KDR_Hsap        LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIG
FLT4_Hsap       LHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIG
FLT1_Hsap       LKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIG
CG3277_Dmel     IQIGRMLGEGAFGQVHEATAINLRRMRGTTIVAVKQLKPNPKADEVAEYLAEIEMLKGVG
Pvr_Dmel        LKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLG
KDR_Mmus        LKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKMLKEGATHSEHRALMSELKILIHIG
FLT4_Mmus       LHLGRVLGHGAFGKVVEASAFGINKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIG
FLT1_Mmus       LKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIG
VEGFR2_Spur     LKLGGVIGKGAFGMVIKAVAVGIDGTENNITVAVKKLKSGATSLEKKALWAELKMLGHIG
VEGFR1_Spur     ------------------------------------------------------------


KDR_Hsap        HHLNVVNLLGACTKP--GGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDY
FLT4_Hsap       NHLNVVNLLGACTKP--QGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRA
FLT1_Hsap       HHLNVVNLLGACTKQ--GGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEK
CG3277_Dmel     THHNVVSFLGCCTIK---PPYLMIMEYVNKGNLLSYLRDAFEY-----------------
Pvr_Dmel        QHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLSTEA-------------------
KDR_Mmus        HHLNVVNLLGACTKP--GGPLMVIVEFCKFGNLSTYLRGKRNEFVPYKSKGARFRQGKDY
FLT4_Mmus       NHLNVVNLLGACTKP--NGPLMVIVEFCKYGNLSNFLRVKRDTFNPYAEKSPEQRRRFRA
FLT1_Mmus       HHLNVVNLLGACTKQ--GGPLMVIVEYCKYGNLSNYLKSKRDLFCLNKDAALHMELKKES
VEGFR2_Spur     KHLNVVNFLGACTQ---NGPVLAIVEFCCHGNLLDFLRSKRKYFSETPEGTG--------
VEGFR1_Spur     ------------------KDLFVISEFCPFGNLSDYLKTKRKNYVAEPDLLA--------
                                     : * *:   **:  :*

KDR_Hsap        V-GAIPVDLKRRLDSITSSQSSASSGFVEEK----SLSD----VEEEEAPEDLY-KDFLT
FLT4_Hsap       MVELARLD---RRRPGSSD-RVLFARFSKTEG---GARR----ASPDQEAEDLW-LSPLT
FLT1_Hsap       MEPGLEQGKKPRLDSVTSSESFASSGFQEDK----SLSD----VEEEEDSDGFY-KEPIT
CG3277_Dmel     ---------------------------------------------------------ILD
Pvr_Dmel        --------------------------------------------------------MTVT
KDR_Mmus        V-GELSVDLKRRLDSITSSQSSASSGFVEEK----SLSD----VEEEEASEELY-KDFLT
FLT4_Mmus       MVEGAKAD---RRRPGSSD-RALFTRFLMGKG---SARR----APLVQEAEDLW-LSPLT
FLT1_Mmus       LEPGLEQGQKPRLDSVSSS-SVTSSSFPEDR----SVSD----VEGDEDYSEIS-KQPLT
VEGFR2_Spur     -----SQS---HTG-HSSS-TGASNTFQTSSGSERRMKAVYDQIIPEEVFSPLQ-DDPIN
VEGFR1_Spur     IACMGPVD---RSS-RGSS-RGGGDGFMGARGG----ST--LEVGDDDVFEYMEKEQPLT
                                                                          :

KDR_Hsap        LEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARD-IYKDPDYV
FLT4_Hsap       MEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARD-IYKDPDYV
FLT1_Hsap       MEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARD-IYKNPDYV
CG3277_Dmel     NKELHNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLSRHGIYT-----
Pvr_Dmel        TVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARS-MYRGDNYK
KDR_Mmus        LEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARD-IYKDPDYV
FLT4_Mmus       MEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDIVKICDFGLARD-IYKDPDYV
FLT1_Mmus       MEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARD-IYKNPDYV
VEGFR2_Spur     SQDLLCYSFQVARGMEFLASKNVIHRDLAARNVLVTENYTLKICDFGLAKH-LYDDPDYV
VEGFR1_Spur     LKDLICYSYQVARGMEFLTSKKCIHRDLAARNVLLAENNIVKICDFGLARD-IYSDPDYV
                  .*  :: *:*.** :* .::  * ******:*: ..  :**.****::  :*

KDR_Hsap        RKG-DARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRL
FLT4_Hsap       RKG-SARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRL
FLT1_Hsap       RKG-DTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRL
CG3277_Dmel     NTR-TRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTISND-ELIPFL
Pvr_Dmel        KSE-NGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKL
KDR_Mmus        RKG-DARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRL
FLT4_Mmus       RKG-SARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRL
FLT1_Mmus       RRG-DTRLPLKWMAPESIFDKVYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRL
VEGFR2_Spur     ASGKQGRLPIKWMAPESIFDKVFTTYSDVWAYAVFLWEVFSLGGSPYPGIQIDEKFYNKI
VEGFR1_Spur     TQT-GGRLPIKWMAPESIFDKVFTIYSDVWSFGVFMWECFALGGSPYPGVVVDEEFYNRL
                      :**::*:: *:: :.:::  **:*::.:.:**  :*.  *** :  : .:   :

KDR_Hsap        KEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL
FLT4_Hsap       RDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEIL
FLT1_Hsap       REGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKL
CG3277_Dmel     MAGNRLERPEICTPQVYTIMLQCWLEEPEERPTFDALYKVL
Pvr_Dmel        NDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRF
KDR_Mmus        KEGTRMRAPDYTTPEMYQTMLDCWHEDPNQRPSFSELVEHL
FLT4_Mmus       KDGTRMRAPELATPAIRHIMQSCWSGDPKARPAFSDLVEIL
FLT1_Mmus       KEGMRMRTPEYATPEIYQIMLDCWHKDPKERPRFAELVEKL
VEGFR2_Spur     KNGYRMNAPDYAPPGVYDTMLECWTPEPEARPSFSIL--AV
VEGFR1_Spur     KSGYRMYTPDYAPIEIYHVMLDCWHTEPKERPHFSELVHKL
                  * *:  *.     :   * .**  :*. ** *  *   .