Gene CK2a (Sea Urchin)

CK2a

Species: Sea Urchin
Alias: CK2a, SPU_012605, Spk158
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CMGC
Family: CK2

Sequence

Name Sequence Type Origin Length Description Download
CK2a.AA Protein None 392 None Fasta, JSON
CK2a.kin_dom Protein Kinase Domain None 386 None Fasta, JSON

Protein domain

Protein domains of CK2a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CK2a.AA CK2 37-322 80 1.7e-239 723.94 In-house 1-288 (288) Show / Hide 
Range on Protein: 37-322
Range on HMM: 1-288/288
Sequence Identity: 80% (233 aa)

YQIVRKLGRGKYSEVFEAVNITSNEKC--VIKILKPVKKKKIKREIKILENLRGGPNIIALQAIVKDPVSRTPALIFEYVNNTDFKQLYQTLKDYEIRYY
|...||.||||||||||..||..||||  |||||||||||||||||||||||.||||||.| .|||||.|..|||.|||||||||.||||||.||.||||
YEVIRKIGRGKYSEVFEGINIKNNEKCKIVIKILKPVKKKKIKREIKILENLNGGPNIIKLYDIVKDPYSKVPALVFEYVNNTDFRQLYQTLTDYDIRYY

LFELLKALDYSHSMGIMHRDVKPHNVMIDHENRRLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQLYDYSLDMWSLGCMLASMIFRKEPFFHGH
.|||||||||.||||||||||||||.|||||.|.||||||||||||||||.|||||||||.|||||||||| |||||||||||||.|||||.||||||||
MFELLKALDYCHSMGIMHRDVKPHNIMIDHEKRKLRLIDWGLAEFYHPGQDYNVRVASRYYKGPELLVDYQYYDYSLDMWSLGCMFASMIFKKEPFFHGH

DNYDQLVRIAKVLGTDELYEYLDKYQIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQERVTAREAMEHPYF
|||||||.|.|||||..||.|||||.|.|||.|.||...|..|.||||.|.||.||..|||.|||||.||||||||.||.||||||||
DNYDQLVKIVKVLGTEDLYKYLDKYGIHLDPQFHDIMQQHKKKPWERFIHQENKHLAHPEAIDFLDKMLRYDHQERITAKEAMEHPYF
Kinase CK2a.AA CMGC 37-322 20 3.5e-100 329.96 In-house 1-513 (513) Show / Hide 
Range on Protein: 37-322
Range on HMM: 1-513/513
Sequence Identity: 20% (103 aa)

YQIVRKLGRGKYSEVFEAVN--------------ITSNEKCVIKILKPVKKKKIK---------------REIKILENLR----------------GGPN
|.|..|.|.| |..|.....              . .||.. ||..| .. ...                ||||||..|.                  .|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIALQAIVKDPVSRTP---------------ALIFEYVNNTDFKQLYQ-----------TLKDYE------------IRYYL------FELLKALD--YS
|. |. |.... |...                |.|||. .. .. ...            |.. .            |.|..      . .|..|.  | 
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSMG--IMHRDVKPHNVMIDHENRR-------------------LRLIDWGLAEFYHPG----------------------QEYNVRVASRYFKGPELLV
||..  |.||| || |..|.|...                    |...|.||| .|||                       . |  .|..|. . ||.|.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

DYQLYD---------YSLDMWSLGCMLASM-------IFRKEPFFHGHDN-----------YDQLVRIAKVLG------------------TDELYEYLD
 .. |.         .. ||||.||..| |       |||..|.|.||..           .||| .| ||||                  ..| .....
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

KYQIELDPR----------FNDI----------LGRHSRKRWERFVHSENQ------------------------------HLVSPEALDFLDKLLRYDH
..  ...|           ...           .... .| |....   .                               .. .|.|.|.|.|.|.||.
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

QERVTAREAMEHPYF
..| || .|..||||
DKRITAEQALQHPYF
Kinase CK2a.AA Pkinase 37-322 26 3.8e-87 300.62 Pfam 1-293 (293) Show / Hide 
Range on Protein: 37-322
Range on HMM: 1-293/293
Sequence Identity: 26% (82 aa)

YQIVRKLGRGKYSEVFEAVNITSNEKCVIKILKPVKKKKIKR-------EIKILENLRGGPNIIALQAIVKDPVSRTPALIFEYVNNT----DFK-----
|.|.||.|.| ...|...... .... ..||.| ...|. |.       ||.|. .| . |||. |  .. |  .. . ...||....    | .     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

QLYQTL--KDYEIRYYLFELLKALDYSHSMGIMHRDVKPHNVMIDHENRR---LRLIDWGLAEF--YHPGQEYNVRVASRYFKGPELLVDYQLYDYSLDM
. . ..   . |.. |. ..|..|.| |||||.|||.|| |..||...     ....|.|||..  | ... ..... ....  ||.. ..| |... ||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSLGCMLASMIFRKEPFFHG---HDNYDQLVRIAKVLGTDELYEYLDKYQIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQER
||.||.|. |.... || .    .. .||...|....|..  ...  .. | ... |..   .        | |... |..|.|..||....|..| ..|
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--------F-HWTF-HNWSEECKDFIKWCLCKDPKKR

VTAREAMEHPYF
 ||.....||.|
PTAEQILQHPWF
Kinase CK2a.AA S_TKc 37-322 25 2.4e-75 257.55 SMART 1-231 (231) Show / Hide 
Range on Protein: 37-322
Range on HMM: 1-231/231
Sequence Identity: 25% (78 aa)

YQIVRKLGRGKYSEVFEAVNITSNEKCVIKILKPVKKKKIKREIKILENLRGGPNIIALQAIVKDPVSRTPALIFEYVNN--TDFKQLYQT---------
|.|.||.|.| ...|. .... ..... |||.|    ..|.|||.||..  . |||. |  .  |       ...||...   | ... .          
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LKDYEIRYYLFELLKALDYSHSMGIMHRDVKPHNVMIDHENRRLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQLYDY-SLDMWSLGCMLASMI
.   ..|.|. ....||.| ||.||.|||.|| |...|.   .. ..| ||| ..      .  . ....  ||.|     |.. . |.||.||.|. |.
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

FRKEPFFHGHDNYDQLVRIAKVLGTDELYEYLDKYQIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQERVTAREAME------
 .. ||        |. .. |..|                                           ||||.||..|.|..| ..| || ||..      
CGYPPFP-------QMQMMFKKIG-------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

-HPYF
 ||.|
CHPWF
Kinase CK2a.AA CDK 37-322 25 4.5e-56 177.83 In-house 1-284 (284) Show / Hide 
Range on Protein: 37-322
Range on HMM: 1-284/284
Sequence Identity: 25% (85 aa)

YQIVRKLGRGKYSEVFEAVNITSN-----EKCVIKILK-PV-----KKKKIK----REIKILENLRGGPNIIALQAIVKDP-VS--------RTPALIFE
|... |.|.| | .|. | .  ..     . . .| ..        .|  .     |||..| .|   |||. |  .. .   .        ..  ..||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

YVNNTDFKQLYQTLKDYEIRYYLFELLKALDYSHSMGIMHRDVKPHNVMIDHENR----RLRLIDWGLAEFYH-------PGQEYNVRVASRYFKGPELL
|.  .| |..        |. |.. ||..|.| || .||||| || | .|..       || . | |||  ..       | ..|  .|  .    ||||
YM-DHDLKKYMD------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELL

VDYQLYD--YSLDMWSLGCMLASMIF--RKEPFFHGHDNYDQLVRIAKVLGT--DELYEYLDKYQIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEA
   . |.   . ||||.|| .| |.    ..|.|.|    ||| .| ...||  ..    . |..                                   
LGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------------

LDFLDKLLRYDHQERVTAREAMEHPYF
 |.|.|.| || . |..| .|..||||
-DLLNKMLCYDPKKRISAEQALQHPYF
Kinase CK2a.AA CAMK 42-230 19 1.7e-45 144.09 In-house 1-334 (425) Show / Hide 
Range on Protein: 42-230
Range on HMM: 1-334/425
Sequence Identity: 19% (64 aa)

KLGRGKYSEVFEAVNITSN------------EKCVIKILK-------------------------------PVKKKKIKREIKILENLRG------GPNI
.|||| ...|...... ..            .|. |||..                               |...|...|||.|. .|.|       |||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IALQAIVKDPVS--------RTPA----------LIF---EYVNNT----D-FKQLYQT-----------------LKDYEIRYYLFELLKALDYSHSMG
| |  .  ||                        ...   ||. .     | |  . .                  ..  | |.|   .. |..| ||..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IMHRDVKPHNVMIDHEN----------------RRLRLIDWGLAEFYHP------------------------GQEYNVRVASRYFKG-PELLVD-----
|.||| || |...|. |                  . .||.|.| .. |                        || .. .. . ..   ||.|       
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------YQLYDYSLDMWSLGCMLASMIFRKEPF
         . |... ||||.|..|  |   . ||
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPF
Kinase CK2a.AA CDC2 37-322 28 3.2e-44 133.46 In-house 1-301 (301) Show / Hide 
Range on Protein: 37-322
Range on HMM: 1-301/301
Sequence Identity: 28% (89 aa)

YQIVRKLGRGKYSEVFEAVNITSNEKCVIKILKPVKKKKIK--------REIKILENLRGGPNIIALQAIVKDPVSRTPALIFEYVNNTDFKQLYQ----
|| ..|.| | | .|. . .  .|. ...|  . ..             ||| .| .|.  |||. |. ...    .   ..|||. . | |..      
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIR-LEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYL-DMDLKKYMDMSIP

---TLKDYEIRYYLFELLKALDYSHSMGIMHRDVKPHNVMIDHENRRLRLIDWGLA-EFYHPGQEYN--VRVASRYFKGPELLVDYQLYDYSLDMWSLGC
    .    .. |.. .|..... |...||||| || |  || . . ... | |||  |  |  .|     |  .    ||.|   . |. . ||||.||
KNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN-IKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGC

MLASM-IF-RKEPFFHGHDNYDQLVRIAKVLGTDELYEYLDKYQIELDPRFNDILGRHSRKRWERFVHS----ENQHLVSPEALDFLDKLLRYDHQERVT
 .| | .   |.|.|||    ||| .| ..|||    .. . .|    | ..   .|  ..  .. . .     ||  . ||..| |...|.|| | |..
IFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQL---PDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRIS

AREAMEHPYF
|.||..||||
AKEALQHPYF
Kinase CK2a.AA Ciliate-E2 37-322 17 1.5e-40 136.93 In-house 1-365 (365) Show / Hide 
Range on Protein: 37-322
Range on HMM: 1-365/365
Sequence Identity: 17% (73 aa)

YQIVRKLGRGKYSEVFEAVNITSNE------------------KCV-----IKILKPVKKKKIKREIKILENLRGG---------------PNIIALQAI
| ...|.|.| .. |... ..  ..                  |.      .||.|. ... ||.||.|.  .. .               |||| .   
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

VKDPVSRTPALIFEYVNNTDFKQLYQ--------------TLKDYEIRYYLFELLK---------------ALDYSHSMG-IMHRDVKPHNVMIDHENRR
 ..    .  |..||..  | ... .               ....||.|.  ..|.               || | || . |.||| || |...      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

LRLIDWGLAEFYHPGQE--------------------------------YNVRVASRYFKGPELLV--------DYQLYDYSLDMWSLGCMLASMIFRKE
. .||.||. .|.. ..                                .|  . . ... || |         . . |||. |.||||..|  |.| | 
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFFHGHDNYDQLVRIAKVLGTDELYEYLDKYQIELDPRFNDILGRHSRKRWERFVHSENQHL---------------------------VSPEALDFLDK
||                                                       ..|..                           .|.|. |.. |
PF-------------------------------------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKK

----LLRYDHQERVT-AREAMEHPYF
    .| .| ..| | . ....||.|
FGKRMLQKDPEKRITGWEQILNHPWF
Kinase CK2a.AA Ciliate-E2-Unclassified 37-322 18 5e-39 133.01 In-house 1-352 (352) Show / Hide 
Range on Protein: 37-322
Range on HMM: 1-352/352
Sequence Identity: 18% (68 aa)

YQIVRKLGRGKYSEVFEAVNITSNEKCVIKILKPVKKKK---------IKREIKILENL----------------RGGPNIIALQAIVKDPVSRTPALIF
| |....|.| ...|......  ... ..|..| ....|         |..|.|...|.                .  |... .  .  .    .. .. 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYVNNTDFKQLYQT--------------------LKDYEIR-----YYLFELLKALDYSHSMG-IMHRDVKPHNVMIDHENR--RLRLIDWGLAEFYH--
||... | .|  .                     . .....     .|. ..|..|.| |. . | ||| || |...| ...  ....||.|.. .|   
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

--------------PGQEYNVRVASRYFK----GPELLVDYQLYD----YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTDELYEYLDKY
              . |... .. . ...     ||.| . | ||    |. |.||||. |  |.| . ||.   .. .| . .... . .         
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVL-QGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-N-N---------

QIELDPRFNDILGRHSRKRWERFVHSENQ--HLVSPEALDFLD----KLLRYDHQERVTAREAMEHPYF
    . ..  ..     | .. . ... |  . .|||| ||.     |.| ..  .| |. ....||.|
----A-YRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase CK2a.AA CAMKL 37-230 27 2e-33 103.94 In-house 1-236 (297) Show / Hide 
Range on Protein: 37-230
Range on HMM: 1-236/297
Sequence Identity: 27% (66 aa)

YQIVRKLGRGKYSEVFEAVN-ITSNEKCVIKILKPVKKKK------------------IKREIKILENLR--GGPNIIALQAIVKDPVS----RTPALIF
|.|.. ||.| ...|  |.. .| .||  |||..  |...                  |.|||.|.. |.  . |||| |  .. .|          |. 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYVNNTD---FKQLYQT------LKDYEIRYYLFELLKALDYSHSMGIMHRDVKPHNVMIDHENR-RLRLIDWGLAEFYHP-----GQEYNVRVASRYFK
||. . .   |  . .       ..  | | |   .. |..| ||.|| ||| || |...|. ..  . .|| |.. .| |     ||  . .  |  . 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

GPELLVD-YQLYD-YSLDMWSLGCMLASMIFRKEPF
 ||.. .  . || .  |.||.| .|  |.. . ||
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPF
Kinase CK2a.AA RCK 37-249 29 4.9e-31 95.5 In-house 1-232 (298) Show / Hide 
Range on Protein: 37-249
Range on HMM: 1-232/298
Sequence Identity: 29% (70 aa)

YQIVRKLGRGKYSEVFEAVNITSNEKCVIKILKPVKKKKIK-----REIKILENLRGGPNIIALQAIVKDPVSRTPALIFEYVNNTDFKQLYQT------
|||...||.| |..|..|.|....|.  || .|  | ....     |||| |  |   |||| |  ...|  ... ...|||.  ..  |....      
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK-QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYM-DMNLYQMMKDFKERRK

-LKDYE--IRYYLFELLKALDYSHSMGIMHRDVKPHNVMIDHE--------NRRLRLIDWGLA-EFY--HPGQEYNVRVASRYFKGPELLVDYQLYDYSL
 |   .  |. ... .|..|.. |. |..|||.|| | |.  .        . .. ..| ||. |..  .|  .|   | .|.   ||.|   . |.. .
YLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDY---VSTRWYRAPECLLRCTYYNSPM

DMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT
|.|..||  .  .  . | | | .  ||.  | ||.||
DIWAVGCIMY-ELYMLRPLFPGSSEIDQIFKICKVMGT
Kinase CK2a.AA GSK 192-322 26 3e-27 79.8 In-house 181-328 (328) Show / Hide 
Range on Protein: 192-322
Range on HMM: 181-328/328
Sequence Identity: 26% (41 aa)

SRYFKGPELLVDYQLYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTDEL---YEYLDKYQIELDPRFNDILGRH-SRKR---------
|||   |||. ... |. . |.||.|| .| |. .. |.| |..  ||||.|.|.|||.      .   .|.   .| . ..     . ..         
SRYYRAPELIFGCTNYTCQIDVWSCGCVMAEMLKGQ-PLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQT

----------WERFVHSENQHLVSPEALDFLDKLLRYDHQERVTAREAMEHPYF
            . .|...|     ...|.. |.|.|| ..| ...||. ||.|
YYHKKYRTVYMFKWCHTDMQ-----DWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase CK2a.AA GSK 108-175 33 3.1e-14 39.28 In-house 89-162 (328) Show / Hide 
Range on Protein: 108-175
Range on HMM: 89-162/328
Sequence Identity: 33% (26 aa)

ALIFEYVNNTDFKQLYQTLKDY----------EIRYYLFELLKALDYSHSMGIMHRDVKPHNVMIDHENRRLRLIDWG
.|..||...|    ||| ...|          .|..| . ....| | ||.|| |||.|| |. .|... .| . | |
CLVMEYMPQT----LYQVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFG
Kinase CK2a.AA RCK 292-322 41 4.7e-12 34.24 In-house 268-298 (298) Show / Hide 
Range on Protein: 292-322
Range on HMM: 268-298/298
Sequence Identity: 41% (13 aa)

SPEALDFLDKLLRYDHQERVTAREAMEHPYF
|..... . |.|..| |.| || .| .||||
SQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase CK2a.AA CAMK 291-322 34 1.1e-10 29.96 In-house 394-425 (425) Show / Hide 
Range on Protein: 291-322
Range on HMM: 394-425/425
Sequence Identity: 34% (11 aa)

VSPEALDFLDKLLRYDHQERVTAREAMEHPYF
||.|. |.. |.|..| ..| |. ....|| .
VSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase CK2a.AA TyrKc 37-279 16 3.2e-10 -57.48 SMART 1-280 (280) Show / Hide 
Range on Protein: 37-279
Range on HMM: 1-280/280
Sequence Identity: 16% (47 aa)

YQIVRKLGRGKYSEVFEAVNITSNEKCVIKILKPVKKKKIKREIKILENL-RGGPNIIALQAIVKDP-----VSRTPALIFEYVNNTDFKQLYQTLKD--
 .  .|||.| . ||.... .   ... .| ||. ... . ||..|. .|    |||..| ... ..      .  . ...||. . | |.  .  ..  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL

--YEIRYYLFELLKALDYSHSMGIMHRDVKPHNVMIDHENRRLRLIDWGLAEFYHPG-------QEYNVRV--ASR-----YFKGPELLVDYQLYDYSLD
   .  .. .   .  .| ||... |||    |....... . .  | ||. . . .       . | ..    ..         || . .|  .    |
CMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTKSD

MWSLGCML---ASMIFRKEPF-----FHGHDNYDQLVRI----AKVL--------GTDELYEYLDK---YQIELDPRFNDILGRHSRKRW
 || | ..    .      |          . . .. .                  .||.|.   .   .. |  |.|..|     ....
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----HECF
Kinase CK2a.AA CAMKL 291-322 31 1.5e-07 19.99 In-house 267-297 (297) Show / Hide 
Range on Protein: 291-322
Range on HMM: 267-297/297
Sequence Identity: 31% (10 aa)

VSPEALDFLDKLLRYDHQERVTAREAMEHPYF
|| .. |.. |.|  .  .| |. . |.|| .
VS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase CK2a.AA GSK 37-96 25 3.3e-07 17.42 In-house 1-70 (328) Show / Hide 
Range on Protein: 37-96
Range on HMM: 1-70/328
Sequence Identity: 25% (18 aa)

YQIVRKLGRGKYSEVFEAVNI----TSNEK----CVIKILKPVKKKKIKREIKILENLR--GGPNIIALQ
|.. .. |.|  . |..|...    ...|.     .||   . |. |  || .|...|.    |||. |.
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIMKMLGKLDHPNIVRLK
Kinase CK2a.AA APH 137-185 26 0.000649 14.23 Pfam 162-210 (248) Show / Hide 
Range on Protein: 137-185
Range on HMM: 162-210/248
Sequence Identity: 26% (14 aa)

ELLKALDYSHSMGIMHRDVKPHNVMID--HENRRL-RLIDWGLAEFYHPGQE
.|.....     ...|.|..|.|||.|   .. |.  .|||. | . .| ..
WLEAHWP---PPCWCHGDFHPGNVMWDPRPDGGRVTGVIDWDDACWGDPHYD