Wnk4_Hsap       LKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKL--SRAERQRFSEEVEMLKGLQHP
Wnk3_Hsap       LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKL--TKAEQQRFKEEAEMLKGLQHP
C46C2.1_Cele    LKFDEELGRGSFKTVFRGLDTETGVAVAWCELQESKL--NKTERQRFREEAEMLKDLQHP
CG7177_Dmel     FKYDKEVGRGSFKTVYRGLDTLTGVPVAWCELLDKQV--KKSERTRFREEADMLKKLQHP
Wnk1_Mmus       LKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKL--TKSERQRFKEEAEMLKGLQHP
Wnk2_Mmus       LKFDIELGRGSFKTVYKGLDTETWVEVAWCELQDRKL--TKLERQRFKEEAEMLKGLQHP
Wnk3_Mmus       LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKL--TKAEQQRFKEEAEMLKGLQHP
Wnk4_Mmus       LKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKL--SRAERQRFSEEVEMLKGLQHP
Wnk1_Hsap       LKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKL--TKSERQRFKEEAEMLKGLQHP
Wnk2_Hsap       LKFDIELGRGSFKTVYKGLDTETWVEVAWCELQDRKL--TKLERQRFKEEAEMLKGLQHP
17822_Tthe      ------------------------------------------------------------
8961_Tthe       IRFNEELGFGAYKTVYRAYDNDSGCEVAWNVIKLQRL--PLNERKRISEEIQLLKNLHHP
WNK_Spur        MKYDVAVGQGSFKTVFRGLDTETGVAVAWCELQERKL--SRSERQRFKEEAEMLKGLSHP
AqueK219_Aque   VKYEQEIGRGSFKTVYKGLDTETGVAVAWCELLEHKF--NKEEQSRFKEEVAILKTLNHP
WNK_e_Smoe      GRYNEVLGRGAFKTVYKAFDEVDGIEVAWNQVNVQDVLGRPEDLERLYSEVHLLRGLKHK
WNK_a_Smoe      GRYSEVLGKGAFKAVYRAFDEVDGLEVAWNQVNVQDLLRSPDDLERLYSEVHLLKTLKHK
WNK_d_Smoe      GRYNEILGKGAFKTVYRAFDEVDGIEVAWNQVKVEDVLQSPEDLERLYSEVHLLKSLKHK
WNK_c_Smoe      GRYNEILGKGAFKTVYRAFDEVDGIEVAWNQVKVEDVLQSPEDLERLYSEVHLLKSLKHK
WNK_b-2_Smoe    GRYKELLGKGAFKTVYKAFDEIDGIEVAWNQVKLHDVLRSPEDLERLYSEVHLLKSLKHK
WNK_b-1_Smoe    GRYKELLGKGAFKTVYKAFDEIDGIEVAWNQVKLHDVLRSPEDLERLYSEVHLLKSLKHK
GK075_Glam      --SGDVLGKGAFKTVYRAFDLIAGREVAWNEVVLDTL--EPMASSKLFQEIKALKDVDHE


Wnk4_Hsap       NIVRFYDSWKSVL--RGQVCIVLVTELMTSGTLKTYLRRFR-EMKPRV-LQRWSRQILRG
Wnk3_Hsap       NIVRFYDSWESIL--KGKKCIVLVTELMTSGTLKTYLKRFK-VMKPKV-LRSWCRQILKG
C46C2.1_Cele    NIVRFYDYWESADLCGKRKYIVLVTELMTSGTLKMYLKRFK-RINIKVVLKSWCRQILKG
CG7177_Dmel     NIVRFYTYWEFPI--GRKKNIVLVTELMLSGTLKSYLKRFK-KIHPKV-LKSWCRQILKG
Wnk1_Mmus       NIVRFYDSWESTV--KGKKCIVLVTELMTSGTLKTYLKRFK-VMKIKV-LRSWCRQILKG
Wnk2_Mmus       NIVRFYDFWESSA--KGKRCIVLVTELMTSGTLKTYLKRFK-VMKPKV-LRSWCRQILKG
Wnk3_Mmus       NIVRFYDSWESTL--KGKKCIVLVTELMTSGTLKTYLKRFK-VMKPKV-LRSWCRQILKG
Wnk4_Mmus       NIVRFYDSWKSVL--RGQVCIVLVTELMTSGTLKTYLRRFR-EMKPRV-LQRWSRQILRG
Wnk1_Hsap       NIVRFYDSWESTV--KGKKCIVLVTELMTSGTLKTYLKRFK-VMKIKV-LRSWCRQILKG
Wnk2_Hsap       NIVRFYDFWESSA--KGKRCIVLVTELMTSGTLKTYLKRFK-VMKPKV-LRSWCRQILKG
17822_Tthe      -------------------------QCLSGGSLK----KIK-KPRLKI-IKQWCKQILSG
8961_Tthe       NIINFINAWINK----SKNEVIFITECVSGGSLKKHLKKIK-KPRLKI-IKNWCRQILKG
WNK_Spur        NIVSFYDYWEEVSP-RGKKHIVLVTELMTSGTLKTYLKRFK-GVKNRV-LRSWCRQILKG
AqueK219_Aque   YILRLFDSWEFVRQSDKKRVLVLITELMTSGTLKSYMRRFK-SIKPRV-IRSWGRQILRG
WNK_e_Smoe      NVIKFFTSWVDPR----TKNVNFITEIFTSGTLRQYRKKHK-NVDMKA-VKNWARQILRG
WNK_a_Smoe      NIIKFYTSWVDSK----RRNVNFITEIFTSGTLRQYRKKHK-NVDMKA-VKNWARQILRG
WNK_d_Smoe      NIIKLYNSWVDTK----TKNVNFITEIFTSGTLRQYRKKHK-HVDMRA-VKNWAKQILRG
WNK_c_Smoe      NIIKLYNSWVDTK----TKNVNFITEIFTSGTLRQYRKKHK-HVDMRA-VKNWAKQILRG
WNK_b-2_Smoe    NIIKFYNSWVDTK----NNNVNFITEIFTSGNLRQYRRKHK-HVDLKA-VKHWARQILRG
WNK_b-1_Smoe    NIIKFYNSWVDTT----SNNVNFITEIFTSGNLRQYRRKHK-HVDLKA-VKHWARQILRG
GK075_Glam      NIIKLYDHWFE-----GSNLLIFTTELMPSGCLKKYLKKNPTALTTPV-LKSWALQILEA
                                         : . .* *:    :          :: *  *** .

Wnk4_Hsap       LHFLHSRVP-PILHRDLKCDNVFITGPTGSVKIGDLGLATL-KRASFAKSVIGTPEFMAP
Wnk3_Hsap       LQFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGDLGLATL-MRTSFAKSVIGTPEFMAP
C46C2.1_Cele    LSFLHTRNP-PVIHRDLKCDNIFITGTTGSVKIGDLGLATL-KNKSFAKSVIGTPEFMAP
CG7177_Dmel     LNFLHTRQF-PIIHRDLKCDNIFITGTTGSVKIGDLGLATL-KNRSHAKSVIGTPEFMAP
Wnk1_Mmus       LQFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGDLGLATL-KRASFAKSVIGTPEFMAP
Wnk2_Mmus       LLFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGDLGLATL-KRASFAKSVIGTPEFMAP
Wnk3_Mmus       LQFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGDLGLATL-MRTSFAKSVIGTPEFMAP
Wnk4_Mmus       LHFLHSRVP-PILHRDLKCDNVFITGPSGSVKIGDLGLATL-KRASFAKSVIGTPEFMAP
Wnk1_Hsap       LQFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGDLGLATL-KRASFAKSVIGTPEFMAP
Wnk2_Hsap       LLFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGDLGLATL-KRASFAKSVIGTPEFMAP
17822_Tthe      LQYLHEQEPHPIIHRDIKCENIFVNTVNNEIRIGDLGLALT-LKSDFTTSVLGTPEFMAP
8961_Tthe       LVYLHEQKPYPIIHRDIKCENVFISTTNNEIRIGDLGLAVSLKNSSHTKSVIGTPEFMAP
WNK_Spur        LHFLHTRQP-PIIHRDLKCDNIFITGTSGAVKIGDLGLATL-KKSSFAKSVIGTPEFMAP
AqueK219_Aque   LSFLHTRTP-PIIHRDLKCDNVFINGTTGLVKIGDLGLATL-KRS-DVKTVIGTPEFMAP
WNK_e_Smoe      LLYLHSHDP-PIIHRDLKCDNIFVNGNQGEVKIGDLGLATILRQAHAAHSVIGTPEFMAP
WNK_a_Smoe      LLYLHSHDP-PIIHRDLKCDNIFVNGNYGEVKIGDLGLATILRQAHAAHSVIGTPEFMAP
WNK_d_Smoe      LLYLHSHNP-PIIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRQAHAAHSVIGTPEFMAP
WNK_c_Smoe      LLYLHSHNP-PIIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRQAHAAHSVIGTPEFMAP
WNK_b-2_Smoe    LLYLHSHDP-PIIHRDLKCDNIFVNGNHGEVKIGDLGLAGILRQAHGAHSVIGTPEFMAP
WNK_b-1_Smoe    LLYLHSHDP-PIIHRDLKCDNIFVNGNHGEVKIGDLGLAGILRQAHGAHSVIGTPEFMAP
GK075_Glam      LNYMHTCQP-KIIHRDIKAQNIFINGATGVVKVGDLGLCASLGLQSTAVSCIGTPEFMAP
                * ::*      ::***:*.:*:*:.   . :::*****.        . : :********

Wnk4_Hsap       EMYE-EKYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHKV--KI
Wnk3_Hsap       EMYE-EHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKV--TD
C46C2.1_Cele    EMYE-EMYDESVDVYAFGMCLLEMVTGEYPYSECMNPATIYRKVISGVKPECFSRIPAQY
CG7177_Dmel     EMYE-EHYDESVDVYAFGMCMLEMAISEYPYSECKGPAQIYKKVISGIKPAALAKV--ED
Wnk1_Mmus       EMYE-EKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKV--AI
Wnk2_Mmus       EMYE-EHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTCGIKPASFEKV--HD
Wnk3_Mmus       EMYE-EHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKV--TD
Wnk4_Mmus       EMYE-EKYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGTKPNSFYKV--KM
Wnk1_Hsap       EMYE-EKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKV--AI
Wnk2_Hsap       EMYE-EHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTCGIKPASFEKV--HD
17822_Tthe      EIYE-EKYGTAVDIYAFGMCLLEMATLQIPYRECTSAAQVYKKVSQGLLPNSLQLI--QN
8961_Tthe       EIYE-EKYGTPVDIYSFGMCVLEMATLSTPYKECTSAAQVYKKVSQGILPYQIDLI--QN
WNK_Spur        EMYE-EHYDEAVDVYAFGMCLLEMATSEYPYAECSNAAQIYRRVTTGVKPQSFEKV--ND
AqueK219_Aque   EMYD-EVYDESVDVYAFGMCLLEMCTLEYPYQECSNPAQIYKKVTSGVMPNSLNKV--ND
WNK_e_Smoe      ELYE-EDYNELVDIYAFGMCVLELVTFDYPYSECTNAAQIYKKVSSGIKPAALDKV--KD
WNK_a_Smoe      ELYE-EEYDELVDIYSFGMCVLEMVTFEYPYSECTNAAQIYKRVTSGKKPAAFEKV--KD
WNK_d_Smoe      ELYE-EEYNELVDIYSFGMCLLEMVTFEYPYSECTNAAQIYKKVTSGKKPAALDRV--KD
WNK_c_Smoe      ELYE-EEYNELVDIYSFGMCLLEMVTFEYPYSECTNAAQIYKKVTSGKKPAALDRV--KD
WNK_b-2_Smoe    ELYE-EDYNELVDIYSFGMCLLEMVTFEYPYSECMNAAQIYKKVTSGKKPAALNKV--QD
WNK_b-1_Smoe    ELYE-EDYNELVDIYSFGMCLLEMVTFEYPYSECMNAAQIYKKVTSGKKPAALNKV--QD
GK075_Glam      ETYSNAHYDEKVDIYAFGMLLLELITRDTPYLECANIVDVLKKVEGNIPPNGLNKV--VH
                * *.   *.  **:*:*** :**:   . ** ** . . : ::*  .  *  :  :

Wnk4_Hsap       PEVKEIIEGCIRTDKNERFTIQDLLAHAFF
Wnk3_Hsap       PEVKEIIEGCIRQNKSERLSIRDLLNHAFF
C46C2.1_Cele    PEIREIIDRCIRVRREERSTVKQLLVDDFF
CG7177_Dmel     PNVRDIIERCIELKKEDRPSCNELLESEFF
Wnk1_Mmus       PEVKEIIEGCIRQNKDERYSIKDLLNHAFF
Wnk2_Mmus       PEIKEIIGECICKNKEERYEIKDLLSHAFF
Wnk3_Mmus       PEVKEIIEGCIRQNKSERLSIKDLLNHAFF
Wnk4_Mmus       PEVKEIIEGCIRTDKNERFTIQDLLAHAFF
Wnk1_Hsap       PEVKEIIEGCIRQNKDERYSIKDLLNHAFF
Wnk2_Hsap       PEIKEIIGECICKNKEERYEIKDLLSHAFF
17822_Tthe      DSLKQFILKCIQRS-ENRPSAAQLLQDDFF
8961_Tthe       EGLKNLILKCLSHY-KDRPSAEELLNDKFL
WNK_Spur        NKIKEIIDGCTKTNNTERYLIQELLKHTFF
AqueK219_Aque   PMLKEIIVACTKLSKSARYTVEMLLNHEFF
WNK_e_Smoe      PEVRSFIQKCLATA-SKRLPARELLKDPFL
WNK_a_Smoe      PEVRKFIEKCLAAV-SRRLPARELLMDPFL
WNK_d_Smoe      LEVRAFIEKCLATV-SKRLPARELLMDPFL
WNK_c_Smoe      LEVRAFIEKCLATV-SKRLPARELLMDPFL
WNK_b-2_Smoe    PQMRAFVEQCLAKA-CRRLPARELLMDPFL
WNK_b-1_Smoe    PQMRAFVEQCLAKA-CRRLPARELLMDPFL
GK075_Glam      KEMKDLILLCINKDPSARPSARELLSKPFL
                  :: ::  *       *     **   *: