mkk-4_Cele MVQEDDEN----------------------------------------------------
VZC374L.1_Cele MDHGDDQD----------------------------------------------------
ZC449.6_Cele MCPRNHYVIT-GGG----------------------GFLGAHLIAALQKNGDRTKCIVVD
Mkk4_Dmel MAERPKNLFATGSSRSRNPPDQLSLNNLSIRHPPSSTSSTSS--------GSTSSG--SS
MAP2K4_Mmus MAAPSPSGGG--------------------------GSGGGG--------G--TPGPIGP
MAP2K4_Hsap MAAPSPSGGG--------------------------GSGGGS--------GSGTPGPVGS
MKK4_Spur MALANRDRDA--------------------------EAGRGR--------LSL-------
AqueK244_Aque MPAKDRFKHL------------------KANV-PSL------------------------
AqueK245_Aque ------------------------------------------------------------
AqueK246_Aque MHIDVKKPR----------PPRMLFNN---RTP-STPSNSGV--------FSV-------
mkk-4_Cele ------------------------------------------------------------
VZC374L.1_Cele ------------------------------------------------------------
ZC449.6_Cele PNPRLSHFSAIDFDKSLVEYEKAQKHREYVYAFNVTGTKFLIEKCKFFGVPRFIYSSSIA
Mkk4_Dmel S-----------------------------------------------------------
MAP2K4_Mmus P-----------------------------------------------------------
MAP2K4_Hsap P-----------------------------------------------------------
MKK4_Spur ------------------------------------------------------------
AqueK244_Aque ------------------------------------------------------------
AqueK245_Aque ------------------------------------------------------------
AqueK246_Aque ------------------------------------------------------------
mkk-4_Cele ------------------------------------------------------------
VZC374L.1_Cele ------------------------------------------------------------
ZC449.6_Cele VVFVGKPIYNCDESEPYPLKSEYLDIYSSSKAEAEAFVRSQSTIQFKTTCLRFRAIYGPQ
Mkk4_Dmel ------------------------------------------------------------
MAP2K4_Mmus ------------------------------------------------------------
MAP2K4_Hsap ------------------------------------------------------------
MKK4_Spur ------------------------------------------------------------
AqueK244_Aque ------------------------------------------------------------
AqueK245_Aque ------------------------------------------------------------
AqueK246_Aque ------------------------------------------------------------
mkk-4_Cele ---------------------------------------LRNSMSLRP------------
VZC374L.1_Cele ---------------------------------------FP--MFARP------------
ZC449.6_Cele DVTVAEKVVQMVRKNLFMVKISRHGRESVSNMSSGENCGLALH-LANQELSKKEGSHGEV
Mkk4_Dmel ----------------------SSQHNHVTRC-FGAQQ----P-QQTP------------
MAP2K4_Mmus ----------------------ASGHPAVSSM-QGKRKALKLN-FANP------------
MAP2K4_Hsap ----------------------APGHPAVSSM-QGKRKALKLN-FANP------------
MKK4_Spur --------------------------------------KLKIH-TSTP------------
AqueK244_Aque ---------------------------------------------VLP------------
AqueK245_Aque ------------------------------------------------------------
AqueK246_Aque ------------------------------------------------------------
mkk-4_Cele ------------------------------------------------------------
VZC374L.1_Cele ------------------------------------------------------------
ZC449.6_Cele YFITDGETVGQYSVWSPLIKALGKTPPHHFVSCLLVSTFVSLSSYLCYKIFNSSPPMTRF
Mkk4_Dmel ------------------------------------------------------------
MAP2K4_Mmus ------------------------------------------------------------
MAP2K4_Hsap ------------------------------------------------------------
MKK4_Spur ------------------------------------------------------------
AqueK244_Aque ------------------------------------------------------------
AqueK245_Aque ------------------------------------------------------------
AqueK246_Aque ------------------------------------------------------------
mkk-4_Cele ------------------------------------------------------------
VZC374L.1_Cele ------------------------------------------------------------
ZC449.6_Cele ELEVLITDNTYSIEKARRELGYCPEQNLFEKTVEYYRLKAKPKLHQSENSKNHMTMEVVL
Mkk4_Dmel ------------------------------------------------------------
MAP2K4_Mmus ------------------------------------------------------------
MAP2K4_Hsap ------------------------------------------------------------
MKK4_Spur ------------------------------------------------------------
AqueK244_Aque ------------------------------------------------------------
AqueK245_Aque ------------------------------------------------------------
AqueK246_Aque ------------------------------------------------------------
mkk-4_Cele ------------------------------------------------------------
VZC374L.1_Cele ------------------------------------------------------------
ZC449.6_Cele FLSISEIFKDESYFLLLNFRLTCLFQLFPYPQIMQSLSSMLSPLNTNNTVYSDDVRPRSQ
Mkk4_Dmel ------------------------------------------------------------
MAP2K4_Mmus ------------------------------------------------------------
MAP2K4_Hsap ------------------------------------------------------------
MKK4_Spur ------------------------------------------------------------
AqueK244_Aque ------------------------------------------------------------
AqueK245_Aque ------------------------------------------------------------
AqueK246_Aque ------------------------------------------------------------
mkk-4_Cele ------------------------------TS-LSTRPT---------------------
VZC374L.1_Cele ------------------------------VF-LANRPT---------------------
ZC449.6_Cele ETTSTNFQTPLTITIPPIEYDIPACQFNQQPLLTSKSPELDALVKLNKEIGNQYTYQMFD
Mkk4_Dmel ------------------------------PVASSQVPP---------------------
MAP2K4_Mmus ------------------------------PVKSTARFT---------------------
MAP2K4_Hsap ------------------------------PFKSTARFT---------------------
MKK4_Spur ------------------------------NL-LEKQPE---------------------
AqueK244_Aque ------------------------------AKKTSPLPP---------------------
AqueK245_Aque ------------------------------------------------------------
AqueK246_Aque ---------------------------------TTPTPT---------------------
mkk-4_Cele ------------------------------------------------------------
VZC374L.1_Cele ------------------------------------------------------------
ZC449.6_Cele VEKASNSNHHLGFQNDPRMAYDKIIYTSTNKLGCNDFYYQCAYGEPKTDRMAIRHKLDND
Mkk4_Dmel ------------------------------------------------------------
MAP2K4_Mmus ------------------------------------------------------------
MAP2K4_Hsap ------------------------------------------------------------
MKK4_Spur ------------------------------------------------------------
AqueK244_Aque ------------------------------------------------------------
AqueK245_Aque ------------------------------------------------------------
AqueK246_Aque ------------------------------------------------------------
mkk-4_Cele ---------------------------------SLSVNGNEKTLPEES------------
VZC374L.1_Cele ---------------------------------LESLSSNDGSVAEEN------------
ZC449.6_Cele DIEPAAKRHCAGELDYSRFGNERKVLTKFVTFSLPPK-SSYSDMPHETKKNSLKRNYPDR
Mkk4_Dmel ---------------------------------VPAASSSSAADRHRE------------
MAP2K4_Mmus ---------------------------------LNPN-TTGVQNPHIE------------
MAP2K4_Hsap ---------------------------------LNPN-PTGVQNPHIE------------
MKK4_Spur ---------------------------------INNG--PSQEREQLN------------
AqueK244_Aque ---------------------------------IVDL--PD-------------------
AqueK245_Aque ------------------------------------------------------------
AqueK246_Aque ---------------------------------TPASSLSSATPVTAE------------
mkk-4_Cele ------------------------------------------------------------
VZC374L.1_Cele ------------------------------------------------------------
ZC449.6_Cele DDDQLHKETEGVLTNVVSILKTQENQDVAPSFTDQSTLLSIKEIEAVGALSDGQVRRMSS
Mkk4_Dmel ------------------------------------------------------------
MAP2K4_Mmus ------------------------------------------------------------
MAP2K4_Hsap ------------------------------------------------------------
MKK4_Spur ------------------------------------------------------------
AqueK244_Aque ------------------------------------------------------------
AqueK245_Aque ------------------------------------------------------------
AqueK246_Aque ------------------------------------------------------------
mkk-4_Cele ------------------------------------------------------------
VZC374L.1_Cele ------------------------------------------------------------
ZC449.6_Cele SRVHANRVASDRGNIPSLMNTPVNNDEISRFFFYTPHILSFCFSKTFEDYEIYHTSFFCS
Mkk4_Dmel ------------------------------------------------------------
MAP2K4_Mmus ------------------------------------------------------------
MAP2K4_Hsap ------------------------------------------------------------
MKK4_Spur ------------------------------------------------------------
AqueK244_Aque ------------------------------------------------------------
AqueK245_Aque ------------------------------------------------------------
AqueK246_Aque ------------------------------------------------------------
mkk-4_Cele ------------------------------------------------------VLRS--
VZC374L.1_Cele ------------------------------------------------------PLRS--
ZC449.6_Cele TSSRKRQLQQPAMPDANGHTYAFAPPRNRHNLAKLNLSGMRNPEPDLTNEDNMNSLDYVK
Mkk4_Dmel ------------------------------------------------------RIRQ--
MAP2K4_Mmus ------------------------------------------------------RLRTHS
MAP2K4_Hsap ------------------------------------------------------RLRTHS
MKK4_Spur ------------------------------------------------------SMRSRS
AqueK244_Aque ------------------------------------------------------------
AqueK245_Aque ------------------------------------------------------------
AqueK246_Aque ------------------------------------------------------IL-PVN
mkk-4_Cele -LSTGTLKYPD-DEHLYTFSSANLQDLGAIGNGNFGTVYKMRHKETGKLIAVKRIRCNN-
VZC374L.1_Cele -MSTGILKFPD-DAHLYPFNHTNLRHLSQVGAGYYGTVHKMQHNESGRLIAVKKIRYN--
ZC449.6_Cele KYLSNTLVLPPN-DRIHEFERDHLQELELLGNGSFGVVRKMLHRPSNVEMAVKQISLINN
Mkk4_Dmel -QACGKLQFGEGGANTHTFTSDDLEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTV-
MAP2K4_Mmus IESSGKLKISP--EQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTV-
MAP2K4_Hsap IESSGKLKISP--EQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTV-
MKK4_Spur MESIGKLSISP--DETYEFTSADLEDMGEIGRGAFGSVNKMWHKQSQSIMAVKRIRSTV-
AqueK244_Aque ---ATTIQI-D--DKSVKLSKTELYDVSEIGRGQFGQVNKMTHMVTGKVMAVKRIRVTP-
AqueK245_Aque ----------------FELSVDDLDVEEELGRGQYGQVNRMKHKPTGKIMAVKRIRATP-
AqueK246_Aque F-EVDKLHIG---DEVYTCGNDDLQDIGSIGEGHFGVVSKMNHTTAKHIMAVKKIPMK--
.* :* * :* * :* . :***:*
mkk-4_Cele -IG---HREQIRLLREHDTIVKSEKGPNIVKFYGAIFSEGDCWICMELMDISMDLLYKRV
VZC374L.1_Cele --N---ICDQTRLLKEHDTHMKSENVPNIVKFFGACFSEGDCWICMELMDISIDFLYKRV
ZC449.6_Cele GPDDAFNKSMQRFRLEVEATKAASNCDEIVRYYGITFNEGVAWMCMELMDLSLDKLYMIA
Mkk4_Dmel --D---EKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICMELMDTSLDKFYKYI
MAP2K4_Mmus --D---EKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYV
MAP2K4_Hsap --D---EKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYV
MKK4_Spur --D---EKDQKQLLMDLDVVKRSANCVYIIKFFGALFKEGDCWICMELMDSSLDKFYRFV
AqueK244_Aque --D---QAKSKSLLMEWKVPKNSVECPYTILFYGAFFCENDVWICMELMDRSLEELYHLV
AqueK245_Aque --D---QAENKRLLMDYNVAMRSIDCPFTITFYGALFREGDVWICMELMDKSLDKLYQLV
AqueK246_Aque --D---LRTSGGNVLELDVIKKVKECPFIVHFYGCLLREGHVWICMELLDSSMAQVSEIV
. : .. . : ::* : *. *:****:. *: .
mkk-4_Cele YMVKNSRLNENVVGHITVCTVDALDYLKKELKIIHRDVKPSNILVDGTGAVKLCDFGICG
VZC374L.1_Cele YSVKKSRLNENIIGHITVCIVDALDYLKRKLNRIHRDVKPSNILINAAGDVKLCDFGICG
ZC449.6_Cele HDIQKVEIPEQILGAVAVATIRALEHLKTTHHIIHRDIKPSNILLDRHGCVKLCDFGICG
Mkk4_Dmel YEKQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISG
MAP2K4_Mmus YSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISG
MAP2K4_Hsap YSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISG
MKK4_Spur HEVQNTYIPENIMGKVAYATVKALNYLKETLKIIHRDVKPSNILLDRGGNIKLCDFGISG
AqueK244_Aque YDKLKESIPEL--------TLKALTYLHDKLNVMHRDVKPSNILINQNGEIKLCDFGIAG
AqueK245_Aque YKKLNEKIPEVIVGKMADSTLKALTYLHDELQVMHRDVKPSNILINKKGEIKLCDFGIAG
AqueK246_Aque YNKMNERIPEDILGKMTVAVINALHFLQKELKIIHRDVKPSNILVSKVGEFKLCDFGISG
: . : * : ** .*: : :***:******: * .*******.*
mkk-4_Cele QLEESFAKTHDAGCQPYLAPERITS---SDKYDVRSDVWSLGITLYEIATGKFPYQ--EW
VZC374L.1_Cele DLVGSYAITVEAGCVQYLAPERIEN---MDKYDIRSDVWSLGITLYEIATGVYPYR--GW
ZC449.6_Cele YLQNSVAQSVDVGCRPYMAPERLAPN--GDGYDIKSEVWSLGITMVEVANGKYPYD--GF
Mkk4_Dmel QLVDSIAKTKDAGCRPYMAPERIDPER-AKGYDVRSDVWSLGITLMEVATGNFPYR--KW
MAP2K4_Mmus QLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYP--KW
MAP2K4_Hsap QLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYP--KW
MKK4_Spur QLVDSIARTMDAGCKPYMAPERIDPFQSRPGYDIRSDVWSLGITMYEVATGEFPYP--KW
AqueK244_Aque ELVDSLAKT-DIGCRPYLAPERIDEP--QHEYDHRSDVWSLGITMYEIAMGEFPYPVDTL
AqueK245_Aque ELVNSLAKT-DIGCRPYLAPERIYGG--QHKYDHRSDVWSLGITLCELATGEFPYP--PY
AqueK246_Aque KLVDSIARTMDVGCRPYMAPERIDPARACLGYTIQSDVWSYGITLVELAQGSFPYK--KW
* * * : : ** *:****: * :*:*** ***: *:* * :**
mkk-4_Cele N--SLFDQIATVVSGDPPILHPDSDDFHYSLPLVKFINTCLTKDRRHRPKYDTLKSFDFY
VZC374L.1_Cele S--NQMEHIEIVVNGDSPILLQNMHNLHYTDPLCRFINTCLRKNKDDRPKYVNLKTFSFY
ZC449.6_Cele MDAPILDQVRMVVYGDPPILDSD---HEVSMSMKRFIALCTIKDRNLRASFDDLKKTNIY
Mkk4_Dmel D--SVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFI
MAP2K4_Mmus N--SVFDQLTQVVKGDPPQLSNS-EEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFI
MAP2K4_Hsap N--SVFDQLTQVVKGDPPQLSNS-EEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFI
MKK4_Spur N--SVFEQLSQVVKGDPPRLKHN-DFYSYSEDFISFVNKCLTKDEKYRPKYKNLLEYKFI
AqueK244_Aque R--SIFGLIEMIVKGSPPRLTSD----RFSGEHKDFVAQCLTKSRDSRPRYKDLNAHSFI
AqueK245_Aque R--NLFEQIKLVVEGAPPQLPDD---GTFSEDFRDFVSKWY-------------------
AqueK246_Aque N--TIFDQLNAVVSGDPPSLPPE----NFTRELREFTAACLVKDSDQRPNYVQLQEKEFF
: : :* * .* * . : *
mkk-4_Cele RIYAVAG--PEIEEAK--------------------------------------------
VZC374L.1_Cele KMYAVGG--PDIEEAK--------------------------------------------
ZC449.6_Cele RDYIQEEHRVTDGCVSVVFHRKFSTCQLYGHDGTHNGAEVVYLEDHDFYIRSSWDGQCQD
Mkk4_Dmel RRGETSH--TDVAVYVA-------------------------------------------
MAP2K4_Mmus LMYEERT--VEVACYVC-------------------------------------------
MAP2K4_Hsap LMYEERA--VEVACYVC-------------------------------------------
MKK4_Spur KDYEHAN--IDVATFVS-------------------------------------------
AqueK244_Aque QTIENTG--VDMHCWYT-------------------------------------------
AqueK245_Aque ------------------------------------------------------------
AqueK246_Aque VLYNSGRVSVDVSSWYE-------------------------------------------
mkk-4_Cele --------------------------RIL-GV----------------------------
VZC374L.1_Cele --------------------------RIL-GL----------------------------
ZC449.6_Cele KIAPIRGYKQNIQQLQTPQISTLPKAQTIPNLPKFENSDFPKDPNPQVIRDNVRKAPVHF
Mkk4_Dmel --------------------------DILESMEK----D---------------------
MAP2K4_Mmus --------------------------KILDQMPA--------------------------
MAP2K4_Hsap --------------------------KILDQMPA--------------------------
MKK4_Spur --------------------------EILLAMRS--------------------------
AqueK244_Aque --------------------------TILTKYND----DLPP------------------
AqueK245_Aque ------------------------------------------------------------
AqueK246_Aque --------------------------R---------------------------------
mkk-4_Cele -------------------------------------EAIDTRNHPVDHRG
VZC374L.1_Cele -------------------------------------EAIDARDHPVEQRA
ZC449.6_Cele ENSIVQEIERQAMEDEFDMDYLTTTSPPKKRTHPDIITSFRNSAHNYSKLQ
Mkk4_Dmel -----------------------------------GIT---QFTANQQAES
MAP2K4_Mmus ------------------------------------------TPSSPMYVD
MAP2K4_Hsap ------------------------------------------TPSSPMYVD
MKK4_Spur ------------------------------------------------TSQ
AqueK244_Aque ----------------------------------DKTE--PSATNVPELVS
AqueK245_Aque ---------------------------------------------VVLKLS
AqueK246_Aque ----------------------------------------------VKESK