TGFbR2_Hsap IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFP--YEEYASWKTEKDIFSD--IN-
MISR2_Hsap LCFSQVIREGGHAVVWAGQLQG------KLVAIKAFP--PRSVAQFQAERALYEL--PG-
MISR2_Mmus LRFSQVIQEGGHAVVWAGRLQG------EMVAIKAFP--PRAVAQFRAERAVYQL--LG-
BMPR2_Mmus LKLLELIGRGRYGAVYKGSLDE------RPVAVKVFS--FANRQNFINEKNIYRV--PL-
ACTR2B_Mmus LQLLEIKARGRFGCVWKAQLMN------DFVAVKIFP--LQDKQSWQSEREIFST--PG-
ACTR2_Mmus ----EVKARGRFGCVWKAQLLN------EYVAVKIFP--IQDKQSWQNEYEVYSL--PG-
daf-4_Cele ITDFQLISKGRFGKVFKAQYTPDS-GEKRLVAVKKLN--EFQKASFLAEKRIFDE--LNE
BMPR2_Hsap LKLLELIGRGRYGAVYKGSLDE------RPVAVKVFS--FANRQNFINEKNIYRV--PL-
put_Dmel IQLLEQKASGRFGDVWQAKLNN------QDVAVKIFR--MQEKESWTTEHDIYKL--PR-
wit_Dmel MNLIGMLGSGKYGTVMKGLLHD------QEVAVKIYP--EEHHQYYVNERNIYAL--PL-
TGFBR2_Mmus IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFP--YEEYSSWKTEKDIFSD--IN-
ACTR2B_Hsap LQLLEIKARGRFGCVWKAQLMN------DFVAVKIFP--LQDKQSWQSEREIFST--PG-
ACTR2_Hsap ----EVKARGRFGCVWKAQLLN------EYVAVKIFP--IQDKQSWQNEYEVYSL--PG-
TGFbRII_Spur ITLDELIGKGRFGAVWRAHWKINNGTKERTVAVKVFL--EYDSASWNVEKELFTDHSVM-
ACTR2_Spur IQLLEIKARGRFGAVWKASCLN------DIVAVKVFP--IQDRNSWANEREIYSL--PH-
BMPR2_Spur LKMMELVGQGRYCNVYRAALSE------NEVAVKVFT--GSSKQCYMNELDIMGL--PH-
AqueK683_Aque ------------------------------------------LSQWKIERDIYLT--PE-
AqueK684_Aque PEFMKIIGHGRFARVYHARMGT------RDVAIKIFNGTLQAKGSWTQEKDIYAT--ER-
AqueK685_Aque FQLIQSIGNGRFGSVWKALYEK------ETVAVRVFS--QRHRTSWQNERDIHLL--NS-
AqueK686_Aque FQLLQPIGNGRFGSVWKALYNN------ETVAVKALS--LHHKLSWQNERDIHLL--DS-
: * :
TGFbR2_Hsap --LKHENILQFLTAEERKTE---LGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSS
MISR2_Hsap --LQHDHIVRFITASRGGPG--RLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALS
MISR2_Mmus --LQHDHIVRFITAGQGGPG--PLPSGPLLVLELYPKGSLCHYLTQYTSDWGSSLRMALS
BMPR2_Mmus --MEHDNIARFIVGDERLTA--DGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHS
ACTR2B_Mmus --MKHENLLQFIAAEKRGSN---LEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAET
ACTR2_Mmus --MKHENILQFIGAEKRGTS---VDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAET
daf-4_Cele YPKWYKSIVEFVCAEKIG-------DEYWIVTEFHERLSLYELLKNNVISITSANRIIMS
BMPR2_Hsap --MEHDNIARFIVGDERVTA--DGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHS
put_Dmel --MRHPNILEFLGVEKHMD-----KPEYWLISTYQHNGSLCDYLKSHTISWPELCRIAES
wit_Dmel --MECPALLSYFGYDERCTM--DGRMEYQLVLSLAPLGCLQDWLIANTLTFSECCGMLRS
TGFBR2_Mmus --LKHENILQFLTAEERKTE---LGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSS
ACTR2B_Hsap --MKHENLLQFIAAEKRGSN---LEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAET
ACTR2_Hsap --MKHENILQFIGAEKRGTS---VDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAET
TGFbRII_Spur --MRHEHIVQFISAEVRRVSVTSPTRQYWLITKYYKNGSLHDYLRQRSVNWIDLCKLCGS
ACTR2_Spur --MHHENLLHFIATEKHGEG---LEVEYWLISEFHHHGSLCDYLKANVISWKELCGIAFS
BMPR2_Spur --MEHSNLLQYVGSGDRMGE--DGWVEHLLVVDMISKGSLMSYLRENTYDWHTMCRLAQT
AqueK683_Aque --LRHESILTLLRAK-RV--KD---IGYQLVLKGSITGSLYQYLQSHSPDELEAAKITHS
AqueK684_Aque --LEHENILKFLYHDHRFHE---GQDTLWLIFDYHSNGSLYDYLQLHRLTFDELFSLCLS
AqueK685_Aque --TPHENILKFISSESRGRG---PSSEYFIITEYLPLGSLHQFLRHNTLSWEQAWNIMYS
AqueK686_Aque --TPHENILKFISSESRGRG---SSSEYFIITEYLPLGSLHQFLRHNTLSWEQAWNIMYS
: . :: * * : :
TGFbR2_Hsap LARGIAHLHSDHTPC----GRPKMPIVHRDLKSSNILVKND-LTCCLCDFGLSLRLDPTL
MISR2_Hsap LAQGLAFLHEERWQ--N--GQYKPGIAHRDLSSQNVLIRED-GSCAIGDLGLALVLPGLT
MISR2_Mmus LAEGLAFLHEERWQ--D--GQYKPGIAHRDLSSQNVLIRED-RSCAIGDLGLALVLPGLA
BMPR2_Mmus VTRGLAYLHTELPR--G--DHYKPAISHRDLNSRNVLVKND-GACVISDFGLSMRLTGNR
ACTR2B_Mmus MSRGLSYLHEDVPWCRG--EGHKPSIAHRDFKSKNVLLKSD-LTAVLADFGLAVRFEPGK
ACTR2_Mmus MARGLAYLHEDIPGL-K--DGHKPAISHRDIKSKNVLLKNN-LTACIADFGLALKFEAGK
daf-4_Cele MIDGLQFLHDDRPYFF---GHPKKPIIHRDIKSKNILVKSD-MTTCIADFGLARIYSYDI
BMPR2_Hsap VTRGLAYLHTELPR--G--DHYKPAISHRDLNSRNVLVKND-GTCVISDFGLSMRLTGNR
put_Dmel MANGLAHLHEEIPASKT--DGLKPSIAHRDFKSKNVLLKSD-LTACIADFGLAMIFQPGK
wit_Dmel ITRGISHLHTELRL--G--DQHKPCVAHRDINTRNVLVQAD-LSCCIADFGFALKVFGSK
TGFBR2_Mmus LARGIAHLHSDHTPC----GRPKMPIVHRDLKSSNILVKND-LTCCLCDFGLSLRLDPTL
ACTR2B_Hsap MSRGLSYLHEDVPWCRG--EGHKPSIAHRDFKSKNVLLKSD-LTAVLADFGLAVRFEPGK
ACTR2_Hsap MARGLAYLHEDIPGL-K--DGHKPAISHRDIKSKNVLLKNN-LTACIADFGLALKFEAGK
TGFbRII_Spur AARGLAHLHAETYGSH---GLHKVPVAHRDLKSTNILVKDD-GSCAIADFGLAIRLDPQS
ACTR2_Spur MAKGLAYLHEDIPPTTA-IPFVKHSVAHRDFKSKNVLIKNN-TTACIADFGLACVFEAGK
BMPR2_Spur TAAGLAHLHQVIDT--Q--VGLKPAVVHRDINSRNVLVNAE-GNCVIGDFGFAMQVCGSS
AqueK683_Aque MSSGLAHLHYMESSQSHS-KYRVITIAHCNINSHNILMKED-GTVFLSDF----------
AqueK684_Aque GAAGLEHLHSVDNC--P--ETYKPAIAHRDLKSKNILVKKD-MTCCISDFGLAIKFDGVD
AqueK685_Aque ITSGITHLHSSSYYSN-GLLADKFSIAHRDIKPSNILVKSPSGQCVVADFGQAFVLDPAA
AqueK686_Aque IASGITHLHSNSYYNSNGLLLEKYSIAHRDIKPSNILVKSVSGHCVVADLGLAFILDPAA
*: .** : * ::.. *:*:. : *:
TGFbR2_Hsap S-------VDD-LANSGQVGTARYMAPEVLESRMNLENV-ESFKQTDVYSMALVLWEMTS
MISR2_Hsap QPPAWTPTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILS
MISR2_Mmus QPPALAPTQPRGPAAILEAGTQRYMAPELLDKTLDLQDWGTALQRADVYSLALLLWEILS
BMPR2_Mmus LV---RPGEED-NAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEVFM
ACTR2B_Mmus ---------PP-GDTHGQVGTRRYMAPEVLEGAINFQR--DAFLRIDMYAMGLVLWELVS
ACTR2_Mmus ---------SA-GDTHGQVGTRRYMAPEVLEGAINFQR--DAFLRIDMYAMGLVLWELAS
daf-4_Cele ---------EQ-SDLLGQVGTKRYMSPEMLEGATEFTP--TAFKAMDVYSMGLVMWEVIS
BMPR2_Hsap LV---RPGEED-NAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFM
put_Dmel ---------PC-GDTHGQVGTRRYMAPEVLEGAINFNR--DAFLRIDVYACGLVLWEMVS
wit_Dmel YEYKGEVAMAE-TKSINEVGTLRYMAPELLEGAVNLRDCETSLKQMDVYALGLVLWEVAT
TGFBR2_Mmus S-------VDD-LANSGQVGTARYMAPEVLESRMNLENV-ESFKQTDVYSMALVLWEMTS
ACTR2B_Hsap ---------PP-GDTHGQVGTRRYMAPEVLEGAINFQR--DAFLRIDMYAMGLVLWELVS
ACTR2_Hsap ---------SA-GDTHGQVGTRRYMAPEVLEGAINFQR--DAFLRIDMYAMGLVLWELAS
TGFbRII_Spur S-------TDH-LANSGQVGTPRYMSPEALECKVNLQDI-ESFKQMDTYALALILWEITS
ACTR2_Spur ---------NP-GDTHGQVGTRRYMAPEVLEGAIQFKR--DAFLRIDMYAFGLVLWELVT
BMPR2_Spur VV---GEGDGD-NSTITDVGTVRYMSPEVLDGAVNLRDCECALKQVDVYALGLVVWEIAM
AqueK683_Aque ------------------------------------------------------------
AqueK684_Aque --------MIL-SEAKGQVGTSRYMAPEILEGAVRFNQ--EAFLKIDIYAFGLILWEM--
AqueK685_Aque D-------DRK-LAVSGQVGTYRYMSPEALDARVNLRDS-ESFKQIDVYAMSLVLWEVCM
AqueK686_Aque D-------DRK-LAVSGQVGTYRYMSPEALDARVNLRDI-ESFKQIDMYALSLVLWEVCM
TGFbR2_Hsap RCNAV----GEVKDYEPPFGSKVREH-PCVESMKDNVLRDRGRPEIPSFWLNHQ-GIQMV
MISR2_Hsap RCPDLR-PDSSPPPFQLAYEAELGNT-PTSDELWALAVQERRRPYIPSTWRCFATDPDGL
MISR2_Mmus RCSDLR-PDHRPPPFQLAYEAELGSN-PSACELWALAVEERKRPNIPSTWSCSATDPRGL
BMPR2_Mmus RCTDLF-PGESVPDYQMAFQTEVGNH-PTFEDMQVLVSREKQRPKFPEAWKENSLAVRSL
ACTR2B_Mmus RCKAA---DGPVDEYMLPFEEEIGQH-PSLEELQEVVVHKKMRPTIKDHWLKHP-GLAQL
ACTR2_Mmus RCTAA---DGPVDEYMLPFEEEIGQH-PSLEDMQEVVVHKKKRPVLRDYWQKHA-GMAML
daf-4_Cele RTKLH-Q-TDEPPNYQMPFQ-VIGFD-PTIGLMRNYVVSKKERPQWRDEIIKH-------
BMPR2_Hsap RCTDLF-PGESVPEYQMAFQTEVGNH-PTFEDMQVLVSREKQRPKFPEAWKENSLAVRSL
put_Dmel RCDFA----GPVGEFQLPFEAELGLR-PSLDEVQESVVMKKLRPRLLNSWRAHP-GLNVF
wit_Dmel RCSDFYAPGQATPPYKAPYEQEVGSH-PSFDQMQALVVRHKARPLFPTGWGGGA-AAKVV
TGFBR2_Mmus RCNAV----GEVKDYEPPFGSKVREH-PCVESMKDSVLRDRGRPEIPSFWLNHQ-GIQIV
ACTR2B_Hsap RCKAA---DGPVDEYMLPFEEEIGQH-PSLEELQEVVVHKKMRPTIKDHWLKHP-GLAQL
ACTR2_Hsap RCTAA---DGPVDEYMLPFEEEIGQH-PSLEDMQEVVVHKKKRPVLRDYWQKHA-GMAML
TGFbRII_Spur RCTLL----KDINEYELPFSRSLGDRRASLEMMKTLVVLRRERPPITDEWLRNP-GLTII
ACTR2_Spur RCTVQ---DGPVPEYRLPFEEELGQG-TSLEDMQEWVVVKRKRPVISDHWLKHR-GLELL
BMPR2_Spur RCKDLY-PRDEMGNYQMPFEEQVGLH-PTFEDMQILVSRERKRPQFPDAWKQNSQALRSL
AqueK683_Aque ------------------------------------------------------------
AqueK684_Aque ------------------------------------------------------------
AqueK685_Aque RYQSN---DVPVPPYQSPFFDMVGEK-PTLDQMKEIVVINKQRPLLPEKWNNDK-NLKRI
AqueK686_Aque RYQSD---DVPVPPYQSPFFDMVGEK-PTLEQMKEIVVNANKRPGFTGVWYSDK-NLKRI
TGFbR2_Hsap CETLTECWDHDPEARLTAQCVAERFS
MISR2_Hsap RELLEDCWDADPEARLTAECVQQR-L
MISR2_Mmus RELLEDCWDADPEARLTAECVQQR-L
BMPR2_Mmus KETIEDCWDQDAEARLTAQCAEER-M
ACTR2B_Mmus CVTIEECWDHDAEARLSAGCVEER-V
ACTR2_Mmus CETIEECWDHDAEARLSAGCVGER-I
daf-4_Cele ----------------------EY-M
BMPR2_Hsap KETIEDCWDQDAEARLTAQCAEER-M
put_Dmel CDTMEECWDHDAEARLSSSCV----M
wit_Dmel RDTCEDCWDHDADARLTS-------L
TGFBR2_Mmus CETLTECWDHDPEARLTAQCVAERFS
ACTR2B_Hsap CVTIEECWDHDAEARLSAGCVEER-V
ACTR2_Hsap CETIEECWDHDAEARLSAGCVGER-I
TGFbRII_Spur KNTVVDCWDEDPEARLT--------A
ACTR2_Spur CETIEECWDQDAEARLS--------A
BMPR2_Spur KETIEDCWDHDAEARLT--------A
AqueK683_Aque --------------------------
AqueK684_Aque -------------------------L
AqueK685_Aque IKLIVEGWDEDPEARLTAANIKIQ-L
AqueK686_Aque IKLIKEGWDEDPEARLTAANIKIQ-L