Cdk8_Dmel MQNVRAYPYQPATSNMNAYCLHNMQYQQQRLPFHQQQQQHHQQLQQQQSQFQPLRSHQLI
CDK8_Mmus ------------------------------------------------------------
CDK19_Mmus ------------------------------------------------------------
F39H11.3_Cele MTLM--------------------------------------------------------
SSN3_Scer ------------------------------------------------------------
CDK19_Hsap ------------------------------------------------------------
CDK8_Hsap ------------------------------------------------------------
Cdk8_Ddis ------------------------------------------------------------
CDK8_Spur ------------------------------------------------------------
CC1G_07887_Ccin ------------------------------------------------------------
AqueK099_Aque ------------------------------------------------------------
CDK8_Smoe ------------------------------------------------------------
Cdk8_Dmel GGIFIYKQLWNLQTFVKMDYDFK-------------------------------------
CDK8_Mmus -----------------MDYDFK-------------------------------------
CDK19_Mmus -----------------MDYDFK-------------------------------------
F39H11.3_Cele -----------------IDENFK-------------------------------------
SSN3_Scer -----------------MYNGKDRAQNSYQPMYQRPMQVQGQQQAQSFVGKK--NTIGSV
CDK19_Hsap -----------------MDYDFK-------------------------------------
CDK8_Hsap -----------------MDYDFK-------------------------------------
Cdk8_Ddis -----------------MNTHNQSS-------------------NQNGGGSGGGGGGGG-
CDK8_Spur -----------------MDYEFK-------------------------------------
CC1G_07887_Ccin -----------------MQQQQQQQ-----------------------------------
AqueK099_Aque -----------------MDSGFI-------------------------------------
CDK8_Smoe -----------------MADGI--------------------------------------
:
Cdk8_Dmel --------------------MKTQIERTKVEDLFN---------------------YEGC
CDK8_Mmus --------------------VKLSSERERVEDLFE---------------------YEGC
CDK19_Mmus --------------------AKLAAERERVEDLFE---------------------YEGC
F39H11.3_Cele --------------------KQLAQRRERVEDLFY---------------------FENS
SSN3_Scer HGKAPMLMANNDVFTIGPY--RARKDRMRVSVLEK---------------------YEVI
CDK19_Hsap --------------------AKLAAERERVEDLFE---------------------YEGC
CDK8_Hsap --------------------VKLSSERERVEDLFE---------------------YEGC
Cdk8_Ddis ----------S---STFSPIVLTSTYRLDVQEKYT---------------------F--S
CDK8_Spur --------------------QQTSGVRESVEDLFD---------------------FEGC
CC1G_07887_Ccin ---------------------QQVSLDEWVSNVMQHDPMRVYRARRDAHHRPVTSKYAIL
AqueK099_Aque --------------------DALSQKREKVEDLFE---------------------YEGK
CDK8_Smoe ------------------------AKRARPAWLQQ---------------------YELL
:
Cdk8_Dmel -KVGRGTYGHVYKAKWKET--S-D------------------------------------
CDK8_Mmus -KVGRGTYGHVYKAKRKDG--K-D------------------------------------
CDK19_Mmus -KVGRGTYGHVYKARRKDG--K-D------------------------------------
F39H11.3_Cele KEIGRGTYGLVYKAVPKKQNGQFP------------------------------------
SSN3_Scer GYIAAGTYGKVYKAKRQINSGTNSANGSSLNGTNAKIPQFDSTQPKSSSSMDMQANTNAL
CDK19_Hsap -KVGRGTYGHVYKARRKDG--K-D------------------------------------
CDK8_Hsap -KVGRGTYGHVYKAKRKDG--K-D------------------------------------
Cdk8_Ddis YEIGSGTYGMVYKADDKKRPN---------------------------------------
CDK8_Spur -KVGRGTYGHVYKATTKKE----P------------------------------------
CC1G_07887_Ccin GFISSGTYGRVYKAQSINGG-E--------------------------------------
AqueK099_Aque -KIGRGTYGHVYKAKKRSG--D-D------------------------------------
CDK8_Smoe GKIGEGTYGLVYLAKSKLVSN--R------------------------------------
:. **** ** *
Cdk8_Dmel --------------------------------------GKEYALKQ----------IDGT
CDK8_Mmus --------------------------------------DKDYALKQ----------IEGT
CDK19_Mmus --------------------------------------EKEYALKQ----------IEGT
F39H11.3_Cele --------------------------------------NKEYALKM----------IEGQ
SSN3_Scer RRNLLKDEGVTPGRIRTTREDVSPHYNSQKQTLIKKPLTVFYAIKKFKTEKDGVEQLHYT
CDK19_Hsap --------------------------------------EKEYALKQ----------IEGT
CDK8_Hsap --------------------------------------DKDYALKQ----------IEGT
Cdk8_Ddis ---------------------------------------NKVAVKKFRS------TKEGE
CDK8_Spur --------------------------------------KKEYALKQ----------IEGT
CC1G_07887_Ccin ----------------------------------------LLAIKKFKPDKEG-DVVTYT
AqueK099_Aque --------------------------------------PKEYALKQ----------IEGT
CDK8_Smoe --------------------------------------GVKIAIKKFKQ------SKEGD
*:*
Cdk8_Dmel GLSMSACREIALLRELKHQNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAKAT
CDK8_Mmus GISMSACREIALLRELKHPNVISLLKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKAN
CDK19_Mmus GISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKAN
F39H11.3_Cele GFSMSACREIALFRELRHPNLICLQRVFLTN-EKKVWLLLDYAEHDLWHVIKHHRTAKSK
SSN3_Scer GISQSACREMALCRELHNKHLTTLVEIFLE--RKCVHMVYEYAEHDLLQIIHFHSHPE--
CDK19_Hsap GISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKAN
CDK8_Hsap GISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKAN
Cdk8_Ddis GLSLTAYREIGLLKELSNENIVKLLDVCLNPKDKLLYLIFDYAEFDLFGIIKYHRENG--
CDK8_Spur GISMSACREVALLRELRHPNVICLRRVFLSHSDRKVYLLCDFSEHDLWHIIKYHRANKAS
CC1G_07887_Ccin GISQSAIREIALNREINHENVVALREVILE--DKSIYMVFEYAEHDFLQVIHHYYQTI--
AqueK099_Aque GISMSACREIALLRELKHSNVISLQRVFLSHADRKVWLLFDYAEHDLWHIIKYHRAVKGG
CDK8_Smoe GVSPTAIREIMLLRECMHENVVKLVDVHINHADMSLYLAFEYAEHDLYEIIRHHREKL--
*.* :* **: * :* : :: * : : : : :::*.*: :*:.:
Cdk8_Dmel KK-QVVVPRGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMG---------------
CDK8_Mmus KKP-VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMG---------------
CDK19_Mmus KKP-MQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMG---------------
F39H11.3_Cele KVP-IMVPRNMVKNILFQILSGMHYLHSNWVLHRDLKPANILLMG---------------
SSN3_Scer ---KRMIPPRMVRSIMWQLLDGVSYLHQNWVLHRDLKPANIMVTI---------------
CDK19_Hsap KKP-MQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMG---------------
CDK8_Hsap KKP-VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMG---------------
Cdk8_Ddis ----SHFSDATIKSLIWQVLNGIHYLHSNWVIHRDLKPSNILVMG---------------
CDK8_Spur KKGPTSVPPVMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGSERGRVKIADMGF
CC1G_07887_Ccin ---RTSIPTAVLKSLIYQLFNGLIYLHASHILHRDLKPANILITS---------------
AqueK099_Aque KKPQVQVPKTMVKSLMYQILSGIHYLHSNWVLHRDLKPANILVMG---------------
CDK8_Smoe ---LFQINPYTVKSLLWQILNGINYLHSNWIIHRDLKPSNILVMGV--------------
. ::.:::*::.*: *** . ::******:**::
Cdk8_Dmel ------------------------------------------------------------
CDK8_Mmus ------------------------------------------------------------
CDK19_Mmus ------------------------------------------------------------
F39H11.3_Cele ------------------------------------------------------------
SSN3_Scer ------------------------------------------------------------
CDK19_Hsap ------------------------------------------------------------
CDK8_Hsap ------------------------------------------------------------
Cdk8_Ddis ------------------------------------------------------------
CDK8_Spur ARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHC
CC1G_07887_Ccin ------------------------------------------------------------
AqueK099_Aque ------------------------------------------------------------
CDK8_Smoe ------------------------------------------------------------
Cdk8_Dmel ------------------------------------------------------------
CDK8_Mmus ------------------------------------------------------------
CDK19_Mmus ------------------------------------------------------------
F39H11.3_Cele ------------------------------------------------------------
SSN3_Scer ------------------------------------------------------------
CDK19_Hsap ------------------------------------------------------------
CDK8_Hsap ------------------------------------------------------------
Cdk8_Ddis ------------------------------------------------------------
CDK8_Spur RQEDIKTSNPYHHDQLDRIFNVMGFPQVPPVMVKSLLYQILDGIHYLHSNWVLHRDLKPA
CC1G_07887_Ccin ------------------------------------------------------------
AqueK099_Aque ------------------------------------------------------------
CDK8_Smoe ------------------------------------------------------------
Cdk8_Dmel ------DGN--ERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTK
CDK8_Mmus ------EGP--ERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTK
CDK19_Mmus ------EGP--ERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTK
F39H11.3_Cele ------DGPPDMRGRVKIADLGFSRIYANPLKPMAELDPVVVTFWYRAPELLLGAKHYTK
SSN3_Scer ------D------GCVKIGDLGLARKFHNMLQTLYTGDKVVVTIWYRAPELLLGARHYTP
CDK19_Hsap ------EGP--ERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTK
CDK8_Hsap ------EGP--ERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTK
Cdk8_Ddis ------EGK--ECGTVKIGDFGLARIFQSPLKPLNE-NGVVVTIWYRSPELLLGSKHYTR
CDK8_Spur NILVMGEGS--ERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTK
CC1G_07887_Ccin ------Q------GVVKIGDLGLARLCYEPLQPLFAGDKVVVTIWYRAPELLMGAKHYNK
AqueK099_Aque ------DGP--ERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGAKHYTK
CDK8_Smoe ----SGDGD--EQGLVKIGDFGLARIYQAPLKPLSD-NGVVVTIWYRAPELLLGAKHYTC
: * ***.*:*::* *:.: : ****:***:****:*::**.
Cdk8_Dmel AIDIWAIGCIFAELLTSEPIFHCRQE--DIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIK
CDK8_Mmus AIDIWAIGCIFAELLTSEPIFHCRQE--DIKTSNPYHHDQLDRIFNVMGFPADKDWEDIK
CDK19_Mmus AIDIWAIGCIFAELLTSEPIFHCRQE--DIKTSNPFHHDQLDRIFSVMGFPADKDWEDIR
F39H11.3_Cele AIDVWAIGCIFAELLTAEPLFFCKEE--DIKAQNPYHYDQVKRIFHLLGYPSDADWPDMK
SSN3_Scer AVDLWSVGCIFAELIGLQPIFKGEEAKLDSKKTVPFQVNQLQRILEVLGTPDQKIWPYLE
CDK19_Hsap AIDIWAIGCIFAELLTSEPIFHCRQE--DIKTSNPFHHDQLDRIFSVMGFPADKDWEDIR
CDK8_Hsap AIDIWAIGCIFAELLTSEPIFHCRQE--DIKTSNPYHHDQLDRIFNVMGFPADKDWEDIK
Cdk8_Ddis AVDIWAIGCIFAELITTKPLFPGKEK--DPKIPSLFQDDQVEKIIRVLGKPTLDMWPDIK
CDK8_Spur AIDIWAIGCIFAELLTSEPIFHCRQE--DIKTSNPYHHDQLDRIFNVMGFPQEKDWEDIK
CC1G_07887_Ccin AIDCWAVGCVMAELASLRPIFKGEEAKLDSKKNVPFQRDQLIKIFEVLGTPDERDWPGVV
AqueK099_Aque AIDIWAIGCIFAELLTFEPIFHCRQE--DVEASSPYHREQLERIFLVMGFPH--------
CDK8_Smoe AVDMWAVGCIFAELLTLKPLFQGA-E--DKTGPNPFQLDQLDKIFKVLGHPTTERWPMLS
*:* *::**::*** .*:* * :: :*: :*: ::* *
Cdk8_Dmel KMPEHHTLTKDFKRS-----TYSTCSLAKYMERHKIKPDSKAFHLLQKLLLMDPNKRITS
CDK8_Mmus KMPEHSTLMKDFRRN-----TYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITS
CDK19_Mmus KMPEYPTLQKDFRRT-----TYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITS
F39H11.3_Cele KMPDHQRLLSDARNEGTPIQTFPN-SLHRYFDKWKINSQSSPYRLLVKLLTVDPTKRVSC
SSN3_Scer KYPEYDQITKFP--------KYRD-NLATWYH-SAGGRDKHALSLLYHLLNYDPIKRIDA
CDK19_Hsap KMPEYPTLQKDFRRT-----TYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITS
CDK8_Hsap KMPEHSTLMKDFRRN-----TYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITS
Cdk8_Ddis HLPEWKRLSSM---E-----AFPN-SLAKC---VGIDENSQAYDLLSKMILYDPSKRITA
CDK8_Spur KMPEHGNLMKDFRRS-----NYASCCLPKYMEKHKVPKDSKAFQLLSKLLTMDPTKRMTS
CC1G_07887_Ccin DMPEYRNMKLLD--------HFSN-RLSDWCH--TRIRSPQGYDLLRQLFAYDPDNRLTA
AqueK099_Aque ------------------------------------------------------------
CDK8_Smoe NLPHWLANRQLIQSR-----KYDNPGLHTV---VNLQPKGLAFDLLSRMLEYDPVKRITA
Cdk8_Dmel EQAMQDQYFQEEP---QPTQ-DVFAGC-----PIPYPKREF------------------L
CDK8_Mmus EQAMQDPYFLEDP---LPTS-DVFAGC-----QIPYPKREF------------------L
CDK19_Mmus EQALQDPYFQEDP---LPTL-DVFAGC-----QIPYPKREF------------------L
F39H11.3_Cele EEAMNDIYFRKMERPPRETD-DVFNKY-----PIPYAKKEQQMTVRASIVEYTANVPKIL
SSN3_Scer FNALEHKYFTESD---IPVSENVFEGL-----TYKYPARRI------------------H
CDK19_Hsap EQALQDPYFQEDP---LPTL-DVFAGC-----QIPYPKREF------------------L
CDK8_Hsap EQAMQDPYFLEDP---LPTS-DVFAGC-----QIPYPKREF------------------L
Cdk8_Ddis SEALDHPYFKELP---LPLP-NAFS-K-----PIPYPPRLP------------------I
CDK8_Spur EQAMEDQYFKEQP---QHTA-DVFDGK-----PIPYPKREF------------------L
CC1G_07887_Ccin EQAIQHKWFHEDP---LPTW-NAFQSL-A-QHQIP-PCRRI------------------T
AqueK099_Aque ------------------------------------------------------------
CDK8_Smoe AQALDHEYFRSDP---LPGR-NALVYGQPGEKVVQYPARPV------------------D
Cdk8_Dmel TDDDQ-EDKSDNKRQQ--QQQQQQQQQQ--QQ-----QQQQQQQQQ-----QQ-Q-----
CDK8_Mmus TEEEP-DEKGDKKTQQ--QQQGNNH-------------------------TNGT------
CDK19_Mmus NEDEP-EEKGDKNQPQ--QQNPHQQPAA--PAQQTAAPPQAPPPQQSSAQTNGTAGGATA
F39H11.3_Cele LQVAP-DQAQQQHQQQ--QVQMQQQPQM--GQQQMMGQPQMVQPQMGQPPMGGAHPGVVA
SSN3_Scer TNDNDIMNLGSRTKNNT-QAS--GI-------------------------TA---GAAAN
CDK19_Hsap NEDDP-EEKGDKNQQQ--QQNQHQQPTA--PPQQAAAPPQAPPPQQNSTQTNGTAGGAGA
CDK8_Hsap TEEEP-DDKGDKKNQQ--QQQGNNH-------------------------TNGT------
Cdk8_Ddis NKKK--------------------------------------------------------
CDK8_Spur TDDDN-DDKSDNNKKS--SSSRNSSHMVDARRQRVA-TSMAGSTSQ-----QGSVGGTRT
CC1G_07887_Ccin QDEA-PSMMPMATQQNTQQAMGGGH-------------------------IA---GGAGA
AqueK099_Aque ------------------------------------------------------------
CDK8_Smoe SSTDF-EGSGSIQNTQ--MVRNRKRKQA--FF-----SP----------LQC---GGGSS
Cdk8_Dmel --------------Q--------------------------------QMNAEPNAKRVRL
CDK8_Mmus -------GHPGNQDS--------------------------------GHAQGPPLKKVRV
CDK19_Mmus GGGGAGAGLQHSQDP--------------------------------GLNQVPPNKKPRI
F39H11.3_Cele PDGHPHQMMQQQQHPQQHHVSFLNIQNEKLTFSVQMQYQGMHDPMQGGMDEGPQAKMMRM
SSN3_Scer ALGGLG------------------------------------------------VNR-RI
CDK19_Hsap GVGGTGAGLQHSQDS--------------------------------SLNQVPPNKKPRL
CDK8_Hsap -------GHPGNQDS--------------------------------SHTQGPPLKKVRV
Cdk8_Ddis ------------------------------------------------------------
CDK8_Spur -------GGS----S--------------------------------SHAQG--AKRLRV
CC1G_07887_Ccin PFSKPG----------------------------------------------------ST
AqueK099_Aque ------------------------------------------------------------
CDK8_Smoe FLM-----------V--------------------------------STFRGSQMSTSNS
Cdk8_Dmel SGA------------GNQ-----QDFHHQ-----------------------Q-------
CDK8_Mmus VPPTTTSGG----------LIMTSDYQRS-----------------------NPHAAYPN
CDK19_Mmus GPSGANSGG----------PVMPSDYQHS-----------------------SSRLNYQS
F39H11.3_Cele GNVPVGRYAPMPPPYGAP-----QDYHPQQGPPMVQMMQQPGPSGYYPQRPGQPTGAVPG
SSN3_Scer LAAAAAAAA---------------------------------------------------
CDK19_Hsap GPSGANSGG----------PVMPSDYQHS-----------------------SSRLNYQS
CDK8_Hsap VPPTTTSGG----------LIMTSDYQRS-----------------------NPHAAYPN
Cdk8_Ddis ------------------------------------------------------------
CDK8_Spur ATTNSSSHG------GAQAGIMPQEYQQQ-----------------------QRMSGYQG
CC1G_07887_Ccin ASFASLSGG---------------------------------------------------
AqueK099_Aque ------------------------------------------------------------
CDK8_Smoe LPASAASAA------A---ASATANAVRP-----------------------MHHQQMPL
Cdk8_Dmel ------Q-----------------------------------------------------
CDK8_Mmus P--GPST-SQ-----------------------------PQSSMGYSA------------
CDK19_Mmus S--VQGS-SQ-----------------------------SQSTLGYSS------------
F39H11.3_Cele P--GPQGYMN----PQMGMQMGMRAPGVPPQGYMPGRGMAPPQMGQQQ------------
SSN3_Scer ----------------------------------------------AV------------
CDK19_Hsap S--VQGS-SQ-----------------------------SQSTLGYSS------------
CDK8_Hsap P--GPST-SQ-----------------------------PQSSMGYSA------------
Cdk8_Ddis ------------------------------------------------------------
CDK8_Spur ANTTQGQ-SQ--------------------------NNKPQQGMMYSSSGSHHSNKMQHG
CC1G_07887_Ccin ----------------------------------------------GP------------
AqueK099_Aque ------------------------------------------------------------
CDK8_Smoe V--GMQR-LQTASMGAFNVGAQPAMAGLAANMFVQRGQQLQQVAHHQQQ-----------
Cdk8_Dmel --------QQQQ---------------QQQQQQQQQQQMMFNQQQNFQRFN
CDK8_Mmus -------------------------------TSQQPPQ---Y--SHQTHRY
CDK19_Mmus --------------------------------SQQSTQ---YHSSHQTHRY
F39H11.3_Cele -----------------------------PGPNQQQQQ---Q--WQQQYHR
SSN3_Scer -----------------------------SGNN------ASDEPSRKKNRR
CDK19_Hsap -------------------------------SSQQSSQ---YHPSHQAHRY
CDK8_Hsap -------------------------------TSQQPPQ---Y--SHQTHRY
Cdk8_Ddis ----------------------------------------------REFDD
CDK8_Spur QHHHHQQQQQQQQQQQHHQQHHQQQQQHQQQQQQQQQQHHQGHNQNQPRHY
CC1G_07887_Ccin -----------------------------YAQSQGGTGGHTAHTRKKARMG
AqueK099_Aque --------------------------------------------------X
CDK8_Smoe --------QQQQ---------------QQQQHQHHQHQQHQVQKLRSFLRS