TGFbR1_Hsap MEAAVAAPRPRLLLLVLAAAA---------------------------------------
BMPR1B_Mmus MLLRSSGK--L---NVGTK-----------------------------------------
BMPR1A_Mmus MTQLYTYIRLLGACLFIISHV---------------------------------------
ALK7_Mmus MTPARGSALS-LALLLVALAA---------------------------------------
ALK4_Mmus MAESAGASSFFPLVVLLLAG----------------------------------------
ALK2_Mmus MVDGVMILPV-LMM-MAFPSPSVE------------------------------------
ALK1_Mmus MTLGSFRRGL-LMLSVAFGLTRGD------------------------------------
daf-1_Cele MRIRHVVFCL--LA-LVYGAETSD------------------------------------
BMPR1A_Hsap MPQLYIYIRLLGAYLFIISRV---------------------------------------
BMPR1B_Hsap MLLRSAGK--L---NVGTK-----------------------------------------
ALK7_Hsap MTRALCSALR-QALLLLAAAA---------------------------------------
ALK4_Hsap MAESAGASSFFPLVVLLLAG----------------------------------------
tkv_Dmel MGSEFSANVQPDVEAMAAAAL---------------------------------------
SAX_Dmel MESNIYLVFL-LTF-LLYNNARAE-----------I-----------------------S
BABO_Dmel MLSALRLI---FLGALLGASVCAS-----------PIEFVMDTSLNGSRSDPATATHPGK
TGFBR1_Mmus MEAAAAAPRRPQLLIVLVAAA---------------------------------------
sma-6_Cele MNITFIFI---LIFGFFNTQKCSKDYDHFDDEDLAL------------------------
ALK2_Hsap MVDGVMILPV-LIM-IALPSPSME------------------------------------
ALK1_Hsap MTLGSPRKGL-LMLLMAL-VTQGD------------------------------------
TGFbR1_Spur MEII--------------------------------------------------------
ALK2_Spur MRASQDVY----VADL--A----H------------------------------------
BMPR1_Spur MSYTYMRYYEVLA-----------------------------------------------
AqueK680_Aque LPFITSE-------ITSATH-SHT------------------------------------
AqueK681_Aque MIILILI-------LFLLSP----------------------------------------
AqueK682_Aque M-----------------------------------------------------------
:
TGFbR1_Hsap ------------------------------------------------------------
BMPR1B_Mmus ------------------------------------------------------------
BMPR1A_Mmus ------------------------------------------------------------
ALK7_Mmus ------------------------------------------------------------
ALK4_Mmus ------------------------------------------------------------
ALK2_Mmus ------------------------------------------------------------
ALK1_Mmus ------------------------------------------------------------
daf-1_Cele ------------------------------------------------------------
BMPR1A_Hsap ------------------------------------------------------------
BMPR1B_Hsap ------------------------------------------------------------
ALK7_Hsap ------------------------------------------------------------
ALK4_Hsap ------------------------------------------------------------
tkv_Dmel ------------------------------------------------------------
SAX_Dmel DHLREDIPDLDMELSSAS------SAHL--------NGK------ELPA--V------P-
BABO_Dmel WPPTTKAPALRAPAGTAGHAYQSPSSSLAADNRSHDNNNASAVSMLLPQDGDASGAVAPA
TGFBR1_Mmus ------------------------------------------------------------
sma-6_Cele ------------------------------------------------------------
ALK2_Hsap ------------------------------------------------------------
ALK1_Hsap ------------------------------------------------------------
TGFbR1_Spur ------------------------------------------------------------
ALK2_Spur ------------------------------------------------------------
BMPR1_Spur ------------------------------------------------------------
AqueK680_Aque ------------------------------------------------------------
AqueK681_Aque ------------------------------------------------------------
AqueK682_Aque ------------------------------------------------------------
TGFbR1_Hsap ---------A--------------------------------------------------
BMPR1B_Mmus --------------------------------K----------------ED---------
BMPR1A_Mmus ---------Q-GQNLDSMLHGTGMKSDLDQKKP----------------EN---------
ALK7_Mmus ------------------------------------------------------------
ALK4_Mmus ---------S--------------------------------------------------
ALK2_Mmus ------------------------------------------------------------
ALK1_Mmus ------------------------------------------------------------
daf-1_Cele ---------DDL--------------------D----------------ERTNIFIRDKL
BMPR1A_Hsap ---------Q-GQNLDSMLHGTGMKSDSDQKKS----------------EN---------
BMPR1B_Hsap --------------------------------K----------------ED---------
ALK7_Hsap ------------------------------------------------------------
ALK4_Hsap ---------S--------------------------------------------------
tkv_Dmel ---------S-G-----MEMGSGPGS-EGYE-D----------------AD---------
SAX_Dmel ------------------------------------------------------------
BABO_Dmel VTPQLPIYIA--------------------------------------------------
TGFBR1_Mmus ------------------------------------------------------------
sma-6_Cele ---------SI---------------------PKNAIGVPKEFRQQVLKEM---------
ALK2_Hsap ------------------------------------------------------------
ALK1_Hsap ------------------------------------------------------------
TGFbR1_Spur ------------------------------------------------------------
ALK2_Spur ------------------------------------------------------------
BMPR1_Spur ------------------------------------------------------------
AqueK680_Aque --------------------------------------------------R---------
AqueK681_Aque ------------------------------------------------------------
AqueK682_Aque ------------------------------------------------------------
TGFbR1_Hsap ------AAAALLPGATALQCF------CHL----CT-------------------KDNFT
BMPR1B_Mmus -----GESTAPTPRPKILRCK------CHH-H--CPE-----------------DSVNNI
BMPR1A_Mmus -----GVTLAPEDTLPFLKCY------CSG-H--CPD-----------------DAINNT
ALK7_Mmus -------D--LA---AGLKCV------CLL----CD-------------------SSNFT
ALK4_Mmus ------GG-SGPRGIQALLCA------CTS----CL-------------------QTNYT
ALK2_Mmus -------DEKPKVNQKLYMCV------CEG-L--S------------------CGN-EDH
ALK1_Mmus -------LAKP---SKLVNCT------CES-P--H------------------CKR--PF
daf-1_Cele IPALKLAEVTKVNFTRLHLCH------CSR-EVGCNARTTGWVPGIEFLNETDRSFYENT
BMPR1A_Hsap -----GVTLAPEDTLPFLKCY------CSG-H--CPD-----------------DAINNT
BMPR1B_Hsap -----GESTAPTPRPKVLRCK------CHH-H--CPE-----------------DSVNNI
ALK7_Hsap -------E--LS---PGLKCV------CLL----CD-------------------SSNFT
ALK4_Hsap ------GG-SGPRGVQALLCA------CTS----CL-------------------QANYT
tkv_Dmel -----NEKSKTVENARSLTCY------CDG-S--CPD-----------------NVSNGT
SAX_Dmel -------QNSVQ-THPRYKCY-----SCEP-P--CRD----------------PYEFTHT
BABO_Dmel ------QPSAKKP-ENKIKCH------CDT----CK-------------------ESNNI
TGFBR1_Mmus ---------TLLPGAKALQCF------CHL----CT-------------------KDNFT
sma-6_Cele -----KLRNRPN-DILKNRCY------CNY-D--QSI----------------C-GNNMT
ALK2_Hsap -------DEKPKVNPKLYMCV------CEG-L--S------------------CGN-EDH
ALK1_Hsap -------PVKPSR-GPLVTCT------CES-P--H------------------CKG--PT
TGFbR1_Spur ------------------------------------------------------------
ALK2_Spur -------Q--VN-NSVTLQCN------CDD-Y--S------------------CEG-TNR
BMPR1_Spur --------------TKMLYCY------CDE-H--CPE-----------------ITRNNT
AqueK680_Aque -----S-L--PLPPLPNNNIYTHPLTSAKTPS--CDI-----------------YAFLHT
AqueK681_Aque -------L--IISGTTGVQCF------ETQDG--CSL-----------------T--AGV
AqueK682_Aque ------------------------------------------------------------
TGFbR1_Hsap CVT--DGLCFVSVTETT-------DKV-----IHNSMCIAEIDLI-----PR--DRPFVC
BMPR1B_Mmus CST--DGYCFTMIEEDD------SGMP-----VVTSGCLGLE------------GSDFQC
BMPR1A_Mmus CIT--NGHCFAIIEEDD------QGET-----TLTSGCMKYE------------GSDFQC
ALK7_Mmus CQT--EGACWASVMLTN-------GKE-----QVIKSCVSLPEL----------NAQVFC
ALK4_Mmus CET--DGACMVSIFNLD-------GVE-----HHVRTCIPKVELV-----PA--GKPFYC
ALK2_Mmus CEG---QQCFSSLSIN-------DGF-----HVYQKGCFQVYE-----------QGKMTC
ALK1_Mmus CQG---SWCTVVLVRE-------QGRH----PQVYRGCGSLNQ--------------ELC
daf-1_Cele CYT--DGSCYQSARPS-------P--E-----ISHFGCMDEKSVTDETEFHD--TAAKVC
BMPR1A_Hsap CIT--NGHCFAIIEEDD------QGET-----TLASGCMKYE------------GSDFQC
BMPR1B_Hsap CST--DGYCFTMIEEDD------SGLP-----VVTSGCLGLE------------GSDFQC
ALK7_Hsap CQT--EGACWASVMLTN-------GKE-----QVIKSCVSLPEL----------NAQVFC
ALK4_Hsap CET--DGACMVSIFNLD-------GME-----HHVRTCIPKVELV-----PA--GKPFYC
tkv_Dmel CETRPGGSCFSAVQQLY------DETTGMYEEERTYGCMPPEDN----------GGFLMC
SAX_Dmel CQN--AIQCWKSRTRDA------DGQ-----VQESRGCSTSPD-----------QLPMIC
BABO_Dmel CET--DGFCFTSVEKNS------DGSI-----IFSYSCMVVKYNM-----QR--SKPFEC
TGFBR1_Mmus CET--DGLCFVSVTETT-------DKV-----IHNSMCIAEIDLI-----PR--DRPFVC
sma-6_Cele CVKQDGAACYHAVEEVY------NKAEKRMETLHKWGCATLERGS------G--ASHLTC
ALK2_Hsap CEG---QQCFSSLSIN-------DGF-----HVYQKGCFQVYE-----------QGKMTC
ALK1_Hsap CRG---AWCTVVLVRE-------EGRH----PQEHRGCGNLHR--------------ELC
TGFbR1_Spur ------------------------------------------------------------
ALK2_Spur CEA--LRKCFSSITEV-------DGI-----IMKRMGCVNTEE-----------QFNMFC
BMPR1_Spur CYPSPGGWCFAQIQAGE------DGVEH-ETPIRSYGCLAPEED----------GGLMQC
AqueK680_Aque CIS--AIERWTSRGRSA------DGY-----SRRGRGCSTCKLTV-----SWSQQNKE--
AqueK681_Aque CNA--ST-CYMRILAKANPRNISEHQ-----FSYIYGCLPEEEGG-----NGPSVIASLC
AqueK682_Aque ------------------------------------------------------------
TGFbR1_Hsap AP-SS---------KTG-SVTTTYCCN-QDHCNKIEL--PTT------------------
BMPR1B_Mmus RD-TP---------IPH-QRRSIECCTERNECNKDLH--PTL------------------
BMPR1A_Mmus KD-SP---------KAQ-LRRTIECCR-TNLCNQYLQ--PTL------------------
ALK7_Mmus HS-SN-------------NVTKTECCF-TDFCNNITLHLPTA------------------
ALK4_Mmus LS-SE-------------DLRNTHCCY-IDFCNKIDLRVPSG------------------
ALK2_Mmus KT-PP-----------S-PGQAVECCQ-GDWCNRNIT--AQL------------------
ALK1_Mmus LG-RP-----------T-EFLNHHCCY-RSFCNHNVS--LML------------------
daf-1_Cele TN-NT---------KDPH-ATVWICCDKGNFCANETI--IHL------------------
BMPR1A_Hsap KD-SP---------KAQ-LRRTIECCR-TNLCNQYLQ--PTL------------------
BMPR1B_Hsap RD-TP---------IPH-QRRSIECCTERNECNKDLH--PTL------------------
ALK7_Hsap HS-SN-------------NVTKTECCF-TDFCNNITLHLPTA------------------
ALK4_Hsap LS-SE-------------DLRNTHCCY-TDYCNRIDLRVPSG------------------
tkv_Dmel KV-AA---------VPHLHGKNIVCCDKEDFCNRDLY--PTY------------------
SAX_Dmel SQ-NSLKINGPSKRNTG-KFVNVVCCA-GDYCNEGDF--PEL------------------
BABO_Dmel LT-SN---------ERF-DTYRIDCCK-SDFCNKNEIMK-RI------------------
TGFBR1_Mmus AP-SS---------KTG-AVTTTYCCN-QDHCNKIEL--PTT------------------
sma-6_Cele NS-WR---------AAHHSPKSIGCCYEGNYCNKNLI--PPA------------------
ALK2_Hsap KT-PP-----------S-PGQAVECCQ-GDWCNRNIT--AQL------------------
ALK1_Hsap RG-RP-----------T-EFVNHYCCD-SHLCNHNVS--LVL------------------
TGFbR1_Spur ------------------------------------------------------------
ALK2_Spur KM-HP-----------Y-PDISVLCCN-RSFCNNDLQ--PTF------------------
BMPR1_Spur KG-QL---------SNHRISRTVYCCNDEPNCNLKLN--PTL------------------
AqueK680_Aque -SPSE---------QPVNKVMHFFCCD-DDYCNQDIM--HSI------------------
AqueK681_Aque SGPAS---------WDRELLISYTCCT-SDHCNKNIE--PRHDIESLLINRYNNDSNDQE
AqueK682_Aque ------------------------------------------------------------
TGFbR1_Hsap --------------------------------------------------------VK--
BMPR1B_Mmus --------------------------------------------------------PPL-
BMPR1A_Mmus --------------------------------------------------------PPV-
ALK7_Mmus --------------------------------------------------------S---
ALK4_Mmus --------------------------------------------------------HL--
ALK2_Mmus ---------------------------------------------------------PT-
ALK1_Mmus ---------------------------------------------------------EA-
daf-1_Cele --------------------------------------------------------APG-
BMPR1A_Hsap --------------------------------------------------------PPV-
BMPR1B_Hsap --------------------------------------------------------PPL-
ALK7_Hsap --------------------------------------------------------S---
ALK4_Hsap --------------------------------------------------------HL--
tkv_Dmel --------------------------------------------------------TPK-
SAX_Dmel --------------------------------------------------------LPF-
BABO_Dmel ---------------------------------------------------------F--
TGFBR1_Mmus --------------------------------------------------------GPF-
sma-6_Cele --------------------------------------------------------YVHH
ALK2_Hsap ---------------------------------------------------------PT-
ALK1_Hsap ---------------------------------------------------------EA-
TGFbR1_Spur ------------------------------------------------------------
ALK2_Spur --------------------------------------------------------LPT-
BMPR1_Spur --------------------------------------------------------PPT-
AqueK680_Aque --------------------------------------------------------LES-
AqueK681_Aque SSSVFVSSSVPSSSSVPILPSVPILLSVPISPSVPISPSVPISFSSSYQYLYDLTSLPT-
AqueK682_Aque ------------------------------------------------------------
TGFbR1_Hsap -------------S--------------------------------------------SP
BMPR1B_Mmus ----------KDRDF---------------------------------------------
BMPR1A_Mmus ----------VIGPF---------------------------------------------
ALK7_Mmus ------------PN--------------------------------------------AP
ALK4_Mmus ----------KEPA--------------------------------------------HP
ALK2_Mmus ----------KGKSF----------------P----------------------------
ALK1_Mmus ----------TQTPS----------------E----------------------------
daf-1_Cele -----------------------------------------------------------P
BMPR1A_Hsap ----------VIGPF---------------------------------------------
BMPR1B_Hsap ----------KNRDF---------------------------------------------
ALK7_Hsap ------------PN--------------------------------------------AP
ALK4_Hsap ----------KEPE--------------------------------------------HP
tkv_Dmel ----------LTTPA----------------P-------------------------DLP
SAX_Dmel ----------DSNDV----------------T-------------------------VIT
BABO_Dmel ----------ETDY--------------------------------------------VP
TGFBR1_Mmus ----------SEKQ--------------------------------------------SA
sma-6_Cele HKEKALQEKTDNPED----------------Y-------------------------DSP
ALK2_Hsap ----------KGKSF----------------P----------------------------
ALK1_Hsap ----------TQPPS----------------E----------------------------
TGFbR1_Spur ------------------------------------------------------------
ALK2_Spur ----------TTPR----------------------------------------------
BMPR1_Spur ----------TTSTT----------------T-------------------------ELP
AqueK680_Aque ----------VS---------------------------------------------ATP
AqueK681_Aque ----------KDTSTFNNPSIIIYFSEPTNDPHLYDLTSLPTKDTSTFNNSSIIIYFSEP
AqueK682_Aque ------------------------------------------------------------
TGFbR1_Hsap G-----L-GPVE-LAAVIAGPVCFVCI---SLMLMVY-I-CH-NRTVIH--HRVP---N-
BMPR1B_Mmus -----VD-GPIHHKALLISVTVCSLLL---VLII-LFCY-FR-YKRQ-E--ARPR-Y-S-
BMPR1A_Mmus -----FD-GSIRWLVVLISMAVCIVAM---IIFSSCFCY-KH-YCKSIS--SRGR-Y-N-
ALK7_Mmus R-----L-GPTE-LTVVITVPVCLLSI---AAMLTIWAC-QD-RQCTYR--KTKR-H-N-
ALK4_Mmus S----MW-GPVE-LVGIIAGPVFLLFL---IIIIVFLVI-NY-HQRVYH--NRQR-L-D-
ALK2_Mmus G----TQ-NFHLEVGLIILSVVFAVCL---LACILGVAL-RK-FKRRNQ--ERLNPR-D-
ALK1_Mmus E-----P-EVDAHLP-LILGPVLALPV---LVALGALGL-WR-VRRRQE--KQRD-L-H-
daf-1_Cele Q----QS-S--TWLILTILA---LLT-FIVLLGIAIFL-TRKSWEAKFDWYIRFKPKPGD
BMPR1A_Hsap -----FD-GSIRWLVLLISMAVCIIAM---IIFSSCFCY-KH-YCKSIS--SRRR-Y-N-
BMPR1B_Hsap -----VD-GPIHHRALLISVTVCSLLL---VLII-LFCY-FR-YKRQ-E--TRPR-Y-S-
ALK7_Hsap K-----L-GPME-LAIIITVPVCLLSI---AAMLTVWAC-QG-RQCSYR--KKKR-P-N-
ALK4_Hsap S----MW-GPVE-LVGIIAGPVFLLFL---IIIIVFLVI-NY-HQRVYH--NRQR-L-D-
tkv_Dmel V----SS-ESLHTLAVFGSIIISLSVF---MLIVASLCF--T-YKRREK--LRKQ-P-R-
SAX_Dmel A----DT-SSISKMLVAVLGPFLVIAL---LGAVTIFFI-RRSHRKRLA--ASRTKQ-D-
BABO_Dmel H----RL-TSWE-FVAIILGATLFICF---TGTSTWYYC-QR-RKRMAS--GR-T-F-A-
TGFBR1_Mmus G-----L-GPVE-LAAVIAGPVCFVCI---ALMLMVY-I-CH-NRTVIH--HRVP---N-
sma-6_Cele L----ENMTRGGKMFIMVFATVMSV--FAV-IGCIYLC-ITRA-EEKSK--ARARAK-T-
ALK2_Hsap G----TQ-NFHLEVGLIILSVVFAVCL---LACLLGVAL-RK-FKRRNQ--ERLNPR-D-
ALK1_Hsap Q-----P-GTDGQLA-LILGPVLALLA---LVALGVLGL-WH-VRRRQE--KQRG-L-H-
TGFbR1_Spur ------------------------------------------------------------
ALK2_Spur ------------------------------------------------------------
BMPR1_Spur GVEDTYN-TTVHQIALLISVTFCAAAF---IIALT-FFY-LR-YKKR-E--VRRR-Y-D-
AqueK680_Aque T----VS-SNDPSLYIIILVTIISSCIILIILFFALFIFCKRK-RDRRL--PRQRTN-D-
AqueK681_Aque T----NDPQQISDLNTVIPVIVVLLVIAAVIILLAI--FIHRR-STKSN--NRGKQR-G-
AqueK682_Aque ------------------------------------------------------------
TGFbR1_Hsap -EEDPSLDRPF----------------------------------ISEGTTLKDLIYD-M
BMPR1B_Mmus -IGL-EQDETY----------------------------------IPPGESLRDLIEQ-S
BMPR1A_Mmus -RDL-EQDEAF----------------------------------IPVGESLKDLIDQ-S
ALK7_Mmus -VEEALAEYSL----------------------------------VNAGKTLKDLIYD-A
ALK4_Mmus -MEDPSC-EMC----------------------------------LSKDKTLQDLVYD-L
ALK2_Mmus -VEYGT-IEGLI-T------------------------------TNVGDSTLAELLDH-S
ALK1_Mmus -SDLGE-SSLILKA------------------------------SEQADSMLGDFLDS-D
daf-1_Cele PLRETENNVPMVTMGDGAGSSVPEVAPIEQQGSTMSTSAGNSFPPGIMPNNMKDMLDVLE
BMPR1A_Hsap -RDL-EQDEAF----------------------------------IPVGESLKDLIDQ-S
BMPR1B_Hsap -IGL-EQDETY----------------------------------IPPGESLRDLIEQ-S
ALK7_Hsap -VEEPLSECNL----------------------------------VNAGKTLKDLIYD-V
ALK4_Hsap -MEDPSC-EMC----------------------------------LSKDKTLQDLVYD-L
tkv_Dmel -L--I--NSMC----------------------------------NSQLSPLSQLVE---
SAX_Dmel -PEAYLVNDELLRA------------------------------TSAGDSTLREYLQH-S
BABO_Dmel -KEDSA-YDPI----------------------------------LNGNTTIHDIIEM--
TGFBR1_Mmus -EEDPSLDRPF----------------------------------ISEGTTLKDLIYD-M
sma-6_Cele -VSL-KTE-----------------------------------------STYMESKSM-L
ALK2_Hsap -VEYGT-IEGLI-T------------------------------TNVGDSTLADLLDH-S
ALK1_Hsap -SELGE-SSLILKA------------------------------SEQGDSMLGDLLDS-D
TGFbR1_Spur ------------------------------------------------------------
ALK2_Spur -----------I----------------------------------TEGLFCFDLFDH-S
BMPR1_Spur -FEVAQQDDSF----------------------------------IGPGETLSELLEK-S
AqueK680_Aque -PDV-HLTEPH--H------------------------------SNGNGNDLTSFLQM-S
AqueK681_Aque -NEG----S----T------------------------------KVRP-EDVEREMEI-L
AqueK682_Aque ------------------------------------------------------------
TGFbR1_Hsap TTSGSG-SGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWF
BMPR1B_Mmus QSSGSG-SGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWF
BMPR1A_Mmus QSSGSG-SGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWF
ALK7_Mmus TASGSG-SGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWF
ALK4_Mmus STSGSG-SGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWF
ALK2_Mmus CTSGSG-SGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWF
ALK1_Mmus CTTGSG-SGLPFLVQRTVARQVALVECVGKGRYGEVWRGSWHGESVAVKIFSSRDEQSWF
daf-1_Cele ETSGSG-MGPTTLHKLTIGGQIRLTGRVGSGRFGNVSRGDYRGEAVAVKVFNALDEPAFH
BMPR1A_Hsap QSSGSG-SGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWF
BMPR1B_Hsap QSSGSG-SGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWF
ALK7_Hsap TASGSG-SGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWF
ALK4_Hsap STSGSG-SGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWF
tkv_Dmel QSSGSG-SGLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEEASWF
SAX_Dmel VTSGSG-SGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWK
BABO_Dmel TTSGSGSAGLPLLVQRSIARQVQLCHVIGKGRFGEVWRGRWRGENVAVKIFSSREECSWF
TGFBR1_Mmus TTSGSG-SGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWF
sma-6_Cele EDSGSG-SGQAALIQRTVRQDLTIIKTIGQGRYGEVRKALYRGSYVAVKTFYTTDEDSWK
ALK2_Hsap CTSGSG-SGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWF
ALK1_Hsap CTTGSG-SGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF
TGFbR1_Spur -----GIQGLPLLVQRTIARQIVIQDCIGKGRYGEVYRGKWRGESVAVKIFSSREERSWF
ALK2_Spur NTSGSG-SGLPYLVQRTVARQINLLQQVGKGRYGEVWMGTWQGDTVAVKIFSSIDEKSWF
BMPR1_Spur SASGSG-SGLPLLVQRTIAKQVQLIRKIGKGRYGEVWKAKWRGENVAVKIYFTAEEASWF
AqueK680_Aque FTSGSG-AGMPFLVKRTIARSILLGESIGGGRFGQVYVGHYQGERYAVKKFFSKDEQSWF
AqueK681_Aque STSGSG-MGERVLTSRTIAMDITIHEHLGRGTYGSISRCTYRGNTFAVKRFTTINESSFR
AqueK682_Aque ------------------SHDVTKISVIGQGRFGKVWRCSYEEKHIAMKVFKNMHMAVFK
: :* * :*.: : *:* : . :
TGFbR1_Hsap REAEIYQTVMLRHENILGFIAADNKD-NGTWTQLWLVSDYHEHGSLFDYLNR-YT-VTVE
BMPR1B_Mmus RETEIYQTVLMRHENILGFIAADIKG-TGSWTQLYLITDYHENGSLYDYLKS-TT-LDAK
BMPR1A_Mmus RETEIYQTVLMRHENILGFIAADIKG-TGSWTQLYLITDYHENGSLYDFLKC-AT-LDTR
ALK7_Mmus REAEIYQTVMLRHENILGFIAADNKD-NGTWTQLWLVSEYHEQGSLYDYLNR-NI-VTVA
ALK4_Mmus REAEIYQTVMLRHENILGFIAADNKD-NGTWTQLWLVSDYHEHGSLFDYLNR-YT-VTIE
ALK2_Mmus RETELYNTVMLRHENILGFIASDMTS-RHSSTQLWLITHYHEMGSLYDYLQL-TT-LDTV
ALK1_Mmus RETEIYNTVLLRHDNILGFIASDMTS-RNSSTQLWLITHYHEHGSLYDFLQR-QT-LEPQ
daf-1_Cele KETEIFETRMLRHPNVLRYIGSDRVD-TGFVTELWLVTEYHPSGSLHDFLLE-NT-VNIE
BMPR1A_Hsap RETEIYQTVLMRHENILGFIAADIKG-TGSWTQLYLITDYHENGSLYDFLKC-AT-LDTR
BMPR1B_Hsap RETEIYQTVLMRHENILGFIAADIKG-TGSWTQLYLITDYHENGSLYDYLKS-TT-LDAK
ALK7_Hsap REAEIYQTVMLRHENILGFIAADNKD-NGTWTQLWLVSEYHEQGSLYDYLNR-NI-VTVA
ALK4_Hsap REAEIYQTVMLRHENILGFIAADNKD-NGTWTQLWLVSDYHEHGSLFDYLNR-YT-VTIE
tkv_Dmel RETEIYQTVLMRHDNILGFIAADIKG-NGSWTQMLLITDYHEMGSLHDYLSM-SV-INPQ
SAX_Dmel RETEIYSTILLRHENILGFIGSDMTS-RNSCTQLWLMTHYYPLGSLFDHLNR-NA-LSHN
BABO_Dmel REAEIYQTVMLRHENILGFIAADNKD-NGTWTQLWLVTDYHENGSLFDYLTT-HP-VDTN
TGFBR1_Mmus REAEIYQTVMLRHENILGFIAADNKD-NGTWTQLWLVSDYHEHGSLFDYLNR-YT-VTVE
sma-6_Cele NERDVYQTNMINHENILQFVAADIWSEEDSMTKMLLITDYHELGSLSDYLCREET-LTTD
ALK2_Hsap RETELYNTVMLRHENILGFIASDMTS-RHSSTQLWLITHYHEMGSLYDYLQL-TT-LDTV
ALK1_Hsap RETEIYNTVLLRHDNILGFIASDMTS-RNSSTQLWLITHYHEHGSLYDFLQR-QT-LEPH
TGFbR1_Spur REAEIYQTVMLRHENILGFIAADNKD-NGTWTQLILVSDYHENGSLFDYLNS-HV-IDVP
ALK2_Spur RETEIYNTVMLRHENILAFFASDMTS-RQSCTQLWLIMEYHERGSLYDYLNR-HV-LDAR
BMPR1_Spur RETDIYQTVLMRHTSILSFIAADIRG-SGAYTQLFLITEYHEWGSLYDFLNV-NI-LDSQ
AqueK680_Aque HESDIYNSVNLRHDNILTCFATDMLS-NNGVTELWLITQYHPRGSLFEELNR-GG-LTPE
AqueK681_Aque RELGIYSF-SLTQTNILTYIAADMIT-IDGVMECWLILQYCPRGSLYMELTS-SP-PSLE
AqueK682_Aque REVEIYDTYMLYHENILRFIGHDQIE-FADTIELRLYTEYHENGTLQDYLKS-KPVFHFP
.* ::. : : .:* .. * : * .* *:* *
TGFbR1_Hsap GMIKLALSTASGLAHLHMEIV--GTQ--GKPAIAHRDLKSKNILVKKNGTCCIADLGLAV
BMPR1B_Mmus SMLKLAYSSVSGLCHLHTEIF--STQ--GKPAIAHRDLKSKNILVKKNGTCCIADLGLAV
BMPR1A_Mmus ALLKLAYSAACGLCHLHTEIY--GTQ--GKPAIAHRDLKSKNILIKKNGSCCIADLGLAV
ALK7_Mmus GMVKLALSIASGLAHLHMEIV--GTQ--GKPAIAHRDIKSKNILVKKCDTCAIADLGLAV
ALK4_Mmus GMIKLALSAASGLAHLHMEIV--GTQ--GKPGIAHRDLKSKNILVKKNGMCAIADLGLAV
ALK2_Mmus SCLRIVLSIASGLAHLHIEIF--GTQ--GKSAIAHRDLKSKNILVKKNGQCCIADLGLAV
ALK1_Mmus LALRLAVSAACGLAHLHVEIF--GTQ--GKPAIAHRDLKSRNVLVKSNLQCCIADLGLAV
daf-1_Cele TYYNLMRSTASGLAFLHNQIG--GSKESNKPAMAHRDIKSKNIMVKNDLTCAIGDLGLSL
BMPR1A_Hsap ALLKLAYSAACGLCHLHTEIY--GTQ--GKPAIAHRDLKSKNILIKKNGSCCIADLGLAV
BMPR1B_Hsap SMLKLAYSSVSGLCHLHTEIF--STQ--GKPAIAHRDLKSKNILVKKNGTCCIADLGLAV
ALK7_Hsap GMIKLALSIASGLAHLHMEIV--GTQ--GKPAIAHRDIKSKNILVKKCETCAIADLGLAV
ALK4_Hsap GMIKLALSAASGLAHLHMEIV--GTQ--GKPGIAHRDLKSKNILVKKNGMCAIADLGLAV
tkv_Dmel KLQLLAFSLASGLAHLHDEIF--GTP--GKPAIAHRDIKSKNILVKRNGQCAIADFGLAV
SAX_Dmel DMVWICLSIANGLVHLHTEIF--GKQ--GKPAMAHRDLKSKNILVTSNGSCVIADFGLAV
BABO_Dmel TMLNMSLSIATGLAHLHMDIV--GTR--GKPAIAHRDLKSKNILVKSNLSCAIGDLGLAV
TGFBR1_Mmus GMIKLALSTASGLAHLHMEIV--GTQ--GKPAIAHRDLKSKNILVKKNGTCCIADLGLAV
sma-6_Cele EALRLIHSCICGIEHLHAAVH--GTGSFRKPEIAHRDIKSKNIIVKRPNVCCIADLGLAL
ALK2_Hsap SCLRIVLSIASGLAHLHIEIF--GTQ--GKPAIAHRDLKSKNILVKKNGQCCIADLGLAV
ALK1_Hsap LALRLAVSAACGLAHLHVEIF--GTQ--GKPAIAHRDFKSRNVLVKSNLQCCIADLGLAV
TGFbR1_Spur GMLRMALSIATGLAHLHMEIM--GMQ--GKPAIAHRDIKSKNILVKRNGQCAIADLGLAV
ALK2_Spur QMCRLALTACSGLVHLHTEIT--CNN--SKPAIAHRDIKTKNILVKRNLTCCIADLGLAV
BMPR1_Spur SMLRLAYSAANGLAHLHTEIC--GMQ--GKPAIAHRDVKSSNIMVRKNGTCMIADMSLAA
AqueK680_Aque TTLKFIHSTCRGLAYLHLEIT--GTQ--GKPSVAHRDIKSKNILVKNDSTCCIADFGLAV
AqueK681_Aque TGVRMVYSACMGLSYLHSSLQGYGPI--AKPRIAHRDIKSKNILMKTAETCCIADFGLSI
AqueK682_Aque ECHQMAVSLSSGLTYLHKTIV--AGK--IKPGIAHRDLKSSNILVKTDYTLCIADLGLAI
: : *: .** : *. :****.*: *::: *.*:.*:
TGFbR1_Hsap R-----------------------------------------------------------
BMPR1B_Mmus K-----------------------------------------------------------
BMPR1A_Mmus K-----------------------------------------------------------
ALK7_Mmus K-----------------------------------------------------------
ALK4_Mmus R-----------------------------------------------------------
ALK2_Mmus M-----------------------------------------------------------
ALK1_Mmus M-----------------------------------------------------------
daf-1_Cele S-----------------------------------------------------------
BMPR1A_Hsap K-----------------------------------------------------------
BMPR1B_Hsap K-----------------------------------------------------------
ALK7_Hsap K-----------------------------------------------------------
ALK4_Hsap R-----------------------------------------------------------
tkv_Dmel K-----------------------------------------------------------
SAX_Dmel T-----------------------------------------------------------
BABO_Dmel R-----------------------------------------------------------
TGFBR1_Mmus R-----------------------------------------------------------
sma-6_Cele R-----------------------------------------------------------
ALK2_Hsap M-----------------------------------------------------------
ALK1_Hsap M-----------------------------------------------------------
TGFbR1_Spur R-----------------------------------------------------------
ALK2_Spur L-----------------------------------------------------------
BMPR1_Spur RFLSEGNEIDLGQNTRLGTTRYLPPEVLDNVLMSNTFDAFKMADMYSFGMVLWEIARRCV
AqueK680_Aque N-----------------------------------------------------------
AqueK681_Aque A-----------------------------------------------------------
AqueK682_Aque K-----------------------------------------------------------
TGFbR1_Hsap ------------------------------------------------------------
BMPR1B_Mmus ------------------------------------------------------------
BMPR1A_Mmus ------------------------------------------------------------
ALK7_Mmus ------------------------------------------------------------
ALK4_Mmus ------------------------------------------------------------
ALK2_Mmus ------------------------------------------------------------
ALK1_Mmus ------------------------------------------------------------
daf-1_Cele ------------------------------------------------------------
BMPR1A_Hsap ------------------------------------------------------------
BMPR1B_Hsap ------------------------------------------------------------
ALK7_Hsap ------------------------------------------------------------
ALK4_Hsap ------------------------------------------------------------
tkv_Dmel ------------------------------------------------------------
SAX_Dmel ------------------------------------------------------------
BABO_Dmel ------------------------------------------------------------
TGFBR1_Mmus ------------------------------------------------------------
sma-6_Cele ------------------------------------------------------------
ALK2_Hsap ------------------------------------------------------------
ALK1_Hsap ------------------------------------------------------------
TGFbR1_Spur ------------------------------------------------------------
ALK2_Spur ------------------------------------------------------------
BMPR1_Spur TRGFIAADIRGSGAYTQLFLITEYHEWGSLYDFLNVNILDSQSMLRLAYSAANGLAHLHT
AqueK680_Aque ------------------------------------------------------------
AqueK681_Aque ------------------------------------------------------------
AqueK682_Aque ------------------------------------------------------------
TGFbR1_Hsap ---------------------------------------HDSAT-DTID-IAPNHRVGTK
BMPR1B_Mmus ---------------------------------------FISDT-NEVD-IPPNTRVGTK
BMPR1A_Mmus ---------------------------------------FNSDT-NEVD-IPLNTRVGTK
ALK7_Mmus ---------------------------------------HDSIM-NTID-IPQNPKVGTK
ALK4_Mmus ---------------------------------------HDAVT-DTID-IAPNQRVGTK
ALK2_Mmus ---------------------------------------HSQST-NQLD-VGNNPRVGTK
ALK1_Mmus ---------------------------------------HSQSS-DYLD-IGNNPRVGTK
daf-1_Cele ---------------------------------------KPEDAASDII-ANENYKCGTV
BMPR1A_Hsap ---------------------------------------FNSDT-NEVD-VPLNTRVGTK
BMPR1B_Hsap ---------------------------------------FISDT-NEVD-IPPNTRVGTK
ALK7_Hsap ---------------------------------------HDSIL-NTID-IPQNPKVGTK
ALK4_Hsap ---------------------------------------HDAVT-DTID-IAPNQRVGTK
tkv_Dmel ---------------------------------------YNSEL-DVIH-IAQNPRVGTR
SAX_Dmel ---------------------------------------HSHVT-GQLD-LGNNPKVGTK
BABO_Dmel ---------------------------------------HVEKN-DSVD-IPSTHRVGTK
TGFBR1_Mmus ---------------------------------------HDSAT-DTID-IAPNHRVGTK
sma-6_Cele ---------------------------------------YQND-K-ILP-EKFNVQVGTK
ALK2_Hsap ---------------------------------------HSQST-NQLD-VGNNPRVGTK
ALK1_Hsap ---------------------------------------HSQGS-DYLD-IGNNPRVGTK
TGFbR1_Spur ---------------------------------------HDSVT-DTVD-IFPNNRIGTK
ALK2_Spur ---------------------------------------HTQRE-DNID-MGTNTRVGTK
BMPR1_Spur EICGMQGKPAIAHRDVKSSNIMVRKNGTCMIADMSLAARFLSEG-NEID-LGQNTRLGTT
AqueK680_Aque ---------------------------------------YLN--------FNNNVQQGTK
AqueK681_Aque ---------------------------------------DSEDF----Q-SFICLKQGTN
AqueK682_Aque ---------------------------------------QSESG-DGVDQIPANKLSGTK
**
TGFbR1_Hsap RYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI--G------GIHE------
BMPR1B_Mmus RYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEIARRCVS--G------GIVE------
BMPR1A_Mmus RYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCIT--G------GIVE------
ALK7_Mmus RYMAPEMLDDTMNLSIFESFKRADIYSVGLVYWEIARRCSV--G------GVVE------
ALK4_Mmus RYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNS--G------GVHE------
ALK2_Mmus RYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS--N------GIVE------
ALK1_Mmus RYMAPEVLDEHIRTDCFESYKWTDIWAFGLVLWEIARRTII--N------GIVE------
daf-1_Cele RYLAPEILNSTMQFTVFESYQCADVYSFSLVMWETLCRCED--G------DVLP------
BMPR1A_Hsap RYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCIT--G------GIVE------
BMPR1B_Hsap RYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVS--G------GIVE------
ALK7_Hsap RYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSV--G------GIVE------
ALK4_Hsap RYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNS--G------GVHE------
tkv_Dmel RYMAPEVLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYT--PVSGTKTTTCE------
SAX_Dmel RYMAPEVLDESIDLECFEALRRTDIYAFGLVLWEVCRRTIS--C------GIAE------
BABO_Dmel RYMAPEVLDESMNDQHFDSYKRADVYAFGLILWEIARRCNM--G------MIYD------
TGFBR1_Mmus RYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI--G------GIHE------
sma-6_Cele RYMAPELISNKLNPKDFSQFKMADIYSMALVMWEVAIRVEV--N------TCEEVLTVDE
ALK2_Hsap RYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS--N------GIVE------
ALK1_Hsap RYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIV--N------GIVE------
TGFbR1_Spur RYMAPEVLDDTINMNHFDSFKRADVYSFGLVLWEIGRRCQV--F------GIYE------
ALK2_Spur RYMAPELLEETMDVRCFESFKRVDVYAFGLVMWEIARRCEV--G------GMVA------
BMPR1_Spur RYLPPEVLDNVLMSNTFDAFKMADMYSFGMVLWEIARRCVT--R------GIVE------
AqueK680_Aque RYMPPEVIKGTIDVHSFESFLRADIYSFGLVMWEVCTRCHL--E------GPLA------
AqueK681_Aque RYMAPEILNETIDVKDFVSFLRADVYSFALVAWEVFNRCNIEQG------GIAR------
AqueK682_Aque RYMSPEILNESLDYGRFICYAQSDIYSFSLIIWEIFNCCEI--D------GVPR------
**:.**::. : * *:::..:: **
TGFbR1_Hsap -----------------------------------------DYQLPYYDLVPSDPSVEEM
BMPR1B_Mmus -----------------------------------------EYQLPYHDLVPSDPSYEDM
BMPR1A_Mmus -----------------------------------------EYQLPYYNMVPSDPSYEDM
ALK7_Mmus -----------------------------------------EYQLPYYDMVPSDPSIEEM
ALK4_Mmus -----------------------------------------DYQLPYYDLVPSDPSIEEM
ALK2_Mmus -----------------------------------------DYKPPFYDVVPNDPSFEDM
ALK1_Mmus -----------------------------------------DYRPPFYDMVPNDPSFEDM
daf-1_Cele --------------------------------------REAATVIPYIEWTDRDPQDAQM
BMPR1A_Hsap -----------------------------------------EYQLPYYNMVPSDPSYEDM
BMPR1B_Hsap -----------------------------------------EYQLPYHDLVPSDPSYEDM
ALK7_Hsap -----------------------------------------EYQLPYYDMVPSDPSIEEM
ALK4_Hsap -----------------------------------------EYQLPYYDLVPSDPSIEEM
tkv_Dmel -----------------------------------------DYALPYHDVVPSDPTFEDM
SAX_Dmel -----------------------------------------EYKVPFYDVVPMDPSFEDM
BABO_Dmel -----------------------------------------EYQLPYYDVVQPDPSIEEM
TGFBR1_Mmus -----------------------------------------DYQLPYYDLVPSDPSVEEM
sma-6_Cele TSPDHSASSGIGESVSSSGNISRMHLQKTNVEGHSTSLKAKQHVPPFDGIVHNDPNFDEM
ALK2_Hsap -----------------------------------------DYKPPFYDVVPNDPSFEDM
ALK1_Hsap -----------------------------------------DYRPPFYDVVPNDPSFEDM
TGFbR1_Spur -----------------------------------------EFCLPYHPWVPMDPPIDDM
ALK2_Spur -----------------------------------------DYKPPFFEYVPSDPSFDDM
BMPR1_Spur -----------------------------------------ECQLPFYDAVPMDPSIQDM
AqueK680_Aque -----------------------------------------DYALPFQSQVPPDPTLDDM
AqueK681_Aque -----------------------------------------EYQLPYSDHLPNNSSIEDC
AqueK682_Aque -----------------------------------------SYQLPYCEWVPTDPDIDQM
*: :. :
TGFbR1_Hsap RKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQ-E-
BMPR1B_Mmus REIVCMKKLRPSFPNRWSSDECLRQMGKLMTECWAQNPASRLTALRVKKTLAKMSES-Q-
BMPR1A_Mmus REVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVES-Q-
ALK7_Mmus RKVVCDQKLRPNLPNQWQSCEALRVMGRIMRECWYANGAARLTALRVKKTISQLCVK-E-
ALK4_Mmus RKVVCDQKLRPNVPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQ-E-
ALK2_Mmus RKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNS-LD
ALK1_Mmus KKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKLSHN-PE
daf-1_Cele FDVVCTRRLRPTENPLWKDHPEMKHIMEIIKTCWNGNPSARFTSYICRKRMDERQQLLLD
BMPR1A_Hsap REVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVES-Q-
BMPR1B_Hsap REIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSES-Q-
ALK7_Hsap RKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVK-E-
ALK4_Hsap RKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQ-E-
tkv_Dmel HAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTALRVKKTLGRLETD-CL
SAX_Dmel RKVVCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASA-DE
BABO_Dmel KKVVCIEKCRPNIPNRWHASDVLHNMAKVMKECWYPNPVARLTALRIKKTLASISVE-D-
TGFBR1_Mmus RKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQ-E-
sma-6_Cele NDVICVRRIRPPPDLAWKNVPALNELSKLMEDSWHSIPHFRHSALKLKKEMAELIKN-PD
ALK2_Hsap RKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNS-LD
ALK1_Hsap KKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNS-PE
TGFbR1_Spur RRIVCIEKRRPPVPNRWNSHKIMESYAKVMKECWYQNGAARLTALRIKKTLAGLMGP-SE
ALK2_Spur RKVACIEKLRPNIPNRWTNNTVLTSMAKLMKECWCPTASARHTSLRVKKTLMKISET-CP
BMPR1_Spur MRVVVIERRRPDIPNRWSGDDILRTISKVMSECWNQNPAARVTSLRVKKTLGKLQEN---
AqueK680_Aque TEFIVGKEVIPEIPETWSNNELLRGMSRVMYECWYHQPTARPSAYYIRKKVDKIAEM-CE
AqueK681_Aque RRVVVEEGTRP-VTSEWSKTRFLEKLSVTIKELWAERGSERPSIELLRKKIEKEART-YD
AqueK682_Aque KQCVCVNNRRPTIPDSWTESETLSPIAKLLDSSWATQASSRISALRISKILKGIDFK-K-
* : : * * . * :
TGFbR1_Hsap ------------------------------------------------------------
BMPR1B_Mmus ------------------------------------------------------------
BMPR1A_Mmus ------------------------------------------------------------
ALK7_Mmus ------------------------------------------------------------
ALK4_Mmus ------------------------------------------------------------
ALK2_Mmus ------------------------------------------------------------
ALK1_Mmus ------------------------------------------------------------
daf-1_Cele K-----------------------------------------------------------
BMPR1A_Hsap ------------------------------------------------------------
BMPR1B_Hsap ------------------------------------------------------------
ALK7_Hsap ------------------------------------------------------------
ALK4_Hsap ------------------------------------------------------------
tkv_Dmel I-----------------------------------------------------------
SAX_Dmel ------------------------------------------------------------
BABO_Dmel ------------------------------------------------------------
TGFBR1_Mmus ------------------------------------------------------------
sma-6_Cele R-----------------------------------------------------------
ALK2_Hsap ------------------------------------------------------------
ALK1_Hsap ------------------------------------------------------------
TGFbR1_Spur P-----------------------------------------------------------
ALK2_Spur ------------------------------------------------------------
BMPR1_Spur ------------------------------------------------------------
AqueK680_Aque ------------------------------------------------------------
AqueK681_Aque DCNNLSTLIDIVQATIFIVVFRMLRLLAKIPLFGIILKSLIRVLVLLIPFLLLGYLFYFE
AqueK682_Aque ------------------------------------------------------------
TGFbR1_Hsap ------------------------------------------------------------
BMPR1B_Mmus ------------------------------------------------------------
BMPR1A_Mmus ------------------------------------------------------------
ALK7_Mmus ------------------------------------------------------------
ALK4_Mmus ------------------------------------------------------------
ALK2_Mmus ------------------------------------------------------------
ALK1_Mmus ------------------------------------------------------------
daf-1_Cele ------------------------------------------------------------
BMPR1A_Hsap ------------------------------------------------------------
BMPR1B_Hsap ------------------------------------------------------------
ALK7_Hsap ------------------------------------------------------------
ALK4_Hsap ------------------------------------------------------------
tkv_Dmel ------------------------------------------------------------
SAX_Dmel ------------------------------------------------------------
BABO_Dmel ------------------------------------------------------------
TGFBR1_Mmus ------------------------------------------------------------
sma-6_Cele ------------------------------------------------------------
ALK2_Hsap ------------------------------------------------------------
ALK1_Hsap ------------------------------------------------------------
TGFbR1_Spur ------------------------------------------------------------
ALK2_Spur ------------------------------------------------------------
BMPR1_Spur ------------------------------------------------------------
AqueK680_Aque ------------------------------------------------------------
AqueK681_Aque FAIVGMAIFRGVNLNDTKAAAECGSYENLKYHPYNFEDFGSTLVLLWNLMIVNNWHVIVD
AqueK682_Aque ------------------------------------------------------------
TGFbR1_Hsap ------------------------------------------------------------
BMPR1B_Mmus ------------------------------------------------------------
BMPR1A_Mmus ------------------------------------------------------------
ALK7_Mmus ------------------------------------------------------------
ALK4_Mmus ------------------------------------------------------------
ALK2_Mmus --------------------------------------------------------K---
ALK1_Mmus --------------------------------------------------------K---
daf-1_Cele --------------------------------------------------------K--A
BMPR1A_Hsap ------------------------------------------------------------
BMPR1B_Hsap ------------------------------------------------------------
ALK7_Hsap ------------------------------------------------------------
ALK4_Hsap ------------------------------------------------------------
tkv_Dmel --------------------------------------------------------D---
SAX_Dmel --------------------------------------------------------K--I
BABO_Dmel ------------------------------------------------------------
TGFBR1_Mmus ------------------------------------------------------------
sma-6_Cele --------------------------------------------------------Q--N
ALK2_Hsap --------------------------------------------------------K---
ALK1_Hsap --------------------------------------------------------K---
TGFbR1_Spur --------------------------------------------------------E--V
ALK2_Spur --------------------------------------------------------K--L
BMPR1_Spur ------------------------------------------------------------
AqueK680_Aque ------------------------------------------------------------
AqueK681_Aque AYVRRTSIYSRIYFVIWWVLSETVINGILLGYLIEILSITTIRLKDVFKDFNNKSKREKL
AqueK682_Aque ------------------------------------------------------------
TGFbR1_Hsap ------------------------------------------------------------
BMPR1B_Mmus ------------------------------------------------------------
BMPR1A_Mmus ------------------------------------------------------------
ALK7_Mmus ------------------------------------------------------------
ALK4_Mmus ------------------------------------------------------------
ALK2_Mmus ------------------------------------------------------------
ALK1_Mmus ------------------------------------------------------------
daf-1_Cele ------KAVAQTAGVTVQDRKILGPQKPKDESPANGAPR-------------IVQKEIDR
BMPR1A_Hsap ------------------------------------------------------------
BMPR1B_Hsap ------------------------------------------------------------
ALK7_Hsap ------------------------------------------------------------
ALK4_Hsap ------------------------------------------------------------
tkv_Dmel ------------------------------------------------------------
SAX_Dmel ------R-----------------------------------------------------
BABO_Dmel ------------------------------------------------------------
TGFBR1_Mmus ------------------------------------------------------------
sma-6_Cele QSQRKVEFQ--------------------------------------------------Q
ALK2_Hsap ------------------------------------------------------------
ALK1_Hsap ------------------------------------------------------------
TGFbR1_Spur ------LL------------------------PPANMQNTC-------D------ASQSG
ALK2_Spur ------T-----------------------------------------------------
BMPR1_Spur ------------------------------------------------------------
AqueK680_Aque ------------------------------------------------------------
AqueK681_Aque ------AL-------------------------------VCLFIFVPQDLREMFRGEADY
AqueK682_Aque ------------------------------------------------------------
TGFbR1_Hsap ------------------------------------------------GIKM
BMPR1B_Mmus ------------------------------------------------DIKL
BMPR1A_Mmus ------------------------------------------------DVKI
ALK7_Mmus ------------------------------------------------DCKA
ALK4_Mmus ------------------------------------------------DVKI
ALK2_Mmus -----------------------------------------------LKTDC
ALK1_Mmus -----------------------------------------------PKVIH
daf-1_Cele EDEQENWRETAKT---PNG--------HISSND-----------DSSRPLLG
BMPR1A_Hsap ------------------------------------------------DVKI
BMPR1B_Hsap ------------------------------------------------DIKL
ALK7_Hsap ------------------------------------------------DCKA
ALK4_Hsap ------------------------------------------------DVKI
tkv_Dmel ----------------------------------------------VPIKIV
SAX_Dmel --------------------------------------------LDFDEVCV
BABO_Dmel ------------------------------------------------KVKN
TGFBR1_Mmus ------------------------------------------------GIKM
sma-6_Cele QD----SG------------------------L-----------VESATNQS
ALK2_Hsap -----------------------------------------------LKTDC
ALK1_Hsap -----------------------------------------------PKVIQ
TGFbR1_Spur DD----L----KGRLPPSAIIPTSHPPN----V-----------PNPYPILS
ALK2_Spur -D------------------------------P-----------YHWEKIIA
BMPR1_Spur ------------------------------------------------EFKV
AqueK680_Aque --------------------------------------------VRRLDFDE
AqueK681_Aque ED----L-------------------------DAFHSWNIFDATFKEKQGES
AqueK682_Aque ----------------------------------------------EKIQNE