Protein (view, download) , Domain (view, download)
SgK288_Hsap     MAADPTE-----------------------------------------------------
RIPK3_Hsap      MSCVKLWP-S-G------------------------------------------------
RIPK2_Hsap      MNGEAICS----------------------------------------------------
RIPK1_Hsap      MQPDMSLN----------------------------------------------------
ANKRD3_Mmus     MEGEGRGR----------------------------------------------------
ANKRD3_Hsap     MEGDGGTP----------------------------------------------------
RIPK1_Mmus      MQPDMSLD----------------------------------------------------
RIPK2_Mmus      MNGDAICS----------------------------------------------------
RIPK3_Mmus      MSSVKLWP-T-G------------------------------------------------
SgK288_Mmus     MVPHRARR-LL-------------------------------------------------
ANKK2_Spur      MLVNGLDYCHIM------------------------------------------------
ANKK1_Spur      MALEAGCD-EVD------------------------------------------------
ANKK3_Spur      MAERAANE-PSDDDKALLGAALNGHLDVVKYLTGQGAQIETRDNDDETPLHCASRNGHLD
ANKK6_Spur      MMH---------------------------------------------------------
ank2_Spur       MAKRAVNE-PAEVDKALLRAALNGCFEMVVYLVGQGAQIE--------------------
ANKK5_Spur      MAERAANE-PTEVDKSLAVAALYGRVNVVKYLVGEGAQID--------------------
ank1_Spur       MAERAANE-PAGTYRALHLAAANGDVNEVQYLIGQGTHID--------------------
ANKK4_Spur      MAERAANE-PAGSDKALLRAALNGHFDLVRYLVGQGAYIET-------------------
                *

SgK288_Hsap     ------------------------------------------------------------
RIPK3_Hsap      ------------------------------------------------------------
RIPK2_Hsap      ------------------------------------------------------------
RIPK1_Hsap      ------------------------------------------------------------
ANKRD3_Mmus     ------------------------------------------------------------
ANKRD3_Hsap     ------------------------------------------------------------
RIPK1_Mmus      ------------------------------------------------------------
RIPK2_Mmus      ------------------------------------------------------------
RIPK3_Mmus      ------------------------------------------------------------
SgK288_Mmus     ------------------------------------------------------------
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      ------------------------------------------------------------
ANKK3_Spur      VVKYLIGQEAQVDYPTKNGTTALFLASNAGHRDLVEYLVGKGAQVEKGGKNGFTPLHAAS
ANKK6_Spur      ------------------------------------------------------------
ank2_Spur       ----------------------------------------------KGGENGFTPLHAAS
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      -----------------------------------------------CDIHGQTSLHYAS


SgK288_Hsap     ------------------------------------------------------------
RIPK3_Hsap      ------------------------------------------------------------
RIPK2_Hsap      ------------------------------------------------------------
RIPK1_Hsap      ------------------------------------------------------------
ANKRD3_Mmus     ------------------------------------------------------------
ANKRD3_Hsap     ------------------------------------------------------------
RIPK1_Mmus      ------------------------------------------------------------
RIPK2_Mmus      ------------------------------------------------------------
RIPK3_Mmus      ------------------------------------------------------------
SgK288_Mmus     ------------------------------------------------------------
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      ------------------------------------------------------------
ANKK3_Spur      QEGHIDVVEYLVGQGAQIDTCDSDGAATPLHGASRNGHLDVVKYLIGQGAQIDKPTKLGG
ANKK6_Spur      ------------------------------------------------------------
ank2_Spur       QDGHLDV----------------------------------VEYLVGQGAHIDKPNEIGT
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      NNGHVDV----------------------------------VKFLIGQRARIDKPSKRGA


SgK288_Hsap     ------------------------------------------------------------
RIPK3_Hsap      ------------------------------------------------------------
RIPK2_Hsap      ------------------------------------------------------------
RIPK1_Hsap      ------------------------------------------------------------
ANKRD3_Mmus     ------------------------------------------------------------
ANKRD3_Hsap     ------------------------------------------------------------
RIPK1_Mmus      ------------------------------------------------------------
RIPK2_Mmus      ------------------------------------------------------------
RIPK3_Mmus      ------------------------------------------------------------
SgK288_Mmus     ------------------------------------------------------------
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      ------------------------------------------------------------
ANKK3_Spur      TAILFASGEGHRDIVEYLVRQGAQIDTCDIDDQTPLHGASRNGHLDVVKYLIGQGAQINK
ANKK6_Spur      ------------------------------------------------------------
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      TALLFASGVGDRDIVEYLVGQGAQIDTCDIDGQTPLHSSSRNGHLDVVKFLIGQGARIDK


SgK288_Hsap     ------------------------------------------------------------
RIPK3_Hsap      ------------------------------------------------------------
RIPK2_Hsap      ------------------------------------------------------------
RIPK1_Hsap      ------------------------------------------------------------
ANKRD3_Mmus     ------------------------------------------------------------
ANKRD3_Hsap     ------------------------------------------------------------
RIPK1_Mmus      ------------------------------------------------------------
RIPK2_Mmus      ------------------------------------------------------------
RIPK3_Mmus      ------------------------------------------------------------
SgK288_Mmus     ------------------------------------------------------------
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      ------------------------------------------------------------
ANKK3_Spur      PTKLGATALLFASNAGHRDVAEYLVGQGAQVERGAFNGLTPVLTASEKGHLDVVEYLVGQ
ANKK6_Spur      ------------------------------------------------------------
ank2_Spur       ------TALILASDAGHLDVVQYLVSHGAQVERGDNNGLTPLHAASQKGHLDVVEYLVGQ
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      PTKSDETALLFASGVGHR---------------------------------DVVEYLVGQ


SgK288_Hsap     ------------------------------------------------------------
RIPK3_Hsap      ------------------------------------------------------------
RIPK2_Hsap      ------------------------------------------------------------
RIPK1_Hsap      ------------------------------------------------------------
ANKRD3_Mmus     ------------------------------------------------------------
ANKRD3_Hsap     ------------------------------------------------------------
RIPK1_Mmus      ------------------------------------------------------------
RIPK2_Mmus      ------------------------------------------------------------
RIPK3_Mmus      ------------------------------------------------------------
SgK288_Mmus     ------------------------------------------------------------
ANKK2_Spur      ----------------------------------------------------------TA
ANKK1_Spur      ------------------------------------------------------------
ANKK3_Spur      GAQIETLNKYDETPLHCSSRNGHLDVVKYLIRQGAQIDKPTELGITALVFGSDAGHRNIV
ANKK6_Spur      ------------------------------------------------------------
ank2_Spur       GAQIETRNNEDSTPLHYASHNGHLDVVKCLIGQGAQIDKPNEFGATALHSGSAAGHRDLV
ANKK5_Spur      --------------------------------------ACGKEGYTPLFNASANGHLDVV
ank1_Spur       --------------------------------------TYDEDGNTPLLYASTNRYLGVV
ANKK4_Spur      GAQVERGTNNGFTPLHAASTKGHLDLVAYLVGRGAQVERGDNTGWTPLLRASQGGHLDVV


SgK288_Hsap     ------------------------------------------------------------
RIPK3_Hsap      ------------------------------------------------------------
RIPK2_Hsap      ------------------------------------------------------------
RIPK1_Hsap      ------------------------------------------------------------
ANKRD3_Mmus     ------------------------------------------------------------
ANKRD3_Hsap     ------------------------------------------------------------
RIPK1_Mmus      ------------------------------------------------------------
RIPK2_Mmus      ------------------------------------------------------------
RIPK3_Mmus      ------------------------------------------------------------
SgK288_Mmus     ------------------------------------------------------------
ANKK2_Spur      KYFVF---------------------------YFD-------------------------
ANKK1_Spur      ------------------------------------------------------------
ANKK3_Spur      EYLVGQGAQVERGS-NSGLTPLIAASEKGHIDVVKYLFGQGAKVKKGNNNGITPLHAAST
ANKK6_Spur      ------------------------------------------------------------
ank2_Spur       EYLVGQGAQVEKCDNNNGMTPLHAASQKGHLDVVEYLVGQGAQVEKGGKNGFTPLHVASQ
ANKK5_Spur      QYLVDHRAQVEKGD-IDGHRPLHIASGNGNLDIVKYLVDQGAQVESGDNDGETPLHIASF
ank1_Spur       QYLVDQGADVDKGN-IGGSTPLHFASGWGFLDVVQCLVGNKAKINKLDDDGNTALYSASK
ANKK4_Spur      QYLLGQAAQVEIGD-NTGWTPLHAASNNGHVDVVQYLVSQGAQVERGDNNGLTPLQDASH


SgK288_Hsap     ------------------------------------------------------------
RIPK3_Hsap      ------------------------------------------------------------
RIPK2_Hsap      ------------------------------------------------------------
RIPK1_Hsap      ------------------------------------------------------------
ANKRD3_Mmus     ------------------------------------------------------------
ANKRD3_Hsap     ------------------------------------------------------------
RIPK1_Mmus      ------------------------------------------------------------
RIPK2_Mmus      ------------------------------------------------------------
RIPK3_Mmus      ------------------------------------------------------------
SgK288_Mmus     ------------------------------------------------------------
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      ------------------------------------------------------------
ANKK3_Spur      QGHLDVVRYLVGQGAQIDTC-DIHGQTPLHCSSCNGHLDVVKYLIGQGAQIDKPTKLGGT
ANKK6_Spur      ------------------------------------------------------------
ank2_Spur       EGHLDVVEYLVGQGAQIETMIEKYDETPLHCSSCNGHLDVVKYLIGQEAQVDYPNKNGIT
ANKK5_Spur      LGRLEVVQYLVGQKA----------------------------------KINVI------
ank1_Spur       QGHLHVVEYLVGQGAQVEKV-DNKGSTSLIIASAKGHIDVVKYLISKGANINKP------
ANKK4_Spur      KGHRDIVEYLVGQGAQIDTC-DIHGQTSLHYASIKGHLDVVKYLIGQGAQIDKPTKLGAT


SgK288_Hsap     ------------------------------------------------------------
RIPK3_Hsap      ------------------------------------------------------------
RIPK2_Hsap      ------------------------------------------------------------
RIPK1_Hsap      ------------------------------------------------------------
ANKRD3_Mmus     ------------------------------------------------------------
ANKRD3_Hsap     ------------------------------------------------------------
RIPK1_Mmus      ------------------------------------------------------------
RIPK2_Mmus      ------------------------------------------------------------
RIPK3_Mmus      ------------------------------------------------------------
SgK288_Mmus     ------------------------------------------------------------
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      ------------------------------------------------------------
ANKK3_Spur      AILFASGEGHRDIVEYLVRQGAQIDTCDIDDQTPLHCSSCYGHLDVVKYLIGQGAQIDKP
ANKK6_Spur      ------------------------------------------------------------
ank2_Spur       ALFFASNAGHRDLVE---------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ALHCSSHNGHR-------------------------------------------------


SgK288_Hsap     ------------------------------------------------------------
RIPK3_Hsap      ------------------------------------------------------------
RIPK2_Hsap      ------------------------------------------------------------
RIPK1_Hsap      ------------------------------------------------------------
ANKRD3_Mmus     ------------------------------------------------------------
ANKRD3_Hsap     ------------------------------------------------------------
RIPK1_Mmus      ------------------------------------------------------------
RIPK2_Mmus      ------------------------------------------------------------
RIPK3_Mmus      ------------------------------------------------------------
SgK288_Mmus     ------------------------------------------------------------
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      ------------------------------------------------------------
ANKK3_Spur      TKLGATALHCSSRNGHLDVVKYLIGQGAQIANPTKLCITALHLASDAGHRDIVEYLVRQG
ANKK6_Spur      ------------------------------------------------------------
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     ------------------------------------------------------------
RIPK3_Hsap      ------------------------------------------------------------
RIPK2_Hsap      ------------------------------------------------------------
RIPK1_Hsap      ------------------------------------------------------------
ANKRD3_Mmus     ------------------------------------------------------------
ANKRD3_Hsap     ------------------------------------------------------------
RIPK1_Mmus      ------------------------------------------------------------
RIPK2_Mmus      ------------------------------------------------------------
RIPK3_Mmus      ------------------------------------------------------------
SgK288_Mmus     ------------------------------------------------------------
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      ------------------------------------------------------------
ANKK3_Spur      AQIDTCDIYGQTPLHFASQKGHLDVVEYLDGQGAQVKRGTNNGSTPLQVASLDGQLDVVQ
ANKK6_Spur      ------------------------------------------------------------
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     ------------------------------------------------------------
RIPK3_Hsap      ------------------------------------------------------------
RIPK2_Hsap      ------------------------------------------------------------
RIPK1_Hsap      ------------------------------------------------------------
ANKRD3_Mmus     ------------------------------------------------------------
ANKRD3_Hsap     ------------------------------------------------------------
RIPK1_Mmus      ------------------------------------------------------------
RIPK2_Mmus      ------------------------------------------------------------
RIPK3_Mmus      ------------------------------------------------------------
SgK288_Mmus     ------------------------------------------------------------
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      ------------------------------------------------------------
ANKK3_Spur      YLVRQGAQVERSNNDGTTSLLAASRHGHLDVVKYLAGQGAKVKEGDNNGFTPLHAASTKG
ANKK6_Spur      ------------------------------------------------------------
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     ------------------------------------------------------------
RIPK3_Hsap      ------------------------------------------------------------
RIPK2_Hsap      ------------------------------------------------------------
RIPK1_Hsap      ------------------------------------------------------------
ANKRD3_Mmus     ------------------------------------------------------------
ANKRD3_Hsap     ------------------------------------------------------------
RIPK1_Mmus      ------------------------------------------------------------
RIPK2_Mmus      ------------------------------------------------------------
RIPK3_Mmus      ------------------------------------------------------------
SgK288_Mmus     ------------------------------------------------------------
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      ------------------------------------------------------------
ANKK3_Spur      HLDLVAYLVGRGAQVERSSNYGLTSLLAASRHGHLDVVKYLVGQGAKVKEGDNNGFTPLH
ANKK6_Spur      ------------------------------------------------------------
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     ------------------------------------------------------------
RIPK3_Hsap      ------------------------------------------------------------
RIPK2_Hsap      ------------------------------------------------------------
RIPK1_Hsap      ------------------------------------------------------------
ANKRD3_Mmus     ------------------------------------------------------------
ANKRD3_Hsap     ------------------------------------------------------------
RIPK1_Mmus      ------------------------------------------------------------
RIPK2_Mmus      ------------------------------------------------------------
RIPK3_Mmus      ------------------------------------------------------------
SgK288_Mmus     ------------------------------------------------------------
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      ------------------------------------------------------------
ANKK3_Spur      AASTKGHLDLVAYLVGRGAQVERGDNTGWTPLLSASQGGHLDVVQYLVVQGAQVERGNND
ANKK6_Spur      ------------------------------------------------------------
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     ------------------------------------------------------------
RIPK3_Hsap      ------------------------------------------------------------
RIPK2_Hsap      ------------------------------------------------------------
RIPK1_Hsap      ------------------------------------------------------------
ANKRD3_Mmus     ------------------------------------------------------------
ANKRD3_Hsap     ------------------------------------------------------------
RIPK1_Mmus      ------------------------------------------------------------
RIPK2_Mmus      ------------------------------------------------------------
RIPK3_Mmus      ------------------------------------------------------------
SgK288_Mmus     ------------------------------------------------------------
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      ------------------------------------------------------------
ANKK3_Spur      GLTPLLAASSNGYLDVVKYLVGQGAQVERGANNGFTPLLAASSNGHLDVVKYLVGQGAKV
ANKK6_Spur      ------------------------------------------------------------
ank2_Spur       ---------------------------------------------------YLVGQGAKV
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      -----------------------------------------------DIVEYLVGQGAQI


SgK288_Hsap     ------------------------------------------------------------
RIPK3_Hsap      ------------------------------------------------------------
RIPK2_Hsap      ------------------------------------------------------------
RIPK1_Hsap      ------------------------------------------------------------
ANKRD3_Mmus     ------------------------------------------------------------
ANKRD3_Hsap     ------------------------------------------------------------
RIPK1_Mmus      ------------------------------------------------------------
RIPK2_Mmus      ------------------------------------------------------------
RIPK3_Mmus      ------------------------------------------------------------
SgK288_Mmus     ------------------------------------------------------------
ANKK2_Spur      -----------------------FEMLLGEDVQ--K------------------------
ANKK1_Spur      ------------------------------------------------------------
ANKK3_Spur      KEGD-NNGFTPLHAASTKGRLDVVKYLVGQGAQVERGANNGFTPLLAASSNGHLDVVKYL
ANKK6_Spur      ------------------------------------------------------------
ank2_Spur       EKCDNNYGMTPLHAASQKGHLDVVEYLVGQGAQVEKGDNDGDTPLHCASKKGHLDVVEYL
ANKK5_Spur      ---N-LNGKTPLYLASHQGHLHVVKCLVNHGAHVELGNNA--------------------
ank1_Spur       ---D-VDGKTPIYGASLKGRLHVVQYLVGQGALIENCDNHGDTPIHAASGNGHLAIVRYL
ANKK4_Spur      DTCD-IDGQTPLHSSSRNGHLDVVKYLIGQGAQIDNPIKLGATALHFASDAGHRDIVEYL


SgK288_Hsap     ------------------------------------------------------------
RIPK3_Hsap      ------------------------------------------------------------
RIPK2_Hsap      ------------------------------------------------------------
RIPK1_Hsap      ------------------------------------------------------------
ANKRD3_Mmus     ------------------------------------------------------------
ANKRD3_Hsap     ------------------------------------------------------------
RIPK1_Mmus      ------------------------------------------------------------
RIPK2_Mmus      ------------------------------------------------------------
RIPK3_Mmus      ------------------------------------------------------------
SgK288_Mmus     ------------------------------------------------------------
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      ------------------------------------------------------------
ANKK3_Spur      VGQGAKVKEGD-NNGFTPLHAASTKGRLDLVAYLVGRGAQVERGDNTGWTPLLSASQGGH
ANKK6_Spur      ------------------------------------------------------------
ank2_Spur       VRQGAHVEKCDNNDGMTPLNAASQKGHLDVVEYLVGQRAQVERGDNKGDTPLIFASCNGH
ANKK5_Spur      --------------GETPLLIASRKGHLDVVQYL--------------------------
ank1_Spur       VRQGAEIERT-DNAGHTPLLLATGHGHIEVVEYL--------------------------
ANKK4_Spur      VGQGAQVERGT-NNGFTPLHAASTKGHLDLVAYLVGQGAQVERGDNTGWTPLLSASQGGH


SgK288_Hsap     ------------------------------------------------------------
RIPK3_Hsap      ------------------------------------------------------------
RIPK2_Hsap      ------------------------------------------------------------
RIPK1_Hsap      ------------------------------------------------------------
ANKRD3_Mmus     ------------------------------------------------------------
ANKRD3_Hsap     ------------------------------------------------------------
RIPK1_Mmus      ------------------------------------------------------------
RIPK2_Mmus      ------------------------------------------------------------
RIPK3_Mmus      ------------------------------------------------------------
SgK288_Mmus     ------------------------------------------------------------
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      ------------------------------------------------------------
ANKK3_Spur      LDVVQYLLGQGAQVKRGTNNGSTPLQVASRDGQLDVVQYLVGQGAQVERGNNDGLTPLLA
ANKK6_Spur      ------------------------------------------------------------
ank2_Spur       LDVVQYLVGQGA---------------------------------QVEKGDNNGMTPL--
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      LDVVKYLVGRGAQVKRGTNNGSTPLQVASRDGQLDVVQYLVGQGAQVERGNNDGLTAL--


SgK288_Hsap     ------------------------------------------------------------
RIPK3_Hsap      ------------------------------------------------------------
RIPK2_Hsap      ------------------------------------------------------------
RIPK1_Hsap      ------------------------------------------------------------
ANKRD3_Mmus     ------------------------------------------------------------
ANKRD3_Hsap     ------------------------------------------------------------
RIPK1_Mmus      ------------------------------------------------------------
RIPK2_Mmus      ------------------------------------------------------------
RIPK3_Mmus      ------------------------------------------------------------
SgK288_Mmus     ------------------------------------------------------------
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      ------------------------------------------------------------
ANKK3_Spur      ASSNGYLDVVKYLVGQGAQVERGANNGFTPLLAASSNGHLDVVKYLVGQGAQVERGANNG
ANKK6_Spur      ------------------------------------------------------------
ank2_Spur       -------------------------------HYASKTGHLDVVEYLVGQGAQIDTCDIDG
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      -------------------------------LAASSNGHIDVVKYLVGQGAQVERGANNG


SgK288_Hsap     ------------------------------------------------------------
RIPK3_Hsap      ------------------------------------------------------------
RIPK2_Hsap      ------------------------------------------------------------
RIPK1_Hsap      ------------------------------------------------------------
ANKRD3_Mmus     ------------------------------------------------------------
ANKRD3_Hsap     ------------------------------------------------------------
RIPK1_Mmus      ------------------------------------------------------------
RIPK2_Mmus      ------------------------------------------------------------
RIPK3_Mmus      ------------------------------------------------------------
SgK288_Mmus     ------------------------------------------------------------
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      ------------------------------------------------------------
ANKK3_Spur      LTPLLAASSNGHLDVAQYLTSKQAQRKEASPEGISTFLHINVYDVIFFFCVKFLIGQGAQ
ANKK6_Spur      ------------------------------------------------------------
ank2_Spur       QTPLYFASHNGHLDAVKFL---QAL-----------------------------------
ANKK5_Spur      -------------------ESEQEQ-----------------------------------
ank1_Spur       -------------------EKELEQ-----------------------------------
ANKK4_Spur      LTPLLAALSNGHLDVAQYLTSKQAK-----------------------------------


SgK288_Hsap     ------------------------------------------------------------
RIPK3_Hsap      ------------------------------------------------------------
RIPK2_Hsap      ------------------------------------------------------------
RIPK1_Hsap      ------------------------------------------------------------
ANKRD3_Mmus     ------------------------------------------------------------
ANKRD3_Hsap     ------------------------------------------------------------
RIPK1_Mmus      ------------------------------------------------------------
RIPK2_Mmus      ------------------------------------------------------------
RIPK3_Mmus      ------------------------------------------------------------
SgK288_Mmus     ------------------------------------------------------------
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      ------------------------------------------------------------
ANKK3_Spur      IDKPTKLGAMALLFASGVGHRDVVEYLVGQGAQVERGANNGLTPLLAASSNGHLDVAQYL
ANKK6_Spur      ------------------------------------------------------------
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     ---------------------------------------------LRL-GSLPVF--TRD
RIPK3_Hsap      -------------------------------------------------APAPLV--SIE
RIPK2_Hsap      --------------------------------------------------ALPTI--PYH
RIPK1_Hsap      --------------------------------------------------VIKMK--SS-
ANKRD3_Mmus     ---------------------------------------------WAL-GLLRTF--DAG
ANKRD3_Hsap     ---------------------------------------------WAL-ALLRTF--DAG
RIPK1_Mmus      --------------------------------------------------NIKMA--SS-
RIPK2_Mmus      --------------------------------------------------ALPPI--PYH
RIPK3_Mmus      ------------------------------------------------ASAVPLV--SRE
SgK288_Mmus     ----------------------NP--------------MAVGPLAQQL-GSLTVF--TRD
ANKK2_Spur      ---------------------NDPVSVHHLEVKLDQIDMVDLNVKVSSGVKFAFHEKKAR
ANKK1_Spur      ----------------------ARLSVH----QLDEIMMADLTVKDSTGRKCTFHEKKAR
ANKK3_Spur      TSKQAQRKEASPEESAGVKVPDARSSVPQPFLNLKTIVMADLTIKDSSGGKHAFHGKKAR
ANKK6_Spur      -----------------------------------------LTVEDSSGKTCAFHEKKAR
ank2_Spur       ------RKEASPEESAGV-----QVPVPQPVLNLQTIAMADLTVKDSSGGKYAFHEKKAR
ANKK5_Spur      ------RTNARP-----------------------EIVMADLTVTDSSGGRFPFHEKKAR
ank1_Spur       ------REDERAE-----------------EVILKNIVMADLTVTDSSGEQCAFHEKKAR
ANKK4_Spur      ------RKEASPEVS------DARSSVPQPFFNLKTIMMADLTIKDSSGGKHAFHKKKAR


SgK288_Hsap     DFEGDWRLVASGGFSQVFQARHRRWRTEYAIKCAPCLPPDAASS-----DVNYLIEEA-A
RIPK3_Hsap      ELE-NQELVGKGGFGTVFRAQHRKWGYDVAVKIVNS--KAI-------------SREV-K
RIPK2_Hsap      KLA-DLRYLSRGASGTVSSARHADWRVQVAVKHLHIH-TPLLDS-----ERKDVLREA-E
RIPK1_Hsap      DFL-ESAELDSGGFGKVSLCFHRTQGL-MIMKTVYK--GPNCIE-----HNEALLEEA-K
ANKRD3_Mmus     EFA-GWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLH--VDDR-----ERMELLEEA-K
ANKRD3_Hsap     EFT-GWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLH--VDDR-----ERMELLEEA-K
RIPK1_Mmus      DLL-EKTDLDSGGFGKVSLCYHRSHGF-VILKKVYT--GPNRAE-----YNEVLLEEG-K
RIPK2_Mmus      KLA-DLHYLSRGASGTVSSARHADWRVRVAVKHLHIH-TPLLDS-----ERNDILREA-E
RIPK3_Mmus      ELK-KLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNS--KKI-------------SWEV-K
SgK288_Mmus     DFEEEWHLVASGGFSKVFQARHKRWRTQYAIKCSPCLQKETTSS-----EVTCLFEEA-V
ANKK2_Spur      ELE-G-CHLGGGSFGEVFKAVHKVHG-DVAVKLAKP--GKGDQL-------KMHQKEARK
ANKK1_Spur      EHE-G-CHLGGGSFGEVYKAVHKVHG-DVAVKLAKP--GKEDQV------VLMYQKEAGK
ANKK3_Spur      KLK-G-CHLGGGSFGEVYKATHAVHG-DVAVKLAKP--GKERQV-------EMYQKEARK
ANKK6_Spur      EHE-G-CHLGGGSFGEVFKATHKVHG-EVAVKLAKP--Gxxxxx------xxxxxxxxxx
ank2_Spur       KLE-G-CHLGGGSFGEVYKATHTVHD-DVAVKLAKP--GKEGQV-------VMYQKEARK
ANKK5_Spur      KLE-G-CHLGGGSFGEVFKATHAVHG-DVAVKLAKG------QV-------VMYQKEAQK
ank1_Spur       DHE-G-CHLGGGSFGEVFKAVHAVHG-DVAVKLAKP--GKERQLEMYKKQVVMYQKEAQK
ANKK4_Spur      KLE-G-CHLGGGSFGEVYKATHAVHG-DVAVKLAKP--GKEDQV-------KMYKKEARK
                .       :  *. . *    *        :*

SgK288_Hsap     KMKKIKFQHIVSIYGVCKQP---------LGIVMEFMANGSLEKVLSTH-----------
RIPK3_Hsap      AMASLDNEFVLRLEGVIEKVNWD-QD-PKPALVTKFMENGSLSGLLQSQ-----------
RIPK2_Hsap      ILHKARFSYILPILGICNEP-------EFLGIVTEYMPNGSLNELLHRKT-E--------
RIPK1_Hsap      MMNRLRHSRVVKLLGVIIEE-------GKYSLVMEYMEKGNLMHVLKAEM----------
ANKRD3_Mmus     KMEMAKFRYILPVYGICQEP---------VGLVMEYMETGSLEKLLASE-----------
ANKRD3_Hsap     KMEMAKFRYILPVYGICREP---------VGLVMEYMETGSLEKLLASE-----------
RIPK1_Mmus      MMHRLRHSRVVKLLGIIIEE-------GNYSLVMEYMEKGNLMHVLKTQI----------
RIPK2_Mmus      ILHKARFSYILPILGICNEP-------EFLGIVTEYMPNGSLNELLHRKT-E--------
RIPK3_Mmus      AMVNLRNENVLLLLGVTEDLQWD-FV-SGQALVTRFMENGSLAGLLQPE-----------
SgK288_Mmus     KMEKIKFQHIVSIYGVCKQP---------LGIVMEFMASGSLEKTLPTH-----------
ANKK2_Spur      HGLSLTCDYIVAIKGFVKCEEDTCPC-GLLGIVMQYMENGSLWDFRISEWQP--------
ANKK1_Spur      HVLSLTSNHIVSIKGFVQCEKAACDCGCLIGIVMEYMKHGSLWDFRISKWQD--------
ANKK3_Spur      HENSLICEHIVPIKGFVECEDDACNC-GLIGIVMKYMENGSLWDFRTTKWQQ--------
ANKK6_Spur      xxxxxxxxxxxxxxxxxxxxxxxxxx-xLFGIVMKYMENGSLWDFRKRRWQD--------
ank2_Spur       HENSLICEHIVPIKGFVECEDDACNC-GLIGIVMKYMENGSLWDFRTTKWLQ--------
ANKK5_Spur      HENSLICEHIVSIKGFVECKDDACTC-GLIGIVMTYMENGSLWDFRTTKWLH--------
ank1_Spur       HENSLKCEHIVPIKGFVQCEDKACDC-ELFGIVIQYMKNGSLWNFRTTKWRQHPDHLDFR
ANKK4_Spur      HENSLICEHIVPIKGFVECEDDACNC-GLIGIVMKYMENGSLWDFRTTKWQQ--------
                                              .:*  :*  *.*      .

SgK288_Hsap     -------S-LCWKLRFRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFG
RIPK3_Hsap      ------CPR-PWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFG
RIPK2_Hsap      ------YPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFG
RIPK1_Hsap      -------S-TPLSVKGRIILEIIEGMCYLHGK--GVIHKDLKPENILVDNDFHIKIADLG
ANKRD3_Mmus     -------P-LPWDLRFRIVHETAVGMNFLHCMSPPLLHLDLKPANILLDAHYHVKISDFG
ANKRD3_Hsap     -------P-LPWDLRFRIIHETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKISDFG
RIPK1_Mmus      -------D-VPLSLKGRIIVEAIEGMCYLHDK--GVIHKDLKPENILVDRDFHIKIADLG
RIPK2_Mmus      ------YPDIAWPLRFRILHEIALGVNYLHNMNPPLLHHDLKTQNILLDNEFHVKIADFG
RIPK3_Mmus      ------CPR-PWPLLCRLLQEVVLGMCYLHSLNPPLLHRDLKPSNILLDPELHAKLADFG
SgK288_Mmus     -------S-LCWPLKLRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDNNMHVKISDFG
ANKK2_Spur      ------FPD-LWPLTNRMVYQISCGMHFLHSKN--IIHRDLKLENVLVDGDLHVKIADLG
ANKK1_Spur      ------RPD-LWPLTNRMVHQISSGMHFLHSKD--IIHRDLKLENVLVDGNLNVKVADLG
ANKK3_Spur      ------HPD-LLPLTNRMVYEMSSGMQFLHSKD--IIHRDLKLENVLVDGDLHVKIADLG
ANKK6_Spur      ------HPD-LWPLTNR-VYEISCGMHFLHSND--IIHRDLKLENVLVDGNLHAKIADLG
ank2_Spur       ------HPD-LLPLINRMVYEMSSGMQFLHSKD--IIHRDLKLENVLVDGDLHVKIADLG
ANKK5_Spur      ------HPD-LWPLTNRMIYQISCGMHFLHSND--IIHRDLKLENVLVDGDLNVKISDLG
ank1_Spur       TTKLLHHPD-LWPLTNRMVYQISRGMHFLHSKY--IIHRDLKLENVLVDRNLNVKIADLG
ANKK4_Spur      ------HPD-LLPLTNRMVYEMSSGMQFLHSKD--IIHRDLKLENVLVDGDLHVKIADLG
                             :  * : :   .: :**     ::* ***  *:*:* . : *::*:*

SgK288_Hsap     LSKWMEQSTRMQ---------Y-IE-RSALRGMLSYIPPEMFLE----SNKAPGPKYDVY
RIPK3_Hsap      LSTFQGGSQSG-------------TGSGEPGGTLGYLAPELFVN----VNRKASTASDVY
RIPK2_Hsap      LSKWRMMSLSQS---------RSSK-SAPEGGTIIYMPPENYEP---GQKSRASIKHDIY
RIPK1_Hsap      LASFKMWSKLNNEEHNELRE-VDGT-AKKNGGTLYYMAPEHLND----VNAKPTEKSDVY
ANKRD3_Mmus     LAKCNGMSHSHD-----------LS-MDGLFGTIAYLPPERIRE----KSRLFDTKHDVY
ANKRD3_Hsap     LAKCNGLSHSHD-----------LS-MDGLFGTIAYLPPERIRE----KSRLFDTKHDVY
RIPK1_Mmus      VASFKTWSKLTKEKDNKQKEVSSTT-KKNNGGTLYYMAPEHLND----INAKPTEKSDVY
RIPK2_Mmus      LSKWRMMSLSQS---------RSYK-SAPEGGTIIYMPPENYEP---GQKSRASVKHDIY
RIPK3_Mmus      LSTFQGGSQSGS---------GSGSGSRDSGGTLAYLDPELLFD----VNLKASKASDVY
SgK288_Mmus     LSKWMEQSTQKQ---------Y-IE-RSALRGTLSYIPPEMFLE----NNKAPGPEYDVY
ANKK2_Spur      LATNLQTSS----------------G-DRCWGTDSHKPPEAFRTDLPNSTKVVTPKYDVY
ANKK1_Spur      LATNLQTSF----------------G-DERCGTNSHKPPEAFRTDLPNSTKVVTPEYDVY
ANKK3_Spur      LATNLQTSF----------------G-DRCCGTHSHKPPEAFRTDIPNSIMIGTPKYDVY
ANKK6_Spur      LAADLRTSF----------------G-DRCWGTDSHKPPEAFRTDLSKSIKVVNPKYDVY
ank2_Spur       LATNLQTSF----------------G-DRCWGTDSHKPPEAFRTDLPNSTKIVTPKYDVY
ANKK5_Spur      LATNLQTSF----------------G-DRCWGTDSHKPPEAFRTDLPDSTKVVTPKYDVY
ank1_Spur       LATNLQTSS----------------G-KGCYGTDSHKPPEAFRTDIPNSTKVVTPKYDVY
ANKK4_Spur      LATNLQTSF----------------G-DRCCGTHSHKPPEAFRTDIPNSIMIGTPKYDVY
                ::     *                       *   :  **                 *:*

SgK288_Hsap     S-FAIVI---WELLTQKKPYSGF-NMMMIIIRVAAGMRPSLQP--VSDQWPSE--AQQMV
RIPK3_Hsap      S-FGILM---WAVLAGREVELPTEPSLVYEAVCNRQNRPSLAE--LPQAGPETPGLEGLK
RIPK2_Hsap      S-YAVIT---WEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHR---ARMI
RIPK1_Hsap      S-FAVVL---WAIFANKEPYENAICEQQLIMCIKSGNRPDVDD--ITEYCPR-----EII
ANKRD3_Mmus     S-FAIVI---WGVLTQKKPFADEKNILHIMMKVVKGHRPELPP--ICRPRPRA--CASLI
ANKRD3_Hsap     S-FAIVI---WGVLTQKKPFADEKNILHIMVKVVKGHRPELPP--VCRARPRA--CSHLI
RIPK1_Mmus      S-FGIVL---WAIFAKKEPYENVICTEQFVICIKSGNRPNVEE--ILEYCPR-----EII
RIPK2_Mmus      S-YAVIM---WEVLSRKQPFEEVTNPLQIMYSVSQGHRPDTSEENLPFDIPHR---GLMI
RIPK3_Mmus      S-FGILV---WAVLAGREAELVDKTSLIRETVCDRQSRPPLTE--LPPGSPETPGLEKLK
SgK288_Mmus     S-FAIVI---WEILTQKKPYAGL-NMMTIIIRVAAGMRPSLQD--VSDEWPEE--VHQMV
ANKK2_Spur      S-FAMTL---YELLTGIHPYSDRGFDMMKLLKVEAKQPPCLQP--VPVNAPK-----DLI
ANKK1_Spur      S-FAMTL---YELLTGIHPYSDRGFYMMMLLKVDSKQSPCLQP--IPASTPE-----DLI
ANKK3_Spur      R-KASEKDTHNEA-----------------------------------------------
ANKK6_Spur      S-FAMTL---YELLTGIHPYAERGLEMVKVFKL-SDQAPCLKP--VPVNTPT-----PLI
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      REFEFVK---QQK-------------------VD-NTTPCEDP--VPENTPE-----ALI
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      S-FAMTL---YEL-----------------------------------------------


SgK288_Hsap     DLMKRCWDQDPKKRPCFLDITIETDILL-SLLQSRVA-VPESKALARKVSCK--------
RIPK3_Hsap      ELMQLCWSSEPKDRPSFQECLPKTDEVF-QMVENNM-NAAVST-VK-DFLSQLRSSNRRF
RIPK2_Hsap      SLIESGWAQNPDERPSFLKCLIELEPVL-RTFEEITFLEAVIQ-LK-KTKLQSVSSAIHL
RIPK1_Hsap      SLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESV-EEDVKS-LK-KEYSNENAVVKRM
ANKRD3_Mmus     GLMQRCWHADPQVRPTFQEITSETEDLC-EKPDEEVK-DLAHE-PGEKSSLESKSEARPE
ANKRD3_Hsap     RLMQRCWQGDPRVRPTFQEITSETEDLC-EKPDDEVK-ETAHD-LDVKSPPEPRSEVVP-
RIPK1_Mmus      SLMERCWQAIPEDRPTFLGIEEEFRPFYLSHFEEYV-EEDVAS-LK-KEYPDQSPVLQRM
RIPK2_Mmus      SLIQSGWAQNPDERPSFLKCLIELEPVL-RTFEDITFLEAVIQ-LK-KAKIQSSSSTIHL
RIPK3_Mmus      ELMIHCWGSQSENRPSFQDCEPKTNEVY-NLVKDKV-DAAVSE-VK-HYLSQHRSSGRNL
SgK288_Mmus     NLMKRCWDQDPKKRPCFLNVAVETDMLL-SLFQSPMT-DPGCEALTQKVSCK--------
ANKK2_Spur      EVMQECWSYEANERPNFREIRDRVKNLG-TEP---T-Y---AS-LG-FYLGEQVVPELI-
ANKK1_Spur      RVMEESWSYEPNDRPNFREITEWVANLD-TEP---T-H---ES-LG-HYLGEQRSPENVG
ANKK3_Spur      ----------------FNVINIF-------------------------------------
ANKK6_Spur      KVMTDSWRYAANSRPAFIEITDWVKNQLNIKP---T-H---RS-LG-ICLGEVTRAQLQ-
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      EVMRDSWSYEANDRPNFGALLHS-------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     ------------------------------------------------------------
RIPK3_Hsap      -SI-PESGQGG-------------------------------------------------
RIPK2_Hsap      C-D-K-----------------------------KKMELSLN------------------
RIPK1_Hsap      QSL-QL----DCVAVPS--------S-RSNSATEQPGSLHSSQGLGMGP-----------
ANKRD3_Mmus     S-S-RL----KRASAPPFD-----ND-CSLS--ELLSQLDSG------------------
ANKRD3_Hsap     --A-RL----KRASAPTFD-----ND-YSLS--ELLSQLDSG------------------
RIPK1_Mmus      FSL-QH----DCVPLPP--------S-RSNS--EQPGSLHSSQGLQMGP-----------
RIPK2_Mmus      C-D-K------------------------------KMDLSLN------------------
RIPK3_Mmus      -SA-REPSQRG-------------------------------------------------
SgK288_Mmus     ------------------------------------------------------------
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      -RADDEPVRRGMQDLPVNDPTPVEQS-NGN--AAIPITETETQNQQNSPENVGR------
ANKK3_Spur      ------------------------------------------------------------
ANKK6_Spur      --ESQDLAQRCMAS----TKTLTERATQQE--AQLLILEEETEKVKNQCSNLKKTVQNLE
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     ----------------------------------LSLRQPGE------------------
RIPK3_Hsap      ---------------------------TEMD-----------------------------
RIPK2_Hsap      ---------------------------------IPVNHGPQE------------------
RIPK1_Hsap      ---------------------------VEESWFAPSLEHPQE------------------
ANKRD3_Mmus     --------------------------------ISQTLEGPEE------------------
ANKRD3_Hsap     --------------------------------VSQAVEGPEE------------------
RIPK1_Mmus      ---------------------------VEESWFSSSPEYPQD------------------
RIPK2_Mmus      ---------------------------------IPANHPPQE------------------
RIPK3_Mmus      ---------------------------T--------------------------------
SgK288_Mmus     ----------------------------------PSLSQPHK------------------
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      -------ADHEPVRRGMQDLPINDPTPVEQSN--GNAAIPITETETQNQVEGHESPPTHP
ANKK3_Spur      ------------------------------------------------------------
ANKK6_Spur      DINTSWASKNQAMKKDMQDLKMELDTQSAE-L--DQLKLPICKCDRDTQTRSSTNSDNCY
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     -VNEDIS--QE-LMDSDSGNYLK------------R-ALQLSD-----------------
RIPK3_Hsap      ----------------GFRRTIENQHSRNDVMVSEW-LNKLNL-----------------
RIPK2_Hsap      -ESCGSS--QLHE-NSGS------------------------------------------
RIPK1_Hsap      -ENEPSL--QSKLQDE-ANYHLYG-SRMDR------------------------------
ANKRD3_Mmus     -LSRSSS--ECKLPSSSSGKRLSGVSSVDSAFSSRG-SLSLSFERE--------------
ANKRD3_Hsap     -LSRSSS--ESKLPSSGSGKRLSGVSSVDSAFSSRG-SLSLSFERE--------------
RIPK1_Mmus      -ENDRSV--QAKLQEE-ASYHAFG-IFAEK------------------------------
RIPK2_Mmus      -ESCGSS--LLSR-NTGS------------------------------------------
RIPK3_Mmus      --------------------EMDCPR---ETMVSKM-LDRLHL-----------------
SgK288_Mmus     -VSKEVN--QE-IADSVSSDSLK------------W-ILQLSD-----------------
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      IIQRSSSKKEGLPPNFGHQRSPENVGRADDEPVRRG-MQDLPVNDPTPVEQSNGNA-AIP
ANKK3_Spur      ------------------------------------------------------------
ANKK6_Spur      ASTTMTDRNECASILAVEELTPESVKVEDTQTVRQSKTQDFQVEGQQEVHQGEERNSLI-
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     ------------------------------------------------------------
RIPK3_Hsap      ------------------------------------------------------EEP--P
RIPK2_Hsap      ------------------------------------------------------------
RIPK1_Hsap      ------------------------------------------------------------
ANKRD3_Mmus     ----------ASTGDL-----------------GP-------------------------
ANKRD3_Hsap     ----------PSTSDL-----------------GT-------------------------
RIPK1_Mmus      ------------------------------------------------------------
RIPK2_Mmus      ------------------------------------------------------------
RIPK3_Mmus      ------------------------------------------------------EEP--S
SgK288_Mmus     ------------------------------------------------------------
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      ITE---------------------------------------------------------
ANKK3_Spur      ------------------------------------------------------------
ANKK6_Spur      -QEADTAHATPSTSARGNLQETMVCSLKDETARGTRDHMNEQRTEEQSLDNFKDNIPIED
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     ------------------------------------------------------------
RIPK3_Hsap      SSVPKKCPSLTKRSRAQE------------------------------------------
RIPK2_Hsap      ------------------------------------------------------------
RIPK1_Hsap      ------------------------------------------------------------
ANKRD3_Mmus     -------------TDIQK-------------------KKLVDAIISGDTSR---------
ANKRD3_Hsap     -------------TDVQK-------------------KKLVDAIVSGDTSK---------
RIPK1_Mmus      ------------------------------------------------------------
RIPK2_Mmus      ------------------------------------------------------------
RIPK3_Mmus      GPVPGKCPERQ----AQD------------------------------------------
SgK288_Mmus     ------------------------------------------------------------
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      ------------------------------------------------------------
ANKK3_Spur      ------------------------------------------------------------
ANKK6_Spur      LPVEVAIVAEQ----IQKCKGEGDTLQDVSAGEEISQNQLRSIVVTGPSNMPGHSSDELS
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     ---RKNLV-------------------------------------PRDEELCIYENKVTP
RIPK3_Hsap      ------------------------------------------------------------
RIPK2_Hsap      ------------------------------------------------------------
RIPK1_Hsap      ---QTKQQ-------------------------------------PRQN-----------
ANKRD3_Mmus     --LMKILQ-------------------------------------PQDVDL-VLDSSASL
ANKRD3_Hsap     --LMKILQ-------------------------------------PQDVDL-ALDSGASL
RIPK1_Mmus      ---QTKPQ-------------------------------------PRQN-----------
RIPK2_Mmus      ------------------------------------------------------------
RIPK3_Mmus      ------------------------------------------------------------
SgK288_Mmus     ---SKSLV-------------------------------------ASD----VYENRVTP
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      ------------------------------------------------------------
ANKK3_Spur      ------------------------------------------------------------
ANKK6_Spur      LNHQKDTQPKRVGTGQSADAFDTLTTTLTTLNTISLKTYSGSLEVPAKANY-ITTSQ---
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     LHFLVA----------QG----------SVEQVRLLLAHEVDVD-CQTASGYTPLLIAAQ
RIPK3_Hsap      ----------------------------------------------------EQVPQ---
RIPK2_Hsap      -------------------------------------------P-ETSRSLPAPQDNDFL
RIPK1_Hsap      ----------------------------------------------------VAYNREEE
ANKRD3_Mmus     LHLAVE----------AG----------QEECVKWLLLNNANPN-LTNRKGSTPLHMAVE
ANKRD3_Hsap     LHLAVE----------AG----------QEECAKWLLLNNANPN-LSNRRGSTPLHMAVE
RIPK1_Mmus      ----------------------------------------------------EAYNREEE
RIPK2_Mmus      -------------------------------------------P-GPSRSLSAPQDKGFL
RIPK3_Mmus      ----------------------------------------------------TSVGP---
SgK288_Mmus     LHFLVA----------GG----------SLEQVRLLLSHDVDVD-CQTASGYTPLLIATQ
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      ---------------------------------------TETQ-NQVEGHESPPTHPIIQ
ANKK3_Spur      ------------------------------------------------------------
ANKK6_Spur      -----ARLGNQQLPAELGNNPGRIIPLDKEETSPPVQESKTSPETYTDNEPDACVGKAEE
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     DQ-------------QPDLCALLLA------HGADAN--RVDEDGWAPLHFAA-QNGDD-
RIPK3_Hsap      --------------------------------------------AW--------------
RIPK2_Hsap      SR-------------KAQDCYFMKL------HHCPGN--HS-WDSTISGS----------
RIPK1_Hsap      RR-------------R-RVSHDPFA------QQRPYENFQNTEGKGTAYSSAA-SHGNAV
ANKRD3_Mmus     RK-------------GRGIVELLLA------RKTSVN--AKDEDQWTALHFAA-QNGDE-
ANKRD3_Hsap     RR-------------VRGVVELLLA------RKISVN--AKDEDQWTALHFAA-QNGDE-
RIPK1_Mmus      RK-------------R-RVSHDPFA------QQRARENIKSAGARGHSDPSTT-SRGIAV
RIPK2_Mmus      SG-------------APQDCSSLKA------HHCPGN--HS-WDGIVSVP----------
RIPK3_Mmus      --------------------------------------------AT--------------
SgK288_Mmus     DQ-------------QPDLCALLLA------HGADTN--LADEDGWAPLHFAA-QNGDD-
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      RSSTKKEGKKDDKSVGRGMKNLTLQEQARARHQSNTN--AAVHDIQTVIHDESVRKGM--
ANKK3_Spur      ------------------------------------------------------------
ANKK6_Spur      AR-------------SHSVVLDVFG------NQNQVD--AYDEDIVIPRTYVE-ENS---
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     -------------------GTARLLLDHGACVDAQEREGW--TPLH---LAAQNNFE-NV
RIPK3_Hsap      ------------------------------------------------------------
RIPK2_Hsap      ------------------------------------------------------------
RIPK1_Hsap      HQPSGLT------------SQPQVLYQNNGLYSSHGF-----------------------
ANKRD3_Mmus     -------------------ASTRLLLEKNASVNEVDFEGR--TPMH---VACQHGQE-NI
ANKRD3_Hsap     -------------------SSTRLLLEKNASVNEVDFEGR--TPMH---VACQHGQE-NI
RIPK1_Mmus      QQLSWP--------------ATQTVW-NNGLYNQHGF-----------------------
RIPK2_Mmus      ------------------------------------------------------------
RIPK3_Mmus      ------------------------------------------------------------
SgK288_Mmus     -------------------HTARLLLDHGALVNAREHEGW--TPLH---LAAQNNFE-NV
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      ------EGLTMNDHTPVEQSNGKTAIPINETVTQHQVEGQESPPTH-------LGQD-NV
ANKK3_Spur      ------------------------------------------------------------
ANKK6_Spur      ---------------------SRCRGEEKGELQ-------EREPVECDSVA--HAHEANV
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     A---------RLLVSRQADPNL-----------------------------HEAEGKTP-
RIPK3_Hsap      ------------------------------------------------------------
RIPK2_Hsap      ------------------------------------------------------------
RIPK1_Hsap      -------------GTRPLDPGT-----------------------------AGPRVWYR-
ANKRD3_Mmus     V---------RTLLRRGVDVGL-----------------------------QGKDAWLP-
ANKRD3_Hsap     V---------RILLRRGVDVSL-----------------------------QGKDAWLP-
RIPK1_Mmus      --------------------GT-----------------------------TGTGVWYP-
RIPK2_Mmus      ------------------------------------------------------------
RIPK3_Mmus      ------------------------------------------------------------
SgK288_Mmus     A---------RLLVSRQADLSP-----------------------------HEAEGKTP-
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      V---------APLEIQHSQPSSQDPSKPSSFGRLKSQISGPQYRCHGDIFQPTVEAEQPM
ANKK3_Spur      ------------------------------------------------------------
ANKK6_Spur      FHEVGKDRLPGGAGTRQGEIGLSL-----------------------------ESGQVSL
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     ------------------------------------------------------------
RIPK3_Hsap      --------TAGTSSD---------------------------------------SMAQPP
RIPK2_Hsap      ------------------------------------------------------------
RIPK1_Hsap      ------------------------------------------------------------
ANKRD3_Mmus     ------------------------------------------------------------
ANKRD3_Hsap     ------------------------------------------------------------
RIPK1_Mmus      ------------------------------------------------------------
RIPK2_Mmus      ------------------------------------------------------------
RIPK3_Mmus      --------PARTSSD---------------------------------------PVAGTP
SgK288_Mmus     ------------------------------------------------------------
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      EFTGFVSAPTENSPD---------------------------------------P-----
ANKK3_Spur      ------------------------------------------------------------
ANKK6_Spur      K------------SDNIEASKTLPVFILSTETIPGNSKFIPTSKLMGISVTSEEP-----
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     ------------------------------------------------------------
RIPK3_Hsap      QTP----------ETSTFRNQMPSPTSTGTPSPGPR------------------------
RIPK2_Hsap      ------------------------------------------------------------
RIPK1_Hsap      ------------------------------------------------------------
ANKRD3_Mmus     ------------------------------------------------------------
ANKRD3_Hsap     ------------------------------------------------------------
RIPK1_Mmus      ------------------------------------------------------------
RIPK2_Mmus      ------------------------------------------------------------
RIPK3_Mmus      QIP----------HTLPFRGTTPGPVFTETPGPHPQ------------------------
SgK288_Mmus     ------------------------------------------------------------
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      SASQPLKSYRKAEQPTEFTGFVSAPTE-NSPGP------SESQPLKSYREAE--------
ANKK3_Spur      ------------------------------------------------------------
ANKK6_Spur      STP----------KDISKRGTLAKSALSETDGT--ETLPQE----------ENGPQDINS
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     ------------------------------------------------------------
RIPK3_Hsap      -------------------------------------------------------GNQGA
RIPK2_Hsap      ------------------------------------------------------------
RIPK1_Hsap      -----------------------------------------------------PIPSHMP
ANKRD3_Mmus     ------------------------------------------------------------
ANKRD3_Hsap     ------------------------------------------------------------
RIPK1_Mmus      -----------------------------------------------------PNLSQMY
RIPK2_Mmus      ------------------------------------------------------------
RIPK3_Mmus      -------------------------------------------------------RNQGD
SgK288_Mmus     ------------------------------------------------------------
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      ------------QPMEFTGFVS-----------------ASTENSPDPSESQPLK-----
ANKK3_Spur      ------------------------------------------------------------
ANKK6_Spur      SQSCYDSTDRKERPLSATNLCEPGNYNILRKKGESSPLTTK------PTFFQTPKRKHAP
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     ------LHVAAYF-----------GHVSLVKLLTSQ-GA------ELD------------
RIPK3_Hsap      ERQGMN-----WS-----------CRTPEPNPVTGRPL----------------------
RIPK2_Hsap      ------------------------------------QRA------AF-------------
RIPK1_Hsap      SLHNIPVPETNYL-----------GNTPTMPFSSLPPTD------ESI------------
ANKRD3_Mmus     ------LHYAAWQ-----------GHLPIVKLLAKQPGV------SVN------------
ANKRD3_Hsap     ------LHYAAWQ-----------GHLPIVKLLAKQPGV------SVN------------
RIPK1_Mmus      STYKTPVPETNIP-----------GSTPTMPYFSGPVAD------DLI------------
RIPK2_Mmus      ------------------------------------PGA------AF-------------
RIPK3_Mmus      GRHGTP-----WY-----------PWTP-PNPMTGPPA----------------------
SgK288_Mmus     ------LHVAAYF-----------GHIGLVKLLSGQ-GA------ELD------------
ANKK2_Spur      -----------------------------------TPGI------TSGL-----------
ANKK1_Spur      ------------SYRKAEQPMEFTGFVS--APTENSPGL------SASQPLKSYREAEQP
ANKK3_Spur      ------------------------------------------------------------
ANKK6_Spur      SLHQVS-----SP-----------PFVP--KPPTFVPDISAFSYMSNSEPLSSLRNIDDR
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     -AQQRNL------RTPLHLAVERGKVRAIQHLLKS----------GA-V---PDA-----
RIPK3_Hsap      ------------------------------VNIYN----------CS-G---VQV-----
RIPK2_Hsap      ---------------------------------------------CDHK---TTP-----
RIPK1_Hsap      -KYTIYN------STG----IQIGAYNYMEIGGTSSSLLDSTNTNFKEE---PAA-----
ANKRD3_Mmus     -AQTLDG------RTPLHLAAQRGHYRVARILIDL----------CS-D---VNI-----
ANKRD3_Hsap     -AQTLDG------RTPLHLAAQRGHYRVARILIDL----------CS-D---VNV-----
RIPK1_Mmus      -KYTIFN------SSG----IQIGNHNYMDVGLNSQ----PPNNTCKEE---STS-----
RIPK2_Mmus      ---------------------------------------------CDRR---ASS-----
RIPK3_Mmus      ------------------------------LVFNN----------CS-E---VQI-----
SgK288_Mmus     -AQQRNL------RTPLHLAVERGKVRAIQHLLKC----------GA-L---PDA-----
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      MEFTGFVSAPTENSPGLSESQPLKSYREAEQLMEF----------TG-F---VSAPTENS
ANKK3_Spur      ------------------------------------------------------------
ANKK6_Spur      QKHPLAKTKSTWSSPSVKKSSE--------------------------FGSAKSYSSWKT
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     -------------------------------LDQSGYGPLHTAAAR-GKYL---IC----
RIPK3_Hsap      ------------------------------------------------------------
RIPK2_Hsap      -------------------------------CSSAIINPLSTAGNS-ERLQ---PG----
RIPK1_Hsap      -------------------------------KYQAIFDN-TTSLTD-KHLDPIREN----
ANKRD3_Mmus     -------------------------------CSLQAQTPLHVAAET-GHTS---TA----
ANKRD3_Hsap     -------------------------------CSLLAQTPLHVAAET-GHTS---TA----
RIPK1_Mmus      -------------------------------RHQAIFDN-TTSLTD-EHLNPIREN----
RIPK2_Mmus      -------------------------------CSLAVISPFLVEKGS-ERPP---IG----
RIPK3_Mmus      ------------------------------------------------------------
SgK288_Mmus     -------------------------------LDHSGYSPLHIAAAR-GKDL---IF----
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      PDPSESQPLKSYREDGKPVPVESSHGNTEYAVAHTAGGPIHQESPVVAPSQPSSTERDPT
ANKK3_Spur      ------------------------------------------------------------
ANKK6_Spur      LDQLRMQPHQHQSNQTTRMPVR--------------------------------------
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     -------------------------------------------KMLLRYGASLELP----
RIPK3_Hsap      ------------------------------------------------------------
RIPK2_Hsap      -------------------------------------------IAQQWIQSKREDI----
RIPK1_Hsap      -------------------------------------------LGKHWKNCARKL-----
ANKRD3_Mmus     -------------------------------------------RLLLHRGAGKEAL----
ANKRD3_Hsap     -------------------------------------------RLLLHRGAGKEAM----
RIPK1_Mmus      -------------------------------------------LGRQWKNCARKL-----
RIPK2_Mmus      -------------------------------------------IAQQWIQSKREAI----
RIPK3_Mmus      ------------------------------------------------------------
SgK288_Mmus     -------------------------------------------KMLLRYGASLELR----
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      IIFDSSQPSDEDFEIKVKVRLNIQLRASMASKLDQIFICLERCKHRDYWDSNSSLSTMFS
ANKK3_Spur      ------------------------------------------------------------
ANKK6_Spur      --FSHLPPSAQQLHQSL-------------------------------------------
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     ---------------------------THQGWTPL-------HLAAYKGHLEI-------
RIPK3_Hsap      ------------------------------------------------------------
RIPK2_Hsap      ---------------------------VNQ-MTEA-------CLNQSLDALLS-------
RIPK1_Hsap      ------------------------------GFTQS-------QIDE-IDHDYE-------
ANKRD3_Mmus     ---------------------------TSEGYTAL-------HLAAQNGHLAT-------
ANKRD3_Hsap     ---------------------------TSDGYTAL-------HLAARNGHLAT-------
RIPK1_Mmus      ------------------------------GFTES-------QIDE-IDHDYE-------
RIPK2_Mmus      ---------------------------VSQ-MTEA-------CLNQSLDALLS-------
RIPK3_Mmus      ------------------------------------------------------------
SgK288_Mmus     ---------------------------TQQGWTPL-------HLATYKGHLEI-------
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      WIDITLKSLQLPATVDDDDFTLYFRVCNKRDLDKL-------HKLSEKGHLRQSLYYFFV
ANKK3_Spur      ------------------------------------------------------------
ANKK6_Spur      ----------------------------------CHTTSSPTLTSSPTIHHPTS------
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     ------IHLLA----------------------ESHANM-------------------GA
RIPK3_Hsap      ------------------------------------------------------------
RIPK2_Hsap      ------RDLIM----------------------KEDYEL-------------------VS
RIPK1_Hsap      ------RDGLK----------------------EK-------------------------
ANKRD3_Mmus     ------VKLLI----------------------EEKADV-------------------MA
ANKRD3_Hsap     ------VKLLV----------------------EEKADV-------------------LA
RIPK1_Mmus      ------RDGLK----------------------EK-------------------------
RIPK2_Mmus      ------RDLIM----------------------KEDYEL-------------------IS
RIPK3_Mmus      ------------------------------------------------------------
SgK288_Mmus     ------IHQLA----------------------KSHVDL-------------------DA
ANKK2_Spur      ------------------------------------------------------------
ANKK1_Spur      DVHLKEVCLPAEPDLKVESWEEQFNKGMAHFQKKEKANESMKSDSERSEPREKQQNETKS
ANKK3_Spur      ------------------------------------------------------------
ANKK6_Spur      ------------------------------------------------------------
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     LGAVNWTPLHLAARHGEEAVVSALLQCGADPNA---------------------AEQSGW
RIPK3_Hsap      ------------------------------------------------------------
RIPK2_Hsap      TKPTRTSKV------------R-----QL-LDT---------------------TDIQGE
RIPK1_Hsap      --------------------VYQMLQ-KW-VMR---------------------EGIKGA
ANKRD3_Mmus     RGPLNQTALHLAAARGHSEVVEELVSADL-IDL---------------------SDEQGL
ANKRD3_Hsap     RGPLNQTALHLAAAHGHSEVVEELVSADV-IDL---------------------FDEQGL
RIPK1_Mmus      --------------------VYQMLQ-KW-LMR---------------------EGTKGA
RIPK2_Mmus      TKPTRTSKV------------R-----QL-LDT---------------------SDIQGE
RIPK3_Mmus      ------------------------------------------------------------
SgK288_Mmus     LGSMQWTPLHLAAFQGEEGVMLALLQCGANPNA---------------------AEQSGW
ANKK2_Spur      -------------------------------------------------------QQSGE
ANKK1_Spur      GASFSQTNCSGATQINTGKVTINMKSA-KNFVVGDQHITHNYFHGSKGAEAGAGGHSSGR
ANKK3_Spur      ------------------------------------------------------------
ANKK6_Spur      ----------------------NLT-----------------------------AQQSTD
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     TPLH------------LAV--------------------QRSTFLSVINLLEHHANVHAR
RIPK3_Hsap      -------------------GDNNYLTM-QQTTAL-----------PTWGLAP------SG
RIPK2_Hsap      EF-----------------------------------------AKVIVQKLKDNKQMGLQ
RIPK1_Hsap      TV-----------------------------------------GK-LAQALHQCSRIDL-
ANKRD3_Mmus     SALH------------LAA--------------------QGRHSQTVETLLKHGAHINLQ
ANKRD3_Hsap     SALH------------LAA--------------------QGRHAQTVETLLRHGAHINLQ
RIPK1_Mmus      TV-----------------------------------------GK-LAQALHQCCRIDL-
RIPK2_Mmus      EF-----------------------------------------AKVVVQKLKDNKQLGLQ
RIPK3_Mmus      -------------------GNYNSLVAPPRTTA---------------------------
SgK288_Mmus     TPLH------------LAV--------------------HKGTFLGITHLLEYGADIHAC
ANKK2_Spur      IPRL------------GNLQ---------RES----------------------------
ANKK1_Spur      QPQMKKQEKTKLCESREKVS---------QQTLL-----------GIEQLIPGKAVKSLG
ANKK3_Spur      ------------------------------------------------------------
ANKK6_Spur      PPRP------------LGLS---------EDSILETSTTRAKEIHSVMPRLTHGR-----
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     NKVGWTPAHLAAL----KGNT-------AILKVLVEAG-AQL-----DV-QDGVSCTPLQ
RIPK3_Hsap      KGRG------------------------------LQHP-PPVGSQEGPKDPEAW-S----
RIPK2_Hsap      P-----------Y-----------------P---------EI------L-VVSRS-PSLN
RIPK1_Hsap      ---------------------------------------------------------LSS
ANKRD3_Mmus     S-----------L----------------------------------KF-QGGQS-SAAT
ANKRD3_Hsap     S-----------L----------------------------------KF-QGGHG-PAAT
RIPK1_Mmus      ---------------------------------------------------------LNH
RIPK2_Mmus      P-----------Y-----------------P---------EV------P-VLSKA-PPSN
RIPK3_Mmus      -------------------------------------------SSSAKYDQAQF-G----
SgK288_Mmus     NKVGWTPAHLAAL----KGNT-------AILKVLVKAA-AQV-----DV-KGGVSCTPLQ
ANKK2_Spur      ----------------------------------------KFDLT----------MVPEL
ANKK1_Spur      RHLGLDHVRIENI----VYENQNETSSEIAYQL-LREWIQQNGHQ----------ATKAV
ANKK3_Spur      ------------------------------------------------------------
ANKK6_Spur      ------SI-IDSSSGRDDHSHFQEKISSTTKQV-TES-NPT--SP----------KYPPV
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ------------------------------------------------------------
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      ------------------------------------------------------------


SgK288_Hsap     L-ALRSRKQGIMSFL--EG-KEPSVATLGGS---------------------K-------
RIPK3_Hsap      --------------------------------------------------------RPQG
RIPK2_Hsap      L-----------------------------------------------------------
RIPK1_Hsap      L-----------------------------------------------------------
ANKRD3_Mmus     L-----------------------------------------------------------
ANKRD3_Hsap     L-----------------------------------------------------------
RIPK1_Mmus      L-----------------------------------------------------------
RIPK2_Mmus      F-----------------------------------------------------------
RIPK3_Mmus      --------------------------------------------------------RGRG
SgK288_Mmus     L-----------------------------------------------------------
ANKK2_Spur      ---------------------------------------------------------ITL
ANKK1_Spur      L---AN------------------------ALWK----------------------AECC
ANKK3_Spur      ----------------------------------------------------------FG
ANKK6_Spur      PVNLATRRLPPRSDQDREGAAGDAGGDASLFSDDECEEDMKDGVASQIDRIQNFLKKDRL
ank2_Spur       ------------------------------------------------------------
ANKK5_Spur      ----------------------------------------------------------ES
ank1_Spur       ------------------------------------------------------------
ANKK4_Spur      -----------------------------------------------------------L


SgK288_Hsap     PGAEMEI
RIPK3_Hsap      WYNHSGK
RIPK2_Hsap      -LQNKSM
RIPK1_Hsap      -IYVSQN
ANKRD3_Mmus     -LRRSKT
ANKRD3_Hsap     -LRRSKT
RIPK1_Mmus      -IRASQS
RIPK2_Mmus      -PQNKSL
RIPK3_Mmus      -WQPFHK
SgK288_Mmus     -AIHSPK
ANKK2_Spur      GITSAEQ
ANKK1_Spur      EAAESVW
ANKK3_Spur      SDVKLAA
ANKK6_Spur      RKRAKLE
ank2_Spur       ------R
ANKK5_Spur      LTFSYFV
ank1_Spur       ------R
ANKK4_Spur      TGIHPYS