KDR_Hsap MQSK--------------------------------------------------------
FLT4_Hsap MQRG--------------------------------------------------------
FLT1_Hsap MVSYWDT-----------------------------------------------------
CG3277_Dmel MHHS--------------------------------------------------------
Pvr_Dmel MAML--------------------------------------------------------
KDR_Mmus MESK--------------------------------------------------------
FLT4_Mmus MQPG--------------------------------------------------------
FLT1_Mmus MVSCWDT-----------------------------------------------------
VEGFR2_Spur MEKQVSSICRSANFHLRNVRRIRKYMSK-------------------------------Q
VEGFR1_Spur MAFAESPEG-LATFQR-----------TTTRSNEEPPDEGGGFPARGSGKTKPQRGRGNP
*
KDR_Hsap ------------------------------VLLAVALWLCVE---TRAASVGLP------
FLT4_Hsap ------------------------------AALCLRLWLCLGL--LDGLVS---------
FLT1_Hsap ------------------------------GVLLCALLSCLL---LTGSSS---------
CG3277_Dmel ------------------------------TKVPSRIVLILLLVLVRNAVGQAPRENA--
Pvr_Dmel ------------------------------PR---LILLPLLLILRISWSDAVPLQQFSP
KDR_Mmus ------------------------------ALLAVALWFCVE---TRAASVGLP------
FLT4_Mmus ------------------------------AALNLRLWLCLGL--LQGLAN---------
FLT1_Mmus ------------------------------AVLPYALLGCLL---LTGYGS---------
VEGFR2_Spur TTEQ-----------------------IIHALVTSRLDCCNAL------LVGVP------
VEGFR1_Spur DPAANSLLGELARVVGDGSIATITGQKARGERLATAQSLSLVE---LG-KTGLP------
KDR_Hsap ---------SVSL-----------------------------------------------
FLT4_Hsap ---------GYSM-----------------------------------------------
FLT1_Hsap ---------GSKL-----------------------------------------------
CG3277_Dmel ------------------------------------------------------------
Pvr_Dmel DPDDSIENCGGEN-----------------------------------------------
KDR_Mmus ---------GDFL-----------------------------------------------
FLT4_Mmus ---------GYSM-----------------------------------------------
FLT1_Mmus ---------GSKL-----------------------------------------------
VEGFR2_Spur ---------SSAISRLQRVHNNAARVLTKAGKYARISHILRQLHWLPHNFYYSSILTVPV
VEGFR1_Spur ---------LNKV-----------------------------------------------
KDR_Hsap ---------------------------------------------------DLPRL----
FLT4_Hsap ---------------------------------------------------TPPTL----
FLT1_Hsap ---------------------------------------------------KDPEL----
CG3277_Dmel ---------------------------------------------------TNPTL----
Pvr_Dmel ---------------------------------------------------GAPLM----
KDR_Mmus ---------------------------------------------------HPPKL----
FLT4_Mmus ---------------------------------------------------TPPTL----
FLT1_Mmus ---------------------------------------------------KVPEL----
VEGFR2_Spur TCQNILVTVHPDTVQVTEGLSATLHCNYTVPIIDSSLDQLDQDLEPVQVSNQDPTITWLK
VEGFR1_Spur ---------------------------------------------------GPPRL----
* :
KDR_Hsap ------------------------------------------------------------
FLT4_Hsap ------------------------------------------------------------
FLT1_Hsap ------------------------------------------------------------
CG3277_Dmel ------------------------------------------------------------
Pvr_Dmel ------------------------------------------------------------
KDR_Mmus ------------------------------------------------------------
FLT4_Mmus ------------------------------------------------------------
FLT1_Mmus ------------------------------------------------------------
VEGFR2_Spur DGAVLRTYSGVGRNTVTQSDRIAIVAPTSLMISRAVDEDAGTYTCQIEQGALIGSASATL
VEGFR1_Spur ------------------------------------------------------------
KDR_Hsap ----------SIQKD-ILTIKANTTLQITCRGQRDLDWLWPNNQSGS------EQRVEVT
FLT4_Hsap ----------NITEE-SHVIDTGDSLSISCRGQHPLEWAWPGAQEAPATGDKDSEDTGVV
FLT1_Hsap ----------SLKGT-QHIMQAGQTLHLQCRGEAAHKWSLPEMVSKE------SERLSIT
CG3277_Dmel ------------------I-------------------------S---------------
Pvr_Dmel ----------TPCKS-AIILDAQTSTTLKCEDDEPMSWWTSQSQYVH------VKSFDNT
KDR_Mmus ----------STQKD-ILTILANTTLQITCRGQRDLDWLWPNAQRDS------EERVLVT
FLT4_Mmus ----------NITED-SYVIDTGDSLSISCRGQHPLEWTWPGAQEVLTTGGKDSEDTRVV
FLT1_Mmus ----------SLKGT-QHVMQAGQTLFLKCRGEAAHSWSLPTTVSQE------DKRLSIT
VEGFR2_Spur NVVGSTPDLLGHEGSYETSILEGETLRLQCKGSYPLSWTYYQGIDHS------KVFIRST
VEGFR1_Spur ----------ETESS-TLLISQNNTLQLSCHGGFRLDWIYPYEIERT------RISIEQE
KDR_Hsap E---C--SDGLFCKTLTIPKVIGNDTGAYKCFYRET--------------------DLAS
FLT4_Hsap -RDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKAR--------------IEGTTAA
FLT1_Hsap K-SACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTS--------------KKKETES
CG3277_Dmel ----------------------------------LVRSSEKEPE--------------QM
Pvr_Dmel E-----DPARPFGTSLHLIEVTADYVAAYYCVKTSKFSQIAKEEQSDEAMIELVNQGYAS
KDR_Mmus E---CGGGDSIFCKTLTIPRVVGNDTGAYKCSYRDV--------------------DIAS
FLT4_Mmus -HDCEGTEARPYCKVLLLAQTHANNTGSYHCYYKYIKAR--------------IEGTTAA
FLT1_Mmus PPSACGRDNRQFCSTLTLDTAQANHTGLYTCRYLPTSTS--------------KKKKAES
VEGFR2_Spur LTPILDSSSWNETSELLVVNATTTDTGYFTCTHTHD------------------SEDFSR
VEGFR1_Spur HC--SACSPKRHRSVLTIASADVGDTGKYQCLYKKYDTK--------------INNETSA
KDR_Hsap VIYVYVQ--DYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRF
FLT4_Hsap SSYVFVR--DFEQPFINKP----DTLLV--NRKDAMWVPCLVSIPGLNVTLRSQ--SSVL
FLT1_Hsap AIYIFIS--DTGRPFVEMYSEIPEIIHM--TEGRELVIPCRVTSPNITVTLKK-FPLDTL
CG3277_Dmel ESHRYVT--GLSEPIAMEP----LTRM-----------------------------RLNP
Pvr_Dmel SIYVYVN--DPDTKLVDSH----NVVTA--RQYTDVVIPCKPAMPDTEVLLETS--NGEM
KDR_Mmus TVYVYVR--DYRSPFIASVSDQHGIVYITENKNKTVVIPCRGSISNLNVSLCARYPEKRF
FLT4_Mmus STYVFVR--DFKHPFINKP----DTLLV--NRKDSMWVPCLVSIPGLNITLRSQ--SSAL
FLT1_Mmus SIYIFVS--DAGSPFIEMHTDIPKLVHM--TEGRQLIIPCRVTSPNVTVTLKK-FPFDTL
VEGFR2_Spur DIYVYVNASDANRLFLPSDTTT---ISV--YALDPFILPCRVTVPSTEVNLV--LPNGGV
VEGFR1_Spur KVYVYIS--SPEHLFVPPEWTQ---NNI--YRGQPFVLPCRTTSPNLNVTLVQ-RGTGRD
: :: . :
KDR_Hsap VPDGNRISWDSKKGFTIPSYMI-SYAGMVFCEAKI----NDESYQSIMYIVVVVGYRIYD
FLT4_Hsap WPDGQEVVWDDRRGMLVSTPLL-HDALYLQCETTW----GDQDFLSNPFLVHITGNELYD
FLT1_Hsap IPDGKRIIWDSRKGFIISNATY-KEIGLLTCEATV----NGHLYKTN-YLTHRQTNTIID
CG3277_Dmel NPDGEIT-----------------------------------------------------
Pvr_Dmel HSSKSVGRYDPQRGFTIEIRSI-VDGGDYYCRPNPPFPHNEEEMTSIEVRFIGNGHIDKD
KDR_Mmus VPDGNRISWDSEIGFTLPSYMI-SYAGMVFCEAKI----NDETYQSIMYIVVVVGYRIYD
FLT4_Mmus HPDGQEVLWDDRRGMRVPTQLL-RDALYLQCETTW----GDQNFLSNLFVVHITGNELYD
FLT1_Mmus TPDGQRITWDSRRGFIIANATY-KEIGLLNCEATV----NGHLYQTN-YLTHRQTNTILD
VEGFR2_Spur VSRDELPSYDNKIGFSVSGVEADLYQGDVSCRATY----EGSTVEQTYFVQIIRKPTI--
VEGFR1_Spur ITDHRYHRYDPKKGFHISANHH-ELDGHVCCKAQN----GEHIDRSCFNLNFQEQAPVLE
.
KDR_Hsap VV------LSPSHGIELSVGEKLVLNCTARTELNVGI-DFNWEYPSSKHQHKKLVNRDLK
FLT4_Hsap IQ------LLPRKSLELLVGEKLVLNCTVWAEFNSGV-TFDWDYPGKQAERGKWVPERRS
FLT1_Hsap VQ------ISTPRPVKLLRGHTLVLNCTATTPLNTRV-QMTWSYPDEKNKRASV-RRRI-
CG3277_Dmel ---------------------ELTTNVTLYMEKIPRL-QVRWQD----------------
Pvr_Dmel GKPLPKPVIRSSVEHHVFTDTNFTLDCEQSAYVESVY-GMEWFTPSRDENRIFASQSRTD
KDR_Mmus VI------LSPPHEIELSAGEKLVLNCTARTELNVGL-DFTWHSPPSKSHHKKIVNRDVK
FLT4_Mmus IQ------LYPKKSMELLVGEKLVLNCTVWAEFDSGV-TFDWDYPGKQAERAKWVPERRS
FLT1_Mmus VQ------IRPPSPVRLLHGQTLVLNCTATTELNTRV-QMSWNYPGKATKRASI-RQRI-
VEGFR2_Spur --------LNSTADIKIKEFTKLTLVCEGAQPL---------------------------
VEGFR1_Spur PR------VSISTTEVLEGWEGFSVSCEVSAPADSLLDDLSWDYPAEMIAERQDSNYKIV
:
KDR_Hsap TQ--------SGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGL----M------------
FLT4_Hsap QQ-----------THTELSSILTIHNVSQHDLGSYVCKANNGI----Q------------
FLT1_Hsap DQ--------SNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGP----S------------
CG3277_Dmel --------------------------------------------NLPQ------------
Pvr_Dmel PKT-------RNSTHQTGRSTLTVLNAQPSDTGLYKCVTTDNSNQNVQ------------
KDR_Mmus PF--------PGTVAKMFLSTLTIESVTKSDQGEYTCVASSGR----M------------
FLT4_Mmus QQ-----------THTELSSILTIHNVSQNDLGPYVCEANNGI----Q------------
FLT1_Mmus DR--------SHSHNNVFHSVLKINNVESRDKGLYTCRVKSGS----S------------
VEGFR2_Spur ------------------------------------------------------------
VEGFR1_Spur TDGSTESVRGSSLAMQKYVSTLNVVRAHSYDNGTYVCIATNFW----DSYFAEASINVIG
KDR_Hsap ----------TKK-NSTFVRVHEKPFVAFGSGMESLVEAT--------------------
FLT4_Hsap ----------RFR-ESTEVIVHENPFISVEWLKGPILEAT--------------------
FLT1_Hsap ----------FKS-VNTSVHIYDKAFITVKHRKQQVLETV--------------------
CG3277_Dmel ----------GTS-YNVLVSAVNNSRC---------------------------------
Pvr_Dmel ----------RAT-YRIKVLKQNESYLNVGEPSGHYNVQE--------------------
KDR_Mmus ----------IKR-NRTFVRVHTKPFIAFGSGMKSLVEAT--------------------
FLT4_Mmus ----------RFR-ESTEVIVHEKPFISVEWLKGPVLEAT--------------------
FLT1_Mmus ----------FQS-FNTSVHVYEKGFISVKHRKQPVQETT--------------------
VEGFR2_Spur -------------------------------------IWVHELPDL-EVNIIVSTLR--R
VEGFR1_Spur VTHLKRIGPPRIRSNTTERFLRENSTLEIRCTGGVALEWIY--PEAVRSRVSLGSQACPT
KDR_Hsap ------------------------------------------------------------
FLT4_Hsap ------------------------------------------------------------
FLT1_Hsap ------------------------------------------------------------
CG3277_Dmel ------------------------------------------------------------
Pvr_Dmel ------------------------------------------------------------
KDR_Mmus ------------------------------------------------------------
FLT4_Mmus ------------------------------------------------------------
FLT1_Mmus ------------------------------------------------------------
VEGFR2_Spur PNGDVYYRSILDIDPAQYSNTGYFSCLFLRYIKSEDLSLRTSVYVFVSSDDETRI-----
VEGFR1_Spur CDSNAHFTSTLTVRSARPQDSGQFQCIYSRYVDHINNATAAEINIFVAADNAQLHSKGPP
KDR_Hsap ---------VGER-VRIPAKYLGYPPPEIKWYK-NGIPLE--S----NHT----IKAGHV
FLT4_Hsap ---------AGDELVKLPVKLAAYPPPEFQWYK-DGKALS--G----RHS-------PHA
FLT1_Hsap ---------AGKRSYRLSMKVKAFPSPEVVWLK-DGLPATEKS----ARY----LTRGYS
CG3277_Dmel ---------------------------------------------------------PD-
Pvr_Dmel ---------YANRTIQMTANFEGFPTPSFSWFKPDGTEVRQSE----NNFKILSTELSTM
KDR_Mmus ---------VGSQ-VRIPVKYLSYPAPDIKWYR-NGRPIE--S----NYT----MIVGDE
FLT4_Mmus ---------AGDELVKLPVKLAAYPPPEFQWYK-DRKAVT--G----RHN-------PHA
FLT1_Mmus ---------AGRRSYRLSMKVKAFPSPEIVWLK-DGSPATLKS----ARY----LVHGYS
VEGFR2_Spur -----------------------------FLPK-YATEHIEYNKSNPVT-----------
VEGFR1_Spur IIYVNNSHIIQNEYQNLELRCTGSSTIDWSWPQ-DATERVEQRSIECPTC-PVALQSTST
KDR_Hsap LTIMEVSERDTGNYTVILTNPISKEKQSHVVSL---------------------------
FLT4_Hsap LVLKEVTEASTGTYTLALWNSAAGLRRNISLEL---------------------------
FLT1_Hsap LIIKDVTEEDAGNYTILLSIKQSNVFKNLTATL---------------------------
CG3277_Dmel ------------------------------------------------------------
Pvr_Dmel LQVLNAQLQDSGTYVLRGSNSFGVVQREYNVSV---------------------------
KDR_Mmus LTIMEVTERDAGNYTVILTNPISMEKQSHMVSL---------------------------
FLT4_Mmus LVLKEVTEASAGVYTLALWNSAAGLRQNISLEL---------------------------
FLT1_Mmus LIIKDVTTEDAGDYTILLGIKQSRLFKNLTATL---------------------------
VEGFR2_Spur ------------------------------------------------------------
VEGFR1_Spur LKVSNASYKDTGFYRCFYSRFSDRLTPETSAEVYAYITSDVDAMKLFTINGWYYWAKIIT
KDR_Hsap -------------------------------VV----YVPPQIGEK--------------
FLT4_Hsap -------------------------------VV----NVPPQIHEK--------------
FLT1_Hsap -------------------------------IV----NVKPQIYEK--------------
CG3277_Dmel ------------------------------------------------------------
Pvr_Dmel -------------------------------M-----DAP--------------------
KDR_Mmus -------------------------------VV----NVPPQIGEK--------------
FLT4_Mmus -------------------------------VV----NVPPHIHEK--------------
FLT1_Mmus -------------------------------IV----NVKPQIYEK--------------
VEGFR2_Spur -----VPCRISDPSRLVTFKVFYKDTYKEYLTFYWTYTYDPKVGYLLEPERIDVEAISLI
VEGFR1_Spur GSSYTIPCTVTDPRINVTLEYGNEILSEEGSVI----TYDPRVGFKVPGDYK-HTQYNDN
KDR_Hsap ------------------------------------------SLISPV--DSYQYGTTQT
FLT4_Hsap ------------------------------------------EASS---PSIYSRHSRQA
FLT1_Hsap ------------------------------------------AVSSFPDPALYPLGSRQI
CG3277_Dmel ------------------------------------------------------------
Pvr_Dmel -------------------------------------------ALKMS-DAYVQVGSVAR
KDR_Mmus ------------------------------------------ALISPM--DSYQYGTMQT
FLT4_Mmus ------------------------------------------EASS---PSIYSRHSRQT
FLT1_Mmus ------------------------------------------SVSSLPSPPLYPLGSRQV
VEGFR2_Spur FTCYAITANRTSNQTLPDNDRNLASMTMILDAGANEKPLLKLQVTQ-DKQEVIAYKEGFQ
VEGFR1_Spur LICKARKG-------------NLTQIKKILLNFEPKAPVPAPQIQG---PIEQVKGYTFN
KDR_Hsap LTC--TVY-------AIPPPHHIHWYWQLEE-ECANEP--SQA-----------------
FLT4_Hsap LTC--TAY-------GVPLPLSIQWHWRPWT-PCKMFA--QRS-----------------
FLT1_Hsap LTC--TAY-------GIPQP-TIKWFWHP----CNHNH--SEA-----------------
CG3277_Dmel APC--SEY-------GIKEK-NASAETHSVNLPVNPNLNVESVDCNYMFGCQYQVIVETS
Pvr_Dmel LEC--TVR-------SYPPA-IVTFFFRP----CSLEP--QWPTCSV----------LNQ
KDR_Mmus LTC--TVY-------ANPPLHHIQWYWQLEE-ACSYRP--GQT-----------------
FLT4_Mmus LTC--TAY-------GVPQPLSVQWHWRPWT-PCKTFA--QRS-----------------
FLT1_Mmus LTC--TVY-------GIPRP-TITWLWHP----CHHNH--SKE-----------------
VEGFR2_Spur LNCIGTVAAYLLSLEN-SVEYQPSFAWVR---PGGQRP--TELERK------------YD
VEGFR1_Spur VTC--NVE-------S-PLGIQIRWKWDY---PGLHNP--NANPNNY----------RTE
* .
KDR_Hsap --VSV------TNPYPCEEWR----SVEDFQGGNKIEV----------------------
FLT4_Hsap --LRRRQQQ--DLMPQCRDWR----AVTTQDAVNPIES----------------------
FLT1_Hsap --R----------CDFCSNNEESFILDADSNMGNRIES----------------------
CG3277_Dmel NAMVRRSAR--VYIPQCLEGK----C-SCQLAPTPP------------------------
Pvr_Dmel NFSLPSEQE--KYQFQTRPRP----GKLSVERIYEV------------------------
KDR_Mmus ------------SPYACKEWR----HVEDFQGGNKIEV----------------------
FLT4_Mmus --LRRRQQR--DGMPQCRDWK----EVTTQDAVNPIES----------------------
FLT1_Mmus --R----------YDFCTENEESFILDPSSNLGNRIES----------------------
VEGFR2_Spur EFG-------FDTTTYDAQFI----KFMIVENATLEEDGTYTCYAENIGLALEEEITVQV
VEGFR1_Spur KSSRELQAEVGDSTRAFRRFK----GTLTVFQASPIDNGTYTCTVINNNGNGSTTHAVSI
KDR_Hsap ------------------------------------------------------NKNQFA
FLT4_Hsap ------------------------------------------------------LDTWTE
FLT1_Hsap ------------------------------------------------------ITQRMA
CG3277_Dmel ------------------------------------------------------------
Pvr_Dmel ------------------------------------------------------------
KDR_Mmus ------------------------------------------------------TKNQYA
FLT4_Mmus ------------------------------------------------------LDSWTE
FLT1_Mmus ------------------------------------------------------ISQRMT
VEGFR2_Spur HARGYAGISHRYNATDPSTNLTAIVNHPKCISFDVPAYPPPQVKLSPQRNWVLTM-----
VEGFR1_Spur LDQGYIHMEPLKGELMQLVSGEEHAKDRDRIMVHLKYFPNADFTWFKDGIEVDALDQYLF
KDR_Hsap LIEGKNK-TVSTLVIQAANVSALYKCEAVNKVGRGERV-I-S--FHVTRGPE-ITL---Q
FLT4_Hsap FVEGKNK-TVSKLVIQNANVSAMYKCVVSNKVGQDERL-I-Y--FYVTTIPDGFTIE-SK
FLT1_Hsap IIEGKNK-MASTLVVADSRISGIYICIASNKVGTVGRN-I-S--FYITDVPNGFHV---N
CG3277_Dmel --------------KVLA--------VAK-------------ML-SNETISINLSILA--
Pvr_Dmel --------------SFLPTEPGILTCIAQNIIDGKERRTLTKAHVLLGNISENMTIYGFD
KDR_Mmus LIEGKNK-TVSTLVIQAANVSALYKCEAINKAGRGERV-I-S--FHVIRGPE-ITV---Q
FLT4_Mmus FVEGKNK-TVSKLVIQDANVSAMYKCVVVNKVGQDERL-I-Y--FYVTTIPDGFSIE-SE
FLT1_Mmus VIEGTNK-TVSTLVVADSQTPGIYSCRAFNKIGTVERN-I-K--FYVTDVPNGFHV---S
VEGFR2_Spur --DSSTKILSMCSPNVSEAHEGDYTVYVWNEYENATIS-F-F--FSVQDTAAGVSIS-TG
VEGFR1_Spur KSRIKQDVAQVKLLNINAQHAGNYTLIGDNGDVQESVT-I-R--VVVHDVEEGLTIE-GQ
. :
KDR_Hsap PDMQPT-EQESVSLWCTADRSTFE-NLTWYKLGPQP-LPIHVGELPTPVCKNLDTL---W
FLT4_Hsap PSEELL-EGQPVLLSCQADSYKYE-HLRWYRLNLST-LHDAHGNPLLLDCKNVHLFATPL
FLT1_Hsap LEKMPT-EGEDLKLSCTVNKFLYR-DVTWILLRTVNNRTMHYSIS---------------
CG3277_Dmel ---------S-ELLRKEQDSHLHE-TLRTYKMQLN-EL----------------------
Pvr_Dmel KDHKIA-KEDNVNFTCEALAYHFDGNLKWFINGED-LK---ESDS---------------
KDR_Mmus PAAQPT-EQESVSLLCTADRNTFE-NLTWYKLGSQA-TSVHMGESLTPVCKNLDAL---W
FLT4_Mmus PSEDPL-EGQSVRLSCRADNYTYE-HLRWYRLNLST-LHDAQGNPLLLDCKNVHLFATPL
FLT1_Mmus LEKMPA-EGEDLKLSCVVNKFLYR-DITWILLRTVNNRTMHHSIS---------------
VEGFR2_Spur S-DIAY-ISDDLTLECHATVFFFT-EIKWVFISPNG-TDV-------------WLNSSAP
VEGFR1_Spur EETTIVEEKGNLTLHCKSSSHIFD-NIKWLVVRSHG-STN-ESR---------LLRPREE
: . :
KDR_Hsap KLNATMFSNSTN-------------DILIMELKNASLQDQGDYVCLAQDRK-TKKRHCVV
FLT4_Hsap AASLEEVAPGARH------------ATLSLSIPRVAPEHEGHYVCEVQDRR-SHDKHCHK
FLT1_Hsap KQ--KMAITKEHS------------ITLNLTIMNVSLQDSGTYACRARNVY-TGEEILQK
CG3277_Dmel --NFR-ATPKGFEGVMKLGLGTQLKEKASLSLQAVIIDPTG-------------------
Pvr_Dmel -VHIE-TSHTKYS------------YKSTVHITTISDRDRGTYECRAYHNDKDAAYSSRE
KDR_Mmus KLNGTMFSNSTN-------------DILIVAFQNASLQDQGDYVCSAQDKK-TKKRHCLV
FLT4_Mmus EANLEEAEPGARH------------ATLSLNIPRVAPEDEGDYVCEVQDRR-SQDKHCHK
FLT1_Mmus KQ--KMATTQDYS------------ITLNLVIKNVSLEDSGTYACRARNIY-TGEDILRK
VEGFR2_Spur KYSFPL----Y-S------------LVSTLLVTNVSFSDAGSYVCVATNGS-NPNWEKNA
VEGFR1_Spur RVTITSYSDGD-F------------NVTQLHIQDMGRSDDGIYICLAHSVLDSRDTKEVE
: . *
KDR_Hsap RQLTVLERVAPTITGNLEN----QTTSIG-ESIEVSCT-ASGNPPPQIMWFKDNETLVE-
FLT4_Hsap KYLSVQALEAPRLTQNLTD----LLVNVS-DSLEMQCL-VAGAHAPSIVWYKDERLLEE-
FLT1_Hsap KEITIRDQEAPYLLRNLSD----HTVAIS-SSTTLDCH-ANGVPEPQITWFKNNHKIQQ-
CG3277_Dmel -------CEGPRSVT----KVPEQLHNC--------------------------------
Pvr_Dmel IDLYVHDPSAPQWTNGGQEGHSKIKRKLS-QTLELECA-STAVPVAIVRWFKDDKEVTE-
KDR_Mmus KQLIILERMAPMITGNLEN----QTTTIG-ETIEVTCP-ASGNPTPHITWFKDNETLVE-
FLT4_Mmus KYLSVQALEAPRLTQNLTD----LLVNVS-DSLEMRCP-VAGAHVPSIVWYKDERLLEK-
FLT1_Mmus TEVLVRDSEAPHLLQNLSD----YEVSIS-GSTTLDCQ-ARGVPAPQITWFKNNHKIQQ-
VEGFR2_Spur SQ-VISVRELPKLKIEIGD----SEVKAG-ENVTIRCFLVRGHPIPKVQLKKENVQVYL-
VEGFR1_Spur AAVQVQAIRVPEMIMGLET----EEINKSLKDFTLECE-ASGFPTPKITWFKDGSKLEIK
*
KDR_Hsap DSGIVLKDGNR--NLTIRRVRKEDEGLYTCQACSVLGCAK-VEAFFIIEGAQ---EKTNL
FLT4_Hsap KSGVDLADSNQ--KLSIQRVREEDAGRYLCSVCNAKGCVN-SSASVAVEGSE---DKGSM
FLT1_Hsap EPGIILGPGSS--TLFIERVTEEDEGVYHCKATNQKGSVE-SSAYLTVQGTS---DKSNL
CG3277_Dmel -----------------------DERHADCHYPSWPDYAASSSPKSQDNG---Q------
Pvr_Dmel SKLRHIIEKES--KLLITHLYPGDEGVYKCVVENRLDRIE-RSFTVVISD---L------
KDR_Mmus DSGIVLRDGNR--NLTIRRVRKEDGGLYTCQACNVLGCAR-AETLFIIEGAQ---EKTNL
FLT4_Mmus ESGIDLADSNQ--RLSIQRVREEDAGRYLCSVCNAKGCVN-SSASVAVEGSE---DKGSM
FLT1_Mmus EPGIILGPGNS--TLFIERVTEEDEGVYRCRATNQKGAVE-SAAYLTVQGTS---DKSNL
VEGFR2_Spur WQGV----GN--ISYTLTA-DINAGGNYYCEALDANSTSE-YA-ELVIEQPP----PGIL
VEGFR1_Spur DSTVVLPNDHAVSTLRRTRINMVDSGLYCCVASNAGGQVN-SSAVIIILEEPYMRVKEDV
* . .
KDR_Hsap EIIILVGTAVI-------------------------------------------------
FLT4_Hsap EIVILVGTGVI-------------------------------------------------
FLT1_Hsap ELITLTCTCVA-------------------------------------------------
CG3277_Dmel ------------------------------------------------------------
Pvr_Dmel PGISMAWVWFG-------------------------------------------------
KDR_Mmus EVIILVGTAVI-------------------------------------------------
FLT4_Mmus EIVILIGTGVI-------------------------------------------------
FLT1_Mmus ELITLTCTCVA-------------------------------------------------
VEGFR2_Spur ERILPYLVSII-------------------------------------------------
VEGFR1_Spur KLVAMGGTANITCHDGGNPKPTIVWYHQPKDQASEMRILPAQMYNSTEGVLVLHDVQKDQ
KDR_Hsap -----------------------------------------AMFFWLL-----LVIILRT
FLT4_Hsap -----------------------------------------AVFFWVL-----LLLIFCN
FLT1_Hsap -----------------------------------------ATLFWLL-----LTLFIRK
CG3277_Dmel ------------------------------------------------------------
Pvr_Dmel -----------------------------------------VILFLIL-----IGLCVFL
KDR_Mmus -----------------------------------------AMFFWLL-----LVIVLRT
FLT4_Mmus -----------------------------------------AVFFWVL-----LLLIFCN
FLT1_Mmus -----------------------------------------ATLFWLL-----LTLFIRK
VEGFR2_Spur -----------------------------------------CVIFLII-----LIYCMYK
VEGFR1_Spur QGTYLCNATNRLGSSTRTVSIKLDMPRPILGPGDVKRNTALGVVFVLLLVVVALIIVIFK
KDR_Hsap V----K--RANGGE--------LKTGYLSIVMDPD--------ELPLDEHCERLPYDASK
FLT4_Hsap M----R--RPAHAD--------IKTGYLSIIMDPG--------EVPLEEQCEYLSYDASQ
FLT1_Hsap M----K--RSS-SE--------IKTDYLSIIMDPD--------EVPLDEQCERLPYDASK
CG3277_Dmel ----------------AAQAG-------A-DLHPD--------LRHLRHRKSQVLGLADI
Pvr_Dmel AVRYQKEHKR-HLALKAAGLANFEEGAVG-HINPD---------LTLDEQAELLPYN-RE
KDR_Mmus V----K--RANEGE--------LKTGYLSIVMDPD--------ELPLDERCERLPYDASK
FLT4_Mmus M----K--RPAHAD--------IKTGYLSIIMDPG--------EVPLEEQCEYLSYDASQ
FLT1_Mmus L----K--RSS-SE--------VKTDYLSIIMDPD--------EVPLDEQCERLPYDASK
VEGFR2_Spur Y----R--RRP-KV--------RRASRLPPIEMPRFGSNRRSIYSVSDDPYENIAYN-QR
VEGFR1_Spur I----KKLRPKYIA--------GGDDMLLPISFGQ--------YNDLLDICEHLPYD-SK
. . :
KDR_Hsap WEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSEL
FLT4_Hsap WEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSEL
FLT1_Hsap WEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTEL
CG3277_Dmel FEVPHSAIQIGRMLGEGAFGQVHEATAINLRRMRGTTIVAVKQLKPNPKADEVAEYLAEI
Pvr_Dmel FEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSEL
KDR_Mmus WEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKMLKEGATHSEHRALMSEL
FLT4_Mmus WEFPRERLHLGRVLGHGAFGKVVEASAFGINKGSSCDTVAVKMLKEGATASEHRALMSEL
FLT1_Mmus WEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTEL
VEGFR2_Spur WEFPRERLKLGGVIGKGAFGMVIKAVAVGIDGTENNITVAVKKLKSGATSLEKKALWAEL
VEGFR1_Spur WEFPRERLKIGPVIGRGAFGRVMRSSAFGIDKVDTCTTVAVKMLKD--------------
:*..:. :::* :* **** * .. * .: **** :*
KDR_Hsap KILIHIGHHLNVVNLLGACTKP--GGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGAR
FLT4_Hsap KILIHIGNHLNVVNLLGACTKP--QGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPE
FLT1_Hsap KILTHIGHHLNVVNLLGACTKQ--GGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALH
CG3277_Dmel EMLKGVGTHHNVVSFLGCCTIK---PPYLMIMEYVNKGNLLSYLRTVRKEASKLRNRNAN
Pvr_Dmel KIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTD
KDR_Mmus KILIHIGHHLNVVNLLGACTKP--GGPLMVIVEFCKFGNLSTYLRGKRNEFVPYKSKGAR
FLT4_Mmus KILIHIGNHLNVVNLLGACTKP--NGPLMVIVEFCKYGNLSNFLRVKRDTFNPYAEKSPE
FLT1_Mmus KILTHIGHHLNVVNLLGACTKQ--GGPLMVIVEYCKYGNLSNYLKSKRDLFCLNKDAALH
VEGFR2_Spur KMLGHIGKHLNVVNFLGACTQ---NGPVLAIVEFCCHGNLLDFLRSKRKYFSETPEGTGS
VEGFR1_Spur ---------------------------LFVISEFCPFGNLSDYLKTKRKNYVAEPDLLAI
: * *: **: :* *.
KDR_Hsap F-RQG--KDYV------------G------------------A--IPVDLKRRLDSITSS
FLT4_Hsap Q-RGR--FRAMV-----------E-----------------------LARLDRRRPG-SS
FLT1_Hsap M-EPK--KEKME-----------P------------------G--LEQGKKPRLDSVTSS
CG3277_Dmel Y-T------------------------------------------SCRPIMTRTNST-SS
Pvr_Dmel HIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSD-ND
KDR_Mmus F-RQG--KDYV------------G------------------E--LSVDLKRRLDSITSS
FLT4_Mmus Q-RRR--FRAMV-----------E-----------------------GAKADRRRPG-SS
FLT1_Mmus M-ELK--KESLE-----------P------------------G--LEQGQKPRLDSVSSS
VEGFR2_Spur --------------------------------------------------QSHTG-H-SS
VEGFR1_Spur -----------A-----------C-----------------------MGPVDRSS-R-GS
: ..
KDR_Hsap QSSASSGFVEEKS-------------L-S---DVEE------------------------
FLT4_Hsap DRVLFARFSKTEGG------------A-R---RASP------------------------
FLT1_Hsap ESFASSGFQEDKS-------------L-S---DVEE------------------------
CG3277_Dmel PKSQSVNYIELKAS-------------SQ-TIEMPQEDSTAHMNGIRQPHPSFAESKLVA
Pvr_Dmel PRSGTRAGRTGSGTATYSYDRQMDTCATV-MTTVPEDDQIMS------------------
KDR_Mmus QSSASSGFVEEKS-------------L-S---DVEE------------------------
FLT4_Mmus DRALFTRFLMGKGS------------A-R---RAPL------------------------
FLT1_Mmus -SVTSSSFPEDRS-------------V-S---DVEG------------------------
VEGFR2_Spur STGASNTFQTSSGS---------ERRMKAVYDQIIP------------------------
VEGFR1_Spur SRGGGDGFMGARGG--------------S-TLEVGD------------------------
.
KDR_Hsap ---------------------EEAPEDLY-KDFLTLEHLICYSFQVAKGMEFLASRKCIH
FLT4_Hsap ---------------------DQEAEDLW-LSPLTMEDLVCYSFQVARGMEFLASRKCIH
FLT1_Hsap ---------------------EEDSDGFY-KEPITMEDLISYSFQVARGMEFLSSRKCIH
CG3277_Dmel LGLTSWAKSVNENLISATY-TIVEDEDAF-EYILDNKELHNFALQIANGMRFLEEQEITH
Pvr_Dmel -----------NNSVQPAWRSNYKTDSTE-AMTVTTVDLISWAFQVARGMDYLSSKKVLH
KDR_Mmus ---------------------EEASEELY-KDFLTLEHLICYSFQVAKGMEFLASRKCIH
FLT4_Mmus ---------------------VQEAEDLW-LSPLTMEDLVCYSFQVARGMEFLASRKCIH
FLT1_Mmus ---------------------DEDYSEIS-KQPLTMEDLISYSFQVARGMEFLSSRKCIH
VEGFR2_Spur ---------------------EEVFSPLQ-DDPINSQDLLCYSFQVARGMEFLASKNVIH
VEGFR1_Spur ---------------------DDVFEYMEKEQPLTLKDLICYSYQVARGMEFLTSKKCIH
. : .* :: *:*.** :* .:: *
KDR_Hsap RDLAARNILLSEKNVVKICDFGLARD-IYKDPDYVRKG-DARLPLKWMAPETIFDRVYTI
FLT4_Hsap RDLAARNILLSESDVVKICDFGLARD-IYKDPDYVRKG-SARLPLKWMAPESIFDKVYTT
FLT1_Hsap RDLAARNILLSENNVVKICDFGLARD-IYKNPDYVRKG-DTRLPLKWMAPESIFDKIYST
CG3277_Dmel RDLAARNVLIDSNKTLKISDFGLSRHGIYT-----NTR-TRKLPLRWLSIEAIRENVYSS
Pvr_Dmel GDLAARNILLCEDNVVKICDFGLARS-MYRGDNYKKSE-NGKLPIKWLALESLSDHVFST
KDR_Mmus RDLAARNILLSEKNVVKICDFGLARD-IYKDPDYVRKG-DARLPLKWMAPETIFDRVYTI
FLT4_Mmus RDLAARNILLSESDIVKICDFGLARD-IYKDPDYVRKG-SARLPLKWMAPESIFDKVYTT
FLT1_Mmus RDLAARNILLSENNVVKICDFGLARD-IYKNPDYVRRG-DTRLPLKWMAPESIFDKVYST
VEGFR2_Spur RDLAARNVLVTENYTLKICDFGLAKH-LYDDPDYVASGKQGRLPIKWMAPESIFDKVFTT
VEGFR1_Spur RDLAARNVLLAENNIVKICDFGLARD-IYSDPDYVTQT-GGRLPIKWMAPESIFDKVFTI
******:*: .. :**.****:: :* :**::*:: *:: :.:::
KDR_Hsap QSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWH
FLT4_Hsap QSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWS
FLT1_Hsap KSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWH
CG3277_Dmel KSDIWAYGVVLWEIGTLGASPYPTISND-ELIPFLMAGNRLERPEICTPQVYTIMLQCWL
Pvr_Dmel YSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWR
KDR_Mmus QSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWH
FLT4_Mmus QSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLKDGTRMRAPELATPAIRHIMQSCWS
FLT1_Mmus KSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLKEGMRMRTPEYATPEIYQIMLDCWH
VEGFR2_Spur YSDVWAYAVFLWEVFSLGGSPYPGIQIDEKFYNKIKNGYRMNAPDYAPPGVYDTMLECWT
VEGFR1_Spur YSDVWSFGVFMWECFALGGSPYPGVVVDEEFYNRLKSGYRMYTPDYAPIEIYHVMLDCWH
**:*::.:.:** :*. *** : : .: : * *: *. : * .**
KDR_Hsap GEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSME------EDSGLSLPTS-
FLT4_Hsap GDPKARPAFSELVEILGDLLQGRGLQEEEEVCM-APRSSQSSE------EGSFSQVSTM-
FLT1_Hsap RDPKERPRFAELVEKLGDLLQANVQQDGKDYI--PINAILTG--------NSGFTYSTP-
CG3277_Dmel EEPEERPTFDALYKVLSPKT------TYVDINS----------------------LSDD-
Pvr_Dmel KNPESRPLFAELEKRFANMLGEDVASHYLDLNN-PYM---QSN------IEYMKKQSTD-
KDR_Mmus EDPNQRPSFSELVEHLGNLLQANAQQDGKDYIVLPMSETLSME------EDSGLSLPTS-
FLT4_Mmus GDPKARPAFSDLVEILGDLLQGGGWQEEEEERM-ALHSSQSSE------EDGFMQASTT-
FLT1_Mmus KDPKERPRFAELVEKLGDLLQANVQQDGKDYI--PLNAILTR--------NSGFTYSTP-
VEGFR2_Spur PEPEARPSFSILAVRLGDMLEANVASDYIELNM-PFEQAN---------NEILQELPS--
VEGFR1_Spur TEPKERPHFSELVHKLGDQLAANVKQEYLDLDC-AYDEQVASRPISFYNEDEEEDASTSH
:*. ** * * :. : .
KDR_Hsap ----PVS-C-MEEEEV-CDPKFHYDNTAGI----------SQYLQNSKR-----------
FLT4_Hsap ----ALH-I-AQADAEDSPPSLQR-HSLAA-----------RYYNWVSFPGCLARG----
FLT1_Hsap ----AFSED-FFKESI-SAPKFNSGSSDDV-----------RYVNAFKF-----------
CG3277_Dmel ----YV------------------------------------------------------
Pvr_Dmel ----YLA---LMGSPDELAP-------AAP-----------RYVNGHIVP----------
KDR_Mmus ----PVS-C-MEEEEV-CDPKFHYDNTAGI----------SHYLQNSKR-----------
FLT4_Mmus ----ALH-I-TEADADDSPPSMHC-HSLAA-----------RYYNCVSFPGRLARG----
FLT1_Mmus ----TFSED-LFKDGF-ADPHFHSGSSDDV-----------RYVNAFKF-----------
VEGFR2_Spur -----PHEH---------TPL-------LQPHPPTHFKP---------------------
VEGFR1_Spur DGQVTLGEDALQVEADISLPSTS-GYQPNHPSTSSTFQLEDERPVCASLEGRTVSSIHAS
KDR_Hsap -----------------KSRPVSVKTFEDIPLEEPEVKVIPDD-NQTDSGMVLASEELKT
FLT4_Hsap ---------------AETRGSSRMKTFEEFPMT-PTTYKGSVD-NQTDSGMVLASEEFEQ
FLT1_Hsap -----------------M-SLERIKTFEELL---PNATSMFDD-YQGDSSTLLASPMLKR
CG3277_Dmel ------------------------------------------------------------
Pvr_Dmel -------------------DI----RIEELP---DDYMEMSRD-SDPDACTAIFSPTRLE
KDR_Mmus -----------------KSRPVSVKTFEDIPLEEPEVKVIPDD-SQTDSGMVLASEELKT
FLT4_Mmus ---------------TKTPGSSRMKTFEELPMT-PTTYKASMD-NQTDSGMVLASEEFEE
FLT1_Mmus -----------------M-SLERIKTFEELS---PNSTSMFED-YQLDTSTLLGSPLLKR
VEGFR2_Spur -------SP-ANSTP---NT-------------PPVT-----------THMV-PSDSGVS
VEGFR1_Spur LTDISSSEPCDEEDDTGGESTKSSTTSARLPLHRPNSLSALDSLQQTMTNPVFHHHHHHH
KDR_Hsap L-----------------EDRTKLSPSFG-G-------------------------MVPS
FLT4_Hsap I-----------------ESRHRQESGFS-C-------------------------KGPG
FLT1_Hsap FTWT--------------DSKPKASLKID-L-------------------------RVTS
CG3277_Dmel ------------------------------------------------------------
Pvr_Dmel GESSDFPDFSSETTFNFPGARQSPTLSNN-LNSGSSKPLRKKNGMPTVDVADQAPEEIPM
KDR_Mmus L-----------------EDRNKLSPSFG-G-------------------------MMPS
FLT4_Mmus L-----------------ESRHRPEGSFS-C-------------------------KGPG
FLT1_Mmus FTWT--------------ETKPKASMKID-L-------------------------RIAS
VEGFR2_Spur A-----------------QDRDPSLPSNGMG-------------------------SQPF
VEGFR1_Spur H-----------------SSNHHHHHNHG-N-------------------------NSTS
KDR_Hsap KSRESV----ASEG--SNQTSGYQ---SG--------------YHSDDTDTTVYSSEEA-
FLT4_Hsap QNVAVTRAHPDSQGRRRRPERGAR---G---------------------GQVFYNSEYG-
FLT1_Hsap KSKESG----LSDV--SRPSFCHS---SC--------------GHVSEG-KRRFTYDHA-
CG3277_Dmel ------------------------------------------------------------
Pvr_Dmel LHRSST----GSDG---SPEQGRR---FNQALKQQYVTPTPSPRHHVETKLNGEPSENYV
KDR_Mmus KSRESV----ASEG--SNQTSGYQ---SG--------------YHSDDTDTTVYSSDEA-
FLT4_Mmus QHMDIPRGHPDPQGRRRRPTQGAQ---G---------------------GKVFYNNEYG-
FLT1_Mmus KSKEAG----LSDL--PRPSFCFS---SC--------------GHIRP-----VQDDES-
VEGFR2_Spur LSKDAV----QNNT--TVQEINELEEEMN--------------SHEDDV----FLAPEA-
VEGFR1_Spur KSEESV----SSDS--S---SGFR---SG--------------GYGSDV----NDEPPP-
KDR_Hsap ELLKLI----------EIGVQTGS-TAQILQPD-----SGTTLSSPPV
FLT4_Hsap ELSEPS-------------------EEDHCSPSA----RVTFFTDNSY
FLT1_Hsap ELERKI----------A---------CCSPPPDY---NSVVLYSTPPI
CG3277_Dmel ------------------------------FP---------PISENRE
Pvr_Dmel NMKPPRKNIPGKTTTGGGGAAAGASTEAFSNPSYQPLSTVNEKEQRRY
KDR_Mmus GLLKMV----------D----------AAVHAD-----SGTTLRSPPV
FLT4_Mmus EVSQPC-------------------TEGDCCPSA----GSTFFADSSY
FLT1_Mmus ELGKE-----------S---------CCSPPPDY---NSVVLYSSPPA
VEGFR2_Spur TTNGLT----------GT--------------------H--TEAHLTV
VEGFR1_Spur EYSKVM----------QVALH----------KET---SLFWPRGTNGQ