TYK2_Hsap MPLRHW--------G---M-------ARGSKP-VGDGAQPM--AAM-GGLKVLL-HWAGP
JAK3_Hsap MAPPS---------E--ETPL----------I-PQRSCSLL--STEAGALHVL-LPARGP
JAK2_Hsap MGMACLTMTEMEGTS--TSSI-----YQNGDI-SGNANSMK--QID-PVLQVYLYHSLGK
JAK1_Hsap MQYLNIKED-CNAMA--FC-------AKMRSS-KKTEVNLE--APE-PGVEVIF-YLS--
hop_Dmel MALANGGEDRMDDSSSGRTSLADSASLTNSSLRSGTSSQSI--HTNDGTIRVFN-FTT--
JAK3_Mmus MAPPS---------E--ETPL----------I-PQRSCSLS--SSEAGALHVL-LPPRGP
JAK2_Mmus MGMACLTMTEMEATS--TSPV-----HQNGDI-PGSANSVK--QIE-PVLQVYLYHSLGQ
JAK1_Mmus MQYLNIKED-CNAMA--FC-------AKMRSF-KKTEVKQV--VPE-PGVEVTF-YLL--
TYK2_Mmus MVGTMPL---CGRRA---I-------LEDSKA-DGTEAQPL--VPT-GCLMVLL-HWPGP
JAK1_Spur MIKNTVSP-----------PN------GSGLG-EG-------------------------
JAK2_Spur MTQKVSIRHMVNM-------------LRLPSIRSSRESPGLPNGMEPDIVEVRT-YMC--
*
TYK2_Hsap GGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPN-HILE----
JAK3_Hsap GPPQ-RLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPS-HIFS----
JAK2_Hsap SEAD-YLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPN-HVFH----
JAK1_Hsap -DRE-PLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPN-RTIT----
hop_Dmel --GEF-ERF-HPNMLCEEICNTMCRQLGIAPIAQLLYGIREHSTSRRPSPLVRLDLTWCL
JAK3_Mmus GPPQ-RLSFSFGDYLAEDLCVRAAKACGILPVYHSLFALATEDFSCWFPPS-HIFC----
JAK2_Mmus AEGE-YLKFPSGEYVAEEICVAASKACGITPVYHNMFALMSETERIWYPPN-HVFH----
JAK1_Mmus -DRE-PLRLGSGEYTAEELCIRAAQECSISPLCHNLFALYDESTKLWYAPN-RIIT----
TYK2_Mmus EGGEPWVTFSQTSLTAEEVCIHIAHKVGITPPCLNLFALYNAQAKVWLPPN-HILD----
JAK1_Spur ------------------------------------------------------------
JAK2_Spur --GNLVLPW-RERLTVEQVCIKAAKLCGIPRLTSNLFALYDKTNKKWLCPKAQVFS----
TYK2_Hsap -IP-RDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEAS--SDQTAQGMQLLDPAS
JAK3_Hsap -VE-DASTQVLLYRIRFYFPNWFGLE----KCHRFGLR----------KDLASAILDLPV
JAK2_Hsap -ID-ESTRHNVLYRIRFYFPRWYCSGSN--RAYRHGIS----------RGAEAPLLDDFV
JAK1_Hsap -VD-DKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASS
hop_Dmel PGERLNCQLVYCFRMRFRVPEL---------------------------DSQLELIDGRS
JAK3_Mmus -IE-DVDTQVLVYRLRFYFPDWFGLE----TCHRFGLR----------KDLTSAILDLHV
JAK2_Mmus -ID-ESTRHDILYRIRFYFPHWYCSGSS--RTYRYGVS----------RGAEAPLLDDFV
JAK1_Mmus -VD-DKTSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKRVPEATPLLDASS
TYK2_Mmus ----TSQDMNLYFRMRFYFRNWHGMNPQEPAVYRCGFPGAETS--SDRAEQGVQLLDSAS
JAK1_Spur ------------------------------------------------------------
JAK2_Spur -RR-QRKSEQLEYRVRFHTATMCPSGD----------------------AQGFMLLEENV
TYK2_Hsap FEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVA-K
JAK3_Hsap LEHLFAQHRSDLVSGRLPVGLS------LKEQGECLSLAVLDLARMAREQAQRPGELL-K
JAK2_Hsap MSYLFAQWRHDFVHGWIKVPVT------HETQEECLGMAVLDMMRIAKENDQTPLAIY-N
JAK1_Hsap LEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELP-K
hop_Dmel HKFLYRQMRYDMRTEQIPEIRY------PEHKDKSTGLAVMDMLIDDQEQSEDQQAMRSI
JAK3_Mmus LEHLFAQHRSDLVSGRLPVGLS------MKEQGEFLSLAVLDLAQMAREQAQRPGELL-K
JAK2_Mmus MSYLFVQWRHDFVHGWIKVPVT------HETQEECLGMAVLDMMRIAKEKDQTPLAVY-N
JAK1_Mmus LEYLFAQGQYDLIKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELP-K
TYK2_Mmus FEYLFEQGKHEFMNDVVSLRDLSSEEEIHHFKNESLGMAFLHLCHLALSRGVPLEEMA-R
JAK1_Spur ------------------------------------------------------------
JAK2_Spur VNYMFCQYRESFLNDEFMG---------L-STEESLGLMVLDFMQHVKEDGTSLTNLN-G
TYK2_Hsap KTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQ-----PGRLSQQMVMVKYLAT
JAK3_Hsap TVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVA-----ACQADRHSLMAKYIMD
JAK2_Hsap SISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFS-----QCKATARNLKLKYLIN
JAK1_Hsap DISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLAT
hop_Dmel EKLYKLYLPPSLWR---AHSFFVGSKIREVFRS----LK-----ANSLSVERLKWHYVHQ
JAK3_Mmus TVSYKACLPPSLRDVIQGQNFVTRRRIRRTVVLALRRVV-----ACQADRYALMAKYILD
JAK2_Mmus SVSYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIQQFS-----QCKATARNLKLKYLIN
JAK1_Mmus DISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLAT
TYK2_Mmus EISFKNCIPHSFRQHIRQHNVLTRLRLHRVFRRFLRAFR-----PGHLSQQVVMVKYLAT
JAK1_Spur ------------------------------------------------------------
JAK2_Spur RLRFGRFLPKSLNE---GLSWWDKRKLRRKVRTALTDFR-----DDPRETFAFRVMFLVS
TYK2_Hsap L-ERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDP----GPESAAGP-PT-HE
JAK3_Hsap L-ERLDPAGAAETFHVGLPGA------------L-----------------GGH-DGLGL
JAK2_Hsap L-ETLQSAFYTEKFEVKEPGS-----------GP-----------------SGE-EIFAT
JAK1_Hsap L-ETLTKHYGAEIFETSMLLISSENEMNWFHSND-----------------GGN-VLYYE
hop_Dmel V-SHLAPTYMTEQFTCTVQYLPN-EEVAR-GSGPIGTSLAHSTSTLA---SSGSTNTL-S
JAK3_Mmus L-ERLHPAATTETFRVGLPGA--------------------------------Q-EEPGL
JAK2_Mmus L-ETLQSAFYTEQFEVKESAR-----------GP-----------------SGE-EIFAT
JAK1_Mmus L-ETLTKHYGAEIFETSMLLISSENELSRCHSND-----------------SGN-VL-YE
TYK2_Mmus L-ERLAPRFGSERIPVCHLEVLAQPERDPCYIQNSGQTAGDP----GPELPSGP-PT-HE
JAK1_Spur ------------------GGS-----------GP-----------------GGS-G----
JAK2_Spur LSEEMKQEWGTEQFTMANGDIY---E----VSGVKG------------------------
TYK2_Hsap VLVTGTGGIQWWPVEEEVN--KEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPL
JAK3_Hsap LRVAGDGGIAWTQGE------------------------------------------QEV
JAK2_Hsap IIITGNGGIQWSRGKH--------------------------------KE--SETLTEQD
JAK1_Hsap VMVTGNLGIQWRHKPNVVSVEKEKNK--L---------KRKKLE-NKHKKDEEKNKIREE
hop_Dmel TLTTNTNSVALGG-------------------------SGK-----KAKR--RSTSGGID
JAK3_Mmus LRVAGDNGISWSSGD------------------------------------------QEL
JAK2_Mmus IIITGNGGIQWSRGKH--------------------------------KE--SETLTEQD
JAK1_Mmus VMVTGNLGIQWRQKPNVVPVEKEKNK--L---------KRKKLEYNKHKKDDERNKLREE
TYK2_Mmus VLVTGTGGIQWHPLQTQES---ERGNS---RGNPHGSRSGKKPKAPKAGEHLTESPQEPP
JAK1_Spur ------------------------------------------------------------
JAK2_Spur ----------------------------------------------VTKK--KLTYGDEA
TYK2_Hsap WAYFCDFR-DITHVVLKE-------------------HCVSIHRQD-----------NKC
JAK3_Hsap LQPFCDFP-EIVDISIKQAPRVGPAGE---------HRLVTVTRTD-----------NQI
JAK2_Hsap LQLYCDFP-NIIDVSIKQANQEG-SNE---------SRVVTIHKQD-----------GKN
JAK1_Hsap WNNFSYFP-EITHIVIKE-------------------SVVSINKQD-----------NKK
hop_Dmel VYVR-VFPHDSLEPGLKVARVTS-EATLKWILVGAVEGIFMISKINDTSVRLEIVGLPKG
JAK3_Mmus FQTFCDFP-EIVDVSIKQAPRVGPAGE---------HRLVTVTRMD-----------GHI
JAK2_Mmus VQLYCDFP-DIIDVSIKQANQEC-SNE---------SRIVTVHKQD-----------GKV
JAK1_Mmus WNNFSYFP-EITHIVIKE-------------------SVVSINKQD-----------NKN
TYK2_Mmus WTYFCDFQ-DISHVVLKE-------------------RRVHIHLQD-----------NKC
JAK1_Spur ------------------------------------------------------------
JAK2_Spur VQDSFPFQ-DIIDITIYPSTAER-A-----------HTLLQINRRS-----------TPP
TYK2_Hsap LELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQA
JAK3_Hsap LEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAIN
JAK2_Hsap LEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAIS
JAK1_Hsap MELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAIN
hop_Dmel YEMQFQTEKEMKSFISYLGIYIRLSSKWMQDLCHSYRTPSLEELSSLHCHGPIGGAYSLM
JAK3_Mmus LEAEFPGLPEALSFVALVDGYFRLICDSRHYFCKEVAPPRLLEEEAELCHGPITLDFAIH
JAK2_Mmus LEIELSSLKEALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIHSNCHGPISMDFAIS
JAK1_Mmus MELKLSSREEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAIN
TYK2_Mmus LLLCLCSQAEALSFVALVDGYFRLTADSSHYLCHEVAPPRLVTSIQNGIHGPLMDPFVQA
JAK1_Spur ------------------------------------------------------------
JAK2_Spur LILEMESRDDAESFACLLDGYYRLLVDYYHYLSETIAPPSLVRLVKNRCHGPIPLSKAKQ
TYK2_Hsap KLRP---EDGLYLIHWSTSHPYRLILTVA-QRSQA-PDGMQSLRLRKFPIE-Q-QDGAFV
JAK3_Hsap KLKTGGSRPGSYVLRRSPQDFDSFLLTVC-VQNPLGP------DYKGCLIRRS-PTGTFL
JAK2_Hsap KLKKAGNQTGLYVLRCSPKDFNKYFLTFA-VERENVI------EYKHCLITKN-ENEEYN
JAK1_Hsap KLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQ-KQFKNFQIE-V-QKGRYS
hop_Dmel KLHENGDKCGSYIVRECDREYNIYYIDIN-TKIMAKKTDQERCKTETFRIVRKDSQWKLS
JAK3_Mmus KLKAAGSLPGTYILRRSPQDYDSFLLTAC-VQTPLGP------DYKGCLIRQD-PSGAFS
JAK2_Mmus KLKKAGNQTGLYVLRCSPKDFNKYFLTFA-VERENVI------EYKHCLITKN-ENGEYN
JAK1_Mmus KLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEVLG-GQ-KQFKNFQIE-V-QKGRYS
TYK2_Mmus KLWP---EDGLYLIQWSTSHLHRLILTVA-HRNPAFSNGPRGLRLRKFPIT-Q-QPGAFV
JAK1_Spur ------------------------------------------------------------
JAK2_Spur KIEETGRQEGVYLIRQNPEDHYSYCLTVR-IHANQ---ELK-----NFKINCY-EDDDQV
TYK2_Hsap LEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGAR-A--S--
JAK3_Hsap LVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGH-S--PPT
JAK2_Hsap LSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVS--DVP
JAK1_Hsap LHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQE--W--
hop_Dmel YNNGEHVLNSLHEVAHIIQADSPDRY----RIPASKYDKPPLLL-LLLPKNLKAKKTDLQ
JAK3_Mmus LVGLSQPHRSLRELLAACWNSGLRVDGAALNLTSCCAPRPKEKSNLIVVRRGC-T--PAP
JAK2_Mmus LSGTKRNFSNLKDLLNCYQMETVRSDSIIFQFTKCCPPKPKDKSNLLVFRTNGIS--DVQ
JAK1_Mmus LHGSMDHFPSLRDLMNHLKKQILRTDNISFVLKRCCQPKPREISNLLVATKKAQE--W--
TYK2_Mmus LDGWGRSFASLGDLRLALQGCSLRAGDDCFPLHHCCLPRPREISNLVIMRGSR-A--H--
JAK1_Spur ------------------------------------------------------------
JAK2_Spur GLDNQRRFNCLRSFVEFYRSR-ENSWCLEGQLRKGVPIEPKDPALRILDRSALNV--DLP
TYK2_Hsap ------PRTLNLSQLSFHRVDQKEITQLS-HLGQGTRTNVYEGRLRVEGSGDPEEGKMDD
JAK3_Hsap SSLVQPQSQYQLSQMTFHKIPADSLEWHE-NLGHGSFTKIYRGCRHEVVD----------
JAK2_Hsap TSPT-LQRPTHMNQMVFHKIRNEDLIFNE-SLGQGTFTKIFKGVRREVGD-Y--------
JAK1_Hsap ------QPVYPMSQLSFDRILKKDLVQGE-HLGRGTRTHIYSGTLMDYKDDE--------
hop_Dmel LSE---AELQRRNPQIFN--PRTDLQWYPDSISLSDDGMMF-TMRGDWIQ----------
JAK3_Mmus APGCS-PSCCALTQLSFHTIPTDSLEWHE-NLGHGSFTKIFRGRRREVVD----------
JAK2_Mmus ISPT-LQRHNNVNQMVFHKIRNEDLIFNE-SLGQGTFTKIFKGVRREVGD-Y--------
JAK1_Mmus ------QPVYSMSQLSFDRILKKDIIQGE-HLGRGTRTHIYSGTLLDYKDEE--------
TYK2_Mmus ------TRPLNLSQLSFHRVHQDEITQLS-HLGQGTRTNVYEGLLRVGGPDE---GKVDN
JAK1_Spur ---------------------------------------------------E--------
JAK2_Spur SQPE-TGPIRWIQE---N--NLSSRTNWR-HLDDGDFTEVWAADLRKKVG----------
TYK2_Hsap EDPLVPGRDRGQELRV-VLKV--LDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRG
JAK3_Hsap --------GEARKTEV-LLKV--MDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAG
JAK2_Hsap --------GQLHETEV-LLKV--LDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCG
JAK1_Hsap ------GTSEEKKIKV-ILKV--LDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRD
hop_Dmel -------QSPVKDVSV-TMKM--LKS-DGNFM-EFFRLAQTWSLIQSPQFLKLYGLTLAD
JAK3_Mmus --------GETHDSEV-LLKV--MDSRHRNCMESFLEAASLMSQVSYPHLVLLHGVCMAG
JAK2_Mmus --------GQLHKTEV-LLKV--LDKAHRNYSESFFEAASMMSQLSHKHLVLNYGVCVCG
JAK1_Mmus ------GIAEEKKIKV-ILKV--LDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRD
TYK2_Mmus GCPPEPGGTSGQQLRV-VLKV--LDPSHHDIALAFYETASLMSQVSHMHLAFLHGVCVRG
JAK1_Spur ------GATGGASILVEIESV--LNPTEEDDIL---------------------------
JAK2_Spur --------NRPRKMRV-AIKCPKMDA-PQSVQQKFSQSVDLMSSWVHKHIIRFEGIGA--
. * . :. .
TYK2_Hsap PENIMVTEYVEHGPLDVWLRR----ERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVC
JAK3_Hsap -DSTMVQEFVHLGAIDMYLRK----RGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVS
JAK2_Hsap DENILVQEFVKFGSLDTYLKK----NKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVC
JAK1_Hsap VENIMVEEFVEGGPLDLFMHR----KSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVC
hop_Dmel -PYTMVMEYSRYGPLNKFLHS----MPN-VTLHCLLDLMHGLVRGMHYLEDNKIIHNYIR
JAK3_Mmus -DSIMVQEFVYLGAIDMYLRK----RGHLVSASWKLQVTKQLAYALNYLEDKGLPHGNVS
JAK2_Mmus EENILVQEFVKFGSLDTYLKK----NKNSINILWKLGVAKQLAWAMHFLEEKSLIHGNVC
JAK1_Mmus VENIMVEEFVEGGPLDLFMHR----KSDALTTPWKFKVAKQLASALSYLEDKDLVHGNVC
TYK2_Mmus SENIIVTEFVEHGPLDVWLRR----QRGQVPMTWKMVVAQQLASALSYLEDKNLVHGNVC
JAK1_Spur ------------------------------------------------------------
JAK2_Spur -GYMLVMEYASEGPLDHYLRSLLENERKRLGLNSQLHAAFQLIDALEYLESRRIVHGNVS
TYK2_Hsap GRNILLARLGL-AEGTSPFIKLSDPGVGLGALSREE----RVERIPWLAPECLPGGAN--
JAK3_Hsap ARKVLLAREGA--DGSPPFIKLSDPGVSPAVLSLEM----LTDRIPWVAPECLRE-AQ--
JAK2_Hsap AKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDI----LQERIPWVPPECIEN-PK--
JAK1_Hsap TKNLLLAREGI-DSECGPFIKLSDPGIPITVLSRQE----CIERIPWIAPECVED-SK--
hop_Dmel CSNLYVTKYDP-N-SYVLDAKISDPGYP-----RPY----RESDSPWIPVKYYRN-LQAA
JAK3_Mmus ARKVLLAREGG--DGNPPFIKLSDPGVSPTVLSLEM----LTDRIPWVAPECLQE-AQ--
JAK2_Mmus AKNILLIREEDRRTGNPPFIKLSDPGISITVLPKDI----LQERIPWVPPECIEN-PK--
JAK1_Mmus TKNLLLAREGI-DSDIGPFIKLSDPGIPVSVLTRQE----CIERIPWIAPECVED-SK--
TYK2_Mmus GRNILLARLGL-EEGTNPFIKLSDPGVGQGALSREE----RVERIPWTAPECLSGGTS--
JAK1_Spur ------------------------------------------------------------
JAK2_Spur AHNTLVLRPAP-N----MHIKLADPMLGVYYHSLEMTSRPKLERVRWTAPELLAT-NS--
TYK2_Hsap SLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPS-C-PQLATLTSQ
JAK3_Hsap TLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPK-W-TELALLIQQ
JAK2_Hsap NLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPK-W-AELANLINN
JAK1_Hsap NLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPS-C-KELADLMTR
hop_Dmel KTDQFAQLWAFATTIYEIFSRCKEDLSTLRQEQLLR------------Q-K-NLDGNILK
JAK3_Mmus TLGLEADKWGFGATTWEVFSGGPAHITSLEPAKKLKFYEDQGQLPALK-W-TELAGLITQ
JAK2_Mmus NLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDKHQLPAPK-W-TELANLINN
JAK1_Mmus NLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPS-C-KELADLMTR
TYK2_Mmus SLGTATDMWGFGATLLEICFDGEAPLQGRGPSEKERFYTKKHQLPEPS-S-PELATLTRQ
JAK1_Spur ------------------------------------------------------------
JAK2_Spur EPTLAGDKFSYAITLWQIMSHGAIPAENLSDExxxxxYRHGVRLDAPPGCPQELLKIMEA
TYK2_Hsap CLTYEPTQ-----------------RPSFRTILRDLTRLQPHNLADVLTVNPDS------
JAK3_Hsap CMAYEPVQ-----------------RPSFRAVIRDLNSLISSDYE-LLSDPTPGALAPRD
JAK2_Hsap CMDYEPDF-----------------RPSFRAIIRDLNSLFTPDYE-LLTENDM-LPNMRI
JAK1_Hsap CMNYDPNQ-----------------RPFFRAIMRDINKLEEQNPD-IVSEKKPA------
hop_Dmel MLDQDICPAPIFETIMDGWSDDETKRFSHHDIFSRLNTIKAE----ILPNYMPP-PE--I
JAK3_Mmus CMAYDPGR-----------------RPSFRAILRDLNGLITSDYE-LLSDPTPGIPSPRD
JAK2_Mmus CMDYEPDF-----------------RPAFRAVIRDLNSLFTPDYE-LLTENDM-LPNMRI
JAK1_Mmus CMNYDPNQ-----------------RPFFRAIMRDINKLEEQNPD-IVSEKQPT------
TYK2_Mmus CLTYEPAQ-----------------RPSFRTILRDLTRLQPQNLVGTSAVNSDS------
JAK1_Spur ----DPDE-----------------ETKFIG-----------------------------
JAK2_Spur CWSHNPRN-----------------RPSCRGVLRDVNSFLSE------------------
: .
TYK2_Hsap --------------------------PASDPTVFHKRYLKKI-RDLGEGHFGKVSLYCYD
JAK3_Hsap GLWNGA-----------------QLYACQDPTIFEERHLKYI-SQLGKGNFGSVELCRYD
JAK2_Hsap GALGFS-----------------GAFEDRDPTQFEERHLKFL-QQLGKGNFGSVEMCRYD
JAK1_Hsap --------------------------TEVDPTHFEKRFLKRI-RDLGEGHFGKVELCRYD
hop_Dmel ATNGTGDETVIDRSDIPFLPFPRSNMLMVIPLTSECRVIYNMENMIGRGHYGTVYKGHLE
JAK3_Mmus ELCGGA-----------------QLYACQDPAIFEERHLKYI-SLLGKGNFGSVELCRYD
JAK2_Mmus GALGFS-----------------GAFEDRDPTQFEERHLKFL-QQLGKGNFGSVEMCRYD
JAK1_Mmus --------------------------TEVDPTHFEKRFLKRI-RDLGEGHFGKVELCRYD
TYK2_Mmus --------------------------PASDPTVFHKRYLKKI-RDLGEGHFGKVSLYCYD
JAK1_Spur ------------------------------VNRIPDGQLKKE-ERLGSGHFGMVFRGVLM
JAK2_Spur ------FG-----------------------TLFHKQEL---------------------
:
TYK2_Hsap P-TNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQL
JAK3_Hsap P-LGDNTGALVAVKQLQH-SGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRL
JAK2_Hsap P-LQDNTGEVVAVKKLQH-STEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKL
JAK1_Hsap P-EGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKL
hop_Dmel FNDKDQPREQVAIKMLNTM---QVSTDFHREIGIMRTLSHPNIVKFKYWA----EKSHCI
JAK3_Mmus P-LGDNTGPLVAVKQLQH-SGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRL
JAK2_Mmus P-LQDNTGEVVAVKKLQH-STEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRL
JAK1_Mmus P-EGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKL
TYK2_Mmus P-TNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVKYKGCCEDQGEKSVQL
JAK1_Spur P-RQGIPAEIVA-KVIKNDSR---SDQFQQEIRAMSYCDHKNIVKVLGYCEDN-SNRLSL
JAK2_Spur -------------------------------------------LKFF-------------
:*
TYK2_Hsap VMEYVPLGSLRDYLPRHS--IGLAQLLLFAQQICEGMAYLHAQH-YIHRDLAARNVLLDN
JAK3_Hsap VMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRR-CVHRDLAARNILVES
JAK2_Hsap IMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKR-YIHRDLATRNILVEN
JAK1_Hsap IMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQ-YVHRDLAARNVLVES
hop_Dmel IMEYLQSGSFDIYLRFTAPNLNNPRLVSFALDIANGMKYLSDMG-LIHRDLAARNILVDH
JAK3_Mmus VMEYLPSGCLRDFLQRHRARLHTDRLLLFAWQICKGMEYLGARR-CVHRDLAARNILVES
JAK2_Mmus IMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEYLGTKR-YIHRDLATRNILVEN
JAK1_Mmus IMEFLPSGSLKEYLPKNKNKINLKQQLKYAIQICKGMDYLGSRQ-YVHRDLAARNVLVES
TYK2_Mmus VMEYVPLGSLRDYLPRHC--VGLAQLLLFAQQICEGMAYLHAQH-YIHRDLAARNVLLDN
JAK1_Spur VMEYFPLGSLEKYLREKKDRVSHKTLYLFGQQICQGMKYLHEERMMVHRDLAARNVLVSN
JAK2_Spur ------------------------------------------------------------
TYK2_Hsap D---RLVKIGDFGLAKAVPEGHEYYRVREDGD-SPVFWYAPECLKEYKFYYASDVWSFGV
JAK3_Hsap E---AHVKIADFGLAKLLPLDKDYYVVREPGQ-SPIFWYAPESLSDNIFSRQSDVWSFGV
JAK2_Hsap E---NRVKIGDFGLTKVLPQDKEYYKVKEPGE-SPIFWYAPESLTESKFSVASDVWSFGV
JAK1_Hsap E---HQVKIGDFGLTKAIETDKEYYTVKDDRD-SPVFWYAPECLMQSKFYIASDVWSFGV
hop_Dmel NGDGDCVKISDFGLAQFANSD-GYYYAKSKRD-IPIRWYSPEAISTCRFSSYSDVWSYGV
JAK3_Mmus E---AHVKIADFGLAKLLPLGKDYYVVREPGQ-SPIFWYAPESLSDNIFSRQSDVWSFGV
JAK2_Mmus E---NRVKIGDFGLTKVLPQDKEYYKVKEPGE-SPIFWYAPESLTESKFSVASDVWSFGV
JAK1_Mmus E---HQVKIGDFGLTKAIETDKEYYTVKDDRD-SPVFWYAPECLIQCKFYIASDVWSFGV
TYK2_Mmus D---RLVKIGDFGLAKAVPEGHEYYRVREDGD-SPVFWYAPECLKECKFYYASDVWSFGV
JAK1_Spur E---NEVKITDFGLARIFGTEKDYYRAKESSQKVPIKWYAPEWLRHQKYQKESDVWSLGI
JAK2_Spur ----------------------------------PVFFCAAFAMYRLY----LHVYFYNI
*: : :. : .*: .:
TYK2_Hsap T-LYELLTHCDSSQSPPTKFLELIGIA-QGQ-MTVLRLTELLERGERLPRPDKCPCEVYH
JAK3_Hsap V-LYELFTYCDKSCSPSAEFLRMMGCE-RDV-PALCRLLELLEEGQRLPAPPACPAEVHE
JAK2_Hsap V-LYELFTYIEKSKSPPAEFMRMIGNDKQGQ-MIVFHLIELLKNNGRLPRPDGCPDEIYM
JAK1_Hsap T-LHELLTYCDSDSSPMALFLKMIGPT-HGQ-MTVTRLVNTLKEGKRLPCPPNCPDEVYQ
hop_Dmel T-LFEMFSRGEEPNLVPI-------------QTSQEDFLNRLQSGERLNRPASCPDFIYD
JAK3_Mmus V-LYELFTYCDKSCSPSAEFLSMMGPE-REG-PPLCRLLELLAEGRRLPPPPTCPTEVQE
JAK2_Mmus V-LYELFTYIEKSKSPPVEFMRMIGNDKQGQ-MIVFHLIELLKSNGRLPRPEGCPDEIYV
JAK1_Mmus T-LHELLTYCDSDFSPMALFLKMIGPT-HGQ-MTVTRLVNTLKEGKRLPCPPNCPDEVYQ
TYK2_Mmus T-LYELLTYCDSNQSPHMKFTELIGHT-QGQ-MTVLRLTELLERGERLPRPDRCPCEIYH
JAK1_Spur V-LWEMFSYGQDPIYQD----------SKGRRVEHIELLDFFEKGMRLTHPPSCPAAIET
JAK2_Spur YIFFKIHTGFDKVA-YIM-----------------CAYI---------------------
: :: : :.
TYK2_Hsap LMKNCWETEASFRPTFENLIPILKTVHE-KY----QGQ-----------APSVFSVC
JAK3_Hsap LMKLCWAPSPQDRPSFSALGPQLDMLWS-GS----RGCETHAFTAHPEGKHHSLSFS
JAK2_Hsap IMTECWNNNVNQRPSFRDLALRVDQIRD-NM------------------------AG
JAK1_Hsap LMRKCWEFQPSNRTSFQNLIEGFEAL-----------------------------LK
hop_Dmel LMQLCWHATPRSRPSFATIVDIITREVATKVTHPTDGHQ--------SPPNQPTDAE
JAK3_Mmus LMQLCWAPSPHDRPAFGTLSPQLDALWR-GR------------------------PG
JAK2_Mmus IMTECWNNNVSQRPSFRDLSLRVDQIRD-SI------------------------AA
JAK1_Mmus LMRKCWEFQPSNRTTFQNLIEGFEAL-----------------------------LK
TYK2_Mmus LMKNCWETEASFRPTFQNLVPILQTAQE-KY----QGQ-----------VPSVFSVC
JAK1_Spur MMNDCWEMDPLKRPKFQSMIVRLGILVQ-NS---ERGE---------MGSSSSSYGL
JAK2_Spur --------------------------------------------------YCCKVLK