Protein (view, download) , Domain (view, download)
TGFbR2_Hsap     MGRGLLR-GLW---------P--------LH-I-VLWTR--I--ASTIPPHVQKSDVEME
MISR2_Hsap      MLGSLG-----------------------------LWALLPT-----AVEAP--------
MISR2_Mmus      MLGTLG-----------------------------LWTLLPA-----AAQVS--------
BMPR2_Mmus      MTSSLHR-PF----------R--------VP-W-LLWAVLLVST---TAASQ--------
ACTR2B_Mmus     MTAPW-A----------------------------ALALLWGSLCAGSGRGE--------
ACTR2_Mmus      MGAAAKL----------------------------AFAVFLISCSSGAILGR--------
daf-4_Cele      MNQKGTV-RLK---------A--------LV-L-ICLPLFLIATPVPVAVTE--------
BMPR2_Hsap      MTSSLQR-PW----------R--------VP-W-LPWTILLVST---AAASQ--------
put_Dmel        MSKYDLL-YLT---------A--------Q----LTLVCCLIGIHGSILPGS--------
wit_Dmel        MNWAIY----------------------------LLLALISLGR---ATPVP--------
TGFBR2_Mmus     MGRGLLR-GLW---------P--------LH-I-VLWTR--I--ASTIPPHVPKSDVEME
ACTR2B_Hsap     MTAPW-V----------------------------ALALLWGSLCAGSGRGE--------
ACTR2_Hsap      MGAAAKL----------------------------AFAVFLISCSSGAILGR--------
TGFbRII_Spur    MAYDVET-DEN---------N--------VP-F-VVTVS--LGVASAFEC-LDCSEVPVE
ACTR2_Spur      MAGKDPLIRLC---------E--------LFLF-LSIAVLLVE--GASVNLP--------
BMPR2_Spur      MHSSEHG-DY----------T--------GK-V-I--SVITIEA---EIAEL--------
AqueK683_Aque   MAELRIL----------------------------VFCLLALLLPVPSYLLV--------
AqueK684_Aque   MCVYLKT---S---------D------------------VFIKCFSTACPGG------AD
AqueK685_Aque   MINVTLF-IDPPDEAENAPSSFHVTDQITSS-IEPSLSMIPS-T---VPAPS--------
AqueK686_Aque   MVAVLRV-VL-------------------------CFCLLST-I---VTAFQ--------
                *

TGFbR2_Hsap     AQKDEIICPSCNRTAHPLRHINNDMIVTDNNGAVKFP-----------------------
MISR2_Hsap      ----------------------------------PNR-----------------------
MISR2_Mmus      ----------------------------------PNR-----------------------
BMPR2_Mmus      ----------------------------------NQE-----------------------
ACTR2B_Mmus     ----------------------------------AET-----------------------
ACTR2_Mmus      ----------------------------------SET-----------------------
daf-4_Cele      ----------------------------------DDRQDRIESEAAEKEWANTLVSKVAQ
BMPR2_Hsap      ----------------------------------NQE-----------------------
put_Dmel        ----------------------------------HGI-----------------------
wit_Dmel        ----------------------------------NRQ-----------------------
TGFBR2_Mmus     AQKDASIHLSCNRTIHPLKHFNSDVMASDNGGAVKLP-----------------------
ACTR2B_Hsap     ----------------------------------AET-----------------------
ACTR2_Hsap      ----------------------------------SET-----------------------
TGFbRII_Spur    CDAE--------------------------------------------------------
ACTR2_Spur      ----------------------------------LGS-----------------------
BMPR2_Spur      ------------------------------------------------------------
AqueK683_Aque   ----------------------------------CYT-----------------------
AqueK684_Aque   ICIELCPEGINKCHTVRRTNSYPVEMRCTNTPSCSQS-----------------------
AqueK685_Aque   ----------------------------------NTL-----------------------
AqueK686_Aque   ----------------------------------CRV-----------------------


TGFbR2_Hsap     -----------------------------QLCK---------------------------
MISR2_Hsap      -----------------------------RTCV---------------------------
MISR2_Mmus      -----------------------------RTCV---------------------------
BMPR2_Mmus      -----------------------------RLCA---------------------------
ACTR2B_Mmus     -----------------------------RECI---------------------------
ACTR2_Mmus      -----------------------------QECL---------------------------
daf-4_Cele      SNGTGTIKVSAPAKPTLRRMDNEEDEVISIECV---------------------------
BMPR2_Hsap      -----------------------------RLCA---------------------------
put_Dmel        -----------------------------IECE---------------------------
wit_Dmel        -----------------------------YSCM---------------------------
TGFBR2_Mmus     -----------------------------QLCK---------------------------
ACTR2B_Hsap     -----------------------------RECI---------------------------
ACTR2_Hsap      -----------------------------QECL---------------------------
TGFbRII_Spur    ------------------------------SCV---------------------------
ACTR2_Spur      -----------------------------THCH---------------------------
BMPR2_Spur      ------------------------------------------------------------
AqueK683_Aque   -----------------------------DDCP---------------------------
AqueK684_Aque   -----------------------------SDCVFETLQNFHSLHYCCCTGDLCNRLDNYT
AqueK685_Aque   -----------------------------RSHS---------------------------
AqueK686_Aque   -----------------------------NSCI---------------------------


TGFbR2_Hsap     -----------------------------FCDV-RFST----C-D---NQK---------
MISR2_Hsap      -----------------------------FFEA-PGVR-----GSTKTLGELL--DTGT-
MISR2_Mmus      -----------------------------FFEA-PGVR-----GSTKTLGEMV--DAGP-
BMPR2_Mmus      -----------------------------FKDP-YQQD----L-G---IGE---------
ACTR2B_Mmus     -----------------------------YYNA-NWEL----E-RTN---Q---------
ACTR2_Mmus      -----------------------------FFNA-NWER----D-RTN---Q---------
daf-4_Cele      -----------------------------YYDEMECEK----S-GD-C--E---------
BMPR2_Hsap      -----------------------------FKDP-YQQD----L-G---IGE---------
put_Dmel        -----------------------------HFDEKMCNT----T-QQ-C--E---------
wit_Dmel        -----------------------------SYQE-DDNSFHDDDGDQDSSGELQ--EQQV-
TGFBR2_Mmus     -----------------------------FCDV-RLST----C-D---NQK---------
ACTR2B_Hsap     -----------------------------YYNA-NWEL----E-RTN---Q---------
ACTR2_Hsap      -----------------------------FFNA-NWEK----D-RTN---Q---------
TGFbRII_Spur    -----------------------------P------IS----C-T---TSV---------
ACTR2_Spur      -----------------------------LYSSQECEK----D-GTKC--G---------
BMPR2_Spur      -----------------------------YTET-FI------------------------
AqueK683_Aque   -----------------------------YDNNL-L-C----Y-KTC---T---------
AqueK684_Aque   DSVDPILNVTSAIPTVPVPVRPSDVLICERYNC-SFND----D-GI-C--Y---------
AqueK685_Aque   ------------------------------------------------------------
AqueK686_Aque   -----------------------------RCSS-SSPV-----DCTVTPVDQYSYNYYCE


TGFbR2_Hsap     ----SCMSNCSI-TSICEKPQEVCVAVW-RKN---DENIT------------LE---TVC
MISR2_Hsap      --------ELPR-AIRCL-YSRCCFGIW-NLT---QDRAQ------------VE--MQGC
MISR2_Mmus      --------GPPK-GIRCL-YSHCCFGIW-NLT---HGRAQ------------VE--MQGC
BMPR2_Mmus      ----SRISHENG-TILCS-KGSTCYGLW-EKS---KGDIN------------LV--KQGC
ACTR2B_Mmus     ----SGLERCEG---EQD-KRLHCYASW-RNS---SGTIE------------LV--KKGC
ACTR2_Mmus      ----TGVEPCYG---DKD-KRRHCFATW-KNI---SGSIE------------IV--KQGC
daf-4_Cele      ----ITKKTCYS---EAHLKAVGCLAVF-GLPT---QEINSTEPYLKVDKPQYK--SLGC
BMPR2_Hsap      ----SRISHENG-TILCS-KGSTCYGLW-EKS---KGDIN------------LV--KQGC
put_Dmel        ----TRIEHCKM---EAD-KFPSCYVLW-SVN-ETTGILR------------IK--MKGC
wit_Dmel        --ESTPIPSEPH-RRTCPDGYTFCFTIW-NQT---ANGAR------------VV--KQGC
TGFBR2_Mmus     ----SCMSNCSI-TAICEKPHEVCVAVW-RKN---DKNIT------------LE---TVC
ACTR2B_Hsap     ----SGLERCEG---EQD-KRLHCYASW-RNS---SGTIE------------LV--KKGC
ACTR2_Hsap      ----TGVEPCYG---DKD-KRRHCFATW-KNI---SGSIE------------IV--KQGC
TGFbRII_Spur    ----PCVGYCLI-ATFPDMTSSSMTNGS-DPS---SQNIN------------GM---FAC
ACTR2_Spur      ----NTTEECDN---KEA-EIPSCYVLW-KNETSSGGGVD------------VM--MRGC
BMPR2_Spur      -----------------------------NIS---RLHQS------------LY--IQGC
AqueK683_Aque   ----PSSNSCVR---IAA-ID--------RSN---FPPAR------------IIFQEFGC
AqueK684_Aque   ----HGYEVCPETFSSNP-DDHSCIATY-HKN-PTTNLIE------------LM--YKGC
AqueK685_Aque   ---------------------------F-DES---TGTIR------------SV---TGF
AqueK686_Aque   APSHCTPQNVPG---SNR-DGYYCYASLFIRN---LNSTD------------F----DGH


TGFbR2_Hsap     ------------------------------------------------------------
MISR2_Hsap      ------------------------------------------------------------
MISR2_Mmus      ------------------------------------------------------------
BMPR2_Mmus      ------------------------------------------------------------
ACTR2B_Mmus     ------------------------------------------------------------
ACTR2_Mmus      ------------------------------------------------------------
daf-4_Cele      MPYQ--------------------------------------------------------
BMPR2_Hsap      ------------------------------------------------------------
put_Dmel        ------------------------------------------------------------
wit_Dmel        ------------------------------------------------------------
TGFBR2_Mmus     ------------------------------------------------------------
ACTR2B_Hsap     ------------------------------------------------------------
ACTR2_Hsap      ------------------------------------------------------------
TGFbRII_Spur    ------------------------------------------------------------
ACTR2_Spur      ------------------------------------------------------------
BMPR2_Spur      ------------------------------------------------------------
AqueK683_Aque   ------------------------------------------------------------
AqueK684_Aque   RHNRLPNPLTLQACSNSTSMCHIDNPLVSDQDSAVYYCCCGESLCNQNITFTHPTQVSTY
AqueK685_Aque   ------------------------------------------------------------
AqueK686_Aque   ------------------------------------------------------------


TGFbR2_Hsap     ------------------------------------------------------------
MISR2_Hsap      ------------------------------------------------------------
MISR2_Mmus      ------------------------------------------------------------
BMPR2_Mmus      ------------------------------------------------------------
ACTR2B_Mmus     ------------------------------------------------------------
ACTR2_Mmus      ------------------------------------------------------------
daf-4_Cele      ------------------------------------------------------------
BMPR2_Hsap      ------------------------------------------------------------
put_Dmel        ------------------------------------------------------------
wit_Dmel        ------------------------------------------------------------
TGFBR2_Mmus     ------------------------------------------------------------
ACTR2B_Hsap     ------------------------------------------------------------
ACTR2_Hsap      ------------------------------------------------------------
TGFbRII_Spur    ------------------------------------------------------------
ACTR2_Spur      ------------------------------------------------------------
BMPR2_Spur      ------------------------------------------------------------
AqueK683_Aque   ------------------------------------------------------------
AqueK684_Aque   DIDECAINNGGCSETCINTPGNYSCECNAGRYLSPHSGRCEDNDGIICLYRNCTLDGSCH
AqueK685_Aque   ------------------------------------------------------------
AqueK686_Aque   ------------------------------------------------------------


TGFbR2_Hsap     --------------------------------------------HDPKLPYHDFILEDAA
MISR2_Hsap      --------------------------------------------RDSDE-------PGCE
MISR2_Mmus      --------------------------------------------RDSDE-------PGCE
BMPR2_Mmus      --------------------------------------------WSHIGDP-----QECH
ACTR2B_Mmus     --------------------------------------------WLDDF-------NCYD
ACTR2_Mmus      --------------------------------------------WLDDI-------NCYD
daf-4_Cele      --------------------------------------------HADSM-------NCEN
BMPR2_Hsap      --------------------------------------------WSHIGDP-----QECH
put_Dmel        --------------------------------------------FTDMH-------EC-N
wit_Dmel        --------------------------------------------WKDNTDRT----SICS
TGFBR2_Mmus     --------------------------------------------HDPKLTYHGFTLEDAA
ACTR2B_Hsap     --------------------------------------------WLDDF-------NCYD
ACTR2_Hsap      --------------------------------------------WLDDI-------NCYD
TGFbRII_Spur    --------------------------------------------INETNP------EIGG
ACTR2_Spur      --------------------------------------------WQNQG-------DCLD
BMPR2_Spur      --------------------------------------------WGNEAKS-----LNCN
AqueK683_Aque   ----------------------------------------------SSL-------RCNT
AqueK684_Aque   TNTTEHCASSHLISDDLRTETHLHYCVALFHFINGTFYPNTQSCFAGSH-------SSCQ
AqueK685_Aque   --------------------------------------------TT---SLT-----SI-
AqueK686_Aque   --------------------------------------------WFSFFQVE-----SCE


TGFbR2_Hsap     -------SPKCIMKE--K----KKPGETFFMCSCSSDECN--------------------
MISR2_Hsap      -------SLHCDPSPRAH----PSPGSTLFTCSCGTDFCN--------------------
MISR2_Mmus      -------SLHCDPVPRAH----PNPSSTLFTCSCGTDFCN--------------------
BMPR2_Mmus      -------YEECVVTTTPP----SIQNGTYRFCCCSTDLCN--------------------
ACTR2B_Mmus     -------RQECVATEE---------NPQVYFCCCEGNFCN--------------------
ACTR2_Mmus      -------RTDCIEKKD---------SPEVYFCCCEGNMCN--------------------
daf-4_Cele      -------ESSCRQGR--------SFRGGIGMCCCSTNNCN--------------------
BMPR2_Hsap      -------YEECVVTTTPP----SIQNGTYRFCCCSTDLCN--------------------
put_Dmel        -------QTECVTSAE------P-RQGNIHFCCCKGSRCN--------------------
wit_Dmel        -------QSECTS--SAP----TSKTSSLYYCCCSGGVCN--------------------
TGFBR2_Mmus     -------SPKCVMKE--K----KRAGETFFMCACNMEECN--------------------
ACTR2B_Hsap     -------RQECVATEE---------NPQVYFCCCEGNFCN--------------------
ACTR2_Hsap      -------RTDCVEKKD---------SPEVYFCCCEGNMCN--------------------
TGFbRII_Spur    -------KKHCQAHPDDY----SYAAEGSYSCSCASDGCN--------------------
ACTR2_Spur      -------MDYCMSSSP--------ADQNLFFCCCVGNLCN--------------------
BMPR2_Spur      -------QENCTAHSKPSEYLVRTKNQTSRICCCAGDYCN--------------------
AqueK683_Aque   -------RDLLCS---------PNITDLTQHCCCTGDRCNNPGGRADALAELMKPKFSYH
AqueK684_Aque   -------NTNCTLTNITR----LSHNNDVYSCCCYGDLCN--------------------
AqueK685_Aque   -----EHSSSRI-I--SS----IP-QSTNSLT----------------------------
AqueK686_Aque   EAAGSELTDDCLSITKRV----SSLEGTNIFCRCTEDNCQ--------------------


TGFbR2_Hsap     ---------------------------------------------------DNII-FSE-
MISR2_Hsap      ---------------------------------------------------ANYS-HL--
MISR2_Mmus      ---------------------------------------------------ANYS-HL--
BMPR2_Mmus      ---------------------------------------------------VNFT-EN--
ACTR2B_Mmus     ---------------------------------------------------ERFT-HL--
ACTR2_Mmus      ---------------------------------------------------EKFS-YF--
daf-4_Cele      ---------------------------------------------------MPDLIEM--
BMPR2_Hsap      ---------------------------------------------------VNFT-EN--
put_Dmel        ---------------------------------------------------SNQK-YI--
wit_Dmel        ---------------------------------------------------AQYS-VV--
TGFBR2_Mmus     ---------------------------------------------------DYII-FSE-
ACTR2B_Hsap     ---------------------------------------------------ERFT-HL--
ACTR2_Hsap      ---------------------------------------------------EKFS-YF--
TGFbRII_Spur    ---------------------------------------------------KVLY-TAEA
ACTR2_Spur      ---------------------------------------------------MNFS-FL--
BMPR2_Spur      ---------------------------------------------------RNVS-DAY-
AqueK683_Aque   LSPPNEPVPSTEPGCSVANTSDITPDCIIDVPFIGALKNEYTCYCNESLCNINES-IT--
AqueK684_Aque   ---------------------------------------------------ERGL-IF--
AqueK685_Aque   --------------------------------------------------------SVST
AqueK686_Aque   ---------------------------------------------------DIFN-VTII


TGFbR2_Hsap     ---EYNT-S---------------------------------------------------
MISR2_Hsap      PPP-GSP-G---------------------------------------------------
MISR2_Mmus      PPS-GNQ-G---------------------------------------------------
BMPR2_Mmus      FPP-PDT-----------------------------------------------------
ACTR2B_Mmus     PEP-GGP-----------------------------------------------------
ACTR2_Mmus      PEM-EVT-----------------------------------------------------
daf-4_Cele      VNP-SLK-----------------------------------------------------
BMPR2_Hsap      FPP-PDT-----------------------------------------------------
put_Dmel        KST---T-----------------------------------------------------
wit_Dmel        EPA-PLELG---------------------------------------------------
TGFBR2_Mmus     ---EYTT-S---------------------------------------------------
ACTR2B_Hsap     PEA-GGP-----------------------------------------------------
ACTR2_Hsap      PEM-EVT-----------------------------------------------------
TGFbRII_Spur    TIPEEPT-V---------------------------------------------------
ACTR2_Spur      PTP-EP------------------------------------------------------
BMPR2_Spur      VPL-PST-----------------------------------------------------
AqueK683_Aque   HPT-RLS-SYGFKECLSYNCEYNCNIVNNTNINCSCPAGFIAIGFTRCRDVNECLVSNGG
AqueK684_Aque   PDF-NAT-----------------------------------------------------
AqueK685_Aque   RS--STE-----------------------------------------------------
AqueK686_Aque   IDP-PNDVS-------------------------------------------SSTLINGV


TGFbR2_Hsap     ------------------------------------------------------------
MISR2_Hsap      -------------------------------------------------TP-G-------
MISR2_Mmus      -------------------------------------------------AP-G-------
BMPR2_Mmus      -------------------------------------------------TP-L-------
ACTR2B_Mmus     -------------------------------------------------EV-T-------
ACTR2_Mmus      -------------------------------------------------QP-T-------
daf-4_Cele      -------------------------------------------------KD-S-------
BMPR2_Hsap      -------------------------------------------------TP-L-------
put_Dmel        -------------------------------------------------EA-T-------
wit_Dmel        -------------------------------------------------SNEG-R-----
TGFBR2_Mmus     ------------------------------------------------------------
ACTR2B_Hsap     -------------------------------------------------EV-T-------
ACTR2_Hsap      -------------------------------------------------QP-T-------
TGFbRII_Spur    -------------------------------------------------PP-S-------
ACTR2_Spur      -------------------------------------------------TP-T-------
BMPR2_Spur      -------------------------------------------------KP-T-------
AqueK683_Aque   CQQTCVNTIGSYYCECFDGYFFDSRTLSCLSKFANFYCSHYSDDDIRLTEI-T-------
AqueK684_Aque   -------------------------------------------------SP-I-------
AqueK685_Aque   -------------------------------------------------SV-LV------
AqueK686_Aque   ITS----------------------------------------------SP-SPPSVYSS


TGFbR2_Hsap     --------------------------------------------------NP------DL
MISR2_Hsap      ---------------------------------------------------S------QG
MISR2_Mmus      ---------------------------------------------------P------QE
BMPR2_Mmus      -------------------------------------------------SPP------H-
ACTR2B_Mmus     -------------------------------------------------YEP------PP
ACTR2_Mmus      -------------------------------------------------SNP------VT
daf-4_Cele      ---------D-------N-------------------------SALLWASTP------SN
BMPR2_Hsap      -------------------------------------------------SPP------H-
put_Dmel        -------------------------------------------------TQV------PK
wit_Dmel        -------------------------------------------------TSI------TN
TGFBR2_Mmus     --------------------------------------------------SP------DL
ACTR2B_Hsap     -------------------------------------------------YEP------PP
ACTR2_Hsap      -------------------------------------------------SNP------VT
TGFbRII_Spur    -------------------------------------------------SEP------DA
ACTR2_Spur      -------------------------------------------------VTQ------TT
BMPR2_Spur      -------------------------------------------------VTQ------YK
AqueK683_Aque   -------------------------------------------------ENTKIGSLDCT
AqueK684_Aque   -------------------------------------------------PMS------ST
AqueK685_Aque   --------------------------------------------------PS------ST
AqueK686_Aque   VPLSLSLSSSTIDLTTSSVSFSINTSPTLITVTNTHTTGILTTSSV---VPS------ST


TGFbR2_Hsap     L-----------------------L-----------------------------------
MISR2_Hsap      P-----------------------Q-A---------------AP----------------
MISR2_Mmus      P-----------------------Q-A---------------TP----------------
BMPR2_Mmus      ------------------------------------------------------------
ACTR2B_Mmus     ------------------------------------------------------------
ACTR2_Mmus      ------------------------------------------------------------
daf-4_Cele      M-----DL----------------E-----------------SL----------------
BMPR2_Hsap      ------------------------------------------------------------
put_Dmel        E-------------------------K---------------TQ----------------
wit_Dmel        R-----------------------A-T---------------EK----------------
TGFBR2_Mmus     L-----------------------L-----------------------------------
ACTR2B_Hsap     ------------------------------------------------------------
ACTR2_Hsap      ------------------------------------------------------------
TGFbRII_Spur    T-----------------------PTK---------------TKGPPIENTDPNKTEEGR
ACTR2_Spur      V--TGSNID---------------E-K---------------KK----------------
BMPR2_Spur      V-----------------------I-S---------------DQ----------------
AqueK683_Aque   P-VQSCFAQLMYSHHHWYLNAMTCG-Q---------------SP----------------
AqueK684_Aque   SLMASSDS------------------ITIFLSSSPYVSATQTAS----------------
AqueK685_Aque   -------------------------------------------V----------------
AqueK686_Aque   G-----------------------V-----------------IP----------------


TGFbR2_Hsap     -------VIFQV-TG---ISLLPPLGVAI---SV-I-IIFYCY-RVNRQQKLS-------
MISR2_Hsap      ----GESIWMAL-VL---LGLFLLLLLLL---GS--IILALLQ---RKNYRVRGE--P--
MISR2_Mmus      ----GGPVWMAL-LL---LGMFLVL--LL---SS--IILALLQ---RKACRVQGG--S--
BMPR2_Mmus      -----SFNRDET-II---IALASVSVLAV---LI--VALCFGY-RMLTGDRKQG---L--
ACTR2B_Mmus     ----TAPTLLTV-LA---YSLLPIGGLSL---IV-LL-AFWMY-RHRKPPYGHVD--IHE
ACTR2_Mmus      ----PKPPYYNI-LL---YSLVPLMLIAG---IV-IC-AFWVY-RHHKMAYPPV------
daf-4_Cele      ----DKFPFYWI-II---IALSVILCIAL---LI-LAYVGWKF-QQNKKEEIKKQQKIK-
BMPR2_Hsap      -----SFNRDET-II---IALASVSVLAV---LI--VALCFGY-RMLTGDRKQG---L--
put_Dmel        ----DGSNLIYIYIG---TSVFSVLM--V---IV-GM-GLLLY-RRRKQAHFN-------
wit_Dmel        ----QHQSFLAS-TM---LGLAGGLTALT---IG--IFLAVQY---CRTAKEKPE--P--
TGFBR2_Mmus     -------VIIQV-TG---VSLLPPLGIAI---AV-I-IIFYCY-RVHRQQKLS-------
ACTR2B_Hsap     ----TAPTLLTV-LA---YSLLPIGGLSL---IV-LL-AFWMY-RHRKPPYGHVD--I--
ACTR2_Hsap      ----PKPPYYNI-LL---YSLVPLMLIAG---IV-IC-AFWVY-RHHKMAYPPV------
TGFbRII_Spur    KGQMLDREILVI-VV---CSVVPAVLLTI---VI-A-VAGYIHFTRYRQPMNDEL--N--
ACTR2_Spur      ----KNEMLTKT-IL---YSIVPIVAIAL---VI-IM-LYWMC-RRHRYH-SLI------
BMPR2_Spur      ----MNHEMERT-IL---IAVIPIFCVSV---AI--AIMYFIF-RMRLRSTKAQ---M--
AqueK683_Aque   ----G-HT-VTV-GFWSA--IGSLSMIIIGIVCALWITIAFKW-KTTRSKYRKA------
AqueK684_Aque   ----SNRVVYPSV-F---AALLLIMVLIL---CS--I-SIILC-RVRVAFRKRLD--M--
AqueK685_Aque   ----TSTAAVTI-GLASGISILALMIALIAVVMM--LILAYSW-RKHS-PKFHRC--S--
AqueK686_Aque   ----STDTMVTI-ILSSVIAFLAITLAIIGLLIA-CTLVCYC--RKYS-SNSRRH--S--
                                    .

TGFbR2_Hsap     -------------------------------STWETGKTR-KLMEFSEHCAIILEDDRSD
MISR2_Hsap      ----------------------------VPEPRPDSGR----------------------
MISR2_Mmus      ----------------------------DPEP--GSGG----------------------
BMPR2_Mmus      ----------------------------HSMNMME--A----------------------
ACTR2B_Mmus     VRQCQRWAGRRDGCADSF----------KPLPFQDPGP----------------------
ACTR2_Mmus      -----------------------------LVPTQDPGP----------------------
daf-4_Cele      -----------------FDMEKTDALEAGNVPLVEPEE----------------------
BMPR2_Hsap      ----------------------------HSMNMME--A----------------------
put_Dmel        -----------------------------EIPTHEAEI----------------------
wit_Dmel        ----------------------------EESPLAPSGP----------------------
TGFBR2_Mmus     -------------------------------PSWESSKPR-KLMDFSDNCAIILEDDRSD
ACTR2B_Hsap     --------------------------------HEDPGP----------------------
ACTR2_Hsap      -----------------------------LVPTQDPGP----------------------
TGFbRII_Spur    -------------------------------TQTQTSNTESTSIDMTTD-----ESETKR
ACTR2_Spur      -----------------------------AIPTTE-------------------------
BMPR2_Spur      ----------------------------SQLPMIE--A----------------------
AqueK683_Aque   ------------------------------IDY---------------------------
AqueK684_Aque   --------------------------------S-NYQL----------------------
AqueK685_Aque   ----------------------------HQIQFSSETS----------------------
AqueK686_Aque   ----------------------------HQIQFPA--A----------------------


TGFbR2_Hsap     ISSTCA--NNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFP--YE
MISR2_Hsap      -----DWS---VELQELPELCFSQVIREGGHAVVWAGQLQ------GKLVAIKAFP--PR
MISR2_Mmus      -----DCS---EELPELAELRFSQVIQEGGHAVVWAGRLQ------GEMVAIKAFP--PR
BMPR2_Mmus      -----AAA---EPSLDLDNLKLLELIGRGRYGAVYKGSLD------ERPVAVKVFS--FA
ACTR2B_Mmus     -----PP---PSPLVGLKPLQLLEIKARGRFGCVWKAQLM------NDFVAVKIFP--LQ
ACTR2_Mmus      -----PP---PSPLLGLKPLQLLEVKARGRFGCVWKAQLL------NEYVAVKIFP--IQ
daf-4_Cele      -----EMI-EMVETPKELPITDFQLISKGRFGKVFKAQYTPDS-GEKRLVAVKKLN--EF
BMPR2_Hsap      -----AAS---EPSLDLDNLKLLELIGRGRYGAVYKGSLD------ERPVAVKVFS--FA
put_Dmel        -----TN---SSPLLSNRPIQLLEQKASGRFGDVWQAKLN------NQDVAVKIFR--MQ
wit_Dmel        -----GYS---SNLRNVDNMNLIGMLGSGKYGTVMKGLLH------DQEVAVKIYP--EE
TGFBR2_Mmus     ISSTCA--NNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFP--YE
ACTR2B_Hsap     -----PP---PSPLVGLKPLQLLEIKARGRFGCVWKAQLM------NDFVAVKIFP--LQ
ACTR2_Hsap      -----PP---PSPLLGLKPLQLLEVKARGRFGCVWKAQLL------NEYVAVKIFP--IQ
TGFbRII_Spur    LGEYSPPDSPLHLNGNYLPITLDELIGKGRFGAVWRAHWKINNGTKERTVAVKVFL--EY
ACTR2_Spur      -----PT---PSPMNSLPPIQLLEIKARGRFGAVWKASCL------NDIVAVKVFP--IQ
BMPR2_Spur      -----PPP---EPTFDLDQLKMMELVGQGRYCNVYRAALS------ENEVAVKVFT--GS
AqueK683_Aque   -------------SLSLDNSN-STLIYSHQIVTVRKA-EN------NRIIAVYKST--VS
AqueK684_Aque   -----SS---PSPTLY-DSPEFMKIIGHGRFARVYHARMG------TRDVAIKIFNGTLQ
AqueK685_Aque   -----TII-ELDEEPGLPPFQLIQSIGNGRFGSVWKALYE------KETVAVRVFS--QR
AqueK686_Aque   -----PNI-ELDERSAPLPFQLLQPIGNGRFGSVWKALYN------NETVAVKALS--LH
                                                 *  .            :*:

TGFbR2_Hsap     EYASWKTEKDIFSD--IN---LKHENILQFLTAEERKTE---LGKQYWLITAFHAKGNLQ
MISR2_Hsap      SVAQFQAERALYEL--PG---LQHDHIVRFITASRGGPG--RLLSGPLLVLELHPKGSLC
MISR2_Mmus      AVAQFRAERAVYQL--LG---LQHDHIVRFITAGQGGPG--PLPSGPLLVLELYPKGSLC
BMPR2_Mmus      NRQNFINEKNIYRV--PL---MEHDNIARFIVGDERLTA--DGRMEYLLVMEYYPNGSLC
ACTR2B_Mmus     DKQSWQSEREIFST--PG---MKHENLLQFIAAEKRGSN---LEVELWLITAFHDKGSLT
ACTR2_Mmus      DKQSWQNEYEVYSL--PG---MKHENILQFIGAEKRGTS---VDVDLWLITAFHEKGSLS
daf-4_Cele      QKASFLAEKRIFDE--LNEYPKWYKSIVEFVCAEKIG-------DEYWIVTEFHERLSLY
BMPR2_Hsap      NRQNFINEKNIYRV--PL---MEHDNIARFIVGDERVTA--DGRMEYLLVMEYYPNGSLC
put_Dmel        EKESWTTEHDIYKL--PR---MRHPNILEFLGVEKHMD-----KPEYWLISTYQHNGSLC
wit_Dmel        HHQYYVNERNIYAL--PL---MECPALLSYFGYDERCTM--DGRMEYQLVLSLAPLGCLQ
TGFBR2_Mmus     EYSSWKTEKDIFSD--IN---LKHENILQFLTAEERKTE---LGKQYWLITAFHAKGNLQ
ACTR2B_Hsap     DKQSWQSEREIFST--PG---MKHENLLQFIAAEKRGSN---LEVELWLITAFHDKGSLT
ACTR2_Hsap      DKQSWQNEYEVYSL--PG---MKHENILQFIGAEKRGTS---VDVDLWLITAFHEKGSLS
TGFbRII_Spur    DSASWNVEKELFTDHSVM---MRHEHIVQFISAEVRRVSVTSPTRQYWLITKYYKNGSLH
ACTR2_Spur      DRNSWANEREIYSL--PH---MHHENLLHFIATEKHGEG---LEVEYWLISEFHHHGSLC
BMPR2_Spur      SKQCYMNELDIMGL--PH---MEHSNLLQYVGSGDRMGE--DGWVEHLLVVDMISKGSLM
AqueK683_Aque   ALSQWKIERDIYLT--PE---LRHESILTLLRAKR-VK--D---IGYQLVLKGSITGSLY
AqueK684_Aque   AKGSWTQEKDIYAT--ER---LEHENILKFLYHDHRFHE---GQDTLWLIFDYHSNGSLY
AqueK685_Aque   HRTSWQNERDIHLL--NS---TPHENILKFISSESRGRG---PSSEYFIITEYLPLGSLH
AqueK686_Aque   HKLSWQNERDIHLL--DS---TPHENILKFISSESRGRG---SSSEYFIITEYLPLGSLH
                    :  *  :               :   .                 ::        *

TGFbR2_Hsap     EYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPC-G---RPKMPIVHRDLKSSNILVKND
MISR2_Hsap      HYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQN-G---QYKPGIAHRDLSSQNVLIRED
MISR2_Mmus      HYLTQYTSDWGSSLRMALSLAEGLAFLHEERWQD-G---QYKPGIAHRDLSSQNVLIRED
BMPR2_Mmus      KYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRG-D---HYKPAISHRDLNSRNVLVKND
ACTR2B_Mmus     DYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCR-G-EGHKPSIAHRDFKSKNVLLKSD
ACTR2_Mmus      DFLKANVVSWNELCHIAETMARGLAYLHEDIPGL--K-DGHKPAISHRDIKSKNVLLKNN
daf-4_Cele      ELLKNNVISITSANRIIMSMIDGLQFLHDDRPYFF---GHPKKPIIHRDIKSKNILVKSD
BMPR2_Hsap      KYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRG-D---HYKPAISHRDLNSRNVLVKND
put_Dmel        DYLKSHTISWPELCRIAESMANGLAHLHEEIPASK-T-DGLKPSIAHRDFKSKNVLLKSD
wit_Dmel        DWLIANTLTFSECCGMLRSITRGISHLHTELRLG-D---QHKPCVAHRDINTRNVLVQAD
TGFBR2_Mmus     EYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPC-G---RPKMPIVHRDLKSSNILVKND
ACTR2B_Hsap     DYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCR-G-EGHKPSIAHRDFKSKNVLLKSD
ACTR2_Hsap      DFLKANVVSWNELCHIAETMARGLAYLHEDIPGL--K-DGHKPAISHRDIKSKNVLLKNN
TGFbRII_Spur    DYLRQRSVNWIDLCKLCGSAARGLAHLHAETYGSHG---LHKVPVAHRDLKSTNILVKDD
ACTR2_Spur      DYLKANVISWKELCGIAFSMAKGLAYLHEDIPPTT-AIPFVKHSVAHRDFKSKNVLIKNN
BMPR2_Spur      SYLRENTYDWHTMCRLAQTTAAGLAHLHQVIDTQ-V---GLKPAVVHRDINSRNVLVNAE
AqueK683_Aque   QYLQSHSPDELEAAKITHSMSSGLAHLHYMESSQS-HSKYRVITIAHCNINSHNILMKED
AqueK684_Aque   DYLQLHRLTFDELFSLCLSGAAGLEHLHSVDNC---P-ETYKPAIAHRDLKSKNILVKKD
AqueK685_Aque   QFLRHNTLSWEQAWNIMYSITSGITHLHSSSYYS-NGLLADKFSIAHRDIKPSNILVKSP
AqueK686_Aque   QFLRHNTLSWEQAWNIMYSIASGITHLHSNSYYNSNGLLLEKYSIAHRDIKPSNILVKSV
                  *            :  :   *: .**                : * ::.. *:*:.

TGFbR2_Hsap     -LTCCLCDFGLSLRLDPTLS-------VD-DLANSGQVGTARYMAPEVLESRMNLENV-E
MISR2_Hsap      -GSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGM
MISR2_Mmus      -RSCAIGDLGLALVLPGLAQPPALAPTQPRGPAAILEAGTQRYMAPELLDKTLDLQDWGT
BMPR2_Mmus      -GACVISDFGLSMRLTGNRLV---RPGEE-DNAAISEVGTIRYMAPEVLEGAVNLRDCES
ACTR2B_Mmus     -LTAVLADFGLAVRFEPGK---------P-PGDTHGQVGTRRYMAPEVLEGAINFQR--D
ACTR2_Mmus      -LTACIADFGLALKFEAGK---------S-AGDTHGQVGTRRYMAPEVLEGAINFQR--D
daf-4_Cele      -MTTCIADFGLARIYSYDI---------E-QSDLLGQVGTKRYMSPEMLEGATEFTP--T
BMPR2_Hsap      -GTCVISDFGLSMRLTGNRLV---RPGEE-DNAAISEVGTIRYMAPEVLEGAVNLRDCES
put_Dmel        -LTACIADFGLAMIFQPGK---------P-CGDTHGQVGTRRYMAPEVLEGAINFNR--D
wit_Dmel        -LSCCIADFGFALKVFGSKYEYKGEVAMA-ETKSINEVGTLRYMAPELLEGAVNLRDCET
TGFBR2_Mmus     -LTCCLCDFGLSLRLDPTLS-------VD-DLANSGQVGTARYMAPEVLESRMNLENV-E
ACTR2B_Hsap     -LTAVLADFGLAVRFEPGK---------P-PGDTHGQVGTRRYMAPEVLEGAINFQR--D
ACTR2_Hsap      -LTACIADFGLALKFEAGK---------S-AGDTHGQVGTRRYMAPEVLEGAINFQR--D
TGFbRII_Spur    -GSCAIADFGLAIRLDPQSS-------TD-HLANSGQVGTPRYMSPEALECKVNLQDI-E
ACTR2_Spur      -TTACIADFGLACVFEAGK---------N-PGDTHGQVGTRRYMAPEVLEGAIQFKR--D
BMPR2_Spur      -GNCVIGDFGFAMQVCGSSVV---GEGDG-DNSTITDVGTVRYMSPEVLDGAVNLRDCEC
AqueK683_Aque   -GTVFLSDFSRSVKFNGGI---------I-AVGRDSEVIILGICLPEVLQGFQSFTI--T
AqueK684_Aque   -MTCCISDFGLAIKFDGVDM--------I-LSEAKGQVGTSRYMAPEILEGAVRFNQ--E
AqueK685_Aque   SGQCVVADFGQAFVLDPAAD-------DR-KLAVSGQVGTYRYMSPEALDARVNLRDS-E
AqueK686_Aque   SGHCVVADLGLAFILDPAAD-------DR-KLAVSGQVGTYRYMSPEALDARVNLRDI-E
                     : *:. :                        :.       ** *:    :

TGFbR2_Hsap     SFKQTDVYSMALVLWEMTSRCNAV----GEVKDYEPPFGSKVRE-HPCVESMKDNVLRDR
MISR2_Hsap      ALRRADIYSLALLLWEILSRCPDL-RPDSSPPPFQLAYEAELGN-TPTSDELWALAVQER
MISR2_Mmus      ALQRADVYSLALLLWEILSRCSDL-RPDHRPPPFQLAYEAELGS-NPSACELWALAVEER
BMPR2_Mmus      ALKQVDMYALGLIYWEVFMRCTDL-FPGESVPDYQMAFQTEVGN-HPTFEDMQVLVSREK
ACTR2B_Mmus     AFLRIDMYAMGLVLWELVSRCKAA---DGPVDEYMLPFEEEIGQ-HPSLEELQEVVVHKK
ACTR2_Mmus      AFLRIDMYAMGLVLWELASRCTAA---DGPVDEYMLPFEEEIGQ-HPSLEDMQEVVVHKK
daf-4_Cele      AFKAMDVYSMGLVMWEVISRTKLH--QTDEPPNYQMPFQ-VIGF-DPTIGLMRNYVVSKK
BMPR2_Hsap      ALKQVDMYALGLIYWEIFMRCTDL-FPGESVPEYQMAFQTEVGN-HPTFEDMQVLVSREK
put_Dmel        AFLRIDVYACGLVLWEMVSRCDFA----GPVGEFQLPFEAELGL-RPSLDEVQESVVMKK
wit_Dmel        SLKQMDVYALGLVLWEVATRCSDFYAPGQATPPYKAPYEQEVGS-HPSFDQMQALVVRHK
TGFBR2_Mmus     SFKQTDVYSMALVLWEMTSRCNAV----GEVKDYEPPFGSKVRE-HPCVESMKDSVLRDR
ACTR2B_Hsap     AFLRIDMYAMGLVLWELVSRCKAA---DGPVDEYMLPFEEEIGQ-HPSLEELQEVVVHKK
ACTR2_Hsap      AFLRIDMYAMGLVLWELASRCTAA---DGPVDEYMLPFEEEIGQ-HPSLEDMQEVVVHKK
TGFbRII_Spur    SFKQMDTYALALILWEITSRCTLL----KDINEYELPFSRSLGDRRASLEMMKTLVVLRR
ACTR2_Spur      AFLRIDMYAFGLVLWELVTRCTVQ---DGPVPEYRLPFEEELGQ-GTSLEDMQEWVVVKR
BMPR2_Spur      ALKQVDVYALGLVVWEIAMRCKDL-YPRDEMGNYQMPFEEQVGL-HPTFEDMQILVSRER
AqueK683_Aque   SLTNSDIYSLGLCIWEVLNCCQIT---G---NSYTPPFHEVSDS-DISMDIMRSMIVEQG
AqueK684_Aque   AFLKIDIYAFGLILWEMLSCCDLN--NITSNPSYYPPFDGWVSA-NPSIDEMKRIVVEEK
AqueK685_Aque   SFKQIDVYAMSLVLWEVCMRYQSN---DVPVPPYQSPFFDMVGE-KPTLDQMKEIVVINK
AqueK686_Aque   SFKQIDMYALSLVLWEVCMRYQSD---DVPVPPYQSPFFDMVGE-KPTLEQMKEIVVNAN
                ::   * *: .*  **:                :  .:             :

TGFbR2_Hsap     GRPEIPSFWLNHQ-GIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRL-SG--RS
MISR2_Hsap      RRPYIPSTWRCFATDPDGLRELLEDCWDADPEARLTAECVQQRLAALAHPQES-HP--FP
MISR2_Mmus      KRPNIPSTWSCSATDPRGLRELLEDCWDADPEARLTAECVQQRLAALAYPHGA-SS--FP
BMPR2_Mmus      QRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELMMIWERNKSV-SP
ACTR2B_Mmus     MRPTIKDHWLKHP-GLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVN-GT-----
ACTR2_Mmus      KRPVLRDYWQKHA-GMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTN-II-----
daf-4_Cele      ERPQWRDEIIKHE-YMSLLKKVTEEMWDPEACARITAGCAFARVWNHIMSSPD-SS----
BMPR2_Hsap      QRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELMMIWERNKSV-SP
put_Dmel        LRPRLLNSWRAHP-GLNVFCDTMEECWDHDAEARLSSSCVMERFAQLNKYPST-Q-----
wit_Dmel        ARPLFPTGWGGGA-AAKVVRDTCEDCWDHDADARLTSLCAEERMQEMSTLRPRAQA--QP
TGFBR2_Mmus     GRPEIPSFWLNHQ-GIQIVCETLTECWDHDPEARLTAQCVAERFSELEHPERL-SG--RS
ACTR2B_Hsap     MRPTIKDHWLKHP-GLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVN-GT-----
ACTR2_Hsap      KRPVLRDYWQKHA-GMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTN-II-----
TGFbRII_Spur    ERPPITDEWLRNP-GLTIIKNTVVDCWDEDPEARLTASCVEARFQELILWHEG-EP--HA
ACTR2_Spur      KRPVISDHWLKHR-GLELLCETIEECWDQDAEARLSAGCVEERIAQFSHSHMNGHM----
BMPR2_Spur      KRPQFPDAWKQNSQALRSLKETIEDCWDHDAEARLTALCVEERIIELMVLWDKHRMI-SP
AqueK683_Aque   IVPALPAVFDEIK-EFSSVRNTVSECFDLEPEARPNSHILKNLFSKLLHDLLEKKSS-SP
AqueK684_Aque   KRPPIPQKFQTNL-KYSFIADIIVECWDDDADGRPAASLISRRLSEFQTAGYTASP----
AqueK685_Aque   QRPLLPEKWNNDK-NLKRIIKLIVEGWDEDPEARLTAANIKIQLESLVGMRPKPPPSSTS
AqueK686_Aque   KRPGFTGVWYSDK-NLKRIIKLIKEGWDEDPEARLTAANIKIQLESLIGMRPKLDSLSSP
                  *               .     : :* :. .*  :      .

TGFbR2_Hsap     ------------------------------------------------------------
MISR2_Hsap      ESCPRG------------------------------------------------------
MISR2_Mmus      ES-PQG------------------------------------------------------
BMPR2_Mmus      TVNPMSTAMQNER--NLSHNRRVPKIG--PYPDY-------------------SSSSYIE
ACTR2B_Mmus     ------------------------------------------------------------
ACTR2_Mmus      ------------------------------------------------------------
daf-4_Cele      ------------------------------------------------------------
BMPR2_Hsap      TVNPMSTAMQNER--NLSHNRRVPKIG--PYPDY-------------------SSSSYIE
put_Dmel        ------------------------------------------------------------
wit_Dmel        SS-PLLNTN------NL------------------------------------VASPTAE
TGFBR2_Mmus     ------------------------------------------------------------
ACTR2B_Hsap     ------------------------------------------------------------
ACTR2_Hsap      ------------------------------------------------------------
TGFbRII_Spur    ------------------------------------------------------------
ACTR2_Spur      ------------------------------------------------------------
BMPR2_Spur      TINPTTQGNAIPTHTMNEYTTRPTDIISREYPGIARLADGTMIAVRSNGQPVLGAA----
AqueK683_Aque   IV----------------------------------------------------------
AqueK684_Aque   HLPPLSNKS---------------------------------------------------
AqueK685_Aque   ----QPDGR------NN------------------------------------FLSPILE
AqueK686_Aque   LS-PPPEGE------GV------------------------------------FLSPVSE


TGFbR2_Hsap     ------CS----------------------------------------------------
MISR2_Hsap      ------------------------------------------------------------
MISR2_Mmus      ------------------------------------------------------------
BMPR2_Mmus      DSIHHTDS-IVKNISSEHSMSS-------------TPLTIGE-KNRNSINYERQQA---Q
ACTR2B_Mmus     ------TS----------------------------------------------------
ACTR2_Mmus      ------TT----------------------------------------------------
daf-4_Cele      ------E--------GYHSGSS-------------M--K-NRGVD---------------
BMPR2_Hsap      DSIHHTDS-IVKNISSEHSMSS-------------TPLTIGE-KNRNSINYERQQA---Q
put_Dmel        ------------------------------------------------------------
wit_Dmel        QGINIIAT-TTTAAAVHHQMSSDTTGLIQPPPNQQIPLAALE-REKNHLSYPQQQLQPYQ
TGFBR2_Mmus     ------CS----------------------------------------------------
ACTR2B_Hsap     ------TS----------------------------------------------------
ACTR2_Hsap      ------TT----------------------------------------------------
TGFbRII_Spur    ------QS----------------------------------------------------
ACTR2_Spur      ------NG--------HHPVSP-------------TPLI---------------------
BMPR2_Spur      SETSGTAS-DTKNHHGLHSSVS-------------SGLE----KN----------E---R
AqueK683_Aque   ------EEEE--------------------------------------------------
AqueK684_Aque   ------SK-----ESGFHSLSG-------------QPLLSSSGVNNDALATDYNINT---
AqueK685_Aque   ----SSES-SCK-------------------------------KYRLSS-----------
AqueK686_Aque   ----TSHS-SCK-------------------------------KVHISA-----------


TGFbR2_Hsap     ------------------------------------------------------------
MISR2_Hsap      ----CP------------------------------------------------------
MISR2_Mmus      ------------------------------------------------------------
BMPR2_Mmus      ARIPSPETSVTSLSTNTTTTNTTGLTPSTGMTTISEMP--YPD-ETHLHATNV---AQSI
ACTR2B_Mmus     ------------------------------------------------------------
ACTR2_Mmus      ------------------------------------------------------------
daf-4_Cele      -----------------------DVEQ-----------SEKPE-----------------
BMPR2_Hsap      ARIPSPETSVTSLSTNTTTTNTTGLTPSTGMTTISEMP--YPD-ETNLHTTNV---AQSI
put_Dmel        ------------------------------------------------------------
wit_Dmel        GRNPCQERNLAPLT----------------------------------------------
TGFBR2_Mmus     ------------------------------------------------------------
ACTR2B_Hsap     ------------------------------------------------------------
ACTR2_Hsap      ------------------------------------------------------------
TGFbRII_Spur    ------------------------------------------------------------
ACTR2_Spur      ------------------------------------------------------------
BMPR2_Spur      LRLMSPGTISTSLSSQS-DLNLIDLTASAPPVDPKNLH--HSDDSIERYTTDLKYGPQQS
AqueK683_Aque   ------------------------------------------------------------
AqueK684_Aque   -----------------------PLPP-----------TPTPS-----------------
AqueK685_Aque   -----------SFSESS-G-----------NAVIFSNPSS----K--LSGR---------
AqueK686_Aque   -----------SFSGST-N------------AML--SPAAAPH-S--FHGR---------


TGFbR2_Hsap     ------------------------------------------------------------
MISR2_Hsap      --------------------PL----------C---------------------------
MISR2_Mmus      --------------------------------C---------------------------
BMPR2_Mmus      GPTPVCLQLTEEDLETNKLDPK----------EVDKNLKES--SDENLMEH---------
ACTR2B_Mmus     ------------------------------------------------------------
ACTR2_Mmus      ------------------------------------------------------------
daf-4_Cele      ------------G--------------------IE----EMQH---------YH---A--
BMPR2_Hsap      GPTPVCLQLTEEDLETNKLDPK----------EVDKNLKES--SDENLMEH---------
put_Dmel        ------------------------------------------------------------
wit_Dmel        ----------------MRTPPV----------LVERSKKHS--FQTQPQEN---------
TGFBR2_Mmus     ------------------------------------------------------------
ACTR2B_Hsap     ------------------------------------------------------------
ACTR2_Hsap      ------------------------------------------------------------
TGFbRII_Spur    ------------------------------------------------------------
ACTR2_Spur      ---------------------------------M-------QT---------MH---N--
BMPR2_Spur      GP-KYCDQYGFSEPSTSPSRPL----------VVNEMRAGL--SKDQMTDNLSHGMGKLK
AqueK683_Aque   ----------------------------------------------------LE---A--
AqueK684_Aque   ------------SPS------------------I-------TLSPTEIKSHTVH---D--
AqueK685_Aque   ---------------------FSVDH-TNNASSH--------------------------
AqueK686_Aque   ---------------------FSLDHGGHNPVTV--------------------------


TGFbR2_Hsap     --------E---------------------------------------------------
MISR2_Hsap      ------------------------------------------------------------
MISR2_Mmus      ------------------------------------------------------------
BMPR2_Mmus      -------SLKQFSGPDPLSSTSSSLLYPLIKLAVEVTGQQ--DFTQ-------------A
ACTR2B_Mmus     --------D-C------L----VS------------------------------------
ACTR2_Mmus      --------E-D------I----VT------------------------------------
daf-4_Cele      ----SSPSKRQHPSPNPFFDSCPP--PPPIPVILENGGILQPD-----------------
BMPR2_Hsap      -------SLKQFSGPDPLSSTSSSLLYPLIKLAVEATGQQ--DFTQ-------------T
put_Dmel        ---------------------L--------------------------------------
wit_Dmel        -------SLSCLEHDVSVE-----EL-----IASHQHQQQ------------KNTIVSTG
TGFBR2_Mmus     --------Q---------------------------------------------------
ACTR2B_Hsap     --------D-C------L----VS------------------------------------
ACTR2_Hsap      --------E-D------I----VT------------------------------------
TGFbRII_Spur    --------F---------------------------------------------------
ACTR2_Spur      ----STSFE-N------TGNTEST------------------------------------
BMPR2_Spur      NKSSSMPSWNHINGVDPRSRGANQP-VNMAKLDTNLHRQQ--ARSASPKQSNQNGYEASG
AqueK683_Aque   ----FTGTE-Q------T------------------------------------------
AqueK684_Aque   ----FSSSS-T------SSSSCPT--RS--------------------------------
AqueK685_Aque   -----------------------RTIL--N------------------------------
AqueK686_Aque   -----------------------SMILSLS------------------------------


TGFbR2_Hsap     ------------------------------------------------------------
MISR2_Hsap      --PEDC------------------------------------------------------
MISR2_Mmus      --PENC------------------------------------------------------
BMPR2_Mmus      ANGQACLIPDVPPAQIYPLPKQQNLPKRPTSLPLNTKN-STKEPRLKFGNKHKSNL-KQV
ACTR2B_Mmus     ------------------------------------------------------------
ACTR2_Mmus      ------------------------------------------------------------
daf-4_Cele      --------------N--AEPEPEELPDLPIVEKI----YDIATNML--------------
BMPR2_Hsap      ANGQACLIPDVLPTQIYPLPKQQNLPKRPTSLPLNTKN-STKEPRLKFGSKHKSNL-KQV
put_Dmel        ------------------------------------------------------------
wit_Dmel        GNGNSCLGQ--------GFPKQQNTDQKLRGW--HGVR-ALIHKK-LFRKEHAEELCRQL
TGFBR2_Mmus     ------------------------------------------------------------
ACTR2B_Hsap     ------------------------------------------------------------
ACTR2_Hsap      ------------------------------------------------------------
TGFbRII_Spur    ------------------------------------------------------------
ACTR2_Spur      ------------------------------------------------------------
BMPR2_Spur      SSGASSEG--------AGPSSIPNMNIRPNSLPLQSTHRGSKKKLMAVYNPNTGPT-TKV
AqueK683_Aque   ----------------------EELPSSE-------------------------------
AqueK684_Aque   -----------------------SLPIHFSPAKK----SDTSDPRS--------------
AqueK685_Aque   ----D--------------------LRRYR------------------------------
AqueK686_Aque   ----DV-----------------QVQYRPP------------------------------


TGFbR2_Hsap     ------------------------------------------------------------
MISR2_Hsap      ---------TSI-------------------------PAPTILPC-RPQ---R-------
MISR2_Mmus      ---------LSA-------------------------PASAVFPC-RPQ---Q-------
BMPR2_Mmus      ETGVAKMN-TIN--------AAEPHVVTVT------------------------------
ACTR2B_Mmus     ------------------------------------------------------------
ACTR2_Mmus      ------------------------------------------------------------
daf-4_Cele      --------------------------------------------F-SR------------
BMPR2_Hsap      ETGVAKMN-TIN--------AAEPHVVTVT------------------------------
put_Dmel        ------------------------------------------------------------
wit_Dmel        QLGEEKSN-LVT--------AL---------------RRPNNLDL-NPR---LD------
TGFBR2_Mmus     ------------------------------------------------------------
ACTR2B_Hsap     ------------------------------------------------------------
ACTR2_Hsap      ------------------------------------------------------------
TGFbRII_Spur    ------------------------------------------------------------
ACTR2_Spur      ------------------------------------------------------------
BMPR2_Spur      QTGIAKMD-SVAPSCHQVKMAANTHKQQPTHNAVEKLRNGNVGNL-EPE---ADRPHSWA
AqueK683_Aque   ----------------------------------------VVLP----------------
AqueK684_Aque   --------------------------------------------R-K-------------
AqueK685_Aque   -DGIGLSNNIST-------------------------TTTDS---T----QPN-------
AqueK686_Aque   -DTVATANSESI-------------------------TVPALIPQSEPTTAPQ-------


TGFbR2_Hsap     ------------------------------------------------------------
MISR2_Hsap      ------------------------------------------------------------
MISR2_Mmus      ------------------------------------------------------------
BMPR2_Mmus      --MNGVAGRSHNVNSHAATTQYANGAVPAGQAANIVAHRSQEMLQNQFIGEDTRLNINSS
ACTR2B_Mmus     ------------------------------------------------------------
ACTR2_Mmus      ------------------------------------------------------------
daf-4_Cele      ---------------------------------------E---------------ELDLM
BMPR2_Hsap      --MNGVAGRNHSVNSHAATTQYANGTVLSGQTTNIVTHRAQEMLQNQFIGEDTRLNINSS
put_Dmel        ------------------------------------------------------------
wit_Dmel        ------------------------------------------------------------
TGFBR2_Mmus     ------------------------------------------------------------
ACTR2B_Hsap     ------------------------------------------------------------
ACTR2_Hsap      ------------------------------------------------------------
TGFbRII_Spur    ------------------------------------------------------------
ACTR2_Spur      ------------------------------------------------------------
BMPR2_Spur      CDSSSGSDRSH-------EIDRKNGNACSGSASCIAKGDNGKRKVTPFRLLTEKLSIHKG
AqueK683_Aque   ------------------------------------------------------------
AqueK684_Aque   ------------------------------------------------------------
AqueK685_Aque   ------------------------GAYTGG------------------------------
AqueK686_Aque   ------------------------L-----------------------------------


TGFbR2_Hsap     ------------------------------------------------------------
MISR2_Hsap      ------------------------------------------------------------
MISR2_Mmus      ------------------------------------------------------------
BMPR2_Mmus      PDEHEP--LLRREQQAGHDEGVLDRLVDRRERPLEG-GRTNSNNNNSNPCSEQDILTQGV
ACTR2B_Mmus     ------------------------------------------------------------
ACTR2_Mmus      ------------------------------------------------------------
daf-4_Cele      NA----------QRQ-------VEYE-------------------------------AGA
BMPR2_Hsap      PDEHEP--LLRREQQAGHDEGVLDRLVDRRERPLEG-GRTNSNNNNSNPCSEQDVLAQGV
put_Dmel        ------------------------------------------------------------
wit_Dmel        --KPPPDQLRSAEQRMGTPAHIVPRSLSSSLIKHIN-GTTNNNSIQS-HGSELQTLTRPA
TGFBR2_Mmus     ------------------------------------------------------------
ACTR2B_Hsap     ------------------------------------------------------------
ACTR2_Hsap      ------------------------------------------------------------
TGFbRII_Spur    ------------------------------------------------------------
ACTR2_Spur      ------------------------------------------------------------
BMPR2_Spur      KDKKEP--KDQTDCNGVNNRNPVELNVNNNARAIAPQTLANGSDNDSVACSDLSNGHAGV
AqueK683_Aque   ------------------------------------------------------------
AqueK684_Aque   ------------------------------------------------------------
AqueK685_Aque   ----------------------------------------GSRDEVSSSESQDEV-----
AqueK686_Aque   ----------------------------------------ASNNEVSNGGSQDEV-----


TGFbR2_Hsap     ------------------------------------------------------------
MISR2_Hsap      ----------SACHFSVQQGPCS-------------------------------------
MISR2_Mmus      ----------SSCLLSVQQGPGS-------------------------------------
BMPR2_Mmus      T------------STAADPGPSKPRRAQRPNSLDLSATNILDGSSIQIGESTQDGKSGSG
ACTR2B_Mmus     -----------LVT--S----V--------------------------------------
ACTR2_Mmus      -----------VVT--M----V--------------------------------------
daf-4_Cele      -----------DTR--A----S--------------------------------------
BMPR2_Hsap      P------------STAADPGPSKPRRAQRPNSLDLSATNVLDGSSIQIGESTQDGKSGSG
put_Dmel        -----------LIK--N----H--------------------------------------
wit_Dmel        SKRRPGHLRTNSLMATTGQGPPTEQQMRRQHSLEVFR-------------EVFSG-RGSS
TGFBR2_Mmus     ------------------------------------------------------------
ACTR2B_Hsap     -----------LVT--S----V--------------------------------------
ACTR2_Hsap      -----------VVT--M----V--------------------------------------
TGFbRII_Spur    ------------------------------------------------------------
ACTR2_Spur      -----------DIA--L----Y--------------------------------------
BMPR2_Spur      -------------SLNGDAYPLN-------------------------------------
AqueK683_Aque   -----------LT---Q--HSQT-------------------------------------
AqueK684_Aque   -----------AVT--P----L---RSNPGKPTDLGSGNISGGDLFS--QYDLSSSSGAG
AqueK685_Aque   ----------NVVD--V-------------------------------------------
AqueK686_Aque   ----------NVID--ATTGQPK-------------------------------------


TGFbR2_Hsap     ------------------------------------------------------------
MISR2_Hsap      -RNPQ-----------P-------------------------------------------
MISR2_Mmus      -RSPD-----------P-------------------------------------------
BMPR2_Mmus      EKIK---RRVKTP----YSLKRWRPSTWVISTEPLDCEVNNNGSDRAVHSKSSTAVYLAE
ACTR2B_Mmus     ------------------------------------------------------------
ACTR2_Mmus      ------------------------------------------------------------
daf-4_Cele      ------------------------------------------------------------
BMPR2_Hsap      EKIK---KRVKTP----YSLKRWRPSTWVISTESLDCEVNNNGSNRAVHSKSSTAVYLAE
put_Dmel        ------------------------------------------------------------
wit_Dmel        ERLRDPSERVKTPGDVPPSVRKARASK-------------------------TLSLY--D
TGFBR2_Mmus     ------------------------------------------------------------
ACTR2B_Hsap     ------------------------------------------------------------
ACTR2_Hsap      ------------------------------------------------------------
TGFbRII_Spur    ------------------------------------------------------------
ACTR2_Spur      ------------------------------------------------------------
BMPR2_Spur      ------------------------------------SKL---------------------
AqueK683_Aque   -GTMS-----------P-------------------------------------------
AqueK684_Aque   D--------VVSP----LCDDVRKFSLQLDYTE---------------------DF----
AqueK685_Aque   ------------------------------------------------------------
AqueK686_Aque   -RLSD-------------------------------------------------------


TGFbR2_Hsap     ----EKIPED-GSLNTTK
MISR2_Hsap      -----------ACTLSPV
MISR2_Mmus      ------VGD-TVQVYVNE
BMPR2_Mmus      GGTATTTVS-KDIGMNCL
ACTR2B_Mmus     -----TNVDL-LPKESSI
ACTR2_Mmus      -----TNVDF-PPKESSL
daf-4_Cele      ----TPTPS-GTFGTFTT
BMPR2_Hsap      GGTATTMVS-KDIGMNCL
put_Dmel        -----TNIDDAKESTNCL
wit_Dmel        -----DRMM-DSSLLNIL
TGFBR2_Mmus     ----EKIPED-GSLNTTK
ACTR2B_Hsap     -----TNVDL-PPKESSI
ACTR2_Hsap      -----TNVDF-PPKESSL
TGFbRII_Spur    ----YTSKGK-RGRTTLV
ACTR2_Spur      ----RNSPSP-PPKESNL
BMPR2_Spur      -VNGSAKLQ-ANFELECV
AqueK683_Aque   -------GHV-IIAETHL
AqueK684_Aque   ----KPDNE-ENPTETTL
AqueK685_Aque   ----------TTGQPKSH
AqueK686_Aque   ------AEH-DDTTTSLS