Gene CK2a1 (Human)

CK2a1

Species: Human
Alias: CKII, CKII alpha, CK2a1, CK2alpha, CK2A1, CSNK2A1
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 20p13,

Classification

Group: CMGC
Family: CK2

Sequence

Name Sequence Type Origin Length Description Download
CK2a1.AA Protein Sugen Kinome 391 None Fasta, JSON
CK2a1.kin_dom Protein Kinase Domain Sugen Kinome 286 None Fasta, JSON
CK2a1.NA RNA Sugen Kinome 2732 None Fasta, JSON

Protein domain

Protein domains of CK2a1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CK2a1.AA CK2 39-324 81 1.8e-241 729.91 In-house 1-288 (288) Show / Hide 
Range on Protein: 39-324
Range on HMM: 1-288/288
Sequence Identity: 81% (236 aa)

YQLVRKLGRGKYSEVFEAINITNNEKV--VVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFY
|...||.||||||||||.|||.||||.  |.|||||||||||||||||||||.||||||.| ||||||.|..||||||.||||||.||||||||||||.|
YEVIRKIGRGKYSEVFEGINIKNNEKCKIVIKILKPVKKKKIKREIKILENLNGGPNIIKLYDIVKDPYSKVPALVFEYVNNTDFRQLYQTLTDYDIRYY

MYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGH
|.|.|||||||||||||||||||||.|||||.||||||||||||||||||.|||||||||.||||||||||.|||||||||||||.|||||.||||||||
MFELLKALDYCHSMGIMHRDVKPHNIMIDHEKRKLRLIDWGLAEFYHPGQDYNVRVASRYYKGPELLVDYQYYDYSLDMWSLGCMFASMIFKKEPFFHGH

DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF
|||||||.|.|||||||||.|.|||.|.|||.|.||...|..|.||||.|.||.||..|||.|||||.|||||| |.||.||||||||
DNYDQLVKIVKVLGTEDLYKYLDKYGIHLDPQFHDIMQQHKKKPWERFIHQENKHLAHPEAIDFLDKMLRYDHQERITAKEAMEHPYF
Kinase CK2a1.AA CMGC 39-324 20 5.1e-104 342.79 In-house 1-513 (513) Show / Hide 
Range on Protein: 39-324
Range on HMM: 1-513/513
Sequence Identity: 20% (107 aa)

YQLVRKLGRGKYSEVFEAIN--------------ITNNEKVVVKILKPVKKKKIK---------------REIKILENLR----------------GGPN
|. ..|.|.| |..|.....              . .||.| .|..| .. ...                ||||||..|.                  .|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IITLADIVKDPVSRTP---------------ALVFEHVNNTDFKQLYQ-----------TLTDYD------------IRFYM------YEILKALD--YC
|..| ||.... |...                ||||.. .. .. ...            |..              |...|      | ||..|.  ||
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSMG--IMHRDVKPHNVMIDHEHRK-------------------LRLIDWGLAEFYHPG----------------------QEYNVRVASRYFKGPELLV
||..  |.||| || |..|.|. .                    |...|.||| .|||                       . |  .|..|. . ||.|.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

DYQMYD---------YSLDMWSLGCMLASM-------IFRKEPFFHGHDN-----------YDQLVRIAKVLG------------------TEDLYDYID
 .. |.         .. ||||.||..| |       |||..|.|.||..           .||| .| ||||                  .|. ...|.
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

KYNIELDPR----------FNDI----------LGRHSRKRWERFVHSENQ------------------------------HLVSPEALDFLDKLLRYDH
... ...|           ...           .... .| |....   .                               .. .|.|.|.|.|.|.||.
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

QSRLTAREAMEHPYF
. |.|| .|..||||
DKRITAEQALQHPYF
Kinase CK2a1.AA Pkinase 39-324 28 9e-100 342.56 Pfam 1-293 (293) Show / Hide 
Range on Protein: 39-324
Range on HMM: 1-293/293
Sequence Identity: 28% (89 aa)

YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR-------EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT----DFK-----
|...||.|.| ...|...... ....|.|||.| ...|. |.       ||.|. .| . |||..| |.. |  .. . .|.|.....    | .     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

QLYQTL--TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRK---LRLIDWGLAEF--YHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDM
. . ..  .. ...||||.||..|.|||||||.|||.|| |..||..      ....|.|||..  | ... ..... ....  ||.. ..|.|... ||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSLGCMLASMIFRKEPFFHG---HDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSR
||.||.|. |.... || .    .. .||...|....|..  .|.  ...| ... |..   .        | |... |..|.|..||....|..| ..|
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--------F-HWTF-HNWSEECKDFIKWCLCKDPKKR

LTAREAMEHPYF
.||.....||.|
PTAEQILQHPWF
Kinase CK2a1.AA S_TKc 39-324 27 1.1e-80 275.23 SMART 1-231 (231) Show / Hide 
Range on Protein: 39-324
Range on HMM: 1-231/231
Sequence Identity: 27% (83 aa)

YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNN--TDFKQLYQT---------
|...||.|.| ...|. ....  ...| .||.|    ..|.|||.||..  . |||..| |.  |       .|.|....   | ... .          
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDY-SLDMWSLGCMLASMI
..  ..|||||.|..||.||||.||.|||.|| |...|.    . ..| ||| ..      .  . ....  ||.|     |.. . |.||.||.|. |.
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

FRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME------
 .. ||        |. .. |..|                                           ||||.||..|.|..| . |.|| ||..      
CGYPPFP-------QMQMMFKKIG-------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

-HPYF
 ||.|
CHPWF
Kinase CK2a1.AA CDK 39-324 27 2.5e-59 188.41 In-house 1-284 (284) Show / Hide 
Range on Protein: 39-324
Range on HMM: 1-284/284
Sequence Identity: 27% (89 aa)

YQLVRKLGRGKYSEVFEAINITNN-----EKVVVKILK-PV-----KKKKIK----REIKILENLRGGPNIITLADIVKDP-VS--------RTPALVFE
|. . |.|.| | .|. |..  ..     . |  | ..        .|  .     |||..| .|   |||..| |.. .   .        ..  .|||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

HVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHR----KLRLIDWGLAEFYH-------PGQEYNVRVASRYFKGPELL
..  .| |..        |. ||. .|..|.|||| .||||| || | .|..       .| . | |||  ..       | ..|  .|  .    ||||
YM-DHDLKKYMD------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELL

VDYQMYD--YSLDMWSLGCMLASMIF--RKEPFFHGHDNYDQLVRIAKVLGT--EDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEA
   . |.   . ||||.|| .| |.    ..|.|.|    ||| .| ...||  ||    . |.                                    
LGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------------

LDFLDKLLRYDHQSRLTAREAMEHPYF
 |.|.|.| || . |..| .|..||||
-DLLNKMLCYDPKKRISAEQALQHPYF
Kinase CK2a1.AA CAMK 44-232 19 4.6e-52 165.66 In-house 1-334 (425) Show / Hide 
Range on Protein: 44-232
Range on HMM: 1-334/425
Sequence Identity: 19% (66 aa)

KLGRGKYSEVFEAINITNN------------EKVVVKILK-------------------------------PVKKKKIKREIKILENLRG------GPNI
.|||| ...|...|.. ..            .|| .||..                               |...|...|||.|. .|.|       |||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ITLADIVKDPVS--------RTPA----------LVF---EHVNNT----D-FKQLYQT-----------------LTDYDIRFYMYEILKALDYCHSMG
| | ..  ||                        .|.   |.. .     | |  . .                  .|  . |.|.  |. |..||||..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IMHRDVKPHNVMIDHEH----------------RKLRLIDWGLAEFYHP------------------------GQEYNVRVASRYFKG-PELLVDYQM--
|.||| || |...|. .                 .. .||.|.| .. |                        || .. .. . ..   ||.|   ..  
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----------YDYSLDMWSLGCMLASMIFRKEPF
           |... ||||.|..|  |   . ||
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPF
Kinase CK2a1.AA CDC2 39-324 30 2e-48 146.65 In-house 1-301 (301) Show / Hide 
Range on Protein: 39-324
Range on HMM: 1-301/301
Sequence Identity: 30% (95 aa)

YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK--------REIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----
|| ..|.| | | .|. ...   |. |..|  . ..             ||| .| .|.  |||..| |...    .   .||| . . | |..      
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIR-LEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYL-DMDLKKYMDMSIP

---TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYN--VRVASRYFKGPELLVDYQMYDYSLDMWSLGC
    ..   .. ||| ||.....||...||||| || |  || . . ... | |||  |  |  .|     |  .    ||.|   . |. . ||||.||
KNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN-IKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGC

MLASM-IF-RKEPFFHGHDNYDQLVRIAKVLGT--EDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHS----ENQHLVSPEALDFLDKLLRYDHQSR
 .| | .   |.|.|||    ||| .| ..|||  |. .  ....     | ..   .|  ..  .. . .     ||  . ||..| |...|.|| | |
IFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQL-----PDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKR

LTAREAMEHPYF
..|.||..||||
ISAKEALQHPYF
Kinase CK2a1.AA Ciliate-E2 39-324 17 1.4e-44 150.97 In-house 1-365 (365) Show / Hide 
Range on Protein: 39-324
Range on HMM: 1-365/365
Sequence Identity: 17% (74 aa)

YQLVRKLGRGKYSEVFEAINITNNEK-----------------------VVVKILKPVKKKKIKREIKILENLRGG---------------PNIITLADI
| ...|.|.| .. |... .. ....                       . .||.|. ... ||.||.|.  .. .               |||| . . 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

VKDPVSRTPALVFEHVNNTDFKQLYQ--------------TLTDYDIRFYMYEILK---------------ALDYCHSMG-IMHRDVKPHNVMIDHEHRK
 ..    .  ||.| ..  | ... .               .|.. |...|..||.               || |.|| . |.||| || |...      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

LRLIDWGLAEFYHPGQE--------------------------------YNVRVASRYFKGPELLV--DYQM------YDYSLDMWSLGCMLASMIFRKE
. .||.||. .|.. ..                                .|  . . ... || |   .|.       |||. |.||||..|  |.| | 
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHL---------------------------VSPEALDFLDK
||                                                       ..|..                           .|.|. |.. |
PF-------------------------------------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKK

----LLRYDHQSRLT-AREAMEHPYF
    .| .| . |.| . ....||.|
FGKRMLQKDPEKRITGWEQILNHPWF
Kinase CK2a1.AA Ciliate-E2-Unclassified 39-324 18 6.7e-41 139.61 In-house 1-352 (352) Show / Hide 
Range on Protein: 39-324
Range on HMM: 1-352/352
Sequence Identity: 18% (70 aa)

YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK---------IKREIKILENL----------------RGGPNIITLADIVKDPVSRTPALVF
| .....|.| ...|...... .... . |..| ....|         |..|.|...|.                .  |... . ..  .    .. .| 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EHVNNTDFKQLYQT--------------------LTDYDIR-----FYMYEILKALDYCHSMG-IMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFYH--
| ... | .|  .                     .|.. ..     ||...||..|.|.|. . | ||| || |...| ...  ....||.|.. .|   
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

--------------PGQEYNVRVASRYFK----GPELLVDYQMYD----YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY
              . |... .. . ...     ||.| . | ||    |. |.||||. |  |.| . ||.   .. .| . .... .       ..  
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVL-QGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-N-------NA--

NIELDPRFNDILGRHSRKRWERFVHSENQ--HLVSPEALDFLD----KLLRYDHQSRLTAREAMEHPYF
      ..  ..     | .. . ... |  . .|||| ||.     |.| ..  .|.|. ....||.|
------YRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase CK2a1.AA ERK7 39-324 28 8.4e-40 133.61 In-house 1-292 (292) Show / Hide 
Range on Protein: 39-324
Range on HMM: 1-292/292
Sequence Identity: 28% (86 aa)

YQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTD
|.. ..||.| |  |  |.     . | .|        ..   .  ||| .| .... |||| | ....    |   ||||.  .||     .    | |
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFM-ETDLHAVIRKGNILKD

YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA------EFYHPGQEYNVR---VASRYFKGPELLVDYQMYDYSLDMWSLGCM
   .. || .|.|. | ||  ..|||.|| |...| | . ... | |||      | |  ...  ..   || | .  || |.  . |    ||||.|| 
IHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECM-VKVCDFGLARSIAQQEEY--DEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCI

LASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH
|. |.  | | | |    .|. .| ....     | |   . ..     . .... ||  . .. .      ...|.| | .|| .  . |||| .|..|
LGEMLRGK-PMFPGTSTMNQIEKILETIPKPTQED-IEAIGSHYAWNMLEQMNQQKRKTLDQMMPQ-----CCDDAIDLLKRLLVFNPKKRLTAEQALQH

PYF
|| 
PYV
Kinase CK2a1.AA RCK 39-251 30 3.5e-36 112.11 In-house 1-232 (298) Show / Hide 
Range on Protein: 39-251
Range on HMM: 1-232/298
Sequence Identity: 30% (72 aa)

YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK-----REIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------
||....||.| |..|..|.|....|.|  | .|  | ....     |||| |  |   |||| | ....|  ... ..|||..  ..  |....      
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK-QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYM-DMNLYQMMKDFKERRK

-LTDYD--IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHE--------HRKLRLIDWGLA-EFY--HPGQEYNVRVASRYFKGPELLVDYQMYDYSL
 |.     |...|| ||..|...|. |..|||.|| | |.  .           . ..| ||. |..  .|  .|   | .|.   ||.|   . |.. .
YLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDY---VSTRWYRAPECLLRCTYYNSPM

DMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT
|.|..||  .  .  . | | | .  ||.  | ||.||
DIWAVGCIMY-ELYMLRPLFPGSSEIDQIFKICKVMGT
Kinase CK2a1.AA GSK 194-324 28 2.7e-26 76.82 In-house 181-328 (328) Show / Hide 
Range on Protein: 194-324
Range on HMM: 181-328/328
Sequence Identity: 28% (45 aa)

SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDI------LGRHSRKR-------
|||   |||. ... |. . |.||.|| .| |. .. |.| |..  ||||.|.|.||| .  . |.. | .  |.|..       . .|. ..       
SRYYRAPELIFGCTNYTCQIDVWSCGCVMAEMLKGQ-PLFPGDSSVDQLVEIIKMLGTPTKEQ-IQSMNPS-YPEFKFPYWSFQQIKPHPWQKNDTKYEY

------------WERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF
              . .|...|     ...|.. |.|.|| ..||...||. ||.|
QTYYHKKYRTVYMFKWCHTDMQ-----DWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase CK2a1.AA GSK 126-177 40 1.8e-14 40.01 In-house 111-162 (328) Show / Hide 
Range on Protein: 126-177
Range on HMM: 111-162/328
Sequence Identity: 40% (21 aa)

QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG
|......|. ||| ....| | ||.|| |||.|| |. .|..  .| . | |
QQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFG
Kinase CK2a1.AA CAMK 293-324 34 6.7e-11 30.63 In-house 394-425 (425) Show / Hide 
Range on Protein: 293-324
Range on HMM: 394-425/425
Sequence Identity: 34% (11 aa)

VSPEALDFLDKLLRYDHQSRLTAREAMEHPYF
||.|. |.. |.|..| . |.|. ....|| .
VSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase CK2a1.AA TyrKc 39-281 17 4.2e-10 -59.25 SMART 1-280 (280) Show / Hide 
Range on Protein: 39-281
Range on HMM: 1-280/280
Sequence Identity: 17% (51 aa)

YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENL-RGGPNIITLADIVKDP-----VSRTPALVFEHVNNTDFKQLYQTLTD--
 .| .|||.| . ||.... .   ..| || ||. ... . ||..|. .|    |||. |  .. ..      .  . .|.|.. . | |.  .   .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL

--YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG-------QEYNVRV--ASR-----YFKGPELLVDYQMYDYSLD
   |   ... | .  .| ||... |||    |......|   .  | ||. . . .       . | ..    ..         || . .| ..    |
CMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTKSD

MWSLGCML---ASMIFRKEPF-----FHGHDNYDQLVRI----AKVL--------GTEDLYDYIDK---YNIELDPRFNDILGRHSRKRW
 || | ..    .      |          . . .. .                  ....|. . .   .. |  |.|..|     ....
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----HECF
Kinase CK2a1.AA RCK 294-324 41 5.8e-10 27.49 In-house 268-298 (298) Show / Hide 
Range on Protein: 294-324
Range on HMM: 268-298/298
Sequence Identity: 41% (13 aa)

SPEALDFLDKLLRYDHQSRLTAREAMEHPYF
|..... . |.|..| | | || .| .||||
SQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase CK2a1.AA GSK 39-97 26 1.6e-08 21.49 In-house 1-69 (328) Show / Hide 
Range on Protein: 39-97
Range on HMM: 1-69/328
Sequence Identity: 26% (18 aa)

YQLVRKLGRGKYSEVFEAINI----TNNEK----VVVKILKPVKKKKIKREIKILENLR--GGPNIITL
|.  .. |.|  . |..|...    ...|.    |..|   . |. |  || .|...|.    |||..|
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIMKMLGKLDHPNIVRL