Gene 15737 (Tetrahymena)

15737

Species: Tetrahymena
Alias: 190.m00047, PreTt15737, 15737, 197, 3820.m00272, TTHERM_01000180
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: CK2

Sequence

Name Sequence Type Origin Length Description Download
15737.AA Protein None 344 None Fasta, JSON
15737.kin_dom Protein Kinase Domain None 286 None Fasta, JSON
15737.NA RNA None 1035 None Fasta, JSON

Protein domain

Protein domains of 15737.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 15737.AA CK2 40-325 72 3.5e-228 689.48 In-house 1-288 (288) Show / Hide 
Range on Protein: 40-325
Range on HMM: 1-288/288
Sequence Identity: 72% (210 aa)

YEVIRKLGRGKYSEVFEGINSLNNEKC--VIKVLKPIRKKKIKREISILKNLSGGPNIVQLLDIVKDPASKCTSFVFEYVNNIDYRELYPKLSDFDVRFY
||||||.|||||||||||||. |||||  |||.|||..||||||||.||.||.|||||..|.||||||.||... |||||||.|.|.||..|.|.|.|.|
YEVIRKIGRGKYSEVFEGINIKNNEKCKIVIKILKPVKKKKIKREIKILENLNGGPNIIKLYDIVKDPYSKVPALVFEYVNNTDFRQLYQTLTDYDIRYY

IFEVLKALDFCHSQGIMHRDVKPHNIMIDHEKKQLRLIDWGLAEYYFPGKDYNVRVASRYFKGPELLVDYQYYDYSLDIWSLGAMFAGMIFKKEPFFQGN
.||.|||||.|||.||||||||||||||||||..||||||||||.|.||.||||||||||.|||||||||||||||||.||||.|||.|||||||||.|.
MFELLKALDYCHSMGIMHRDVKPHNIMIDHEKRKLRLIDWGLAEFYHPGQDYNVRVASRYYKGPELLVDYQYYDYSLDMWSLGCMFASMIFKKEPFFHGH

DNYDQLEKIARVLGTNELYDYLNTYNLELDPKFEGILGKHTKKPWSKFVNNDNKNLAVNEAIDLLSKMLVYDHAQRITPKEAMQHAYF
|||||| ||..||||..||.||..|...|||.|. |...|.||||..|....||.||..||||.|.|||.|||..|||.||||.|.||
DNYDQLVKIVKVLGTEDLYKYLDKYGIHLDPQFHDIMQQHKKKPWERFIHQENKHLAHPEAIDFLDKMLRYDHQERITAKEAMEHPYF
Kinase 15737.AA CMGC 40-325 21 6e-102 335.86 In-house 1-513 (513) Show / Hide 
Range on Protein: 40-325
Range on HMM: 1-513/513
Sequence Identity: 21% (108 aa)

YEVIRKLGRGKYSEVFEGINSLNN--------------EKCVIKVLK----PIRKK----------KIKREISILKNLS----------------GGPNI
||.|.|.|.| |..|..... ..|              |.. || .|    .. .|          .. |||.|||.|.                  .||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VQLLDIVKDPASK---------------CTSFVFEYVNNIDYRELYP-----------KLSDFD------------VRFYI------FEVLKALD--FCH
|.|.||.... |.               .  .||||. .  |. ..            .||.              .....      . .|..|.  .||
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SQG--IMHRDVKPHNIMIDHEKKQ-------------------LRLIDWGLAEYYFPG----------------------KDYNVRVASRYFKGPELLVD
|..  |.||| || ||.|.|...                    |...|.||| .| |                       . |  .|..|. . ||.|. 
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

YQYYD---------YSLDIWSLGAMFAGM-------IFKKEPFFQGNDN-----------YDQLEKIARVLG------------------TNELYDYLNT
...|.         .. |.||.| .|| |       ||...|.|.|...           .|||.|| .|||                  ..| ..... 
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

YNLELDPK----------FEGI----------LGKHTKKPWSKFVNNDNK------------------------------NLAVNEAIDLLSKMLVYDHA
.. ...||          .             .... .|||.... ....                              ...  .|||||.|||.||..
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

QRITPKEAMQHAYF
.|||...|.|| ||
KRITAEQALQHPYF
Kinase 15737.AA Pkinase 40-325 25 3.3e-79 274.25 Pfam 1-293 (293) Show / Hide 
Range on Protein: 40-325
Range on HMM: 1-293/293
Sequence Identity: 25% (80 aa)

YEVIRKLGRGKYSEVFEGINSLNNEKCVIKVLKPIRKKKIKR-------EISILKNLSGGPNIVQLLDIVKDPASKCTSFVFEYVNNI----DYR-----
|...||.|.| ...|.....  .... ..|..|  ..|. |.       ||.|.|.| . ||||.|.|.. |. . .  .|.||...     |       
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIY--MVMEYCEGGLYVMDLFDYIST

ELYPKL--SDFDVRFYIFEVLKALDFCHSQGIMHRDVKPHNIMIDHEKKQL----RLIDWGLAEY--YFPGKDYNVRVASRYFKGPELLVDYQYYDYSLD
. . ..  |. ...||. ..|..|..|||.||.|||.|| ||.|| .. ..    ...|.|||.   | ..  ..... ....  ||.. ..|||... |
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

IWSLGAMFAGMIFKKEPFFQGN----DNYDQLEKIARVLGTNELYDYLNTYNLELDPKFEGILGKHTKKPWSKFVNNDNKNLAVNEAIDLLSKMLVYDHA
.||.| ... |.... ||  |     . .||...|.|..|.   .|. ....  ... |     .        | .  .  ..  |..|.....| .| .
MWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--------F-HWTF-HNWSEECKDFIKWCLCKDPK

QRITPKEAMQHAYF
.|.|.....|| .|
KRPTAEQILQHPWF
Kinase 15737.AA S_TKc 40-325 25 4.8e-75 256.53 SMART 1-231 (231) Show / Hide 
Range on Protein: 40-325
Range on HMM: 1-231/231
Sequence Identity: 25% (77 aa)

YEVIRKLGRGKYSEVFEGINSLNNEKCVIKVLKPIRKKKIKREISILKNLSGGPNIVQLLDIVKDPASKCTSFVFEYVNN-----IDYRELYPK------
||..||.|.| ...|. ...   .... ||..|    ..|.|||.|||.  . ||||.|.|.  |   ..  .|.||...      || . ...      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LSDFDVRFYIFEVLKALDFCHSQGIMHRDVKPHNIMIDHEKKQLRLIDWGLAEYYFPGKDYNVRVASRYFKGPELLVDYQYYDY-SLDIWSLGAMFAGMI
..  ..|||. ....||..|||.||.|||.|| ||..|.   .. ..| |||  .      .  . ....  ||.|     |.. . |.||.| ... |.
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

FKKEPFFQGNDNYDQLEKIARVLGTNELYDYLNTYNLELDPKFEGILGKHTKKPWSKFVNNDNKNLAVNEAIDLLSKMLVYDHAQRITPKEAMQ------
  . ||        |.... ...|                                             ||.|...|.|..| ..|.|  ||.|      
CGYPPFP-------QMQMMFKKIG-------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

-HAYF
 | .|
CHPWF
Kinase 15737.AA CDK 40-325 27 5.3e-66 210.11 In-house 1-284 (284) Show / Hide 
Range on Protein: 40-325
Range on HMM: 1-284/284
Sequence Identity: 27% (90 aa)

YEVIRKLGRGKYSEVFEGINSLNN-----EKCVIKVLKPIR------KKKIK----REISILKNLSGGPNIVQLLDIVKDPAS---------KCTSFVFE
|| . |.|.| | .|. ... ...     . . .| ..         |  .     ||||.||.|   ||||.|.|.. . ..         .  ..|||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

YVNN-----IDYRELYPKLSDFDVRFYIFEVLKALDFCHSQGIMHRDVKPHNIMIDHEKK----QLRLIDWGLAEYYF-------PGKDYNVRVASRYFK
|.       .|            .. |..  |..|..|||..||||| || ||.|..  .    .| . | |||  .        | . |  .|  .   
YMDHDLKKYMD------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYR

GPELLVDYQYYD--YSLDIWSLGAMFAGMIF--KKEPFFQGNDNYDQLEKIARVLGTNELYDYLNTYNLELDPKFEGILGKHTKKPWSKFVNNDNKNLAV
 ||||   . |.   . |.||.|  || |.    ..|.|.|.   |||.|| |..||    .  .   | .                             
APELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY----------------------------

NEAIDLLSKMLVYDHAQRITPKEAMQHAYF
    |||.|||.|| ..||. ..|.|| ||
----DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 15737.AA CDC2 40-325 32 4.2e-54 164.41 In-house 1-301 (301) Show / Hide 
Range on Protein: 40-325
Range on HMM: 1-301/301
Sequence Identity: 32% (101 aa)

YEVIRKLGRGKYSEVFEGINSLNNEKCVIKVLKPIRKKKI-------KREISILKNLSGGPNIVQLLDIVKDPASKCTSFVFEYVNN--IDYRE-LYP--
|. |.|.| | | .|. ...   |. ...|  .  .   .        ||||.||.|   ||||.| |...    .    ||||..     | . . |  
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN

-KLSDFDVRFYIFEVLKALDFCHSQGIMHRDVKPHNIMIDHEKKQLRLIDWGLA-EYYFPGKDYN--VRVASRYFKGPELLVDYQYYDYSLDIWSLGAMF
 ...   |. |..  |....|||...||||| || || || . . ... | |||    .| . |     |  .    ||.|   ..|. . |.||.|  |
KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN-IKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIF

AGM-IF-KKEPFFQGNDNYDQLEKIARVLGTNELYDYLNTYNLELDPKFEGILGKHTKKPWSKFVNN--DNKNL--AVNEAIDLLSKMLVYDHAQRITPK
| | .   |.|.|.|    ||| || |.|||    .. . ..|   | .    .. ...  || . |   .||.  . .|.||||..||.|| ..||. |
AEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQL---PDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAK

EAMQHAYF
||.|| ||
EALQHPYF
Kinase 15737.AA CAMK 45-220 18 8.2e-50 158.28 In-house 1-321 (425) Show / Hide 
Range on Protein: 45-220
Range on HMM: 1-321/425
Sequence Identity: 18% (59 aa)

KLGRGKYSEVFEGINSLNN------------EKCVIKVLK-------------------------------PIRKKKIKREISILKNLSG------GPNI
.|||| ...|...|. ...            .|. ||...                               |  .|...|||.|.|.|.|       |||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLLDIVKDPA-----------------SKCTSFVF---EYVNNIDY----------RELY------------PKLSDFDVRFYIFEVLKALDFCHSQGI
..|...  ||                   |.  .|.   ||. . .           .. |             ...  ..|.|.  .. |...|||..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

MHRDVKPHNIMIDHEK----------------KQLRLIDWGLAEYYFP------------------------GKDYNVRVASRYFKG-PELLVD------
.||| || ||..|. .                 .. .||.|.| ...|                        |. .. .. . ..   ||.|        
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------YQYYDYSLDIWSLG
        .||... |.||.|
QNATDEEKPYYGPKCDMWSCG
Kinase 15737.AA Ciliate-E2 40-325 16 1.1e-44 151.34 In-house 1-365 (365) Show / Hide 
Range on Protein: 40-325
Range on HMM: 1-365/365
Sequence Identity: 16% (71 aa)

YEVIRKLGRGKYSEVFEGINSLNNE------------------KCV-----IKVLKPIRKKKIKREISILK---------N------LSGGPNIVQLLDI
|..|.|.|.| .. |... . ....                  |.      .|..|.  .. ||.||.|..         |      .   |||... . 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

VKDPASKCTSFVFEYVNNIDYRE---------------LYPKLSDFDVRFYIFEVLK---------------ALDFCHSQG-IMHRDVKPHNIMIDHEKK
 ..   ..  .|.||..  | ..                  ..... ..... ..|.               || ..||.. |.||| || ||..     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

QLRLIDWGLAE----------------YYFPGK-----------------DYNVRVASRYFKGPELLV--------DYQYYDYSLDIWSLGAMFAGMIFK
 . .||.||.                  |   |                  .|  . . ... || |         . ..|||. |||||| ..  |.|.
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

KEPFFQGNDNYDQLEKIARVLGTNELYDYLNTYNLELDPKFEGILGKHTKKPWSKFVNNDNKNLAVN-----------------------EAIDLLSK--
| ||                                                   . .. ....  .                       |..||..|  
KPPF---------------------------------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFG

--MLVYDHAQRIT-PKEAMQHAYF
  ||..|  .||| ......| .|
KRMLQKDPEKRITGWEQILNHPWF
Kinase 15737.AA Ciliate-E2-Unclassified 40-325 18 3.4e-39 133.6 In-house 1-352 (352) Show / Hide 
Range on Protein: 40-325
Range on HMM: 1-352/352
Sequence Identity: 18% (70 aa)

YEVIRKLGRGKYSEVFEGINSLNNEKCVIKVLKPIRKKK---------IKREISILKNL------------------SGGPNIVQLLDIVKDPASKCTSF
|..|...|.| ...|.. ... .... ..| .| |...|         |..|. ...|.                  .  |.|| .... .|   ..  .
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQD--KQNIYI

VFEYVNNI---DYRELYPK-----------------LSDFDVR-----FYIFEVLKALDFCHSQG-IMHRDVKPHNIMIDHEKK--QLRLIDWGLAE--Y
| ||...    .| . ..|                 .... ..     ||. ..|..|...|... | ||| || ||..| ..|  ....||.|..    
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

YFPGKDYNVR---------------VASRYFK----GPELLVDYQYYD---YSLDIWSLGAMFAGMIFKKEPFFQGNDNYDQLEKIARVLGTNELYDYLN
.....| .                 . . ...     ||.|   .|..   |. ||||||  .  |.| . ||.. |.. .| .... . . |       
QNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-N-N-------

TYNLELDPKFEGILGKHTKKPWSKFVNN-----DNKNLAVNEAID-LLSKMLVYDHAQRITPKEAMQHAYF
      .  .. .. .  .|.....  .     .. .  . . |  ||.|||...  .|||......| .|
------A-YRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 15737.AA CAMKL 40-220 26 5.3e-38 118.76 In-house 1-223 (297) Show / Hide 
Range on Protein: 40-220
Range on HMM: 1-223/297
Sequence Identity: 26% (59 aa)

YEVIRKLGRGKYSEVFEGIN-SLNNEKCVIKVLK-------PIRKKK-----------IKREISILKNLS--GGPNIVQLLDIVKDPAS----KCTSFVF
|.... ||.| ...|  ... ....||  ||...       |. ||.           |.|||.|.| |.  . |||..|.... .|      |.   | 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYVNNID-------YRELYPK--LSDFDVRFYIFEVLKALDFCHSQGIMHRDVKPHNIMIDHEKK-QLRLIDWGLAEYYFP-----GKDYNVRVASRYFK
||. . .        .. ...  ..  . |.|   .. |...|||.|| ||| || ||..|. .. .. .|| |.. .| |     |.  . .  |  . 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

GPELLVD--YQYYDYSLDIWSLG
 ||.. .   .|. .  ||||.|
APEIFQGNNKPYDGPKVDIWSCG
Kinase 15737.AA CDK5 40-252 32 1.1e-33 103.41 In-house 1-218 (287) Show / Hide 
Range on Protein: 40-252
Range on HMM: 1-218/287
Sequence Identity: 32% (73 aa)

YEVIRKLGRGKYSEVFEGINSLNNEKCVIKVLKPIRKKKI--------KREISILKNLSGGPNIVQLLDIVKDPASKCTSFVFEYVNN-----IDYRELY
|| . |.| | |  |. .   .| |  .|  || .|             |||..|| |   .||| | |..   . |    |||.. .     .| ..  
YEKMEKIGEGTYGTVYKA---RNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELK-HKNIVRLHDVIH--SEKKLTLVFEFCDQDLKKYMDSCNG-

PKLSDFDVRFYIFEVLKALDFCHSQGIMHRDVKPHNIMIDHEKKQLRLIDWGLAEYY-FPGKDYNVRVASRYFKGPELLVDYQYYDYSLDIWSLGAMFAG
 ...   .. ...  || | |||.. ..||| || | .|   . .|.| | |||  .  | . |   |    .  |  |   . |  | |.|| |  || 
-EMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINK-NGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAE

MIFKKEPFFQGNDNYDQLEKIARVLGT
|.    | | |||  ||| .| ...||
MANAGRPLFPGNDVEDQLKRIFKIMGT
Kinase 15737.AA RCK 40-252 30 1.7e-33 103.44 In-house 1-232 (298) Show / Hide 
Range on Protein: 40-252
Range on HMM: 1-232/298
Sequence Identity: 30% (72 aa)

YEVIRKLGRGKYSEVFEGINSLNNEKCVIKVLKPIRK-KKIK-----REISILKNLSGGPNIVQLLDIVKDPASKCTSFVFEYV-NNI-----DYRELYP
| .|..||.| |..|....|  ..|.  || .|  .| ....     |||  |. |.  |||..|.....|  .   .|||||. .|.     |. |   
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK--QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKE-RR

K-LSDFD--VRFYIFEVLKALDFCHSQGIMHRDVKPHNIMIDHE--------KKQLRLIDWGLA-EYYFPGKD-YNVRVASRYFKGPELLVDYQYYDYSL
| |. .   ...... .|..|...|..|..|||.|| |||.  .           . ..| ||. | .   |  |   | .|.   ||.|   .||.. .
KYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIR--SKPPYTDYVSTRWYRAPECLLRCTYYNSPM

DIWSLGAMFAGMIFKKEPFFQGNDNYDQLEKIARVLGT
|||..|. ..  .  . | | |..  ||. ||  |.||
DIWAVGCIMYE-LYMLRPLFPGSSEIDQIFKICKVMGT
Kinase 15737.AA CDK5 300-325 53 4.5e-11 30.73 In-house 262-287 (287) Show / Hide 
Range on Protein: 300-325
Range on HMM: 262-287/287
Sequence Identity: 53% (14 aa)

DLLSKMLVYDHAQRITPKEAMQHAYF
|||.|||... .|||. |.|..|.||
DLLQKMLQCNPNQRISAKAALHHPYF
Kinase 15737.AA RCK 297-325 48 4.6e-11 31.06 In-house 270-298 (298) Show / Hide 
Range on Protein: 297-325
Range on HMM: 270-298/298
Sequence Identity: 48% (14 aa)

EAIDLLSKMLVYDHAQRITPKEAMQHAYF
..|.|. ||| .|   |||...| || ||
DCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase 15737.AA TyrKc 40-277 17 2.7e-10 -56.33 SMART 1-280 (280) Show / Hide 
Range on Protein: 40-277
Range on HMM: 1-280/280
Sequence Identity: 17% (49 aa)

YEVIRKLGRGKYSEVFEGINSLNNEKCVIKVLKPIRKKKIKREISILKNL-SGGPNIVQLLDIVKDP-----ASKCTSFVFEYVNNID---YRELYPK-L
 . ..|||.| . ||..|. .   ... .|.||.  .. . ||..|...|    ||||.|. .. ..      ..    |.||. . |   |   . . |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL

SDFDVRFYIFEVLKALDFCHSQGIMHRDVKPHNIMIDHEKKQLRLIDWGLAEYYFPG-------KDYNVRV--ASR-----YFKGPELLVDYQYYDYSLD
.  |   . . . .  .. ||... |||    |....... . .  | ||. .   .       . | ..    ..         || . .. .   | |
CMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS-D

IWS----------LGAMFAGMI----FKKEPFFQGNDNYDQLEKIARVL------GTNELYDYLNT---YNLELDPKFEGILGKH
.||          .|..    .     . .  ..  .. . ... . ..       . |.|.   .   .. |  | |. |  . 
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 15737.AA CAMK 297-325 34 4e-10 28.08 In-house 397-425 (425) Show / Hide 
Range on Protein: 297-325
Range on HMM: 397-425/425
Sequence Identity: 34% (10 aa)

EAIDLLSKMLVYDHAQRITPKEAMQHAYF
|..||..|||..|  .|.| .....|  .
ECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 15737.AA CAMKL 297-325 31 1.6e-08 23.19 In-house 269-297 (297) Show / Hide 
Range on Protein: 297-325
Range on HMM: 269-297/297
Sequence Identity: 31% (9 aa)

EAIDLLSKMLVYDHAQRITPKEAMQHAYF
...||..|||. .  .|.| .. |.|  .
DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 15737.AA Pkinase_Tyr 40-99 28 5e-06 20.96 Pfam 1-70 (270) Show / Hide 
Range on Protein: 40-99
Range on HMM: 1-70/270
Sequence Identity: 28% (20 aa)

YEVIRKLGRGKYSEVFEGINS----LNNEKCVIKVLKP---IR---KKKIKREISILKNLSGGPNIVQLL
 . ..|||.| . ||..|.       .. .. .|.||.    .   ...  ||..|.|.|   ||||.|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY