TGFbR1_Hsap IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA
BMPR1B_Mmus IQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA
BMPR1A_Mmus IQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA
ALK7_Mmus IVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIA
ALK4_Mmus IVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA
ALK2_Mmus ITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIA
ALK1_Mmus VALVECVGKGRYGEVWRGSWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIA
daf-1_Cele IRLTGRVGSGRFGNVSRGDYRGEAVAVKVFNALDEPAFHKETEIFETRMLRHPNVLRYIG
BMPR1A_Hsap IQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA
BMPR1B_Hsap IQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA
ALK7_Hsap IVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIA
ALK4_Hsap IVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA
tkv_Dmel IQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEEASWFRETEIYQTVLMRHDNILGFIA
SAX_Dmel VTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENILGFIG
BABO_Dmel VQLCHVIGKGRFGEVWRGRWRGENVAVKIFSSREECSWFREAEIYQTVMLRHENILGFIA
TGFBR1_Mmus IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA
sma-6_Cele LTIIKTIGQGRYGEVRKALYRGSYVAVKTFYTTDEDSWKNERDVYQTNMINHENILQFVA
ALK2_Hsap ITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIA
ALK1_Hsap VALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIA
TGFbR1_Spur IVIQDCIGKGRYGEVYRGKWRGESVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA
ALK2_Spur INLLQQVGKGRYGEVWMGTWQGDTVAVKIFSSIDEKSWFRETEIYNTVMLRHENILAFFA
BMPR1_Spur VQLIRKIGKGRYGEVWKAKWRGENVAVKIYFTAEEASWFRETDIYQTVLMRHTSILSFIA
AqueK680_Aque ILLGESIGGGRFGQVYVGHYQGERYAVKKFFSKDEQSWFHESDIYNSVNLRHDNILTCFA
AqueK681_Aque ITIHEHLGRGTYGSISRCTYRGNTFAVKRFTTINESSFRRELGIYSF-SLTQTNILTYIA
AqueK682_Aque VTKISVIGQGRFGKVWRCSYEEKHIAMKVFKNMHMAVFKREVEIYDTYMLYHENILRFIG
: :* * :*.: : *:* : . : .* ::. : : .:* ..
TGFbR1_Hsap ADNKD-NGTWTQLWLVSDYHEHGSLFDYLNR-YT-VTVEGMIKLALSTASGLAHLHMEIV
BMPR1B_Mmus ADIKG-TGSWTQLYLITDYHENGSLYDYLKS-TT-LDAKSMLKLAYSSVSGLCHLHTEIF
BMPR1A_Mmus ADIKG-TGSWTQLYLITDYHENGSLYDFLKC-AT-LDTRALLKLAYSAACGLCHLHTEIY
ALK7_Mmus ADNKD-NGTWTQLWLVSEYHEQGSLYDYLNR-NI-VTVAGMVKLALSIASGLAHLHMEIV
ALK4_Mmus ADNKD-NGTWTQLWLVSDYHEHGSLFDYLNR-YT-VTIEGMIKLALSAASGLAHLHMEIV
ALK2_Mmus SDMTS-RHSSTQLWLITHYHEMGSLYDYLQL-TT-LDTVSCLRIVLSIASGLAHLHIEIF
ALK1_Mmus SDMTS-RNSSTQLWLITHYHEHGSLYDFLQR-QT-LEPQLALRLAVSAACGLAHLHVEIF
daf-1_Cele SDRVD-TGFVTELWLVTEYHPSGSLHDFLLE-NT-VNIETYYNLMRSTASGLAFLHNQIG
BMPR1A_Hsap ADIKG-TGSWTQLYLITDYHENGSLYDFLKC-AT-LDTRALLKLAYSAACGLCHLHTEIY
BMPR1B_Hsap ADIKG-TGSWTQLYLITDYHENGSLYDYLKS-TT-LDAKSMLKLAYSSVSGLCHLHTEIF
ALK7_Hsap ADNKD-NGTWTQLWLVSEYHEQGSLYDYLNR-NI-VTVAGMIKLALSIASGLAHLHMEIV
ALK4_Hsap ADNKD-NGTWTQLWLVSDYHEHGSLFDYLNR-YT-VTIEGMIKLALSAASGLAHLHMEIV
tkv_Dmel ADIKG-NGSWTQMLLITDYHEMGSLHDYLSM-SV-INPQKLQLLAFSLASGLAHLHDEIF
SAX_Dmel SDMTS-RNSCTQLWLMTHYYPLGSLFDHLNR-NA-LSHNDMVWICLSIANGLVHLHTEIF
BABO_Dmel ADNKD-NGTWTQLWLVTDYHENGSLFDYLTT-HP-VDTNTMLNMSLSIATGLAHLHMDIV
TGFBR1_Mmus ADNKD-NGTWTQLWLVSDYHEHGSLFDYLNR-YT-VTVEGMIKLALSTASGLAHLHMEIV
sma-6_Cele ADIWSEEDSMTKMLLITDYHELGSLSDYLCREET-LTTDEALRLIHSCICGIEHLHAAVH
ALK2_Hsap SDMTS-RHSSTQLWLITHYHEMGSLYDYLQL-TT-LDTVSCLRIVLSIASGLAHLHIEIF
ALK1_Hsap SDMTS-RNSSTQLWLITHYHEHGSLYDFLQR-QT-LEPHLALRLAVSAACGLAHLHVEIF
TGFbR1_Spur ADNKD-NGTWTQLILVSDYHENGSLFDYLNS-HV-IDVPGMLRMALSIATGLAHLHMEIM
ALK2_Spur SDMTS-RQSCTQLWLIMEYHERGSLYDYLNR-HV-LDARQMCRLALTACSGLVHLHTEIT
BMPR1_Spur ADIRG-SGAYTQLFLITEYHEWGSLYDFLNV-NI-LDSQSMLRLAYSAANGLAHLHTEIC
AqueK680_Aque TDMLS-NNGVTELWLITQYHPRGSLFEELNR-GG-LTPETTLKFIHSTCRGLAYLHLEIT
AqueK681_Aque ADMIT-IDGVMECWLILQYCPRGSLYMELTS-SP-PSLETGVRMVYSACMGLSYLHSSLQ
AqueK682_Aque HDQIE-FADTIELRLYTEYHENGTLQDYLKS-KPVFHFPECHQMAVSLSSGLTYLHKTIV
* : * .* *:* * : : *: .** :
TGFbR1_Hsap --GTQ--GKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSAT-DTID-IAPNHRVGT
BMPR1B_Mmus --STQ--GKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDT-NEVD-IPPNTRVGT
BMPR1A_Mmus --GTQ--GKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDT-NEVD-IPLNTRVGT
ALK7_Mmus --GTQ--GKPAIAHRDIKSKNILVKKCDTCAIADLGLAVKHDSIM-NTID-IPQNPKVGT
ALK4_Mmus --GTQ--GKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVT-DTID-IAPNQRVGT
ALK2_Mmus --GTQ--GKSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQST-NQLD-VGNNPRVGT
ALK1_Mmus --GTQ--GKPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQSS-DYLD-IGNNPRVGT
daf-1_Cele --GSKESNKPAMAHRDIKSKNIMVKNDLTCAIGDLGLSLSKPEDAASDII-ANENYKCGT
BMPR1A_Hsap --GTQ--GKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDT-NEVD-VPLNTRVGT
BMPR1B_Hsap --STQ--GKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDT-NEVD-IPPNTRVGT
ALK7_Hsap --GTQ--GKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSIL-NTID-IPQNPKVGT
ALK4_Hsap --GTQ--GKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVT-DTID-IAPNQRVGT
tkv_Dmel --GTP--GKPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSEL-DVIH-IAQNPRVGT
SAX_Dmel --GKQ--GKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVT-GQLD-LGNNPKVGT
BABO_Dmel --GTR--GKPAIAHRDLKSKNILVKSNLSCAIGDLGLAVRHVEKN-DSVD-IPSTHRVGT
TGFBR1_Mmus --GTQ--GKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSAT-DTID-IAPNHRVGT
sma-6_Cele --GTGSFRKPEIAHRDIKSKNIIVKRPNVCCIADLGLALRYQND--KILP-EKFNVQVGT
ALK2_Hsap --GTQ--GKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQST-NQLD-VGNNPRVGT
ALK1_Hsap --GTQ--GKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGS-DYLD-IGNNPRVGT
TGFbR1_Spur --GMQ--GKPAIAHRDIKSKNILVKRNGQCAIADLGLAVRHDSVT-DTVD-IFPNNRIGT
ALK2_Spur --CNN--SKPAIAHRDIKTKNILVKRNLTCCIADLGLAVLHTQRE-DNID-MGTNTRVGT
BMPR1_Spur --GMQ--GKPAIAHRDVKSSNIMVRKNGTCMIADMSLAARFLSEG-NEID-LGQNTRLGT
AqueK680_Aque --GTQ--GKPSVAHRDIKSKNILVKNDSTCCIADFGLAVNYL-------N-FNNNVQQGT
AqueK681_Aque GYGPI--AKPRIAHRDIKSKNILMKTAETCCIADFGLSIADSED-F---QS-FICLKQGT
AqueK682_Aque --AGK--IKPGIAHRDLKSSNILVKTDYTLCIADLGLAIKQSESG-DGVDQIPANKLSGT
*. :****.*: *::: *.*:.*: **
TGFbR1_Hsap KRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI--G---------------
BMPR1B_Mmus KRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEIARRCVS--G---------------
BMPR1A_Mmus KRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCIT--G---------------
ALK7_Mmus KRYMAPEMLDDTMNLSIFESFKRADIYSVGLVYWEIARRCSV--G---------------
ALK4_Mmus KRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNS--G---------------
ALK2_Mmus KRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS--N---------------
ALK1_Mmus KRYMAPEVLDEHIRTDCFESYKWTDIWAFGLVLWEIARRTII--N---------------
daf-1_Cele VRYLAPEILNSTMQFTVFESYQCADVYSFSLVMWETLCRCED--G---------------
BMPR1A_Hsap KRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCIT--G---------------
BMPR1B_Hsap KRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVS--G---------------
ALK7_Hsap KRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSV--G---------------
ALK4_Hsap KRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNS--G---------------
tkv_Dmel RRYMAPEVLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTK------------
SAX_Dmel KRYMAPEVLDESIDLECFEALRRTDIYAFGLVLWEVCRRTIS--C---------------
BABO_Dmel KRYMAPEVLDESMNDQHFDSYKRADVYAFGLILWEIARRCNM--G---------------
TGFBR1_Mmus KRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI--G---------------
sma-6_Cele KRYMAPELISNKLNPKDFSQFKMADIYSMALVMWEVAIRVEV--NTCEEVLTVDETSPDH
ALK2_Hsap KRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS--N---------------
ALK1_Hsap KRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIV--N---------------
TGFbR1_Spur KRYMAPEVLDDTINMNHFDSFKRADVYSFGLVLWEIGRRCQV--F---------------
ALK2_Spur KRYMAPELLEETMDVRCFESFKRVDVYAFGLVMWEIARRCEV--G---------------
BMPR1_Spur TRYLPPEVLDNVLMSNTFDAFKMADMYSFGMVLWEIARRC--------------------
AqueK680_Aque KRYMPPEVIKGTIDVHSFESFLRADIYSFGLVMWEVCTRCHL--E---------------
AqueK681_Aque NRYMAPEILNETIDVKDFVSFLRADVYSFALVAWEVFNRCNIEQG---------------
AqueK682_Aque KRYMSPEILNESLDYGRFICYAQSDIYSFSLIIWEIFNCCEI--D---------------
**:.**::. : * *:::..:: **
TGFbR1_Hsap --------------------------------GIHE---DYQLPYYDLVPSDPSVEEMRK
BMPR1B_Mmus --------------------------------GIVE---EYQLPYHDLVPSDPSYEDMRE
BMPR1A_Mmus --------------------------------GIVE---EYQLPYYNMVPSDPSYEDMRE
ALK7_Mmus --------------------------------GVVE---EYQLPYYDMVPSDPSIEEMRK
ALK4_Mmus --------------------------------GVHE---DYQLPYYDLVPSDPSIEEMRK
ALK2_Mmus --------------------------------GIVE---DYKPPFYDVVPNDPSFEDMRK
ALK1_Mmus --------------------------------GIVE---DYRPPFYDMVPNDPSFEDMKK
daf-1_Cele --------------------------------DVLPREAATVIPYIEWTDRDPQDAQMFD
BMPR1A_Hsap --------------------------------GIVE---EYQLPYYNMVPSDPSYEDMRE
BMPR1B_Hsap --------------------------------GIVE---EYQLPYHDLVPSDPSYEDMRE
ALK7_Hsap --------------------------------GIVE---EYQLPYYDMVPSDPSIEEMRK
ALK4_Hsap --------------------------------GVHE---EYQLPYYDLVPSDPSIEEMRK
tkv_Dmel -------------------------------TTTCE---DYALPYHDVVPSDPTFEDMHA
SAX_Dmel --------------------------------GIAE---EYKVPFYDVVPMDPSFEDMRK
BABO_Dmel --------------------------------MIYD---EYQLPYYDVVQPDPSIEEMKK
TGFBR1_Mmus --------------------------------GIHE---DYQLPYYDLVPSDPSVEEMRK
sma-6_Cele SASSGIGESVSSSGNISRMHLQKTNVEGHSTSLKAK---QHVPPFDGIVHNDPNFDEMND
ALK2_Hsap --------------------------------GIVE---DYKPPFYDVVPNDPSFEDMRK
ALK1_Hsap --------------------------------GIVE---DYRPPFYDVVPNDPSFEDMKK
TGFbR1_Spur --------------------------------GIYE---EFCLPYHPWVPMDPPIDDMRR
ALK2_Spur --------------------------------GMVA---DYKPPFFEYVPSDPSFDDMRK
BMPR1_Spur ------------------------------------------------------------
AqueK680_Aque --------------------------------GPLA---DYALPFQSQVPPDPTLDDMTE
AqueK681_Aque --------------------------------GIAR---EYQLPYSDHLPNNSSIEDCRR
AqueK682_Aque --------------------------------GVPR---SYQLPYCEWVPTDPDIDQMKQ
TGFbR1_Hsap VVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTA-LRIKKT--L
BMPR1B_Mmus IVCMKKLRPSFPNRWSSDECLRQMGKLMTECWAQNPASRLTA-LRVKKT--L
BMPR1A_Mmus VVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTA-LRIKKT--L
ALK7_Mmus VVCDQKLRPNLPNQWQSCEALRVMGRIMRECWYANGAARLTA-LRVKKT--I
ALK4_Mmus VVCDQKLRPNVPNWWQSYEALRVMGKMMRECWYANGAARLTA-LRIKKT--L
ALK2_Mmus VVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTA-LRIKKT--L
ALK1_Mmus VVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTA-LRIKKT--L
daf-1_Cele VVCTRRLRPTENPLWKDHPEMK-----------------------------H
BMPR1A_Hsap VVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTA-LRIKKT--L
BMPR1B_Hsap IVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTA-LRVKKT--L
ALK7_Hsap VVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTA-LRIKKT--I
ALK4_Hsap VVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTA-LRIKKT--L
tkv_Dmel VVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTA-LRVKKT--L
SAX_Dmel VVCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPA-LRIKKT--I
BABO_Dmel VVCIEKCRPNIPNRWHASDVLHNMAKVMKECWYPNPVARLTA-LRIKKT--L
TGFBR1_Mmus VVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTA-LRIKKT--L
sma-6_Cele VICVRRIRPPPDLAWKNVPALNELSKLMEDSWHSIPHFRHSA-LKLKKEMAE
ALK2_Hsap VVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTA-LRIKKT--L
ALK1_Hsap VVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTA-LRIKKT--L
TGFbR1_Spur IVCIEKRRPPVPNRWNSHKIMESYAKVMKECWYQNGAARLTA-LRIKKT--L
ALK2_Spur VACIEKLRPNIPNRWTNNTVLTSMAKLMKECWCPTASARHTS-LRVKKT--L
BMPR1_Spur ----------------------------------------------------
AqueK680_Aque FIVGKEVIPEIPETWSNNELLRGMSRVMYECWYHQPTARPSA-YYIRK---K
AqueK681_Aque VVVEEGTRP-VTSEWSKTRFLEKLSVTIKELWAERGSERPSIELLRKKI--E
AqueK682_Aque CVCVNNRRPTIPDSWTESETLSPIAKLLDSSWATQASSRISA-LRISK---I