IRAKg_e-1_Smoe MAFCN-VA-------LFILILPV---AVLASE-------IEKGSSIQ-TGESLKADEILI
IRAKg_d-2_Smoe MFLMF-LA-------FRILLFCCLCYIILTSVAADG---GSPGTTIIVRGEDP--QTWIT
IRAKg_r-1_Smoe MK------L-----LTLMLLLSS---IYYSRVL-AD---FLRGSTVTT-G-----S-PWR
IRAKg_d-1_Smoe MLLMF-LA-------FRILLFCCLCYVILTSVAADG---GSPGTTIIVRGEDP--QTWIT
IRAKg_f_Smoe MPLLL-LF-------LAAALV-V-----LAN-GKSS---LQVGDVLAV-N-----Q-FLV
IRAKg_e-2_Smoe ------------------------------------------------------------
IRAKg_o_Smoe MSETTFMKL-----LTLMLLLSS---TYYSRVL-AD---FLRGSTVTT-G-----S-PWR
IRAKg_v_Smoe MVAVS-SFF-------FGVLT----CSIGAAEAQQQARKHGPGSN------------STQ
IRAKg_s_Smoe ------------------------------------------------------------
IRAKg_q_Smoe ------------------------------------------------------------
IRAKg_a-1_Smoe MVDAL-LSS-------AIAILW-ISCSLPSSLAQDQ---FASGQTIAT-A-----GAAAS
IRAKg_a-2_Smoe MVDAL-LSS-------AIAILW-ISSSLPSSLAQDQ---FASGQTIAT-A-----GAATS
IRAKg_g_Smoe M-----------------------------------------------------------
IRAKg_u-2_Smoe MAAKL-VT-------LVLLVL-L---V-LNC---EG---IGLGDKLGA-R-----QPPWM
IRAKg_p_Smoe MSETTFMKL-----HTLMLLLSS---TYYSRVL-AD---FLRGSTVTT-G-----S-PWR
IRAKg_b_Smoe MLSMF-LA-------FRILLLCCLCYVILTSVATDG---GSPGTTINVRGEDP--QTWIT
IRAKg_n-2_Smoe MFLY-----------FRILMLC---SFILTFVAADG---GSPGTTTIVRGEDL--QPWIT
IRAKg_k-1_Smoe MASQI-VVMVTAKIMALLQFLF-LS-LLPLALAYDR---MPLGSSLLT-T-----ES-LI
IRAKg_n-1_Smoe M-----------------------------------------------------------
IRAKg_h_Smoe MLSMF-LA-------FRILLLCCLCYVILTSVATDG---GSPGTTINVRGEDP--QTWIT
IRAKg_k-2_Smoe MASQI-VVMVTAKIMALLQFLF-LS-LLPLALAYDR---MPLGSSLLT-T-----ES-LI
IRAKg_r-2_Smoe MK------L-----LTLMLLLSS---IYYSRVL-AD---FLRGSTVTT-G-----S-PWR
IRAKg_m-1_Smoe MAL-----------AFLLLVAFA---IACS--A-ME---IEIGSSLKL-G-----S-QWN
IRAKg_u-1_Smoe MAAKL-VT-------LVLLVL-L---V-LNC---KG---IGLGDKLGA-G-----QPPWM
IRAKg_c_Smoe MPLLL-LF-------LASALV-V-----LAN-GKSS---LQVGDVLAV-N-----Q-FLV
IRAKg_o-1_Smoe MAKAL-SL-------VLIATLSS---V-LSS---RA---VQLGEKLSA-G-----NPPWI
IRAKg_m-2_Smoe MAL-----------AFLLLVAFA---IACS--A-ME---IEIGSSLKL-G-----S-QWN
IRAKg_o-2_Smoe MAKAL-SL-------VLIATLSS---V-LSS---RA---VQLGEKLSA-G-----NPPWI
IRAKg_e-1_Smoe SPGKNFGFGFVNDTG-APGKLNVAIRVR-SV-ET----IIWTA-TAL------------K
IRAKg_d-2_Smoe SPNATFSAGFSHINH-TFPLYSFSIWYTKMP-NT----VVWSA-MSN---DT---GGFPI
IRAKg_r-1_Smoe SPGGTFGFGFVMST----RNFNLAIWYDIDPKKT----VIWMA-MAN---------GQLI
IRAKg_d-1_Smoe SPNATFSAGFGHLNP-TSPLYSFSIWYTKMP-NT----VVWSA-MSN---DT---GGFPI
IRAKg_f_Smoe SPDNTFELGFVDDE--ASGKFTLVIRFHHINLKT----IVWTA-PAA----------PSV
IRAKg_e-2_Smoe ------------------------------------------------------------
IRAKg_o_Smoe SPEGTFGFGFVMPESSRTRNFNLAIWYDIDPKKT----VVWMA-MAN---------GQLV
IRAKg_v_Smoe VPNG-------------------------------------DKDGLP------------A
IRAKg_s_Smoe ------------------------------------------------------------
IRAKg_q_Smoe ------------------------------------------------------------
IRAKg_a-1_Smoe ISSGSFSLGFAPSP-RSPGEFELGIWYRADSQQV----LVWDT-AA-------------P
IRAKg_a-2_Smoe VSSGSFSLGFAPSP-RSPGEFELGIWYRADPQQV----LVWDT-AA-------------P
IRAKg_g_Smoe ------------------------------------------------------------
IRAKg_u-2_Smoe SLNNTFAFGFHTSDG-IGELFTLAIWHQS-T-GT----VVWEA-TEALIKNGSTTEKPKI
IRAKg_p_Smoe SPGGTFGFGFVMPETSSTRNFNLAIWYDIDPKKT----VVWMA-MAN---------GQLV
IRAKg_b_Smoe SPNATFSTGFSHLNP-KSPLYSFSIWYTKMP-NT----VVWSA-MSN---DT---GGFPI
IRAKg_n-2_Smoe SLKATFCAGFRHLDS-KSSLYSFSIWYTKMP-NT----VIWSA-MSN---DT---GGSPI
IRAKg_k-1_Smoe SANGRVKLEFFSPTGGNSSDLYLGISFNTRTREFMEFIPIWIA-NRD------------T
IRAKg_n-1_Smoe ------------------------------P-NT----VIWSA-MSN---DT---GGSPI
IRAKg_h_Smoe SPNATFSTGFSHLNP-KSPLYSFSIWYTKMP-NT----VVWSA-MSN---DT---GGFPI
IRAKg_k-2_Smoe SANGRVKLEFFSPTGGNSSDLYLGISFNTTTREIMEFIPIWIA-NRD------------T
IRAKg_r-2_Smoe SPGGTFGLGFVMPESSSTRNFNLAIWYDIDPKKT----VIWMA-MAN---------GLLV
IRAKg_m-1_Smoe SSGGTFSLGFHLMD----EAYNLAIWYQIDP-EE----IVWMA-TTD---N-----GQFV
IRAKg_u-1_Smoe SLNSTFAFGFHTSDG-IGELFTLAIWHQR-T-GT----VVWEA-TEALIKNGSTTEKPKI
IRAKg_c_Smoe SPDNTFELGFVDDE--ASGKFTLVIRFHHINLKT----IVWTA-PGA----------PSV
IRAKg_o-1_Smoe SRGNTFAFGFYSTT---SGMSTLAIWYQS-T-GT----VVWEA-TLD---NGAST-KERV
IRAKg_m-2_Smoe SSGGTFSLGFRLMD----EAYNLAIWYQIDP-EE----IVWMA-TTD---N-----GQFV
IRAKg_o-2_Smoe SRGNTFAFGFYSTT---SGMSTLAIWYQS-T-GT----VVWEA-TLD---NGAST-KERV
IRAKg_e-1_Smoe GVTANAQLVLNEAQGLFVLDNGVAQVIVSCK---SSNCSGVRLDMQDDGNLVLKHS----
IRAKg_d-2_Smoe GLIKGDQLVFQIDGRLVLTSNA-AGIIWGTS---TSTLGVIKALLQENGNLQLLTS----
IRAKg_r-1_Smoe QVSENAKLELKAEGGLSVTDGSSV-PLWQTN---PGQCCAESAALLENGNLVVLGK----
IRAKg_d-1_Smoe GLIKGDQLVFQTDGRLVLTSNA-AGIIWGTS---TSTLAVTKALLQENGNLQLLTS----
IRAKg_f_Smoe AFTANARLQLTAQG-LFVSDGAQ--LITI--AN---VPSVASAELQDNGNFVVISS----
IRAKg_e-2_Smoe --------------------------------------------MQDDGNLVLKHS----
IRAKg_o_Smoe QVSENAKLELKAEGGLSVTDGSSSAPLWQTN---PGQCCAESASLLENGNLVVLGK----
IRAKg_v_Smoe ASIAAGVLSLIVVGGLLL------------------------------------------
IRAKg_s_Smoe ------------------------------------------------------------
IRAKg_q_Smoe ------------------------------------------------------------
IRAKg_a-1_Smoe ASRAGAILQLSSDGSLAVRDGAS-TTSWT--SG-A--TGASSGQLQESGNLALRNS----
IRAKg_a-2_Smoe ASRPGAILELSSDGSLAVRDGAS-ITSWT--SG-A--TGASSGQLQESGNLALRNS----
IRAKg_g_Smoe ------------------------------------------------------------
IRAKg_u-2_Smoe KVGKTGELELKETG-LIVTDK--SMTVWLVR---CENCSIATASLEETGNFVLLDR----
IRAKg_p_Smoe QVSENAKLELKAKGGLSVTDGSSSVPFWQTN---PGQCCAESAALLENGNLVVLQK----
IRAKg_b_Smoe GLIKGDQLVFQTDGRLVLTSNA-AGIIWGTS---TSTLGVTKALLQENANLQLLTS----
IRAKg_n-2_Smoe GLIKCDQLAFQTDGRLILTSKA-AGIVWGTS---TTTLSVTKALLQENGNLELLAS----
IRAKg_k-1_Smoe PVTSNASLLLTSKGELQIIDRGS--IIWSGAPS-SSNSGITQAVLLDSGNFVLTDNSFDP
IRAKg_n-1_Smoe GLIKGDQLAFQTDGRLILTSNA-AGIVWGTS---TTTLSVTKALLQENGNLELLAS----
IRAKg_h_Smoe GLIKGDQLVFQTDGRLVLTSNA-AGIIWGTS---TSTLGVTKALLQENGNLQLLTS----
IRAKg_k-2_Smoe PVTSNASLLLTSKGELQIIDRGS--IIWSGAPS-SSNSGITQAVLLDSGNFVLTDNAFDP
IRAKg_r-2_Smoe QVSENAKLELKAEGGLSVTDGSSSVPLWQTN---PGQCCAESATLLENGNLVVLGK----
IRAKg_m-1_Smoe HASGSAQLQLRSDGGLVIIDRAS--ILWRTN---SGQ--AKGASLLETGNLVVYGE----
IRAKg_u-1_Smoe KVGKTGELELKETG-LIVTDK--SMTVWLVR---CENCSIATASLEETGNFVLLDR----
IRAKg_c_Smoe AFTANARLQLTAQG-LFVSDGAQ--LITI--AN---VPSVASAELQDNGNFVVISS----
IRAKg_o-1_Smoe SVSRNGVLELTATG-LVVTDA--SKPVWTSNLRCNNRCSVTVASLEENGNLVLLG-----
IRAKg_m-2_Smoe HASGSAQLQLRSDGGLVIIDRAS--ILWRTN---SGQ--AKGASLLETGNLVVYGE----
IRAKg_o-2_Smoe SVSRNGVLELTATG-LVVTDA--SKPVWTSNLRCNNRCSVTVASLEENGNLVLLG-----
IRAKg_e-1_Smoe ---NNSVLWQSFNLPTDTLLQDQVFK-------GRQALIS--GRYSLQMTDVSAQLIFLA
IRAKg_d-2_Smoe ---NGVPVWQSFERPTDTLLPYQQLI-------GNTRLVSSNRKYDLRMDVSRVALYS--
IRAKg_r-1_Smoe ---DKKVAWQSFDSPTNNLLPEQQLRTQGNPSLGYMRLISQSGAYQLVLNSGQVLLKNL-
IRAKg_d-1_Smoe ---NGVPVWQSFERPTDTLLPYQQLI-------GNTRLVSSNRKYDLRMDVSRVALYS--
IRAKg_f_Smoe ---SG--SWQSFDVPTDTLLTGQLIQ-------GNKDIL-RSGSFSLYLNQNSIGLKSY-
IRAKg_e-2_Smoe ---NNSVLWQSFDLPTDTLLQDQVFK-------GRQALIS--GRYSLQMTDVSAQLIFLA
IRAKg_o_Smoe ---DKKVAWQSFDSPTNNLLPEQQLRTQGNPSLGYTRLISQSGAYQLVLNSGQVLLKNL-
IRAKg_v_Smoe ------------------------------------------------------------
IRAKg_s_Smoe ------------------------------------------------------------
IRAKg_q_Smoe ------------------------------------------------------------
IRAKg_a-1_Smoe ---SGQVVWSSFDHPSSTLLPGQFLPRGRNLT-------SRAGGYTLTMDQSGNLTLRW-
IRAKg_a-2_Smoe ---SGQVVWSSFDHPSSTLLPGQFLSRGRNLT-------SRAGGYSLAMDQSGNLTLRW-
IRAKg_g_Smoe ------------------------------------------------------------
IRAKg_u-2_Smoe ---SSDRIWQSFDFPTDTLLPGQELR-------GNTSLVA--GKYRLSMNRRGIELYF--
IRAKg_p_Smoe ---DKKVAWQSFDSPTNNLLPEQQLRTQGNPSLGYTRLISQSGAYQLVLNSGQVLLKNL-
IRAKg_b_Smoe ---NGVPVWQSFDRPTDTILPDQQLI-------GNAQLVSNNRKYDLQMDGSRVALYS--
IRAKg_n-2_Smoe ---NGVPAWQSFDRPTDTILPDQQLI-------GITQLVSNNRKYFLQMDGSKVALYY--
IRAKg_k-1_Smoe RDDNAAYPWQSFDHPADAWVPRMKVSLRTNLTAWISKVSPARGRFVMTMRTSNEFVISP-
IRAKg_n-1_Smoe ---NGVPAWQSFDRPTDTILPDQQLI-------GITQLVSNNRKYFLQMDGSKVAFYY--
IRAKg_h_Smoe ---NGVPVWQSFDRPTDTILPDQQLI-------GNAQLVSNNQKYDLQMDGSRVALYS--
IRAKg_k-2_Smoe RDDNATYPWQSFDHPADAWVPRMKMFLGANLTAWKSSVSPASGRFVMTMRTSNEFVIST-
IRAKg_r-2_Smoe ---DKKVVWQSFDSPTDNLLPEQQLRTQGNPSLGYTRLISQSGAYQLVLNSGQVLLKNL-
IRAKg_m-1_Smoe ---NEQFAWKSFDVPTTTILPEQQFHTET--VSDTKILFSQSRNYALQLNRGQVFLRNN-
IRAKg_u-1_Smoe ---SSDRIWQSFDFPTDTLLPGQELR-------GNTSLVA--GKYRLSMNRRGIELYF--
IRAKg_c_Smoe ---SG--SWQSFDVPTDTLLTGQLIQ-------GNKDIL-RSGSFSLYLNQNSIGLKSY-
IRAKg_o-1_Smoe ---NGTRLWQSFDSPTDTILPEQDLV-------GNMTLVS--GKYRLSMNKSSVGLYF--
IRAKg_m-2_Smoe ---NEQFAWKSFDVPTTTILPEQQFHTET--VSDTKILFSQSRNYALQLNRGQVFLRNN-
IRAKg_o-2_Smoe ---NGTRLWQSFDSPTDTILPEQDLV-------GNMTLVS--GKYRLSMNKSSVGLYF--
IRAKg_e-1_Smoe APELKNLTSYWTIPQ-NLPSSSTGS-----------------NNSTSQSSRLVMNSSGIV
IRAKg_d-2_Smoe -RG-YWLEPYWQIAN-DNCSSSA--------------------L---SPPRLNISTSGML
IRAKg_r-1_Smoe --KLEIPQKYWSIAN-PTLNSTMTCLDDETGEHVLNNNACQPDRSLKFPAVMNLSSQGVL
IRAKg_d-1_Smoe -QG-YWLEPYWKIAN-DNHSDSA--------------------V---SPPRLNFSTSGML
IRAKg_f_Smoe AVPESNSQSYWDVQR-SPTSSNN-----------------------A--STLVMNSTGIL
IRAKg_e-2_Smoe APELKNLTSYWTIPQ-NLPSSSTGS-----------------NNSTSQSSRLVMNSSGIV
IRAKg_o_Smoe --KLEIPQKYWSIAN-PTLNSTMTCLDDETGEHVLNNNACQPDRSLKFPAVLNLS---VL
IRAKg_v_Smoe ------------------------------------------------------------
IRAKg_s_Smoe ------------------------------------------------------------
IRAKg_q_Smoe ------------------------------------------------------------
IRAKg_a-1_Smoe -----RSAQYWSSDT-DGSGNSS-----------------------I-PTNAVVDVNGVL
IRAKg_a-2_Smoe -----GSAQYWSSDT-DGNGNSS-----------------------I-PTNAVVDVNGVL
IRAKg_g_Smoe ------------------------------------------------------------
IRAKg_u-2_Smoe -QDY-LNHSYWGIIN-KQLNTSE--------------------STMTSTPKFTFSIDGHL
IRAKg_p_Smoe --KLEVPQKYWSIAN-PTLNSTMTCLDDETGE----------------------------
IRAKg_b_Smoe -QG-YWLEPYWTIKN-DNQSNSA--------------------V---SPPRLNFSTTGML
IRAKg_n-2_Smoe -QG-YWLEPYWRIEN-ENQSNSA--------------------NS-VVSPRLNFSTSGML
IRAKg_k-1_Smoe --TNDTSREYWTSGAWNGKIFSL-----------------------V-PQ-MTDNYLYTF
IRAKg_n-1_Smoe -QG-YWLEPYWRIEN-ENQSNSA--------------------NS-VVSPRLNFST----
IRAKg_h_Smoe -QG-YWLEPYWTIKN-DNQSNSA--------------------V---SPPRLNFSTTGML
IRAKg_k-2_Smoe --TNDTSREYWTSGAWNGKIFSL-----------------------V-PQ-MTDNYLYTF
IRAKg_r-2_Smoe --KLEIPQKYWSIAN-PTLNSTMTCLDDETGEHVLNNNACQPDRSLKFPAVLNLSSQGVL
IRAKg_m-1_Smoe NKKFVIPQRYWYIAN-PAVNSSQTCLIDDTGEQVNSNIQCQTDGSLRFPAVLNLSSDGVL
IRAKg_u-1_Smoe -QDY-LNQSYWGIIN-KQLNTSE--------------------STMTSTPKFTFSIDGHL
IRAKg_c_Smoe AVPESNSQSYWDVQR-SPTSSNN-----------------------A--STLVMNSTGIL
IRAKg_o-1_Smoe -DGFSANESYWSVLN-KDLDVTM--------------------K--NSIPRLTFNRNGSL
IRAKg_m-2_Smoe NKKFVIPQRYWYIAN-PAVNSSQTCLIDDTGEQVNSNIQCQTDGSLRFPAVLNLSSDGVL
IRAKg_o-2_Smoe -DGFSANESYWSVLN-KDLDVTM--------------------K--NSIPRLTFNRNGSL
IRAKg_e-1_Smoe TFTDASNVS----------NY-QYSLDFTFANTRVMRMLKLEPSGNLRIYGLSTDN--SS
IRAKg_d-2_Smoe SFFDGNGSSWKNPDKVYDTAQ-RYALDY--PEIGLTRRLTLDDDGNLRIYTLDEIK--NR
IRAKg_r-1_Smoe SFYDATGKSWASG---SMSSQ-DYALDY--DDANVLRRLTLDDDGNLRIYSFGPKNKSGS
IRAKg_d-1_Smoe SFFDGNGSSWKNPDKVYDTAQ-RYALDY--PEIGLTRRLTLDDDGNLRIYTLDEIK--NR
IRAKg_f_Smoe TFTDGQGPWYIN---REQNSY-FYVLDF--GTPKVARRLTLERNGTLRVYSLTQDN--SS
IRAKg_e-2_Smoe TFTDASNVS----------NY-QYSLDFTFANTRVMRMLKLEPSGNLRIYSLSTDN--SS
IRAKg_o_Smoe SFYDATGKSWASG---SMSSQ-DYALDY--DDANVLRKLMLDKR----------------
IRAKg_v_Smoe ------------------------------------------------------------
IRAKg_s_Smoe ------------------------------------------------------------
IRAKg_q_Smoe ------------------------------------------------------------
IRAKg_a-1_Smoe NLNA-----------TSTVRQ-FFPEDY--G-PGQSRRLTLDDDGNLRLYTLI--E--AV
IRAKg_a-2_Smoe NLNA-----------TSTVRQ-FFPEDY--G-PGQSRRLTLDDDGNLRLYTLI--E--AV
IRAKg_g_Smoe ------------------------------------------------------------
IRAKg_u-2_Smoe AFFDANGSSWYRY--KFDNAQ-KYPIDL--GDTSVTRRLTLEKNGTLRSYSCGSRE--KR
IRAKg_p_Smoe -------------------------------------------------HDL--EE--QE
IRAKg_b_Smoe SFFDGNGSSWKNPDKVYDTAQ-RYALDY--PKVGLTRRLTLDDDGNLRIYTLDEIK--KR
IRAKg_n-2_Smoe SFFDGSGSSWKNPVKVYDTAQ-RYALDY--PKVGLTRRLTVDDDGNLRIYTLDEIN--KR
IRAKg_k-1_Smoe IFNA-----------TNPPSFTWFE-----K-SFQHSIFRLGHDGRIEVKQLDG-N--GN
IRAKg_n-1_Smoe SFFDGSGSSWKNPVKVYDTAQ-RYALDY--PKVGLTRRLTVDDDGNLRIYTLDEIN--KR
IRAKg_h_Smoe SFFDGNGSSWKNPDKVYDTAQ-RYALDY--PKVGLTRRLTLDDDGNLRIYTLDEIK--KR
IRAKg_k-2_Smoe IFNA-----------TNPPSFTWFE-----K-SFQHSIFRLGHDGRIEVKQLDG-N--GN
IRAKg_r-2_Smoe SFYDATGKSWASG---SMSSQ-DYALDY--DDANVLRRLTLDDDGNLRIYSFGPKNKSGS
IRAKg_m-1_Smoe SYYDATGIA-------TENSH-KYALDY--GISNVLRRLKLDDDGNLRMYSFSNDT--RS
IRAKg_u-1_Smoe AFFDANGSSWYRY--KFDNAQ-KYPIDL--GDTSVIRRLTLEKNGMLRSYSCGSGE--KR
IRAKg_c_Smoe TFTDGQGPWYIN---REQNSY-FYVLDF--GTPKVARRLTLERNGTLRVYSLTQDN--SS
IRAKg_o-1_Smoe EFFDANGSSWYRY--KYDNAQ-RYPIDY--GNSSVLRRLTLEKNGTLRSYSTYGER--SL
IRAKg_m-2_Smoe SYYDATGIG-------TENSH-KYALDY--GISNVLRRLKLDDDGNLRMYSFSNDT--RS
IRAKg_o-2_Smoe EFFDANGSSWYRY--KYDNAQ-RYPIDY--GNSSVLRRLTLEKNGTLRSYSTYGER--SL
IRAKg_e-1_Smoe WNIVWQAMLLE--CQIHGVCGPFGLCTYAPR---------STCVCPPGFHFIDPQDHH--
IRAKg_d-2_Smoe WLITWQAVLLE--CDIFGKCGRFGICTYRPT---------ATCICPPGFHPTNASDPS--
IRAKg_r-1_Smoe WSVVWQAVMLE--CDIFGTCGPFALCTYRPT---------KICSCPPGFHRVDPNDES--
IRAKg_d-1_Smoe WLITWQAVLLE--CDIFGKCGRFGICTYRPT---------ATCICPPGFHPTNASDPS--
IRAKg_f_Smoe WNIVWQALTAD--CKVFGMCGPFGICTYRPG---------LVCTCPPGFHFVDPGDHS--
IRAKg_e-2_Smoe WNIVWQAMLLE--CQIHGVCGPFGLCTYAPR---------STCVCPPGFHFIDPQDHH--
IRAKg_o_Smoe W-----------------------------------------------------------
IRAKg_v_Smoe ------------------------------------------------------------
IRAKg_s_Smoe ------------------------------------------------------------
IRAKg_q_Smoe ------------------------------------------------------------
IRAKg_a-1_Smoe WSARWQAVSDQ--CQVYNYCGNYGICSYRAVPSQAPVAYRTVCDCPTGLGFVDPSRR---
IRAKg_a-2_Smoe WSARWQAVSDQ--CQVYNYCGNYGICSYRAVASQAPLVYRTVCDCPTGLGFVDPSRR---
IRAKg_g_Smoe ------------------------------------------------------------
IRAKg_u-2_Smoe WRVVWQSALLE--CEVFGTCGAFGLCGYKPR---------KSCSCPPGFYAVDSSE-S--
IRAKg_p_Smoe WLLEHRLASRHARVRRPGTCGPFALCTYRPT---------KTCSCPPGFHRVDPNDES--
IRAKg_b_Smoe WIITWQAVLLE--CDIFGKCGRFGICAYRPT---------ATCICPPGFHPTNASDPS--
IRAKg_n-2_Smoe WIITWQAVLLE--CNIFGKCGRFGICTYRPT---------ATCTCPPGFHPTNASDSS--
IRAKg_k-1_Smoe WYTPWAVPANI--CDVTSLCGSNSVCSSSLN---------PPCSCPTGSSPSNDTNWRT-
IRAKg_n-1_Smoe WIITWQAVLLE--CNIFGKCGRFGICTYRPT---------ATCTCPLGFHPTNASDSS--
IRAKg_h_Smoe WIITWQAVLLE--CDIFGKCGRFGICAYRPT---------ATCICPPGFHPTNASDPS--
IRAKg_k-2_Smoe WYTPWAVPANI--CDVTSLCGSNSVCSSSLN---------PPCSCPTGSSPSNDTNWRT-
IRAKg_r-2_Smoe WSVVWQAVMLE--CDIFGTCGPFALCTYRPT---------KICSCPPGFHRVDPNDES--
IRAKg_m-1_Smoe WSIVWQALMQE--CDVFGACGAFGLCTYRPK---------KTCSCPPGFHRVDPIDDS--
IRAKg_u-1_Smoe WRVVWQSALLE--CEIFGTCGAFGLCGYKPR---------KSCSCPPGFHAVDSSE-S--
IRAKg_c_Smoe WNIVWQALTAD--CKVFGMCGPFGICTYRPG---------LVCTCPPGFHFVDPGDHS--
IRAKg_o-1_Smoe WRVVWQSLLLE--CDVFGTCGNFGLCKYQPR---------KSCVCPPGFHTVRDRSSGQL
IRAKg_m-2_Smoe WSIVWQALMQE--CDVFGACGAFGLCTYRPK---------KTCSCPPGFHRVDPIDDS--
IRAKg_o-2_Smoe WRVVWQSLLLE--CDVFGTCGNFGLCKYQPR---------KSCVCPPGFHTVRDRSSGQL
IRAKg_e-1_Smoe ----QGCTYDVPLQLSCNGSSN-----HHDWVRVDRASYNGNDYVKD--LSPTSLEGCRR
IRAKg_d-2_Smoe ----QDCVYNTPLT-KCPAGQNSTDPRNFKMIQLVRTDFQYNDYNSHPLPNPSSQEDCIQ
IRAKg_r-1_Smoe ----KGCDYDIPLG-ACQNSPN-----SVKLVQVNRADYYFNDYNFD--SSIKSLEKCKD
IRAKg_d-1_Smoe ----QDCVYNTPLT-KCPTGQNSTDPRNFKMIQLVRTDFQYNDYNSHPLPNPSSQEDCIQ
IRAKg_f_Smoe ----KGCEYNVPLK-SCNGSD-------NRWVRLERTDYTYNDKTY---ISVISLEDCKS
IRAKg_e-2_Smoe ----QGCTYDVPLQLSCNGSSN-----HHDWVRVDRASYDGNDYVKD--LSPTSLEGCRR
IRAKg_o_Smoe ------------------------------------------------------------
IRAKg_v_Smoe ------------------------------------------------------------
IRAKg_s_Smoe ------------------------------------------------------------
IRAKg_q_Smoe ------------------------------------------------------------
IRAKg_a-1_Smoe ---NAGCTNTGNVASDCATESN-------QLIATNSTAWLDSGS---TVTSNSNSEQCTS
IRAKg_a-2_Smoe ---NAGCTNTGNVASDCATESN-------QLIATNFTAWLESGS---TVTSNSNSEQCTS
IRAKg_g_Smoe ------------------------------------------------------------
IRAKg_u-2_Smoe ----AGCVRKFPLS--CSSGNATS--SASKMVEVQRAMYVGNLLQQL-SKDPISLEQCKV
IRAKg_p_Smoe ----KGCDYDIPLG-GCQNSSN-----SVKLVQVNRADYYFNDYNFD--SAIKSLEKCKD
IRAKg_b_Smoe ----QDCAYNTPLT-ECPTGQNSTDPRNFKMIQLVRTDFQYNDYNSHPLPSPSSQEDCIQ
IRAKg_n-2_Smoe ----QDCAYNTPLA-KCPTGQNSTDPRNFKLIQLVRTDFKYNDYNSDPLPTPSSQEDCIQ
IRAKg_k-1_Smoe EDWAEGCTALSSQ-ARRS------------------------------------------
IRAKg_n-1_Smoe ----QDCAYNTPLA-KCPTGQNSTDPRNFKLIQLVRTDFKYNDYNSDPLPTPSSQEDCIQ
IRAKg_h_Smoe ----QDCAYNTPLT-KCPTGQNSTDPRNFKMIQLVRTDFQYNDYNSHPLPSPSSQEDCIQ
IRAKg_k-2_Smoe EDWAEGCTALSSQ-ARRS------------------------------------------
IRAKg_r-2_Smoe ----KGCDYDIPLG-ACQNSPN-----SVKLVQVNRADYYFNDYNFD--SSIKSLEKCKD
IRAKg_m-1_Smoe ----QGCDYNVPMD--CEH--------PTKLVLATRADYYYSDYRFD--AAVTTLEQCKA
IRAKg_u-1_Smoe ----AGCVRNFPLS--CSSGNATS--SASKMVEVQRAMYVGNLLQQL-SKDPISLEQCKV
IRAKg_c_Smoe ----KGCEYNVPLK-SCNGSD-------NRWVRLERTDYTYNDKTY---ISVISLEDCKS
IRAKg_o-1_Smoe DGDFPGCSYNFPLN--CS---------NSKMVELARADFLGSGYIVG-LNSSMSLEQCKK
IRAKg_m-2_Smoe ----QGCDYNVPMD--CEH--------PTKLVLATRADYYYSDYRFD--AAVTTLEQCKA
IRAKg_o-2_Smoe DGDFPGCSYNFPLN--CS---------NSKMVELARADFLGSGYIVG-LNSSMSLEQCKK
IRAKg_e-1_Smoe RCDRDCGCLGFVYRV-DRHGTCYTKGPAPG-----VIYNGFQIPSDEMAPSLVFLKVSTA
IRAKg_d-2_Smoe RCLRECECLGAAFQM-GGAGICWLKGLDPS-----GLFNGKQSVD---VDNVFFLKVSAK
IRAKg_r-1_Smoe TCMQDCKCLAAAYKY-DGTGLCFLKGNS-N-----KLYNGKQTLN---EMNMVFMKLSSL
IRAKg_d-1_Smoe RCLRECECLGAAFQM-GGAGICWLKGLDPS-----GLFNGKQSVD---VDNVFFLKVSAK
IRAKg_f_Smoe LCKENCGCLGIAYRA-DGSGQCFLKGPDSTRGPKQVIYNGFQIAS---GPNLFFLKVSAS
IRAKg_e-2_Smoe RCDRDCGCLGFVYRV-DRHGTCYTKGSAPG-----VIYNGFQIPSDEMAPSLVFLKVSTA
IRAKg_o_Smoe ------------------------------------------------------------
IRAKg_v_Smoe ------------------------------------------------VAALIFIKQRFL
IRAKg_s_Smoe ------------------------------------------------------------
IRAKg_q_Smoe ------------------------------------------------------------
IRAKg_a-1_Smoe NCRGDSSCFGCLVPN-DGSGHCVQFRST--------SMSGYSSPS---IQSTAFLKVCTS
IRAKg_a-2_Smoe NCRGDSSCFGCLVPN-DGSGHCVQFRST--------SMSGYSSPS---IRSTAFLKVCTS
IRAKg_g_Smoe ------------------------------------------------------------
IRAKg_u-2_Smoe SCLKDCRCLGATYML-AGTKRCSLLGGEDG-----RLFNGVQAME---RASIALLKVSAL
IRAKg_p_Smoe TCMQDCKCLAAAYKY-DGTGLCFLKGSS-N-----KLYNGKQTLN---EINMVFMKLSSL
IRAKg_b_Smoe RCLRECECLGAAFQM-GGAGICWLKGLDPS-----GLFNGKQSVD---VDNVFFLKVSAK
IRAKg_n-2_Smoe RCLRECECLGAAFQM-AGAGICWLKGLDPS-----GLFNGKQSLD---VDNVFFLKLSAK
IRAKg_k-1_Smoe ------------------------------------------------------------
IRAKg_n-1_Smoe RCLRECECLGAAFQM-AGAGICWLKGLDPS-----GLFNGKQSLD---VDNVFFLKLSAK
IRAKg_h_Smoe RCLRECECLGAAFQM-GGAGICWLKGLDPS------------------------------
IRAKg_k-2_Smoe ------------------------------------------------------------
IRAKg_r-2_Smoe TCMQDCKCLAAAYKY-DGTGLCFLKGNS-N-----KLYNGKQTLN---EMNMVFMKLSSL
IRAKg_m-1_Smoe NCLKDCQCLAAAYKAQDGDSLCFLKGGQ-D-----RLYNGMQSFD---KPNLVYMKVSIN
IRAKg_u-1_Smoe SCLKDCRCLGATYML-AGTKRCSLLGGEDG-----RLFNGVQAME---RTSIALLKVSAL
IRAKg_c_Smoe ICKENCGCLGIAYRA-DGSGQCFLKGPDSTRGPKQVIYNGFQIAS---GQNLFFLKISAS
IRAKg_o-1_Smoe LCLDDCQCVGAAYTL-DGSGQCRLRKGG-S-----TPYNIVQSPQ---KASIALIKLSAS
IRAKg_m-2_Smoe NCLKDCQCLAAAYKAQDGDSLCFLKGGQ-D-----RLYNGMQSFD---KPNLVYMKVSIN
IRAKg_o-2_Smoe LCLDDCQCVGAAYTL-DGSGQCRLRKGG-S-----TPYNIVQSPQ---KASIALIKLSAS
IRAKg_e-1_Smoe SRVQPEA-P---LNELFSTIVNATNVKSYAELKQVREAF----KLVIPAAIAAAELLLFL
IRAKg_d-2_Smoe DPGQSPD------ANVYVTNANATVVPGFQWLVLHRPFFR--DGPRIALFITTLVLMVFL
IRAKg_r-1_Smoe DTSAADD-QH----DPFLADANATVSDQAMPKINKRTVYLSRHLQSIILSVAIVEFGLFA
IRAKg_d-1_Smoe DPGQNG--------------------------------------PRIALFITTLVLMVFL
IRAKg_f_Smoe DTSVPAEDDHSLNQLLYVTDMDATNNVETLFV--KEVEVP--IKHKLAVALAIAELLVFL
IRAKg_e-2_Smoe SSFQPEA-P---LNQLFSTIVNATNVKSYAELKQVREAF----KLVIPAAIAAAELLLFL
IRAKg_o_Smoe ------------------------------------------------------------
IRAKg_v_Smoe DPRAKA------------------------------------------------------
IRAKg_s_Smoe ------------------------------------------------------------
IRAKg_q_Smoe ------------------------------------------------------------
IRAKg_a-1_Smoe AANSPPT-S--VS---------------------SEPR-SSNQGRAIGIAVGVTVAALVL
IRAKg_a-2_Smoe AANSPPT-S--VL---------------------SEPG-SSNQGRAIGIAVGVTVAALVL
IRAKg_g_Smoe ------------------------------------------------------------
IRAKg_u-2_Smoe DPLTTSF-SE----DVFVTVLDAYTPSLPD-SLRNWSYFS-DAGHRLVFAIAIGELASFL
IRAKg_p_Smoe DTSAADD-QH----DPFLADANATVSDQVMRKINKWTVYLSR--HPIILSVAIVELGLFA
IRAKg_b_Smoe DPGQSPD------ANIYVTNANATVVPGFQWLVLHRSFFR--DTPRVALFITTLVLMVFL
IRAKg_n-2_Smoe DPGKSPD------ANIYVTNANATVVPGFQWLVIHRPFFR--DAPRVALFITTLVLVVFL
IRAKg_k-1_Smoe ----------------------------------------SSKNSGVAIGVGAGIVLLLL
IRAKg_n-1_Smoe DPGQSPD------ANIYVTNANATVVPGFQWLVIHRPFFR--DAPRVALFITTLVLVVFL
IRAKg_h_Smoe ------------------------------------------------------------
IRAKg_k-2_Smoe ----------------------------------------SSKNSGVAIGVGAGIVLLLL
IRAKg_r-2_Smoe DTSAADD-QH----DPFLADANATVSDQVMPKINKRTVYLSRHLQSIILSVAIVEFGLFA
IRAKg_m-1_Smoe DKLAADD-HY----DYFMSNTNATLSNIFTAH-HKE-SYLSMHLHSVVIAIATAELVAFA
IRAKg_u-1_Smoe DPLTTSF-SE----D------------------------------VLVFAIAIGELASFL
IRAKg_c_Smoe DTSVPAEDDHSLNQLLYVTDMDATNNMETLFV--KEVEVP--IKHKLAVALAIAELVVFL
IRAKg_o-1_Smoe DTRAQAD-PN-DMKNLFVTSMNASDLYQADSRKSSGTKFF-TASRALVFGVAVGEFVILC
IRAKg_m-2_Smoe DKLAADD-HY----DYFMSNTNATLSNIFTAH-HKE-SYLSMHLHSVVIAIATAELVAFA
IRAKg_o-2_Smoe DTRAQAD-PN-DMKNLFVTSMNASDLYQADSRKSSGTKFF-TASRALVFGVAVGEFVILC
IRAKg_e-1_Smoe AAGVIWWLYTE--K-RIKRLSQ----------ALDQVDGVVTKFTYHQLEVATGNFKDKL
IRAKg_d-2_Smoe LVTCFMGLCWIISA-RVRNNIM----------DL-DFGSGPAIFTYQQLQNFTDNFYDRL
IRAKg_r-1_Smoe TGAAIVAAVWKKTS-RKKWEEM----------TA-EIEGLPTKFTYRQLQDATDNFRDEL
IRAKg_d-1_Smoe LVTCFMGLCWIISA-RARNNMM----------DL-DFGSGPAIFTYQQLQNFTDNFYDRL
IRAKg_f_Smoe ICGAVYGHHVKEKV---RHIRQ----------QM-EFEGGTTRFTYHQLEIATNFFKDKL
IRAKg_e-2_Smoe AAGVIWWLYTE--K-RIKRLSQ----------ALDQVDGVVTKFTYHQLELATGNFKDKL
IRAKg_o_Smoe ------------------------------------------------------------
IRAKg_v_Smoe -------------------STTA------ASIISAPGSPQLVQFSFKAIVATTRNFSDKI
IRAKg_s_Smoe ------------------------------------------------------------
IRAKg_q_Smoe ------------------------------------------------------------
IRAKg_a-1_Smoe AELAVGWAVYRRRY-SRRVQEAA------RHAILDYASGAPMRFTYKELQNATYNFQTRI
IRAKg_a-2_Smoe AELAVGWAVYRRRY-SRRVQEAA------RHAILDYASGAPMRFTYKELQNATYNFQTRI
IRAKg_g_Smoe ------------------------------------------------------------
IRAKg_u-2_Smoe CIALSAWFCWRRSL-RGMWKKA----------AK-DH-RGPTWFSYEQLEVATNHFSCKL
IRAKg_p_Smoe TGAAVVAAVWTKTS-RRKWEEM----------TG-EIEGLPTKFTYRQLQDATDNFRNEL
IRAKg_b_Smoe LVTCFLGLSWIIST-RARNNIM----------DL-DFGSGPARFTYQQLQNFTDNFCDKL
IRAKg_n-2_Smoe LV---VGLCWTISA-RARNNMM----------DL-DFSSGPARFTYQQLQTFTDNFCDKL
IRAKg_k-1_Smoe AGL-AAFVIARRRRKAKRVSSSSGSSKSDQRSIYNFVDGELANFTFKQLHAATDGFKKRL
IRAKg_n-1_Smoe LV---VGLCWTISA-RARNNMM----------DL-DFSSGPARFTYQQLQTFTDNFCDKL
IRAKg_h_Smoe ----------------ARNNIM----------DL-DFGSGPARFTYQQLQNFTDNFCDKL
IRAKg_k-2_Smoe AGL-AAFVIARRRRKAKRVSSSSGSSKSDQRSIYNFVEGELANFTFKQLHAATDGFKKRL
IRAKg_r-2_Smoe TGAAIVAAVWKKTS-RKKWEEM----------TA-EIEGLPTKFTYRQLQDATDNFRDEL
IRAKg_m-1_Smoe AIGVAMFSMWKRRS-RKEWEAL----------TA-EIEGSPTKFTYKQLQEATNNFEETL
IRAKg_u-1_Smoe CIALSAWFCWRRSL-REMWKKA----------AK-DH-RGPTWFSYEQLEVATNHFSCKL
IRAKg_c_Smoe ICGAVYGHHVKEKV---RHIKQ----------QM-EVEGGATRFTYHQLEIATNFFKDKL
IRAKg_o-1_Smoe CVVIATSMCWRRSN-KKMWNKH----------AG-DH-HGPTRFSYEQLEIATGNFRHKL
IRAKg_m-2_Smoe AIGVAMFSMWKRRS-RKEWEAL----------TA-EIEGSPTKFTYKQLQEATNNFEETL
IRAKg_o-2_Smoe CVVIATSMWWRRSN-KKMWNKH----------AG-DH-HGPTRFSYEQLEIATGNFRHKL
IRAKg_e-1_Smoe GAGAFGTVYKGVL--ADGTSLVAVKSLMM-ATHAEKQFKAEVATLGKIHHINLVRMLGYC
IRAKg_d-2_Smoe GSGGFGTVYKGRL--PNG-TLVAVKELEM-AMQADKQFQAEVKTLGKIHHINLVRLLGYC
IRAKg_r-1_Smoe GSGGFGSVYRGNI--PEKGGIVAVKKITT-VNQAKKQFKAEVSTIGRVHHVNLVRLLGYC
IRAKg_d-1_Smoe GSGGFGTVYKGRL--PNG-TLVAVKELEM-AMQADKQFQAEVKTLGKIHHINLVRLLGYC
IRAKg_f_Smoe GTGGFGTVFKGLL--PDG-IIVAVKNIEM-EIQAEKQFQAEVTTLGNIHHINLVRLLGYS
IRAKg_e-2_Smoe GAGAFGTVYKGVL--ADGTSLVAVKSLMM-ATHAEKQFKAEVATLGKIHHINLVRMLGYC
IRAKg_o_Smoe -----------------------------------QSQDAEVSTIGRVHHVNLVRLLGYC
IRAKg_v_Smoe GAGILGSVYKGVF--PDSETVVAVKKLEI-N-TSDRDFRNCVSEIGFLSHDSLVQLHGFC
IRAKg_s_Smoe -----------------------------------------VTTLGRVHHVNLVKLLGYC
IRAKg_q_Smoe ---------------------------------------ARNTTLGRVHHVNLVKLLGYC
IRAKg_a-1_Smoe GEGGFGPVYKGSLALPVSKTAIAVKKLEG-IFQGEKEFRTEVATIGSTHHMNLMRLVGFC
IRAKg_a-2_Smoe GEGGFGPVYKGSIALPVSKTAIAVKKLEG-IFQGEKEFRTEVATIGSTHHMNLMRLVGFC
IRAKg_g_Smoe ----------------------------------------EDATLGKIHHISLVRMLGYC
IRAKg_u-2_Smoe GAGGFGSVYKGVL--PDM-TVVAVKTLEGAASHGEKQFKAEVATLGRVHHVNLVKLLGYC
IRAKg_p_Smoe GSGGFESVYRGNI--PEKGGIVAVKKITT-VNQAEKQCKAEVSTIGRVHHVNLVRLLGYC
IRAKg_b_Smoe GSGGFGTVYKGRL--PNG-TLVAVKELEM-AMQADKQFQAEVKTLGKIHHINLVRLLGYC
IRAKg_n-2_Smoe GSGGFGTVYKGRL--LNG-TLVAVKELEM-AMQADKQFQTEVETLGKIHHINLVRLLGYC
IRAKg_k-1_Smoe GSGGFGEVFKGSI--Q--GQAVAVKRLIK-------------------------------
IRAKg_n-1_Smoe GSGGFGTVYKGRL--LNG-TLVAVKELQM-AMQADKQFQTEVETLGKIHHINLVRLLGYC
IRAKg_h_Smoe GSGGFGTVYKGRL--PNG-TLVAVKELEI-AMQADKQFQAEVKTLGKIHHINLVRLLG--
IRAKg_k-2_Smoe GSGGFGEVFKGSI--Q--GQAVAVKRLIK-------------------------------
IRAKg_r-2_Smoe GSGGFGSVYRGNI--PEKGGIVAVKKITT-VNQAKKQFKAEVSTIGRVHHVNLVRLLGYC
IRAKg_m-1_Smoe GSGGYGTVYRGEI--PEKGGIVAVKVIKA-VTHAEKQFKAEVNTIGKVHHVNLVRLLGYC
IRAKg_u-1_Smoe GAGGFGSVYKGVL--PDM-TVVAVKTLEGAASHGEKQFKAEVATLGRVHHVNLVKLLGYC
IRAKg_c_Smoe GTGGFGTVFKGLL--PDG-IIVAVKNIEM-EIQAEKQFQAEVTTLGKIHHINLVRLLGYC
IRAKg_o-1_Smoe GSGGFGSVYKGVL--PDK-TVVAVKTLEV-ATHGENQFKAEVATLGTIHHVNLVKLLGYC
IRAKg_m-2_Smoe GSGGYGTVYRGEI--PEKGGIVAVKVIKA-VTHAEKQFKAEVNTIGKVHHVNLVRLLGYC
IRAKg_o-2_Smoe GSGGFGSVYKGVL--PDK-TVVAVKTLEV-ATHGENQFKAEVATLGTIHHVNLVKLLGYC
IRAKg_e-1_Smoe AEGS--HRLLVYEYMENSSLEKVLS-QV--------------PKTLCEWKTRLAIALGIS
IRAKg_d-2_Smoe YEDN--RKLLVYEYMPNGSLEKLLFLND--------------TEHFCGWASRFNIALGIA
IRAKg_r-1_Smoe AEGD--HHLLVYEFMPNGSLDHHLSASSSF---------AASQEIFSTWETRHSIALGIA
IRAKg_d-1_Smoe YEDN--RKLLVYEYMPNSSLEKLLFLND--------------TEHFCGWASRFNIALGIA
IRAKg_f_Smoe GQSR--K-----------------------------------------------------
IRAKg_e-2_Smoe AEGS--HRLLVYEYMANSSLEKVLS-QV--------------PQTLCEWKTRLAIALGIS
IRAKg_o_Smoe AEGG--CHLLVYEFMPNGSLDHHLSASSSF---------AASQEIFSTWETQHSIALGIA
IRAKg_v_Smoe ADCGPDNKMLVYEFLSNGSLDKLLFED--------------SEDNRLDWKFRFDTALSIA
IRAKg_s_Smoe AEGS--HRLLVYEFLSNGSLDQDLST---------------------KLVCRFSIALGVA
IRAKg_q_Smoe AEGS--HRLLVYEFLSNGSLDQECID---------------------LWGTRFSIALGVA
IRAKg_a-1_Smoe AEGA-ATRLLVYEFLPNGSLDRFLFQPLAPGEDED--DSYQEARPSLDWPTRFKIALGTA
IRAKg_a-2_Smoe AEGA-ETRLLVYEFLPNGSLDRFLFQPLAPGEDED--DSYQGARPSLDWPTRFKIALGTA
IRAKg_g_Smoe AEGS--HRLLVYEYMANSLQVDEASSQI--------------PQTLCKWKTRLAIALSIS
IRAKg_u-2_Smoe AEGS--HRLLVYEFLSNGSLDQECID---------------------LWGTRYSIALGVA
IRAKg_p_Smoe AEGD--RHLLVYQFMTNGSLDHHLSASSSS---------AASQEIFSTSETQHSIALGIA
IRAKg_b_Smoe YEDN--RKLLVYEYMPNGSLDKLLFL--------------------DSWASRFNIALGIA
IRAKg_n-2_Smoe YEDN--RKLLVYEYMPNGSLEKLLFLDD--------------AKHFCSWANRFSIALGIA
IRAKg_k-1_Smoe -----LQRLLVYEFIERGSLDRTLFNRD------------AENSVVLSWSQRFGIALGTA
IRAKg_n-1_Smoe YEDN--RKLLVYEYMPNGSLEKLLFLDD--------------AKHFCSWASRFSIALGIA
IRAKg_h_Smoe ------------------------------------------------WASRFNIALGIA
IRAKg_k-2_Smoe -----LQRLLVYEFVERGSLDRTLFNRD------------AENSVVLSWSQRFGIALGTA
IRAKg_r-2_Smoe AEGD--HHLLVYEFMPNGSLDHHLSASSSF---------AASQEIFSTWETRHSIALGIA
IRAKg_m-1_Smoe VEGV--HRLLVYEFMPNGSLDNYLSSNS--------------GSSDSSWQTRFSIALGIA
IRAKg_u-1_Smoe AEGS--HRLLVYEFLSNGSLDQECSD---------------------LWGTRYSIALGVA
IRAKg_c_Smoe AEGS--HRLLVYEYMQNGSLEKSIISNE------------DIDESLCDWKTRFSIAVGIA
IRAKg_o-1_Smoe VEGS--HRVLVYEYMTNGSLDKVLTSIRAPWKTRYCHRKSQSPKVKLTLLFRYSIAMGIA
IRAKg_m-2_Smoe VEGV--HRLLVYEFMPNGSLDNYLSSNS--------------GSSDSSWQTRFSIALGIA
IRAKg_o-2_Smoe VEGS--HRVLVYEYMTNGSLDKVLTSIRAPWKTRYCHRKSQSPKVKLTLLFRYSIAMGIA
IRAKg_e-1_Smoe RGITYLHEQCQECIIHCDIKPQNILLDDNFRPKVSDFGLAKLMKRESSANVTTARGTRGY
IRAKg_d-2_Smoe RGITYLHDECQECILHCDIKPQNILLDESFIPKVADFGLAKLMKRERELSVTTVRGTRGY
IRAKg_r-1_Smoe KGLTYLHEKCGERIVHCDIKPQNVLLNESFRPKVSDFGLARMMTKE-SMSITTVQGTRGY
IRAKg_d-1_Smoe RGITYLHDECQECILHCDIKPQNILLDESFIPKVADFGLAKLMKRERALSVTTVRGTRGY
IRAKg_f_Smoe -----------------------------------------NHKRDHGARNSRIHGTG--
IRAKg_e-2_Smoe RGITYLHEQCQECIIHCDIKPQNILLDDNFRPKVSDFGLAKLMKRESSANVTTARGTRGY
IRAKg_o_Smoe KGLTYLHEKCGERIVHCDIKPQNVLLDESSGQRCPTLGW---------------------
IRAKg_v_Smoe RGVAHLHQQ-QVPVIHGNLKTENILLDKNFQPKISDTGLGLLVDRRKIKTALSSGRVHGY
IRAKg_s_Smoe KRITYLHKECYDCILR-DIKPQNILLHENFCPKVSDFGLAKLIDKERALDVTTIRGTRGY
IRAKg_q_Smoe KGITYLHE-CYDCILR-DIKPQNILLDENFCPKVLDFGLAKLIDKERALDVTTIRGTRGY
IRAKg_a-1_Smoe RALAYLHEECREPIVHCDLKPENILLDDSFAPKVSDFGLARLIDEGNARNLTTVRGTRGY
IRAKg_a-2_Smoe RALAYLHEECREPIVHCDLKPENILLDDSFAPKVSDFGLARLIDEGNARNLTTVRGTRGY
IRAKg_g_Smoe RGITYLHQQCQECIIHCDVKPQNILFDDNFHPKVSDFGLAKLMKRESSANVTTARDTRGY
IRAKg_u-2_Smoe KGITYLHEECYDCVLHCDIKPQNVLLDENFCPKVSDFGLAKLIDKERALDVTTIRGTRGY
IRAKg_p_Smoe KGLTYLLWRAHRPLRYQATK------RAAGRPKVADFGLARMMRKE-SMSVTTVQGTRGY
IRAKg_b_Smoe RGITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLMKRERALSVTTVRGTRGY
IRAKg_n-2_Smoe RGITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLMKRERALSVTTVRGTRGY
IRAKg_k-1_Smoe KGLAYLHEDCRHRIIHCDIKPENILLDAEMKPKIADFGLAKLLGREFSRVVTSMRGTRGY
IRAKg_n-1_Smoe RGITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLMKRERALSVTTVRGTRGY
IRAKg_h_Smoe RGITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLMKRERALK----------
IRAKg_k-2_Smoe KGLAYLHEDCRHRIIHCDIKPENILLDAEMKPKIADFGLAKLLGREFSRVVTSMRGTRGY
IRAKg_r-2_Smoe KGLTYLHEKCGERIVHCDIKPQNVLLNESFRPKVSDFGLARMMTKE-SMSITTVQGTRGY
IRAKg_m-1_Smoe KGIAYLHEECQECIIHCDIKPQNILLDDQMSPKIADFGLAKLTKREHSMSVTTVRGTRGY
IRAKg_u-1_Smoe KGITYLHEECYDCILHCDIKPQNVLLDENFCPKVSDFGLAKLTDKERALDVTTIRGTRGY
IRAKg_c_Smoe RGITYLHEQCQECIVHCDIKPQNILLDEKFCPKVSDFGLAKLASRERTINVTTVQGTRGY
IRAKg_o-1_Smoe RGITYLHEECYECILHCDIKPQNILLDQNLCPKVADFGLAKLTKREMALNVTTIRGTRGY
IRAKg_m-2_Smoe KGIAYLHEECQECIIHCDIKPQNILLDDQMSPKIADFGLAKLTKREHSMSVTTVRGTRGY
IRAKg_o-2_Smoe RGITYLHEECYECILHCDIKPQNILLDQNLCPKVADFGLAKLTKKEMALNVTTIRGTRGY
IRAKg_e-1_Smoe MAPEWISNVAITPKVDVYSFGMVLLELMSGRDKFMFTP-SAMNS----------GRWYFP
IRAKg_d-2_Smoe LAPEWISNLPITTKVDVYSFGMVLLEIISGREKYLMTI-SAINS--------ENNRWCLS
IRAKg_r-1_Smoe LAPEWLESQSITPKADVYSFGMLLLDILGGKRKALMEL-GSGDREYENAPLPPPREWYFP
IRAKg_d-1_Smoe LAPEWISDLPITTKADVYSFGMVLLEIISGREKYLMTI-SAINS--------ENNRWCLS
IRAKg_f_Smoe ----------MGPQRHHYSKGGRV------------------------------QLWH--
IRAKg_e-2_Smoe MAPEWISNVAITPKVDVYSFGMVLLELMSGRDKFMFTP-SAMNS----------GRWYFP
IRAKg_o_Smoe ------------------------------------------------------------
IRAKg_v_Smoe FSPEWIADSPLTTKTDVYGFGMILLEIIGGRRILDLS----QKS----------EQWNFV
IRAKg_s_Smoe MAPEWVGDRPITSKVDVYIYGMVLLELLSGNDKSRI-------S----------QNRYFP
IRAKg_q_Smoe MAPVWVGDRPITSKVDVYSYGMVLLELLSGNDKSRI-------G----------QNRYFP
IRAKg_a-1_Smoe MAPEWLANMPITAKSDVYSYGMVLLELVGGRRNFDTC--RAVPR----------GMQRYP
IRAKg_a-2_Smoe MAPEWLANMPITAKSDVYSYGMVVLELVGGRRNFDTC--RAVPR----------GMQRYP
IRAKg_g_Smoe MAPEWISMVAIAPKVDVYSFGMVLLG--SGRDKFMFF-----------------------
IRAKg_u-2_Smoe MAPEWVGDRPITSKVDVYSYGMVLLELLSGNDKSRI-------G----------QNRYFP
IRAKg_p_Smoe LAPEWLESQSITPKANVYSFGMLLLDILSGKRKALMEL-GSGDKEYE-------------
IRAKg_b_Smoe LAPEWISNLPITTKVDVYSFGMVLLEIISGREKYLMTI-SAINS--------ENNRWCLS
IRAKg_n-2_Smoe LAPEWISNLPITTKVDVYSFGMVLLEIISGREKYIMTI-SAINS--------ENSRWCLS
IRAKg_k-1_Smoe LAPEWLSNMPITPKADVYSYGMTLLEIISGRRNIDF-----RND----------QIFFYP
IRAKg_n-1_Smoe LAPEWISNLPITTKVDVYSFGMVLLEIISGREKYIMTI-SAINS--------ENSRWCLS
IRAKg_h_Smoe -----------------------------------------------------NNRWCLS
IRAKg_k-2_Smoe LAPEWLSNMPITPKADVYSYGMTLLEIISGRRNIDF-----RND----------QIFFYP
IRAKg_r-2_Smoe LAPEWLESQSITPKADVYSFGMLLLDILGGKRKALMEL-GSGDKEYENAPLPPPREWYFP
IRAKg_m-1_Smoe LAPEWLDGLSVTPKIDVYSFGMLLFDILSGTNKMIFNE-LAGTS-FE------SFPSGME
IRAKg_u-1_Smoe MAPEWVGDRPITSKVDVYSYGMVLLELLSGNDKSRI-------G----------QNRYFP
IRAKg_c_Smoe MAPEWVRNVTITPKVDVYSYGMVLFELLSGGKIIPVDGAPATNS----------ERGHFP
IRAKg_o-1_Smoe LAPEWISNRPITTKVDVYSYGMVLLELLSGHDKSRS-------G----------QNTSFS
IRAKg_m-2_Smoe LAPEWLDGLSVTPKIDVYSFGMLLFDILSGTNKMIFNE-LAGTS-FE------SFPSGME
IRAKg_o-2_Smoe LAPEWISNRPITTKVDVYSYGMVLLELLSGHDKSRS-------G----------QNTYFS
IRAKg_e-1_Smoe VWAFEQCATGNMKST-ADPRMA-ETIDWEQFEMALRVAFWCIQPEPESRPSMSKVVQMLE
IRAKg_d-2_Smoe DWAYNMYQAGDLESI-IDKKLVREDVDLVQFKRLLKVALWCIQHDANARPSMGKVVQMME
IRAKg_r-1_Smoe IYAFHKYMTSELESV-ADPNLASGSVDWEQFETALKIALSCIHQDPGSRPAMSRVVQILE
IRAKg_d-1_Smoe DWAYNMYQAGDLESI-VDKKLVREEVDLVQFKRLLKVALWCIQHDANARPSMGKVVQMME
IRAKg_f_Smoe --------------------------------GPLRAAEWRKNNSSRWRSCHE-------
IRAKg_e-2_Smoe VWAFEQCATGNMKST-ADPRMA-ETIDWEQFEMALRVAFWCIQPEPESRPSMSRVVQMLE
IRAKg_o_Smoe ------------------------------------------------------------
IRAKg_v_Smoe DWVSKQVKAGNYVGV-ADPRLS--SIDLEQLRRGIDVAVWCIQDDAKSRPSIAKVVEELE
IRAKg_s_Smoe VWAFQKYVAGEQVELDASKRHLDHPLELVPL-----------------------------
IRAKg_q_Smoe VWAFQKYVAGERVELDASKRHLDHPLELVPLQ----VFKPRVR---NGVDSSRPVVKMLE
IRAKg_a-1_Smoe AYLYRELEAGRLEGA-VDERMYRADVDGVQLERVVKVAFWCIQDVASARPVMSKVVQMLE
IRAKg_a-2_Smoe AYLYRELEAGRLEGA-VDERMYRADVDGVQLERVVKAAFWCIQDVASARPVMSKVVQMLE
IRAKg_g_Smoe ------------------------------------------------------------
IRAKg_u-2_Smoe VWAFQKYVAGELHAI-ADPGLKN--LEWNEFERMIKVAFWCIQLDARSRPSMSRVVQMLE
IRAKg_p_Smoe ------------------------------------------------------------
IRAKg_b_Smoe DWAYNMYQAGDLESI-VDKKLVQEEVNVVQFKRLLKVALWCIQHDANARPSMGKVVQMME
IRAKg_n-2_Smoe DWAYNMYQAGDMESI-VDKKLVGEEVDFMQFKRLLKVALWCIQHDAHARPSMGKVVQMME
IRAKg_k-1_Smoe LWAAEQVCNGEFSKL-PDDRLD--EWDEEELRRAARTAIWCVQDEEINRPSMKTVVQMLE
IRAKg_n-1_Smoe DWAYNMYQAGDMESI-VDKKLVGEEVDFVQFKRLLKVALWCIQHDAHARPSMGKVVQMME
IRAKg_h_Smoe DWAYNMYQAGDLESI-VDKKLVQEEVNVVQFKRLLKVALWCIQHDANARPSMGKVVQMME
IRAKg_k-2_Smoe LWAAEQVCNGEFAKL-PDDRLD--EWDEEELRRAARTAIWCVQDEEINRPSMKTVVQMLE
IRAKg_r-2_Smoe IYAFHKYMTSELESV-ADPTLASGSVDWGQFETALKIALSCIHQDPGSRPAMSRVVQILE
IRAKg_m-1_Smoe D-YFQKYIASELQCI-ADPKMEMAETDWPQFKLLLKVALWCIQQNPSSRPSMSRIVQLLE
IRAKg_u-1_Smoe VWAFQKYVAGELHAI-ADPGLKS--LEWNEFERMIKVAFWCIQLDARSRPSMSRVVQMLE
IRAKg_c_Smoe IWAFQHYVAGSVSSI-ADTKMA-EKIDMVQFNMVLRVAFWCVQPDASLRPNMSKVVEMLE
IRAKg_o-1_Smoe VWAFQKYMAGEFESI-VDPKLVT-SVEWSQFERMLKTAFWCIQLDANLRPSMSRVIQMLE
IRAKg_m-2_Smoe D-YFQKYIASELQCI-ADPKMEMAETDWPQFKLLLKVALWCIQQNPSSRPSMSRIVQLLE
IRAKg_o-2_Smoe VWAFQKYMAGEFESI-VDPKPVT-SVEWSQFERMLKTAFWCIQLDANLRPSMSRVIQMLE
IRAKg_e-1_Smoe EN-APVPAPPLPRIFEDGGSGGVSR---------ELS---------VMYPSESGR
IRAKg_d-2_Smoe DT-IQVPEPLSPNLSSEIAL-DPSM---------VPSL--------EVGSLTNGR
IRAKg_r-1_Smoe GK-AEAPPPPFPDAGENDL-----------------F---------VALQTSTIC
IRAKg_d-1_Smoe DT-VQVPEPLSPNLSSEIAL-DPS-----------------------VGSLTNGR
IRAKg_f_Smoe -----LGTRAFS---------------------------------------NLGF
IRAKg_e-2_Smoe EN-APVPAPPLPRIFEDGGS-GVSR---------ELS---------VMYPSESGR
IRAKg_o_Smoe -----------------------------------------------------RG
IRAKg_v_Smoe KVLV-IEATPARKKR-S------------------YGQ----------LQEIEAS
IRAKg_s_Smoe ----QVF---KPR--S-----------------------------AMAWTAPGRA
IRAKg_q_Smoe QPDLEVAVPPFPTPASEKVLSGNSP---------SFLP-------PLSQSVIDPG
IRAKg_a-1_Smoe GNLA-VLLPPPPKVAMDSSASSS-GSATAASSSTAFSISSQSSGTSSAPHSLIGR
IRAKg_a-2_Smoe GNLA-VLLPPPPKVAMDSSAASSSGSATATSSSTAFSISSQSSGTSSAPHSLIGR
IRAKg_g_Smoe ---------------------------------------------------PSHE
IRAKg_u-2_Smoe EPDLEVAVPPFPTPASEEVVSGNSP---------SFLP-------PLSQSVIDPR
IRAKg_p_Smoe -N-APLPPP---------------------------------------GECSTSK
IRAKg_b_Smoe DI-VQVPEPSSPNPSFEIAL-DPS-----------------------MDPSGSLR
IRAKg_n-2_Smoe DT-VQFPEPSSPNSSFSIGL-DPSM---------DYSE-------DTIGSLTNGR
IRAKg_k-1_Smoe GSATDFPDPVKPSS-FEMW------------------L----------EFQEQSG
IRAKg_n-1_Smoe DT-VQFPEPSSPNSSFSIGL-DPSM---------DYSE-------DTVGSLTNGR
IRAKg_h_Smoe DI-VQVPEPSSPNPSFEIAL-DPS-----------------------MDPSGSLR
IRAKg_k-2_Smoe GRATDFPDPVKPSS-FEIW------------------L----------EFQEQSA
IRAKg_r-2_Smoe GK-AEAPPPPFPDAGENDL-----------------F---------VALQTSTIC
IRAKg_m-1_Smoe HN-DPE----------------------------------------NKIFDQDLC
IRAKg_u-1_Smoe EPDLEVAVPPFPTPASEEVVSGNSP---------SFLP-------PLSQSVIDPR
IRAKg_c_Smoe EN-VPVPEPPFP---------------------------------------RMIE
IRAKg_o-1_Smoe DNSSEVAVPPFPTPLDHEAGTGNSS---------S-IP-------LETQSFLEAR
IRAKg_m-2_Smoe HN-DPE----------------------------------------NKIFDQDLC
IRAKg_o-2_Smoe DNSSELAVPPFPTPLDHEAGTGNSS---------S-IP-------LETQSFLEAR