.5e-07 -104.15 SMART 1-280 (280) Show / Hide 
Range on Protein: 67-306
Range on HMM: 1-280/280
Sequence Identity: 16% (46 aa)

YEIGRKLGHGKYSDVFEGYCVDTDSSVVIKILKPVRRKKIYREIKILTNL-LAGPNCINLLDVVSVR-----DSDYPALILEHGG-------LSLAHSVQ
 . |.|||.| .  |..|        | .| ||.  |. ..||..|...|    || ..|. |..        .. . ...|.         |   .   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-

MLNDEQIRIVLFQTLRALEWFHIHGIVHRDTKPGNIAYDPTSHRLKLLDYGLAEFYSYG------TPLHHR---VASR-----HYKSPEILVNYQLYDYS
 |. ..     .|  .  |  | ....|||    |. ..    . |  | ||. .   .      .   .      ..        .|| . ||  .   
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTK

LDIWSLG-----------TLAAGLI---FKRHPFFRGTNNINQLDKIVEVL------GSADFFAMINKYNIKLSSSRTYDLQGYERM
 |.|| |           .   | |    .    ..   . . ...  ...       ... . .. .      ..|    . .|..
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase GL50803_27520.AA MAPK 67-128 30 3.6e-07 20.6 In-house 1-73 (328) Show / Hide 
Range on Protein: 67-128
Range on HMM: 1-73/328
Sequence Identity: 30% (22 aa)

YEIGRKLGHGKYSDVFEGYCVD------TDSSVVIKILK-----PVRRKKIYREIKILTNLLAGPNCINLLDV
|.| ...|.| |  |.  ...       ..  |.|| .      |.  | .|||||.|  .   .| |.|||.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDI
Kinase GL50803_27520.AA Pkinase_Tyr 67-116 30 9e-06 20.2 Pfam 1-60 (270) Show / Hide 
Range on Protein: 67-116
Range on HMM: 1-60/270
Sequence Identity: 30% (18 aa)

YEIGRKLGHGKYSDVFEGYCV----DTDSSVVIKILKP---VR---RKKIYREIKILTNL
 ..|.|||.| . .|..|..     .|.  | .|.||.    .   |..  ||.||...|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQL
Kinase GL50803_27520.AA p38 67-128 30 0.00151 7.67 In-house 1-69 (289) Show / Hide 
Range on Protein: 67-128
Range on HMM: 1-69/289
Sequence Identity: 30% (21 aa)

YEIGRKLGHGKYSDVFEGYCVDTDSS---VVIKIL-----KPVRRKKIYREIKILTNLLAGPNCINLLDV
|.  . .| | |  |   ....|.     | || |     ...  | .|||.. |  ..   | | ||||
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLL-KHMRHENVICLLDV