Gene PIK3R4 (Mouse)
PIK3R4
Sequence
Protein domains of PIK3R4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | PIK3R4.AA | VPS15 | 26-314 | 58 | 9.80000000001e-215 | 719.66 | In-house | 1-296 (296) | Show / Hide |
Range on Protein: 26-314 Range on HMM: 1-296/296 Sequence Identity: 58% (173 aa) FEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELK--IRLHSAQNCLPFQKAAEKASEKAAMLFRQYVRDNLYDRISTRPFLNNI ..|.|.||||||.||..|||.||..|||||...|.|..|..|||..||.| ...|.|.||.|.|| .....|||...||||..||||||||||||..| CHYVKNLGSTRFMKVCKAKHHEGYIVVKVFVKHDDTYSLEPYKQRIEEIKKNLMQHPAFNCCPYQK--VIETDKAAYMMRQYVKHNLYDRISTRPFLQMI EKRWIAFQILTAVDQAHKSG-VRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDGGMFATELEY--MRDPST ||.|||||.|.|..|.||.| |.|||||.||..||||||..|||||.|||.||||||||||..||||||||||||||||||........... |||..| EKKWIAFQTLCALEQCHKQGNVCHGDIKSENILVTSWNWCYLTDFACFKPCYLPEDNPADFTFFFDTSRRRTCYIAPERFVSNTEQDQDSNNGNMRDIHT PLVDLNSNQRARGELKRAMDIFSAGCVIAELFTEG-VPLFDLSQLLAYRNG--HFFPEQVLNKIEDRSIRDLVTQMINRE-PEKRLEAEDYLKQQRGN ...|...|....|||..|||||||||||||||.|| .|.||.|||..||.| |...||...||.|..||.|...||... |.||...|.||.. || DSIDRQQNPWLFGELTPAMDIFSAGCVIAELFCEGDQPPFDYSQLCKYRSGEYHPNREQIMEKIQDEHIRNLCHHMIQKDNPMKRMSCEEYLNKWRGF |
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| Kinase | PIK3R4.AA | S_TKc | 26-320 | 15 | 6.1e-14 | 27.57 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 26-320
Range on HMM: 1-231/231
Sequence Identity: 15% (50 aa)
FEYDKSLGSTRFFKVARAKHRE--GLVVVKVFAIQDPTLPLTSYKQELEELKIRLHSAQNCLPFQKAAEKASEKAAMLFRQYVRD---NLYDRISTRPF-
.| . .|. | || ...|.. .| .|. .. . |..| . . . . . .. |. .|.|.| |.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRH
-----LNNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDF--ASFKPTYLPEDNPADFNYFFDTSRRRTC----YIAPERFVDGGMF
.. . | .. ||. |.. |. |. | |.| ||..... . ..|| | . . | |.||| .
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------------TTFCGTPWYMAPEVL------
ATELEYMRDPSTPLVDLNSNQRARGELKR-AMDIFSAGCVIAELFTEGVPLFDLSQLLAYRNGHFFPEQVLNKIEDRSIRDLVTQMINREPEKRLEAEDY
. . |. | ||...|... | |.|. . . ... ... .|.. .. ...||||. | .
-------------------------GYGKCKCDWWSCGCILYEMLC-GYPPFP-QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EA
LKQQRGNAFPEIF
|. .. . . |
LQDEWDIKCHPWF
|
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| Kinase | PIK3R4.AA | NIM1 | 110-167 | 43 | 3.1e-09 | 23.29 | In-house | 87-144 (258) | Show / Hide |
Range on Protein: 110-167 Range on HMM: 87-144/258 Sequence Identity: 43% (25 aa) LYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDF || .|... | |. | ||. || | .. | ||| |||| || | | . || LYTHIHQEGKLREIHCKPIFAQIVSAVKHMHSRNIVHRDIKAENVMYTSNNCVKVGDF |
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| Kinase | PIK3R4.AA | CK2 | 118-156 | 33 | 4.3e-09 | 22.5 | In-house | 90-128 (288) | Show / Hide |
Range on Protein: 118-156 Range on HMM: 90-128/288 Sequence Identity: 33% (13 aa) PFLNNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMV . |. . |. |..| |.|..|. |. | |.| .|.|. QTLTDYDIRYYMFELLKALDYCHSMGIMHRDVKPHNIMI |
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| Kinase | PIK3R4.AA | NuaK | 109-155 | 40 | 6.3e-09 | 19.05 | In-house | 85-131 (252) | Show / Hide |
Range on Protein: 109-155 Range on HMM: 85-131/252 Sequence Identity: 40% (19 aa) NLYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVM .||| || . | | | . || .|| || .. | | | ||.. ELYDYISECKSLPEREARHFFRQIVSAVHYCHKHRICHRDLKLENIL |
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| Kinase | PIK3R4.AA | CMGC | 126-158 | 27 | 2e-07 | 19.5 | In-house | 184-219 (513) | Show / Hide |
Range on Protein: 126-158 Range on HMM: 184-219/513 Sequence Identity: 27% (10 aa) RWIAFQILTAVD--QAHKSG--VRHGDIKTENVMVTS | ...|||.... |. . . | |.| ||..... R-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINH |
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| Kinase | PIK3R4.AA | Ciliate-C3 | 128-167 | 40 | 3.6e-07 | 22.06 | In-house | 101-140 (140) | Show / Hide |
Range on Protein: 128-167 Range on HMM: 101-140/140 Sequence Identity: 40% (16 aa) IAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDF |. ||| |.| | . ||||| .|... | . . . || ISKQILQAIDYLHEHNIVHGDIKFSNILINSKDEIKIIDF |
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| Kinase | PIK3R4.AA | MELK | 26-167 | 25 | 6.9e-07 | 19.24 | In-house | 1-141 (254) | Show / Hide |
Range on Protein: 26-167 Range on HMM: 1-141/254 Sequence Identity: 25% (37 aa) FEYDKSLGSTRFFKVARAKH--REGLVVVKVFAIQDPTLPLTSYKQELEELKIRLHSAQNCLPFQKAAEKASEKAAMLFRQYVRDNLYDRISTRPFLNNI .| . .|. | || | | . | .|. . | | |.. || | |. . | . .| |.. ...| | . |.. YEVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGHDLPRVKTEMDALKNLRH--QHICQLYHYIE-TEDKIFMVMEYCPGGEMFDYIIRQDRLEEE EKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDF | | . ||. |. | | | |.| ||.... . | || ETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDF |
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| Kinase | PIK3R4.AA | CMGC | 238-264 | 26 | 8.9e-07 | 17.31 | In-house | 315-363 (513) | Show / Hide |
Range on Protein: 238-264 Range on HMM: 315-363/513 Sequence Identity: 26% (13 aa) AMDIFSAGCVIAELFTE-------GVPLFD---------------LSQL ..|. |.||..||..| | ||| . || PIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQL |
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| Kinase | PIK3R4.AA | CDKL | 126-167 | 41 | 4e-06 | 16.79 | In-house | 101-143 (286) | Show / Hide |
Range on Protein: 126-167 Range on HMM: 101-143/286 Sequence Identity: 41% (18 aa) RWIAFQILTAVDQAHKSGVRHGDIKTENVMVT-SWNWVLLTDF | . .||| |... || . | ||| || .| . | | || RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDF |
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| Kinase | PIK3R4.AA | MSK | 126-167 | 35 | 5e-06 | 16.43 | In-house | 104-148 (277) | Show / Hide |
Range on Protein: 126-167 Range on HMM: 104-148/277 Sequence Identity: 35% (16 aa) RWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSW---NWVLLTDF | | .. |||. |. |. |.|.| ||.. .. | |.|| RMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDF |
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| Kinase | PIK3R4.AA | Ciliate-E2 | 128-167 | 26 | 0.000109 | 12.0 | In-house | 165-200 (365) | Show / Hide |
Range on Protein: 128-167 Range on HMM: 165-200/365 Sequence Identity: 26% (11 aa) IAFQILTAVDQAHKSG-VRHGDIKTENVMVTSWNWVLLTDF .. .|. |. |. . . | ||| ||... . ..|| YIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDF |
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| Kinase | PIK3R4.AA | Ciliate-E2 | 240-309 | 16 | 0.000703 | 9.18 | In-house | 278-361 (365) | Show / Hide |
Range on Protein: 240-309 Range on HMM: 278-361/365 Sequence Identity: 16% (17 aa) DIFSAGCVIAELFTEGVPLFDLSQLLAYRNGHFFPEQVLNKIEDRSIR----------------------------DLVTQ----MINREPEKRLE-AED ||.|.|... |. . | ...|.. |. || . |....||||. .|. DIWSLGVILYEMLFGKPPF-------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQ YLK |. ILN |
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| Kinase | PIK3R4.AA | Pkinase | 240-302 | 14 | 0.001137 | 14.06 | Pfam | 194-282 (293) | Show / Hide |
Range on Protein: 240-302 Range on HMM: 194-282/293 Sequence Identity: 14% (13 aa) DIFSAGCVIAELFTEGVPLFDL-------SQLLAYRNGH---FFPEQVLNKIED----------------RSIRDLVTQMINREPEKRL |..|.||...|... | . . . .|... |... .. | . .. .|... .... |.||. DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP |
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| Kinase | PIK3R4.AA | MSK | 287-313 | 25 | 0.002033 | 7.41 | In-house | 251-277 (277) | Show / Hide |
Range on Protein: 287-313 Range on HMM: 251-277/277 Sequence Identity: 25% (7 aa) RDLVTQMINREPEKRLEAEDYLKQQRG .||.... . |.||| ..| ... KDLIQWLLTKDPKKRLGMNDLRAHEWK |
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| Kinase | PIK3R4.AA | CDKL | 238-259 | 45 | 0.013299 | 4.72 | In-house | 180-200 (286) | Show / Hide |
Range on Protein: 238-259 Range on HMM: 180-200/286 Sequence Identity: 45% (10 aa) AMDIFSAGCVIAELFTEGVPLF . || ..|||.||... | ||. PVDIWAIGCVMAEMID-GQPLW |
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| Kinase | PIK3R4.AA | CK2 | 238-259 | 31 | 0.090803 | 0.2 | In-house | 176-197 (288) | Show / Hide |
Range on Protein: 238-259 Range on HMM: 176-197/288 Sequence Identity: 31% (7 aa) AMDIFSAGCVIAELFTEGVPLF ..|. | ||..| . . .|.| SLDMWSLGCMFASMIFKKEPFF |
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| Kinase | PIK3R4.AA | Pkinase | 128-156 | 34 | 0.13198 | 6.76 | Pfam | 113-141 (293) | Show / Hide |
Range on Protein: 128-156 Range on HMM: 113-141/293 Sequence Identity: 34% (10 aa) IAFQILTAVDQAHKSGVRHGDIKTENVMV .. ||| ... |. |. | |.| ||... YMYQILRGLEYCHSMGIIHRDLKPENILI |
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| HEAT | PIK3R4.AA | HEAT | 418-448 | 32 | 3.8e-05 | 21.68 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 418-448 Range on HMM: 1-31/31 Sequence Identity: 32% (10 aa) ITPYLLHFSNDSVPRVRAEALRTLTKVLALV | |.||. ||....||. |...|.... . ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
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| HEAT | PIK3R4.AA | HEAT | 463-493 | 29 | 0.003646 | 14.82 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 463-493 Range on HMM: 1-31/31 Sequence Identity: 29% (9 aa) ILPGIAHLAQDDATIVRLAYAENIALLAETA ||| . .. .|. ||.| .. .. |.| . ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
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| HEAT | PIK3R4.AA | HEAT | 577-608 | 28 | 0.217681 | 8.67 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 577-608 Range on HMM: 1-31/31 Sequence Identity: 28% (9 aa) LLSHMITFLNDKNDWHLRGAFFDSIVGVAAYV .|.|... |||. ||. | | . ... .. .. ILPHLLKCLNDP-DWEVREAACWCLGQLCEHC |
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| HEAT | PIK3R4.AA | HEAT | 616-646 | 25 | 0.159254 | 9.14 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 616-646 Range on HMM: 1-31/31 Sequence Identity: 25% (8 aa) LKPLLQQGLSDAEEFVIVKALNALTCMCQLG . |.| ..|.| .. | |...|. .|. ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
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| WD40 | PIK3R4.AA | WD40 | 983-1021 | 22 | 1.3e-12 | 38.92 | Pfam | 1-39 (39) | Show / Hide |
Range on Protein: 983-1021 Range on HMM: 1-39/39 Sequence Identity: 22% (9 aa) GLLVAHLHEHKSAVNRIRVSDE-HLLFATCSNDGTVKIWN . ... . .|...|. ...... ..|..| |||..||. WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD |
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| WD40 | PIK3R4.AA | WD40 | 982-1021 | 20 | 1.6e-10 | 42.24 | SMART | 1-46 (46) | Show / Hide |
Range on Protein: 982-1021 Range on HMM: 1-46/46 Sequence Identity: 20% (10 aa) KGLLVAHLHEHKS--AVNRIRVSDEH------LLFATCSNDGTVKIWN . .|. .. |.. .|. ..... . ..|..| |||..||. T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD |
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| WD40 | PIK3R4.AA | WD40 | 1031-1070 | 18 | 0.025025 | 10.47 | SMART | 1-46 (46) | Show / Hide |
Range on Protein: 1031-1070 Range on HMM: 1-46/46 Sequence Identity: 18% (9 aa) TTRSILTYSRIGG--RVKTLTFCQGS------HYLAIASDNGAVQLLG | . . |.. | .| ...... . .||| .| .| . . T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD |
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| WD40 | PIK3R4.AA | WD40 | 1132-1169 | 18 | 0.185439 | 4.98 | SMART | 1-46 (46) | Show / Hide |
Range on Protein: 1132-1169 Range on HMM: 1-46/46 Sequence Identity: 18% (9 aa) AWTLKHDLK--SG--LITSFAVDIHQ------CWLCIGTSSGAMACWD .. | .| .| .|. ... . .|. | | .|| T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD |
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| WD40 | PIK3R4.AA | WD40 | 1171-1214 | 12 | 0.66229 | 1.49 | SMART | 1-46 (46) | Show / Hide |
Range on Protein: 1171-1214 Range on HMM: 1-46/46 Sequence Identity: 12% (6 aa) RFQLPISSHCHPSRARIRRLSMHPLY----QSWVIAAVQGNNEVSMWD .. . ..| . .... .. || .. ..|. .. . .|| T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD |
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| WD40 | PIK3R4.AA | WD40 | 1229-1269 | 21 | 1.5e-05 | 18.61 | Pfam | 1-39 (39) | Show / Hide |
Range on Protein: 1229-1269 Range on HMM: 1-39/39 Sequence Identity: 21% (9 aa) APPLSELQPSPHSVHGIYCSPADGNPILLTAGSDMKIRFWD ..... |.| . ..| . ..|.... | .|| || WKCKHTF-GHTHWVTCCAWHPD-MGHYLASGSRDGTIRIWD |
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| WD40 | PIK3R4.AA | WD40 | 1228-1269 | 16 | 0.000112 | 22.79 | SMART | 1-46 (46) | Show / Hide |
Range on Protein: 1228-1269 Range on HMM: 1-46/46 Sequence Identity: 16% (8 aa) SAPPLSELQPSPH--SVHGIYCSPAD----GNPILLTAGSDMKIRFWD . ...... . .|... .| . .. .|.... | .||.|| T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD |
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| WD40 | PIK3R4.AA | WD40 | 1319-1358 | 22 | 5.2e-07 | 22.79 | Pfam | 1-39 (39) | Show / Hide |
Range on Protein: 1319-1358 Range on HMM: 1-39/39 Sequence Identity: 22% (9 aa) RGPESLPVGHHDIITDIATFQTTQGFIVTASRDGIVKVWK . . . || . .|..| . . .....|||| ...|. WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD |
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| WD40 | PIK3R4.AA | WD40 | 1317-1358 | 14 | 0.000117 | 22.72 | SMART | 1-46 (46) | Show / Hide |
Range on Protein: 1317-1358 Range on HMM: 1-46/46 Sequence Identity: 14% (7 aa) PRRGPESLPVGHHD--IITDIATFQTT-----QGFIVTASRDGIVKVWK . . ... || . .|... .. .....| || ...|. T-KCVHTFK-GHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD |
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